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Protein

Rho GDP-dissociation inhibitor 3

Gene

ARHGDIG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • Rho GDP-dissociation inhibitor activity Source: ProtInc

GO - Biological processi

  • negative regulation of cell adhesion Source: ProtInc
  • regulation of protein localization Source: Ensembl
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • Rho protein signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GDP-dissociation inhibitor 3
Short name:
Rho GDI 3
Alternative name(s):
Rho-GDI gamma
Gene namesi
Name:ARHGDIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:680. ARHGDIG.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: ProtInc
  • cytosol Source: Reactome
  • membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24965.

Polymorphism and mutation databases

BioMutaiARHGDIG.
DMDMi38258951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Rho GDP-dissociation inhibitor 3PRO_0000219018Add
BLAST

Proteomic databases

PaxDbiQ99819.
PRIDEiQ99819.

PTM databases

PhosphoSiteiQ99819.

Expressioni

Tissue specificityi

Primarily expressed in pancreas and brain.

Gene expression databases

BgeeiENSG00000242173.
CleanExiHS_ARHGDIG.
ExpressionAtlasiQ99819. baseline and differential.
GenevisibleiQ99819. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP170P1Q96L143EBI-10295284,EBI-743488
KXD1Q9BQD33EBI-10295284,EBI-739657

Protein-protein interaction databases

BioGridi106891. 11 interactions.
IntActiQ99819. 2 interactions.
STRINGi9606.ENSP00000219409.

Structurei

3D structure databases

ProteinModelPortaliQ99819.
SMRiQ99819. Positions 48-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho GDI family.Curated

Phylogenomic databases

eggNOGiKOG3205. Eukaryota.
ENOG4111K44. LUCA.
GeneTreeiENSGT00390000006233.
HOGENOMiHOG000175765.
HOVERGENiHBG000206.
InParanoidiQ99819.
KOiK12462.
OMAiMLGLDAC.
OrthoDBiEOG091G0MBU.
PhylomeDBiQ99819.
TreeFamiTF105387.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view]
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiPF02115. Rho_GDI. 1 hit.
[Graphical view]
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLDACELG AQLLELLRLA LCARVLLADK EGGPPAVDEV LDEAVPEYRA
60 70 80 90 100
PGRKSLLEIR QLDPDDRSLA KYKRVLLGPL PPAVDPSLPN VQVTRLTLLS
110 120 130 140 150
EQAPGPVVMD LTGDLAVLKD QVFVLKEGVD YRVKISFKVH REIVSGLKCL
160 170 180 190 200
HHTYRRGLRV DKTVYMVGSY GPSAQEYEFV TPVEEAPRGA LVRGPYLVVS
210 220
LFTDDDRTHH LSWEWGLCIC QDWKD
Length:225
Mass (Da):25,098
Last modified:October 31, 2003 - v2
Checksum:iAFC4576E6BE0E9BD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141D → N (PubMed:9113980).Curated
Sequence conflicti114 – 1141D → N (PubMed:9787082).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82532 mRNA. Translation: AAC33138.1.
AF080237 Genomic DNA. Translation: AAC72354.1.
AB127078 mRNA. Translation: BAE48733.1.
AF498928 mRNA. Translation: AAM21076.1.
AE006463 Genomic DNA. Translation: AAK61222.1.
Z69667 Genomic DNA. Translation: CAI95584.1.
BC047699 mRNA. Translation: AAH47699.1.
CCDSiCCDS10404.1.
RefSeqiNP_001167.2. NM_001176.3.
UniGeneiHs.647388.

Genome annotation databases

EnsembliENST00000219409; ENSP00000219409; ENSG00000242173.
GeneIDi398.
KEGGihsa:398.
UCSCiuc002cgm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82532 mRNA. Translation: AAC33138.1.
AF080237 Genomic DNA. Translation: AAC72354.1.
AB127078 mRNA. Translation: BAE48733.1.
AF498928 mRNA. Translation: AAM21076.1.
AE006463 Genomic DNA. Translation: AAK61222.1.
Z69667 Genomic DNA. Translation: CAI95584.1.
BC047699 mRNA. Translation: AAH47699.1.
CCDSiCCDS10404.1.
RefSeqiNP_001167.2. NM_001176.3.
UniGeneiHs.647388.

3D structure databases

ProteinModelPortaliQ99819.
SMRiQ99819. Positions 48-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106891. 11 interactions.
IntActiQ99819. 2 interactions.
STRINGi9606.ENSP00000219409.

PTM databases

PhosphoSiteiQ99819.

Polymorphism and mutation databases

BioMutaiARHGDIG.
DMDMi38258951.

Proteomic databases

PaxDbiQ99819.
PRIDEiQ99819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219409; ENSP00000219409; ENSG00000242173.
GeneIDi398.
KEGGihsa:398.
UCSCiuc002cgm.2. human.

Organism-specific databases

CTDi398.
GeneCardsiARHGDIG.
HGNCiHGNC:680. ARHGDIG.
MIMi602844. gene.
neXtProtiNX_Q99819.
PharmGKBiPA24965.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3205. Eukaryota.
ENOG4111K44. LUCA.
GeneTreeiENSGT00390000006233.
HOGENOMiHOG000175765.
HOVERGENiHBG000206.
InParanoidiQ99819.
KOiK12462.
OMAiMLGLDAC.
OrthoDBiEOG091G0MBU.
PhylomeDBiQ99819.
TreeFamiTF105387.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

GeneWikiiARHGDIG.
GenomeRNAii398.
PROiQ99819.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242173.
CleanExiHS_ARHGDIG.
ExpressionAtlasiQ99819. baseline and differential.
GenevisibleiQ99819. HS.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view]
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiPF02115. Rho_GDI. 1 hit.
[Graphical view]
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGDIR3_HUMAN
AccessioniPrimary (citable) accession number: Q99819
Secondary accession number(s): Q4TT69, Q96S29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 31, 2003
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.