Reviewed, UniProtKB/Swiss-Prot Q99819 (GDIR3_HUMAN)

Names and origin

Protein names

Recommended name:
    Rho GDP-dissociation inhibitor 3
      Short name=Rho GDI 3
Alternative name(s):
    Rho-GDI gamma

Gene names

Name:

ARHGDIG

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.
Subcellular location	Cytoplasm.
Tissue specificity	Primarily expressed in pancreas and brain.
Sequence similarities	Belongs to the Rho GDI family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	GTPase activation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Rho protein signal transduction Ref.1 Traceable author statement. Source: ProtInc negative regulation of cell adhesion Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasmic membrane-bounded vesicle Ref.1 Traceable author statement. Source: ProtInc
Molecular function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW Rho GDP-dissociation inhibitor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Rho GDP-dissociation inhibitor 3		PRO_0000219018
Experimental info
	Sequence conflict	114	1	D → N Ref.1
	Sequence conflict	114	1	D → N Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q99819-1 [UniParc]. Last modified October 31, 2003. Version 2. Checksum: AFC4576E6BE0E9BD	FASTA	225	25,098
	10 20 30 40 50 60 MLGLDACELG AQLLELLRLA LCARVLLADK EGGPPAVDEV LDEAVPEYRA PGRKSLLEIR 70 80 90 100 110 120 QLDPDDRSLA KYKRVLLGPL PPAVDPSLPN VQVTRLTLLS EQAPGPVVMD LTGDLAVLKD 130 140 150 160 170 180 QVFVLKEGVD YRVKISFKVH REIVSGLKCL HHTYRRGLRV DKTVYMVGSY GPSAQEYEFV 190 200 210 220 TPVEEAPRGA LVRGPYLVVS LFTDDDRTHH LSWEWGLCIC QDWKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas." Adra C.N., Manor D., Ko J.L., Zhu S., Horiuchi T., van Aelst L., Cerione R.A., Lim B. Proc. Natl. Acad. Sci. U.S.A. 94:4279-4284(1997) [PubMed: 9113980] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3." Adra C.N., Iyengar A.R., Syed F.A., Kanaan I.N., Rilo H.L.R., Yu W., Kheraj R., Lin S.R., Horiuchi T., Khan S., Weremowicz S., Lim B., Morton C.C., Higgs D.R. Genomics 53:104-109(1998) [PubMed: 9787082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"A human polycistronic mRNA composed of ARHGDIG and PDIP." Hayashi A., Tabata Y., Sato S., Mitsuyama M., Kanai S., Furuya T., Saito T. Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U82532 mRNA. Translation: AAC33138.1. AF080237 Genomic DNA. Translation: AAC72354.1. AB127078 mRNA. Translation: BAE48733.1. AF498928 mRNA. Translation: AAM21076.1. AE006463 Genomic DNA. Translation: AAK61222.1. Z69667 Genomic DNA. Translation: CAI95584.1. BC047699 mRNA. Translation: AAH47699.1.
IPI	IPI00018435.
RefSeq	NP_001167.2.
UniGene	Hs.647388
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q99819.
Genome annotation databases
Ensembl	ENST00000219409; ENSP00000219409; ENSG00000242173; Homo sapiens. [Genome view]
GeneID	398.
KEGG	hsa:398.
UCSC	uc002cgm.1. human.
Organism-specific databases
CTD	398.
GeneCards	GC16P000270.
H-InvDB	HIX0079747. HIX0079838.
HGNC	HGNC:680. ARHGDIG.
MIM	602844. gene.
PharmGKB	PA24965.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q99819.
OMA	VVTSFFT.
Enzyme and pathway databases
Reactome	REACT_11044. Signaling by Rho GTPases.
Gene expression databases
ArrayExpress	Q99819.
Bgee	Q99819.
CleanEx	HS_ARHGDIG.
Genevestigator	Q99819.
GermOnline	ENSG00000206156. Homo sapiens.
Family and domain databases
InterPro	IPR014756. Ig_E-set. IPR000406. Rho_GDI. [Graphical view]
Gene3D	G3DSA:2.70.50.30. Rho_GDI. 1 hit.
PANTHER	PTHR10980. Rho_GDI. 1 hit.
Pfam	PF02115. Rho_GDI. 1 hit. [Graphical view]
PRINTS	PR00492. RHOGDI.
ProtoNet	Search...
Other Resources
NextBio	1669.
SOURCE	Search...

Entry information

Entry name

GDIR3_HUMAN

Accession

Primary (citable) accession number: Q99819
Secondary accession number(s): Q4TT69, Q96S29

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	October 31, 2003
Last modified:	December 15, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.