##gff-version 3 Q99816 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22814378;Dbxref=PMID:19413330,PMID:22814378 Q99816 UniProtKB Chain 2 390 . . . ID=PRO_0000082606;Note=Tumor susceptibility gene 101 protein Q99816 UniProtKB Domain 2 145 . . . Note=UEV;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00652 Q99816 UniProtKB Domain 322 390 . . . Note=SB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00644 Q99816 UniProtKB Region 158 162 . . . Note=Interaction with CEP55 Q99816 UniProtKB Region 198 220 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99816 UniProtKB Coiled coil 235 316 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q99816 UniProtKB Motif 320 323 . . . Note=PTAP motif Q99816 UniProtKB Compositional bias 199 220 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99816 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22814378;Dbxref=PMID:19413330,PMID:22814378 Q99816 UniProtKB Modified residue 220 220 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q99816 UniProtKB Alternative sequence 15 119 . . . ID=VSP_004440;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q99816 UniProtKB Natural variant 167 167 . . . ID=VAR_034572;Note=M->I;Dbxref=dbSNP:rs34385327 Q99816 UniProtKB Mutagenesis 43 43 . . . Note=Reduces interaction with ubiquitin%3B inhibits down-regulation of EGFR. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12006492;Dbxref=PMID:12006492 Q99816 UniProtKB Mutagenesis 45 45 . . . Note=Reduces interaction with ubiquitin. No effect on MGRN1-binding. N->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12006492,ECO:0000269|PubMed:12802020,ECO:0000269|PubMed:17229889;Dbxref=PMID:12006492,PMID:12802020,PMID:17229889 Q99816 UniProtKB Mutagenesis 46 46 . . . Note=Reduces interaction with ubiquitin. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12006492;Dbxref=PMID:12006492 Q99816 UniProtKB Mutagenesis 63 63 . . . Note=Reduces interaction with HIV-1 p6%3B impairs HIV-1 budding. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12006492;Dbxref=PMID:12006492 Q99816 UniProtKB Mutagenesis 88 88 . . . Note=Reduces interaction with ubiquitin%3B no effect on in interaction with HIV-1 p6. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12006492;Dbxref=PMID:12006492 Q99816 UniProtKB Mutagenesis 89 89 . . . Note=No change in interaction with p6%3B no effect on HIV-1 budding. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12006492;Dbxref=PMID:12006492 Q99816 UniProtKB Mutagenesis 95 95 . . . Note=Reduces interaction with VPS37B and HIV-1 p6%3B abolishes interaction with PDCD6IP%3B impairs HIV-1 budding%3B inhibits down-regulation of EGFR. Abolishes MGRN1-binding. Loss of interaction with ARRDC1. M->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12006492,ECO:0000269|PubMed:12802020,ECO:0000269|PubMed:14505570,ECO:0000269|PubMed:15218037,ECO:0000269|PubMed:17229889,ECO:0000269|PubMed:22315426;Dbxref=PMID:12006492,PMID:12802020,PMID:14505570,PMID:15218037,PMID:17229889,PMID:22315426 Q99816 UniProtKB Mutagenesis 141 141 . . . Note=Reduces interaction with HIV-1 p6. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12006492;Dbxref=PMID:12006492 Q99816 UniProtKB Mutagenesis 158 162 . . . Note=Abolishes interaction with CEP55 and midbody localization%3B no effect on interaction with ESCRT-I proteins%2C PDCD6IP and viral proteins. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17556548;Dbxref=PMID:17556548 Q99816 UniProtKB Mutagenesis 158 160 . . . Note=Abolishes interaction with CEP55. PPN->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17853893;Dbxref=PMID:17853893 Q99816 UniProtKB Mutagenesis 368 371 . . . Note=Loss of interaction with VPS28. No effect on interaction with VPS37C. RKQF->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15509564;Dbxref=PMID:15509564 Q99816 UniProtKB Sequence conflict 343 343 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q99816 UniProtKB Helix 5 11 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Turn 12 14 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Helix 18 29 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Beta strand 35 43 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Beta strand 45 47 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4ZNY Q99816 UniProtKB Beta strand 49 63 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Beta strand 66 75 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Turn 78 81 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Beta strand 86 89 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Beta strand 95 97 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Beta strand 100 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S1Q Q99816 UniProtKB Beta strand 107 109 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KPP Q99816 UniProtKB Helix 112 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Turn 119 121 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Helix 124 137 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Beta strand 140 143 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NLC Q99816 UniProtKB Helix 230 299 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IV1 Q99816 UniProtKB Helix 314 316 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VME Q99816 UniProtKB Beta strand 317 322 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VME Q99816 UniProtKB Helix 323 350 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VME Q99816 UniProtKB Helix 356 383 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VME