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Q99811

- PRRX2_HUMAN

UniProt

Q99811 - PRRX2_HUMAN

Protein

Paired mesoderm homeobox protein 2

Gene

PRRX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi104 – 16360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. artery morphogenesis Source: Ensembl
    2. cartilage development Source: Ensembl
    3. embryonic cranial skeleton morphogenesis Source: Ensembl
    4. embryonic limb morphogenesis Source: Ensembl
    5. inner ear morphogenesis Source: Ensembl
    6. middle ear morphogenesis Source: Ensembl
    7. positive regulation of mesenchymal cell proliferation Source: Ensembl
    8. positive regulation of smoothened signaling pathway Source: Ensembl
    9. regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired mesoderm homeobox protein 2
    Alternative name(s):
    Paired-related homeobox protein 2
    Short name:
    PRX-2
    Gene namesi
    Name:PRRX2
    Synonyms:PMX2, PRX2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:21338. PRRX2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134871679.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253Paired mesoderm homeobox protein 2PRO_0000049255Add
    BLAST

    Proteomic databases

    PaxDbiQ99811.
    PRIDEiQ99811.

    PTM databases

    PhosphoSiteiQ99811.

    Expressioni

    Tissue specificityi

    In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis.1 Publication

    Developmental stagei

    Higher expression in fetus than in adult.1 Publication

    Gene expression databases

    BgeeiQ99811.
    CleanExiHS_PRRX2.
    GenevestigatoriQ99811.

    Organism-specific databases

    HPAiHPA026808.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000361547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99811.
    SMRiQ99811. Positions 104-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi230 – 24314OARAdd
    BLAST

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG309174.
    HOGENOMiHOG000231518.
    HOVERGENiHBG021349.
    InParanoidiQ99811.
    KOiK09329.
    OMAiSPEYLSW.
    OrthoDBiEOG7DFXD8.
    PhylomeDBiQ99811.
    TreeFamiTF351612.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003654. OAR_dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99811-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSAAAAFAL DKPALGPGPP PPPPALGPGD CAQARKNFSV SHLLDLEEVA    50
    AAGRLAARPG ARAEAREGAA REPSGGSSGS EAAPQDGECP SPGRGSAAKR 100
    KKKQRRNRTT FNSSQLQALE RVFERTHYPD AFVREELARR VNLSEARVQV 150
    WFQNRRAKFR RNERAMLASR SASLLKSYSQ EAAIEQPVAP RPTALSPDYL 200
    SWTASSPYST VPPYSPGSSG PATPGVNMAN SIASLRLKAK EFSLHHSQVP 250
    TVN 253
    Length:253
    Mass (Da):27,079
    Last modified:January 11, 2001 - v2
    Checksum:iC7A861D46DC46DD3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 901P → S in AAB39864. (PubMed:9665387)Curated
    Sequence conflicti96 – 983SAA → RPP in AAB39864. (PubMed:9665387)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061970 mRNA. Translation: AAF17708.1.
    AL590369 Genomic DNA. Translation: CAI14511.1.
    CH471090 Genomic DNA. Translation: EAW87901.1.
    BC014645 mRNA. Translation: AAH14645.1.
    U81600 mRNA. Translation: AAB39864.1.
    CCDSiCCDS6926.1.
    RefSeqiNP_057391.1. NM_016307.3.
    UniGeneiHs.660115.

    Genome annotation databases

    EnsembliENST00000372469; ENSP00000361547; ENSG00000167157.
    GeneIDi51450.
    KEGGihsa:51450.
    UCSCiuc004byh.3. human.

    Polymorphism databases

    DMDMi12644475.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061970 mRNA. Translation: AAF17708.1 .
    AL590369 Genomic DNA. Translation: CAI14511.1 .
    CH471090 Genomic DNA. Translation: EAW87901.1 .
    BC014645 mRNA. Translation: AAH14645.1 .
    U81600 mRNA. Translation: AAB39864.1 .
    CCDSi CCDS6926.1.
    RefSeqi NP_057391.1. NM_016307.3.
    UniGenei Hs.660115.

    3D structure databases

    ProteinModelPortali Q99811.
    SMRi Q99811. Positions 104-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000361547.

    PTM databases

    PhosphoSitei Q99811.

    Polymorphism databases

    DMDMi 12644475.

    Proteomic databases

    PaxDbi Q99811.
    PRIDEi Q99811.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372469 ; ENSP00000361547 ; ENSG00000167157 .
    GeneIDi 51450.
    KEGGi hsa:51450.
    UCSCi uc004byh.3. human.

    Organism-specific databases

    CTDi 51450.
    GeneCardsi GC09P132427.
    HGNCi HGNC:21338. PRRX2.
    HPAi HPA026808.
    MIMi 604675. gene.
    neXtProti NX_Q99811.
    PharmGKBi PA134871679.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309174.
    HOGENOMi HOG000231518.
    HOVERGENi HBG021349.
    InParanoidi Q99811.
    KOi K09329.
    OMAi SPEYLSW.
    OrthoDBi EOG7DFXD8.
    PhylomeDBi Q99811.
    TreeFami TF351612.

    Miscellaneous databases

    ChiTaRSi PRRX2. human.
    GeneWikii PRRX2.
    GenomeRNAii 51450.
    NextBioi 55055.
    PROi Q99811.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99811.
    CleanExi HS_PRRX2.
    Genevestigatori Q99811.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003654. OAR_dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome."
      Norris R.A., Scott K.K., Moore C.S., Stetten G., Brown C.R., Jabs E.W., Wulfsberg E.A., Yu J., Kern M.J.
      Mamm. Genome 11:1000-1005(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds."
      Stelnicki E.J., Arbeit J., Cass D.L., Saner C., Harrison M., Largman C.
      J. Invest. Dermatol. 111:57-63(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 90-253, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Fetal fibroblast.

    Entry informationi

    Entry nameiPRRX2_HUMAN
    AccessioniPrimary (citable) accession number: Q99811
    Secondary accession number(s): Q5SZB5, Q9UIB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3