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Protein

Paired mesoderm homeobox protein 2

Gene

PRRX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi104 – 16360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. artery morphogenesis Source: Ensembl
  2. cartilage development Source: Ensembl
  3. embryonic cranial skeleton morphogenesis Source: Ensembl
  4. embryonic limb morphogenesis Source: Ensembl
  5. inner ear morphogenesis Source: Ensembl
  6. middle ear morphogenesis Source: Ensembl
  7. positive regulation of mesenchymal cell proliferation Source: Ensembl
  8. positive regulation of smoothened signaling pathway Source: Ensembl
  9. regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2
Alternative name(s):
Paired-related homeobox protein 2
Short name:
PRX-2
Gene namesi
Name:PRRX2
Synonyms:PMX2, PRX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21338. PRRX2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Paired mesoderm homeobox protein 2PRO_0000049255Add
BLAST

Proteomic databases

PaxDbiQ99811.
PRIDEiQ99811.

PTM databases

PhosphoSiteiQ99811.

Expressioni

Tissue specificityi

In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis.1 Publication

Developmental stagei

Higher expression in fetus than in adult.1 Publication

Gene expression databases

BgeeiQ99811.
CleanExiHS_PRRX2.
GenevestigatoriQ99811.

Organism-specific databases

HPAiHPA026808.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361547.

Structurei

3D structure databases

ProteinModelPortaliQ99811.
SMRiQ99811. Positions 104-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi230 – 24314OARAdd
BLAST

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG309174.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiQ99811.
KOiK09329.
OMAiSPEYLSW.
OrthoDBiEOG7DFXD8.
PhylomeDBiQ99811.
TreeFamiTF351612.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAAAAFAL DKPALGPGPP PPPPALGPGD CAQARKNFSV SHLLDLEEVA
60 70 80 90 100
AAGRLAARPG ARAEAREGAA REPSGGSSGS EAAPQDGECP SPGRGSAAKR
110 120 130 140 150
KKKQRRNRTT FNSSQLQALE RVFERTHYPD AFVREELARR VNLSEARVQV
160 170 180 190 200
WFQNRRAKFR RNERAMLASR SASLLKSYSQ EAAIEQPVAP RPTALSPDYL
210 220 230 240 250
SWTASSPYST VPPYSPGSSG PATPGVNMAN SIASLRLKAK EFSLHHSQVP

TVN
Length:253
Mass (Da):27,079
Last modified:January 11, 2001 - v2
Checksum:iC7A861D46DC46DD3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901P → S in AAB39864 (PubMed:9665387).Curated
Sequence conflicti96 – 983SAA → RPP in AAB39864 (PubMed:9665387).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061970 mRNA. Translation: AAF17708.1.
AL590369 Genomic DNA. Translation: CAI14511.1.
CH471090 Genomic DNA. Translation: EAW87901.1.
BC014645 mRNA. Translation: AAH14645.1.
U81600 mRNA. Translation: AAB39864.1.
CCDSiCCDS6926.1.
RefSeqiNP_057391.1. NM_016307.3.
UniGeneiHs.660115.

Genome annotation databases

EnsembliENST00000372469; ENSP00000361547; ENSG00000167157.
GeneIDi51450.
KEGGihsa:51450.
UCSCiuc004byh.3. human.

Polymorphism databases

DMDMi12644475.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061970 mRNA. Translation: AAF17708.1.
AL590369 Genomic DNA. Translation: CAI14511.1.
CH471090 Genomic DNA. Translation: EAW87901.1.
BC014645 mRNA. Translation: AAH14645.1.
U81600 mRNA. Translation: AAB39864.1.
CCDSiCCDS6926.1.
RefSeqiNP_057391.1. NM_016307.3.
UniGeneiHs.660115.

3D structure databases

ProteinModelPortaliQ99811.
SMRiQ99811. Positions 104-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361547.

PTM databases

PhosphoSiteiQ99811.

Polymorphism databases

DMDMi12644475.

Proteomic databases

PaxDbiQ99811.
PRIDEiQ99811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372469; ENSP00000361547; ENSG00000167157.
GeneIDi51450.
KEGGihsa:51450.
UCSCiuc004byh.3. human.

Organism-specific databases

CTDi51450.
GeneCardsiGC09P132427.
HGNCiHGNC:21338. PRRX2.
HPAiHPA026808.
MIMi604675. gene.
neXtProtiNX_Q99811.
PharmGKBiPA134871679.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG309174.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiQ99811.
KOiK09329.
OMAiSPEYLSW.
OrthoDBiEOG7DFXD8.
PhylomeDBiQ99811.
TreeFamiTF351612.

Miscellaneous databases

ChiTaRSiPRRX2. human.
GeneWikiiPRRX2.
GenomeRNAii51450.
NextBioi55055.
PROiQ99811.
SOURCEiSearch...

Gene expression databases

BgeeiQ99811.
CleanExiHS_PRRX2.
GenevestigatoriQ99811.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome."
    Norris R.A., Scott K.K., Moore C.S., Stetten G., Brown C.R., Jabs E.W., Wulfsberg E.A., Yu J., Kern M.J.
    Mamm. Genome 11:1000-1005(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds."
    Stelnicki E.J., Arbeit J., Cass D.L., Saner C., Harrison M., Largman C.
    J. Invest. Dermatol. 111:57-63(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 90-253, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Fetal fibroblast.

Entry informationi

Entry nameiPRRX2_HUMAN
AccessioniPrimary (citable) accession number: Q99811
Secondary accession number(s): Q5SZB5, Q9UIB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2001
Last modified: January 7, 2015
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.