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Protein

Paired mesoderm homeobox protein 2

Gene

PRRX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi104 – 163HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2
Alternative name(s):
Paired-related homeobox protein 2
Short name:
PRX-2
Gene namesi
Name:PRRX2
Synonyms:PMX2, PRX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000167157.10
HGNCiHGNC:21338 PRRX2
MIMi604675 gene
neXtProtiNX_Q99811

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51450
OpenTargetsiENSG00000167157
PharmGKBiPA134871679

Polymorphism and mutation databases

BioMutaiPRRX2
DMDMi12644475

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492551 – 253Paired mesoderm homeobox protein 2Add BLAST253

Proteomic databases

EPDiQ99811
PaxDbiQ99811
PeptideAtlasiQ99811
PRIDEiQ99811

PTM databases

iPTMnetiQ99811
PhosphoSitePlusiQ99811

Expressioni

Tissue specificityi

In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis.1 Publication

Developmental stagei

Higher expression in fetus than in adult.1 Publication

Gene expression databases

BgeeiENSG00000167157
CleanExiHS_PRRX2
ExpressionAtlasiQ99811 baseline and differential
GenevisibleiQ99811 HS

Organism-specific databases

HPAiHPA006607
HPA026808

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361547

Structurei

3D structure databases

ProteinModelPortaliQ99811
SMRiQ99811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi230 – 243OARPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000231518
HOVERGENiHBG021349
InParanoidiQ99811
KOiK09329
OMAiSPEYLSW
OrthoDBiEOG091G0B1L
PhylomeDBiQ99811
TreeFamiTF351612

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequencei

Sequence statusi: Complete.

Q99811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAAAAFAL DKPALGPGPP PPPPALGPGD CAQARKNFSV SHLLDLEEVA
60 70 80 90 100
AAGRLAARPG ARAEAREGAA REPSGGSSGS EAAPQDGECP SPGRGSAAKR
110 120 130 140 150
KKKQRRNRTT FNSSQLQALE RVFERTHYPD AFVREELARR VNLSEARVQV
160 170 180 190 200
WFQNRRAKFR RNERAMLASR SASLLKSYSQ EAAIEQPVAP RPTALSPDYL
210 220 230 240 250
SWTASSPYST VPPYSPGSSG PATPGVNMAN SIASLRLKAK EFSLHHSQVP

TVN
Length:253
Mass (Da):27,079
Last modified:January 11, 2001 - v2
Checksum:iC7A861D46DC46DD3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90P → S in AAB39864 (PubMed:9665387).Curated1
Sequence conflicti96 – 98SAA → RPP in AAB39864 (PubMed:9665387).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061970 mRNA Translation: AAF17708.1
AL590369 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87901.1
BC014645 mRNA Translation: AAH14645.1
U81600 mRNA Translation: AAB39864.1
CCDSiCCDS6926.1
RefSeqiNP_057391.1, NM_016307.3
UniGeneiHs.660115

Genome annotation databases

EnsembliENST00000372469; ENSP00000361547; ENSG00000167157
GeneIDi51450
KEGGihsa:51450
UCSCiuc004byh.4 human

Similar proteinsi

Entry informationi

Entry nameiPRRX2_HUMAN
AccessioniPrimary (citable) accession number: Q99811
Secondary accession number(s): Q5SZB5, Q9UIB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health