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Q99808

- S29A1_HUMAN

UniProt

Q99808 - S29A1_HUMAN

Protein

Equilibrative nucleoside transporter 1

Gene

SLC29A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).

    Kineticsi

    Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.

    1. KM=0.62 mM for adenosine1 Publication

    GO - Molecular functioni

    1. nucleoside transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. cellular response to glucose stimulus Source: Ensembl
    2. cellular response to hypoxia Source: Ensembl
    3. lactation Source: Ensembl
    4. nucleobase-containing compound metabolic process Source: ProtInc
    5. nucleoside transmembrane transport Source: GOC
    6. nucleoside transport Source: UniProtKB
    7. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    8. sleep Source: Ensembl
    9. transmembrane transport Source: Reactome
    10. uridine transport Source: Ensembl

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.57.1.1. the equilibrative nucleoside transporter (ent) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Equilibrative nucleoside transporter 1
    Alternative name(s):
    Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter
    Short name:
    Equilibrative NBMPR-sensitive nucleoside transporter
    Nucleoside transporter, es-type
    Solute carrier family 29 member 1
    Gene namesi
    Name:SLC29A1
    Synonyms:ENT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:11003. SLC29A1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. basolateral plasma membrane Source: UniProtKB
    3. integral component of plasma membrane Source: ProtInc
    4. membrane Source: UniProtKB
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi453 – 4564Missing: No effect on subcellular localization and inosine transport. 1 Publication
    Mutagenesisi453 – 4531R → A: No effect on subcellular localization and inosine transport. 1 Publication

    Organism-specific databases

    PharmGKBiPA154.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 456455Equilibrative nucleoside transporter 1PRO_0000209337Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ99808.
    PaxDbiQ99808.
    PRIDEiQ99808.

    PTM databases

    PhosphoSiteiQ99808.

    Expressioni

    Tissue specificityi

    Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen.2 Publications

    Gene expression databases

    ArrayExpressiQ99808.
    BgeeiQ99808.
    CleanExiHS_SLC29A1.
    GenevestigatoriQ99808.

    Organism-specific databases

    HPAiHPA012383.
    HPA012384.

    Interactioni

    Subunit structurei

    Identified in a complex with STOM.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    STK19P498421EBI-347907,EBI-347581

    Protein-protein interaction databases

    BioGridi108344. 2 interactions.
    IntActiQ99808. 3 interactions.
    MINTiMINT-1034227.
    STRINGi9606.ENSP00000360773.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99808.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini30 – 8253ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 1114CytoplasmicSequence Analysis
    Topological domaini131 – 1388ExtracellularSequence Analysis
    Topological domaini158 – 17417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini200 – 2067ExtracellularSequence Analysis
    Topological domaini228 – 29164CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini312 – 32312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini343 – 35917CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini379 – 39315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini414 – 43118CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini453 – 4564ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 2917HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10725HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19925HelicalSequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei360 – 37819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei394 – 41320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249415.
    HOGENOMiHOG000007684.
    HOVERGENiHBG074626.
    InParanoidiQ99808.
    KOiK15014.
    OrthoDBiEOG7PP56W.
    PhylomeDBiQ99808.
    TreeFamiTF313950.

    Family and domain databases

    InterProiIPR002259. Eqnu_transpt.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PANTHERiPTHR10332. PTHR10332. 1 hit.
    PfamiPF01733. Nucleoside_tran. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016379. ENT. 1 hit.
    PRINTSiPR01130. DERENTRNSPRT.
    SUPFAMiSSF103473. SSF103473. 3 hits.
    TIGRFAMsiTIGR00939. 2a57. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99808-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTSHQPQDR YKAVWLIFFM LGLGTLLPWN FFMTATQYFT NRLDMSQNVS    50
    LVTAELSKDA QASAAPAAPL PERNSLSAIF NNVMTLCAML PLLLFTYLNS 100
    FLHQRIPQSV RILGSLVAIL LVFLITAILV KVQLDALPFF VITMIKIVLI 150
    NSFGAILQGS LFGLAGLLPA SYTAPIMSGQ GLAGFFASVA MICAIASGSE 200
    LSESAFGYFI TACAVIILTI ICYLGLPRLE FYRYYQQLKL EGPGEQETKL 250
    DLISKGEEPR AGKEESGVSV SNSQPTNESH SIKAILKNIS VLAFSVCFIF 300
    TITIGMFPAV TVEVKSSIAG SSTWERYFIP VSCFLTFNIF DWLGRSLTAV 350
    FMWPGKDSRW LPSLVLARLV FVPLLLLCNI KPRRYLTVVF EHDAWFIFFM 400
    AAFAFSNGYL ASLCMCFGPK KVKPAEAETA GAIMAFFLCL GLALGAVFSF 450
    LFRAIV 456
    Length:456
    Mass (Da):50,219
    Last modified:January 23, 2007 - v3
    Checksum:iF18535A95DEBC95D
    GO
    Isoform 2 (identifier: Q99808-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MRRERTRGPQ...PGKTENTITM

    Note: No experimental confirmation available.

    Show »
    Length:535
    Mass (Da):58,963
    Checksum:iE58D6674A3C519D7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti216 – 2161I → T.
    Corresponds to variant rs45573936 [ dbSNP | Ensembl ].
    VAR_053668
    Natural varianti293 – 2931A → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036221
    Natural varianti391 – 3911E → K.
    Corresponds to variant rs45458701 [ dbSNP | Ensembl ].
    VAR_053669
    Natural varianti455 – 4551I → V in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036222

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MRRERTRGPQAWEFPSPTKS GCSLQSLSRDLRELREGEKP EDQAETEESWQGLARKTPGK ACAPEGGSCQPGKTENTITM in isoform 2. 1 PublicationVSP_056579

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81375 mRNA. Translation: AAC51103.1.
    AF190884 Genomic DNA. Translation: AAF02777.1.
    AF079117 mRNA. Translation: AAC62495.1.
    AF495730 Genomic DNA. Translation: AAM11785.1.
    AK090491 mRNA. Translation: BAG52169.1.
    AK090615 mRNA. Translation: BAG52197.1.
    AL139392 Genomic DNA. Translation: CAI20093.1.
    CH471081 Genomic DNA. Translation: EAX04255.1.
    BC001382 mRNA. Translation: AAH01382.1.
    BC008954 mRNA. Translation: AAH08954.1.
    CCDSiCCDS4908.1.
    RefSeqiNP_001071642.1. NM_001078174.1.
    NP_001071643.1. NM_001078175.2.
    NP_001071644.1. NM_001078176.2.
    NP_001071645.1. NM_001078177.1.
    NP_004946.1. NM_004955.2.
    XP_005248932.1. XM_005248875.2.
    XP_005248935.1. XM_005248878.2.
    XP_005248936.1. XM_005248879.2.
    XP_005248937.1. XM_005248880.2.
    XP_005248938.1. XM_005248881.2.
    XP_005248939.1. XM_005248882.2.
    UniGeneiHs.25450.

    Genome annotation databases

    EnsembliENST00000313248; ENSP00000319152; ENSG00000112759.
    ENST00000371708; ENSP00000360773; ENSG00000112759.
    ENST00000371713; ENSP00000360778; ENSG00000112759.
    ENST00000371724; ENSP00000360789; ENSG00000112759.
    ENST00000371731; ENSP00000360796; ENSG00000112759.
    ENST00000371740; ENSP00000360805; ENSG00000112759.
    ENST00000371755; ENSP00000360820; ENSG00000112759.
    ENST00000393841; ENSP00000377424; ENSG00000112759.
    ENST00000393844; ENSP00000377427; ENSG00000112759.
    ENST00000427851; ENSP00000392668; ENSG00000112759.
    GeneIDi2030.
    KEGGihsa:2030.
    UCSCiuc003owu.1. human.

    Polymorphism databases

    DMDMi9296956.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81375 mRNA. Translation: AAC51103.1 .
    AF190884 Genomic DNA. Translation: AAF02777.1 .
    AF079117 mRNA. Translation: AAC62495.1 .
    AF495730 Genomic DNA. Translation: AAM11785.1 .
    AK090491 mRNA. Translation: BAG52169.1 .
    AK090615 mRNA. Translation: BAG52197.1 .
    AL139392 Genomic DNA. Translation: CAI20093.1 .
    CH471081 Genomic DNA. Translation: EAX04255.1 .
    BC001382 mRNA. Translation: AAH01382.1 .
    BC008954 mRNA. Translation: AAH08954.1 .
    CCDSi CCDS4908.1.
    RefSeqi NP_001071642.1. NM_001078174.1.
    NP_001071643.1. NM_001078175.2.
    NP_001071644.1. NM_001078176.2.
    NP_001071645.1. NM_001078177.1.
    NP_004946.1. NM_004955.2.
    XP_005248932.1. XM_005248875.2.
    XP_005248935.1. XM_005248878.2.
    XP_005248936.1. XM_005248879.2.
    XP_005248937.1. XM_005248880.2.
    XP_005248938.1. XM_005248881.2.
    XP_005248939.1. XM_005248882.2.
    UniGenei Hs.25450.

    3D structure databases

    ProteinModelPortali Q99808.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108344. 2 interactions.
    IntActi Q99808. 3 interactions.
    MINTi MINT-1034227.
    STRINGi 9606.ENSP00000360773.

    Chemistry

    BindingDBi Q99808.
    ChEMBLi CHEMBL1997.
    DrugBanki DB00197. Troglitazone.
    GuidetoPHARMACOLOGYi 1117.

    Protein family/group databases

    TCDBi 2.A.57.1.1. the equilibrative nucleoside transporter (ent) family.

    PTM databases

    PhosphoSitei Q99808.

    Polymorphism databases

    DMDMi 9296956.

    Proteomic databases

    MaxQBi Q99808.
    PaxDbi Q99808.
    PRIDEi Q99808.

    Protocols and materials databases

    DNASUi 2030.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313248 ; ENSP00000319152 ; ENSG00000112759 .
    ENST00000371708 ; ENSP00000360773 ; ENSG00000112759 .
    ENST00000371713 ; ENSP00000360778 ; ENSG00000112759 .
    ENST00000371724 ; ENSP00000360789 ; ENSG00000112759 .
    ENST00000371731 ; ENSP00000360796 ; ENSG00000112759 .
    ENST00000371740 ; ENSP00000360805 ; ENSG00000112759 .
    ENST00000371755 ; ENSP00000360820 ; ENSG00000112759 .
    ENST00000393841 ; ENSP00000377424 ; ENSG00000112759 .
    ENST00000393844 ; ENSP00000377427 ; ENSG00000112759 .
    ENST00000427851 ; ENSP00000392668 ; ENSG00000112759 .
    GeneIDi 2030.
    KEGGi hsa:2030.
    UCSCi uc003owu.1. human.

    Organism-specific databases

    CTDi 2030.
    GeneCardsi GC06P044187.
    HGNCi HGNC:11003. SLC29A1.
    HPAi HPA012383.
    HPA012384.
    MIMi 602193. gene.
    neXtProti NX_Q99808.
    PharmGKBi PA154.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249415.
    HOGENOMi HOG000007684.
    HOVERGENi HBG074626.
    InParanoidi Q99808.
    KOi K15014.
    OrthoDBi EOG7PP56W.
    PhylomeDBi Q99808.
    TreeFami TF313950.

    Enzyme and pathway databases

    Reactomei REACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

    Miscellaneous databases

    GeneWikii Equilibrative_nucleoside_transporter_1.
    GenomeRNAii 2030.
    NextBioi 8235.
    PROi Q99808.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99808.
    Bgeei Q99808.
    CleanExi HS_SLC29A1.
    Genevestigatori Q99808.

    Family and domain databases

    InterProi IPR002259. Eqnu_transpt.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    PANTHERi PTHR10332. PTHR10332. 1 hit.
    Pfami PF01733. Nucleoside_tran. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016379. ENT. 1 hit.
    PRINTSi PR01130. DERENTRNSPRT.
    SUPFAMi SSF103473. SSF103473. 3 hits.
    TIGRFAMsi TIGR00939. 2a57. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs."
      Griffiths M., Beaumont N., Yao S.Y.M., Sundaram M., Boumah C.E., Davies A., Kwong F.Y.P., Coe I., Cass C.E., Young J.D., Baldwin S.A.
      Nat. Med. 3:89-93(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 2-22.
      Tissue: Placenta.
    2. "Genomic sequence of the human equilibrative nucleoside transporter 1 (hENT1)."
      Graham K.A., Coe I.R., Carpenter P., Baldwin S.A., Young J.D., Cass C.E.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles."
      Lum P.Y., Ngo L.Y., Bakken A.H., Unadkat J.D.
      Cancer Chemother. Pharmacol. 45:273-278(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Jejunum and Small intestine.
    4. "Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity."
      Sankar N., Machado J., Abdulla P., Hilliker A.J., Coe I.R.
      Nucleic Acids Res. 30:4339-4350(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells."
      Mangravite L.M., Xiao G., Giacomini K.M.
      Am. J. Physiol. 284:F902-F910(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF ARG-453 AND 453-ARG--VAL-456.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Adrenal gland.
    7. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon and Muscle.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-48.
      Tissue: Leukemic T-cell.
    12. "Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains."
      Rungaldier S., Oberwagner W., Salzer U., Csaszar E., Prohaska R.
      Biochim. Biophys. Acta 1828:956-966(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION IN A COMPLEX WITH STOM, SUBUNIT.
    13. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-293 AND VAL-455.

    Entry informationi

    Entry nameiS29A1_HUMAN
    AccessioniPrimary (citable) accession number: Q99808
    Secondary accession number(s): B3KQV7
    , B3KQY5, Q5T9W9, Q9UJY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 134 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3