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Protein

Transmembrane 9 superfamily member 2

Gene

TM9SF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In the intracellular compartments, may function as a channel or small molecule transporter.

GO - Biological processi

  • transport Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125304-MONOMER.

Protein family/group databases

TCDBi8.A.68.1.6. the endomembrane protein-70 (emp70) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 2
Alternative name(s):
p76
Gene namesi
Name:TM9SF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:11865. TM9SF2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 300LumenalSequence analysisAdd BLAST272
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 374CytoplasmicSequence analysisAdd BLAST53
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 398LumenalSequence analysis3
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 437CytoplasmicSequence analysisAdd BLAST18
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 466LumenalSequence analysis8
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 522CytoplasmicSequence analysisAdd BLAST35
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 554LumenalSequence analysisAdd BLAST11
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21
Topological domaini576 – 591CytoplasmicSequence analysisAdd BLAST16
Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
Topological domaini613 – 631LumenalSequence analysisAdd BLAST19
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 663CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • endosome Source: ProtInc
  • endosome membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9375.
OpenTargetsiENSG00000125304.
PharmGKBiPA36566.

Polymorphism and mutation databases

DMDMi13878805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003436529 – 663Transmembrane 9 superfamily member 2Add BLAST635

Proteomic databases

EPDiQ99805.
MaxQBiQ99805.
PaxDbiQ99805.
PeptideAtlasiQ99805.
PRIDEiQ99805.

PTM databases

iPTMnetiQ99805.
PhosphoSitePlusiQ99805.
SwissPalmiQ99805.

Expressioni

Tissue specificityi

Ubiquitously expressed. Especially abundant in pancreas, highly expressed in kidney, lower levels in heart, brain, skeletal muscle and placenta. Lowest expression in lung and liver.

Gene expression databases

BgeeiENSG00000125304.
CleanExiHS_TM9SF2.
ExpressionAtlasiQ99805. baseline and differential.
GenevisibleiQ99805. HS.

Organism-specific databases

HPAiHPA005657.

Interactioni

Protein-protein interaction databases

BioGridi114776. 10 interactors.
IntActiQ99805. 11 interactors.
MINTiMINT-1181019.
STRINGi9606.ENSP00000365567.

Structurei

3D structure databases

ProteinModelPortaliQ99805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1278. Eukaryota.
ENOG410XPIW. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216679.
HOVERGENiHBG054197.
InParanoidiQ99805.
KOiK17086.
OMAiNFCEEGK.
OrthoDBiEOG091G03BD.
PhylomeDBiQ99805.
TreeFamiTF300394.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARLPVLSP PRWPRLLLLS LLLLGAVPGP RRSGAFYLPG LAPVNFCDEE
60 70 80 90 100
KKSDECKAEI ELFVNRLDSV ESVLPYEYTA FDFCQASEGK RPSENLGQVL
110 120 130 140 150
FGERIEPSPY KFTFNKKETC KLVCTKTYHT EKAEDKQKLE FLKKSMLLNY
160 170 180 190 200
QHHWIVDNMP VTWCYDVEDG QRFCNPGFPI GCYITDKGHA KDACVISSDF
210 220 230 240 250
HERDTFYIFN HVDIKIYYHV VETGSMGARL VAAKLEPKSF KHTHIDKPDC
260 270 280 290 300
SGPPMDISNK ASGEIKIAYT YSVSFEEDDK IRWASRWDYI LESMPHTHIQ
310 320 330 340 350
WFSIMNSLVI VLFLSGMVAM IMLRTLHKDI ARYNQMDSTE DAQEEFGWKL
360 370 380 390 400
VHGDIFRPPR KGMLLSVFLG SGTQILIMTF VTLFFACLGF LSPANRGALM
410 420 430 440 450
TCAVVLWVLL GTPAGYVAAR FYKSFGGEKW KTNVLLTSFL CPGIVFADFF
460 470 480 490 500
IMNLILWGEG SSAAIPFGTL VAILALWFCI SVPLTFIGAY FGFKKNAIEH
510 520 530 540 550
PVRTNQIPRQ IPEQSFYTKP LPGIIMGGIL PFGCIFIQLF FILNSIWSHQ
560 570 580 590 600
MYYMFGFLFL VFIILVITCS EATILLCYFH LCAEDYHWQW RSFLTSGFTA
610 620 630 640 650
VYFLIYAVHY FFSKLQITGT ASTILYFGYT MIMVLIFFLF TGTIGFFACF
660
WFVTKIYSVV KVD
Length:663
Mass (Da):75,776
Last modified:May 1, 1997 - v1
Checksum:iC21A4D224534734D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81006 mRNA. Translation: AAB38973.1.
AK290514 mRNA. Translation: BAF83203.1.
AL139035 Genomic DNA. Translation: CAH71381.1.
BC110656 mRNA. Translation: AAI10657.1.
BC130293 mRNA. Translation: AAI30294.1.
CCDSiCCDS9493.1.
RefSeqiNP_004791.1. NM_004800.2.
UniGeneiHs.607896.

Genome annotation databases

EnsembliENST00000376387; ENSP00000365567; ENSG00000125304.
GeneIDi9375.
KEGGihsa:9375.
UCSCiuc001voj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81006 mRNA. Translation: AAB38973.1.
AK290514 mRNA. Translation: BAF83203.1.
AL139035 Genomic DNA. Translation: CAH71381.1.
BC110656 mRNA. Translation: AAI10657.1.
BC130293 mRNA. Translation: AAI30294.1.
CCDSiCCDS9493.1.
RefSeqiNP_004791.1. NM_004800.2.
UniGeneiHs.607896.

3D structure databases

ProteinModelPortaliQ99805.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114776. 10 interactors.
IntActiQ99805. 11 interactors.
MINTiMINT-1181019.
STRINGi9606.ENSP00000365567.

Protein family/group databases

TCDBi8.A.68.1.6. the endomembrane protein-70 (emp70) family.

PTM databases

iPTMnetiQ99805.
PhosphoSitePlusiQ99805.
SwissPalmiQ99805.

Polymorphism and mutation databases

DMDMi13878805.

Proteomic databases

EPDiQ99805.
MaxQBiQ99805.
PaxDbiQ99805.
PeptideAtlasiQ99805.
PRIDEiQ99805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376387; ENSP00000365567; ENSG00000125304.
GeneIDi9375.
KEGGihsa:9375.
UCSCiuc001voj.3. human.

Organism-specific databases

CTDi9375.
DisGeNETi9375.
GeneCardsiTM9SF2.
HGNCiHGNC:11865. TM9SF2.
HPAiHPA005657.
MIMi604678. gene.
neXtProtiNX_Q99805.
OpenTargetsiENSG00000125304.
PharmGKBiPA36566.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1278. Eukaryota.
ENOG410XPIW. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216679.
HOVERGENiHBG054197.
InParanoidiQ99805.
KOiK17086.
OMAiNFCEEGK.
OrthoDBiEOG091G03BD.
PhylomeDBiQ99805.
TreeFamiTF300394.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125304-MONOMER.

Miscellaneous databases

ChiTaRSiTM9SF2. human.
GeneWikiiTM9SF2.
GenomeRNAii9375.
PROiQ99805.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125304.
CleanExiHS_TM9SF2.
ExpressionAtlasiQ99805. baseline and differential.
GenevisibleiQ99805. HS.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM9S2_HUMAN
AccessioniPrimary (citable) accession number: Q99805
Secondary accession number(s): A8K399, Q2TAY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.