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Q99801

- NKX31_HUMAN

UniProt

Q99801 - NKX31_HUMAN

Protein

Homeobox protein Nkx-3.1

Gene

NKX3-1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (26 Sep 2001)
      Previous versions | rss
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    Functioni

    Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi124 – 18360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. androgen receptor activity Source: UniProtKB
    2. core promoter binding Source: UniProtKB
    3. estrogen receptor activity Source: UniProtKB
    4. estrogen receptor binding Source: UniProtKB
    5. histone deacetylase binding Source: UniProtKB
    6. protein binding Source: UniProtKB
    7. protein kinase activator activity Source: UniProtKB
    8. protein self-association Source: UniProtKB
    9. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: Ensembl
    10. sequence-specific DNA binding Source: UniProtKB
    11. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    12. transcription factor binding Source: UniProtKB
    13. transcription regulatory region DNA binding Source: UniProtKB
    14. transcription regulatory region sequence-specific DNA binding Source: BHF-UCL

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    2. androgen receptor signaling pathway Source: UniProtKB
    3. branching involved in prostate gland morphogenesis Source: UniProtKB
    4. branching morphogenesis of an epithelial tube Source: UniProtKB
    5. cellular response to drug Source: UniProtKB
    6. cellular response to hypoxia Source: UniProtKB
    7. cellular response to interleukin-1 Source: UniProtKB
    8. cellular response to steroid hormone stimulus Source: UniProtKB
    9. cellular response to tumor necrosis factor Source: UniProtKB
    10. dorsal aorta development Source: Ensembl
    11. epithelial cell proliferation involved in salivary gland morphogenesis Source: UniProtKB
    12. heart development Source: Ensembl
    13. male gonad development Source: Ensembl
    14. metanephros development Source: Ensembl
    15. mitotic cell cycle arrest Source: UniProtKB
    16. multicellular organismal development Source: ProtInc
    17. negative regulation of cell proliferation Source: UniProtKB
    18. negative regulation of epithelial cell proliferation Source: UniProtKB
    19. negative regulation of epithelial cell proliferation involved in prostate gland development Source: UniProtKB
    20. negative regulation of estrogen receptor binding Source: UniProtKB
    21. negative regulation of gene expression Source: UniProtKB
    22. negative regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
    23. negative regulation of mitotic cell cycle Source: UniProtKB
    24. negative regulation of transcription, DNA-templated Source: UniProtKB
    25. pharyngeal system development Source: Ensembl
    26. positive regulation of androgen secretion Source: UniProtKB
    27. positive regulation of apoptotic signaling pathway Source: UniProtKB
    28. positive regulation of cell death Source: UniProtKB
    29. positive regulation of cell division Source: BHF-UCL
    30. positive regulation of cell proliferation Source: UniProtKB
    31. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    32. positive regulation of gene expression Source: UniProtKB
    33. positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
    34. positive regulation of mitotic cell cycle Source: BHF-UCL
    35. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
    36. positive regulation of protein kinase activity Source: GOC
    37. positive regulation of protein phosphorylation Source: UniProtKB
    38. positive regulation of response to DNA damage stimulus Source: UniProtKB
    39. positive regulation of transcription, DNA-templated Source: UniProtKB
    40. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    41. protein kinase B signaling Source: UniProtKB
    42. regulation of transcription, DNA-templated Source: UniProtKB
    43. response to testosterone Source: UniProtKB
    44. salivary gland development Source: UniProtKB
    45. somitogenesis Source: Ensembl
    46. steroid hormone mediated signaling pathway Source: GOC

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ99801.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Nkx-3.1
    Alternative name(s):
    Homeobox protein NK-3 homolog A
    Gene namesi
    Name:NKX3-1
    Synonyms:NKX3.1, NKX3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:7838. NKX3-1.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. intracellular Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA31645.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234Homeobox protein Nkx-3.1PRO_0000048945Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ99801.
    PaxDbiQ99801.
    PRIDEiQ99801.

    PTM databases

    PhosphoSiteiQ99801.

    Expressioni

    Tissue specificityi

    Highly expressed in the prostate and, at a lower level, in the testis.2 Publications

    Inductioni

    By androgens and, in the LNCaP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen-independent phase.3 Publications

    Gene expression databases

    BgeeiQ99801.
    CleanExiHS_NKX3-1.
    GenevestigatoriQ99801.

    Organism-specific databases

    HPAiHPA025693.

    Interactioni

    Subunit structurei

    Interacts with serum response factor (SRF) By similarity. Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TOP1P113876EBI-1385894,EBI-876302

    Protein-protein interaction databases

    BioGridi110888. 34 interactions.
    IntActiQ99801. 1 interaction.
    STRINGi9606.ENSP00000370253.

    Structurei

    Secondary structure

    1
    234
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi133 – 14513
    Helixi151 – 16010
    Helixi165 – 17814
    Beta strandi182 – 1854

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L9RNMR-A132-189[»]
    DisProtiDP00683.
    ProteinModelPortaliQ99801.
    SMRiQ99801. Positions 134-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NK-3 homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG238786.
    HOGENOMiHOG000231923.
    HOVERGENiHBG006689.
    InParanoidiQ99801.
    KOiK09348.
    OMAiGAQRQGG.
    OrthoDBiEOG7QZG9Z.
    PhylomeDBiQ99801.
    TreeFamiTF315720.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q99801-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRVPEPRPG EAKAEGAAPP TPSKPLTSFL IQDILRDGAQ RQGGRTSSQR    50
    QRDPEPEPEP EPEGGRSRAG AQNDQLSTGP RAAPEEAETL AETEPERHLG 100
    SYLLDSENTS GALPRLPQTP KQPQKRSRAA FSHTQVIELE RKFSHQKYLS 150
    APERAHLAKN LKLTETQVKI WFQNRRYKTK RKQLSSELGD LEKHSSLPAL 200
    KEEAFSRASL VSVYNSYPYY PYLYCVGSWS PAFW 234
    Length:234
    Mass (Da):26,350
    Last modified:September 26, 2001 - v2
    Checksum:iC99A0943E15B2A55
    GO
    Isoform 2 (identifier: Q99801-2) [UniParc]FASTAAdd to Basket

    Also known as: V2

    The sequence of this isoform differs from the canonical sequence as follows:
         8-56: Missing.

    Show »
    Length:185
    Mass (Da):21,099
    Checksum:i5A3A3233AA1C05EB
    GO
    Isoform 3 (identifier: Q99801-3) [UniParc]FASTAAdd to Basket

    Also known as: V4

    The sequence of this isoform differs from the canonical sequence as follows:
         13-87: Missing.

    Show »
    Length:159
    Mass (Da):18,423
    Checksum:iAEE13D060B421ED8
    GO
    Isoform 4 (identifier: Q99801-4) [UniParc]FASTAAdd to Basket

    Also known as: V3

    The sequence of this isoform differs from the canonical sequence as follows:
         15-83: Missing.

    Show »
    Length:165
    Mass (Da):19,049
    Checksum:i2B8B0D19FBD83A8D
    GO
    Isoform 5 (identifier: Q99801-5) [UniParc]FASTAAdd to Basket

    Also known as: V1

    The sequence of this isoform differs from the canonical sequence as follows:
         40-83: Missing.

    Show »
    Length:190
    Mass (Da):21,626
    Checksum:i985A34212DCEDA27
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81R → W in AAG39737. (PubMed:11137288)Curated
    Sequence conflicti85 – 851E → D in AAB38747. (PubMed:9537602)Curated
    Sequence conflicti135 – 1351Q → R in AAG39738. (PubMed:11137288)Curated
    Sequence conflicti196 – 1961S → F in AAB38747. (PubMed:9537602)Curated
    Sequence conflicti224 – 2241Y → H in AAB38747. (PubMed:9537602)Curated
    Sequence conflicti234 – 2341W → G in AAB68662. (PubMed:9226374)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti52 – 521R → C.1 Publication
    Corresponds to variant rs2228013 [ dbSNP | Ensembl ].
    VAR_011612

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei8 – 5649Missing in isoform 2. 1 PublicationVSP_002230Add
    BLAST
    Alternative sequencei13 – 8775Missing in isoform 3. 1 PublicationVSP_002231Add
    BLAST
    Alternative sequencei15 – 8369Missing in isoform 4. 1 PublicationVSP_002232Add
    BLAST
    Alternative sequencei40 – 8344Missing in isoform 5. 1 PublicationVSP_002233Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91540 mRNA. Translation: AAB68662.1.
    U80669 mRNA. Translation: AAB38747.1.
    AF247704 mRNA. Translation: AAG09781.1.
    AF249669 mRNA. Translation: AAG39735.1.
    AF249670 mRNA. Translation: AAG39736.1.
    AF249671 mRNA. Translation: AAG39737.1.
    AF249672 mRNA. Translation: AAG39738.1.
    BC074863 mRNA. Translation: AAH74863.1.
    BC074864 mRNA. Translation: AAH74864.1.
    CCDSiCCDS59095.1. [Q99801-3]
    CCDS6042.1. [Q99801-1]
    RefSeqiNP_001243268.1. NM_001256339.1. [Q99801-3]
    NP_006158.2. NM_006167.3. [Q99801-1]
    UniGeneiHs.55999.

    Genome annotation databases

    EnsembliENST00000380871; ENSP00000370253; ENSG00000167034. [Q99801-1]
    ENST00000523261; ENSP00000429729; ENSG00000167034. [Q99801-3]
    GeneIDi4824.
    KEGGihsa:4824.
    UCSCiuc011kzx.2. human. [Q99801-1]
    uc031tao.1. human. [Q99801-3]

    Polymorphism databases

    DMDMi17377578.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91540 mRNA. Translation: AAB68662.1 .
    U80669 mRNA. Translation: AAB38747.1 .
    AF247704 mRNA. Translation: AAG09781.1 .
    AF249669 mRNA. Translation: AAG39735.1 .
    AF249670 mRNA. Translation: AAG39736.1 .
    AF249671 mRNA. Translation: AAG39737.1 .
    AF249672 mRNA. Translation: AAG39738.1 .
    BC074863 mRNA. Translation: AAH74863.1 .
    BC074864 mRNA. Translation: AAH74864.1 .
    CCDSi CCDS59095.1. [Q99801-3 ]
    CCDS6042.1. [Q99801-1 ]
    RefSeqi NP_001243268.1. NM_001256339.1. [Q99801-3 ]
    NP_006158.2. NM_006167.3. [Q99801-1 ]
    UniGenei Hs.55999.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L9R NMR - A 132-189 [» ]
    DisProti DP00683.
    ProteinModelPortali Q99801.
    SMRi Q99801. Positions 134-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110888. 34 interactions.
    IntActi Q99801. 1 interaction.
    STRINGi 9606.ENSP00000370253.

    PTM databases

    PhosphoSitei Q99801.

    Polymorphism databases

    DMDMi 17377578.

    Proteomic databases

    MaxQBi Q99801.
    PaxDbi Q99801.
    PRIDEi Q99801.

    Protocols and materials databases

    DNASUi 4824.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380871 ; ENSP00000370253 ; ENSG00000167034 . [Q99801-1 ]
    ENST00000523261 ; ENSP00000429729 ; ENSG00000167034 . [Q99801-3 ]
    GeneIDi 4824.
    KEGGi hsa:4824.
    UCSCi uc011kzx.2. human. [Q99801-1 ]
    uc031tao.1. human. [Q99801-3 ]

    Organism-specific databases

    CTDi 4824.
    GeneCardsi GC08M023536.
    HGNCi HGNC:7838. NKX3-1.
    HPAi HPA025693.
    MIMi 602041. gene.
    neXtProti NX_Q99801.
    PharmGKBi PA31645.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238786.
    HOGENOMi HOG000231923.
    HOVERGENi HBG006689.
    InParanoidi Q99801.
    KOi K09348.
    OMAi GAQRQGG.
    OrthoDBi EOG7QZG9Z.
    PhylomeDBi Q99801.
    TreeFami TF315720.

    Enzyme and pathway databases

    SignaLinki Q99801.

    Miscellaneous databases

    ChiTaRSi NKX3-1. human.
    GeneWikii NKX3-1.
    GenomeRNAii 4824.
    NextBioi 18580.
    PROi Q99801.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99801.
    CleanExi HS_NKX3-1.
    Genevestigatori Q99801.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer."
      He W.-W., Sciavolino P.J., Wing J., Augustus M., Hudson P., Meissner P.S., Curtis R.T., Shell B.K., Bostwick D.G., Tindall D.J., Gelmann E.P., Abate-Shen C., Carter K.C.
      Genomics 43:69-77(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION BY ANDROGENS.
      Tissue: Prostate.
    2. "Isolation and androgen regulation of the human homeobox cDNA, NKX3.1."
      Prescott J.L., Blok L., Tindall D.J.
      Prostate 35:71-80(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION BY ANDROGENS.
    3. "Full-length cDNA sequence and genomic organization of human NKX3A --alternative mRNA forms and regulation by both androgens and estrogens."
      Korkmaz K.S., Korkmaz C.G., Ragnhildstveit E., Kizildag S., Pretlow T.G., Saatcioglu F.
      Gene 260:25-36(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), SUBCELLULAR LOCATION, INDUCTION BY ESTROGENS.
      Tissue: Prostate.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    5. "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter."
      Chen H., Nandi A.K., Li X., Bieberich C.J.
      Cancer Res. 62:338-340(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SPDEF.
    6. "Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription."
      Hosohata K., Li P., Hosohata Y., Qin J., Roeder R.G., Wang Z.
      Mol. Cell. Biol. 23:7019-7029(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WDR77.
    7. "Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1."
      Guan B., Pungaliya P., Li X., Uquillas C., Mutton L.N., Rubin E.H., Bieberich C.J.
      J. Biol. Chem. 283:4834-4840(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TOPORS, UBIQUITINATION BY TOPORS.
    8. "Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1."
      Zhang P., Liu W., Zhang J., Guan H., Chen W., Cui X., Liu Q., Jiang A.
      Mol. Biol. Rep. 37:1505-1512(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS TUMOR SUPPRESSOR.
    9. "Solution NMR structure of homeobox domain of homeobox protein NKX-3.1 from Homo sapiens, Northeast structural genomics consortium target HR6470A."
      Northeast structural genomics consortium (NESG)
      Submitted (APR-2011) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 132-189.
    10. "Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers."
      Voeller H.J., Augustus M., Madike V., Bova G.S., Carter K.C., Gelmann E.P.
      Cancer Res. 57:4455-4459(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYS-52.
    11. Erratum
      Voeller H.J., Augustus M., Madike V., Bova G.S., Carter K.C., Gelmann E.P.
      Cancer Res. 57:5613-5613(1997)

    Entry informationi

    Entry nameiNKX31_HUMAN
    AccessioniPrimary (citable) accession number: Q99801
    Secondary accession number(s): O15465
    , Q9H2P4, Q9H2P5, Q9H2P6, Q9H2P7, Q9HBG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: September 26, 2001
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3