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Protein

Non-structural protein V

Gene

P/V/C

Organism
Nipah virus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host STAT1 and STAT2 and thereby inhibiting their phosphorylation and subsequent nuclear translocation. Efficiently blocks the type II interferon signaling pathway.2 Publications

Miscellaneous

The P/V/C gene has two overlapping open reading frames. One encodes the P/V/W proteins and the other the C protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi408Zinc 1By similarity1
Metal bindingi427Zinc 1By similarity1
Metal bindingi431Zinc 2By similarity1
Metal bindingi443Zinc 2By similarity1
Metal bindingi445Zinc 2By similarity1
Metal bindingi448Zinc 2By similarity1
Metal bindingi452Zinc 1By similarity1
Metal bindingi455Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host MDA5 by virus, Inhibition of host RLR pathway by virus, Inhibition of host STAT1 by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Viral immunoevasion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein V
Gene namesi
Name:P/V/C
OrganismiNipah virus
Taxonomic identifieri121791 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeHenipavirus
Virus hostiCynopterus brachyotis (Lesser short-nosed fruit bat) (Pachysoma brachyotis) [TaxID: 58060]
Eonycteris spelaea (Lesser dawn bat) (Macroglossus spelaeus) [TaxID: 58065]
Homo sapiens (Human) [TaxID: 9606]
Pteropus hypomelanus (Island flying fox) (Variable flying fox) [TaxID: 9405]
Pteropus vampyrus (Large flying fox) [TaxID: 132908]
Scotophilus kuhlii (Lesser asiatic yellow bat) [TaxID: 153297]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000002330 Componenti: Genome
  • UP000008676 Componenti: Genome
  • UP000007527 Componenti: Genome
  • UP000170143 Componenti: Genome
  • UP000100567 Componenti: Genome
  • UP000130871 Componenti: Genome
  • UP000110983 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002360151 – 456Non-structural protein VAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257Phosphoserine; by hostBy similarity1
Modified residuei350Phosphoserine; by hostBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with host IFIH1/MDA5, DHX58/LGP2, STAT1 and STAT2.3 Publications

Protein-protein interaction databases

IntActiQ997F2. 34 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ997F2.
SMRiQ997F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paramyxoviruses V protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000AV.

Family and domain databases

InterProiView protein in InterPro
IPR024279. Paramyx_V_Zn-bd.
IPR025909. Soyouz_module.
PfamiView protein in Pfam
PF14313. Soyouz_module. 1 hit.
PF13008. zf-Paramyx-P. 1 hit.

Sequencei

Sequence statusi: Complete.

Q997F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLELVNDG LNIIDFIQKN QKEIQKTYGR SSIQQPSIKD QTKAWEDFLQ
60 70 80 90 100
CTSGESEQVE GGMSKDDGDV ERRNLEDLSS TSPTDGTIGK RVSNTRDWAE
110 120 130 140 150
GSDDIQLDPV VTDVVYHDHG GECTGYGFTS SPERGWSDYT SGANNGNVCL
160 170 180 190 200
VSDAKMLSYA PEIAVSKEDR ETDLVHLENK LSTTGLNPTA VPFTLRNLSD
210 220 230 240 250
PAKDSPVIAE HYYGLGVKEQ NVGPQTSRNV NLDSIKLYTS DDEEADQLEF
260 270 280 290 300
EDEFAGSSSE VIVGISPEDE EPSSVGGKPN ESIGRTIEGQ SIRDNLQAKD
310 320 330 340 350
NKSTDVPGAG PKDSAVKEEP PQKRLPMLAE EFECSGSEDP IIRELLKENS
360 370 380 390 400
LINCQQGKDA QPPYHWSIER SISPDKTEIV NGAVQTADRQ RPGTPMPKSR
410 420 430 440 450
GIPIKKGHRR EISICWDGKR AWVEEWCNPA CSRITPLPRR QECQCGECPT

ECFHCG
Length:456
Mass (Da):50,325
Last modified:June 1, 2001 - v1
Checksum:i5E6735DC205B0EF9
GO

RNA editingi

Edited at position 406.
Partially edited. RNA editing at this position consists of an insertion of one or two guanine nucleotides. The sequence displayed here is the V protein, derived from the +1G edited RNA. The unedited RNA gives rise to the P protein (AC Q9IK91), the +2G edited RNA gives rise to the W protein (AC P0C1C7).

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti206P → L in strain: Isolate Malaysian flying-fox. 1
Natural varianti274S → R in strain: Isolate NV/MY/99/VRI-0626. 1
Natural varianti304T → A in strain: Isolate NV/MY/99/VRI-0626. 1
Natural varianti378E → K in strain: Isolate NV/MY/99/VRI-0626. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212302 Genomic RNA. Translation: AAK29090.1.
AY029768 Genomic RNA. Translation: AAK50551.1.
AY029767 Genomic RNA. Translation: AAK50547.1.
AF376747 Genomic RNA. Translation: AAM13407.1.
AJ564621 Genomic RNA. No translation available.
AJ564622 Genomic RNA. No translation available.
AJ564623 Genomic RNA. No translation available.
AJ627196 Genomic RNA. No translation available.
RefSeqiNP_112023.1. NC_002728.1.

Genome annotation databases

GeneIDi920952.

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiV_NIPAV
AccessioniPrimary (citable) accession number: Q997F2
Secondary accession number(s): Q8QU01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2001
Last modified: March 15, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families