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Protein

Cell surface A33 antigen

Gene

GPA33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell-cell recognition and signaling.

GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface A33 antigen
Alternative name(s):
Glycoprotein A33
Gene namesi
Name:GPA33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000143167.11
HGNCiHGNC:4445 GPA33
MIMi602171 gene
neXtProtiNX_Q99795

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 235ExtracellularSequence analysisAdd BLAST214
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 319CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10223
OpenTargetsiENSG00000143167
PharmGKBiPA28826

Polymorphism and mutation databases

BioMutaiGPA33
DMDMi2842765

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001477022 – 319Cell surface A33 antigenAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 117PROSITE-ProRule annotation
Glycosylationi112N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi146 ↔ 222PROSITE-ProRule annotation
Disulfide bondi162 ↔ 211PROSITE-ProRule annotation
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated, contains approximately 8 kDa of N-linked carbohydrate.1 Publication
Palmitoylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

EPDiQ99795
MaxQBiQ99795
PaxDbiQ99795
PeptideAtlasiQ99795
PRIDEiQ99795

PTM databases

iPTMnetiQ99795
PhosphoSitePlusiQ99795
SwissPalmiQ99795

Expressioni

Tissue specificityi

Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.

Gene expression databases

BgeeiENSG00000143167
CleanExiHS_GPA33
ExpressionAtlasiQ99795 baseline and differential
GenevisibleiQ99795 HS

Organism-specific databases

HPAiCAB025943
HPA018858

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-4289554,EBI-752420

Protein-protein interaction databases

BioGridi115517, 2 interactors
IntActiQ99795, 1 interactor
STRINGi9606.ENSP00000356842

Structurei

3D structure databases

ProteinModelPortaliQ99795
SMRiQ99795
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 134Ig-like V-typeAdd BLAST113
Domaini140 – 227Ig-like C2-typeAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 261Poly-Cys4

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWKU Eukaryota
ENOG410YJEV LUCA
GeneTreeiENSGT00760000119145
HOGENOMiHOG000112779
HOVERGENiHBG051792
InParanoidiQ99795
KOiK06790
OMAiVRSPSMN
OrthoDBiEOG091G05PI
PhylomeDBiQ99795
TreeFamiTF330875

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGKMWPVLW TLCAVRVTVD AISVETPQDV LRASQGKSVT LPCTYHTSTS
60 70 80 90 100
SREGLIQWDK LLLTHTERVV IWPFSNKNYI HGELYKNRVS ISNNAEQSDA
110 120 130 140 150
SITIDQLTMA DNGTYECSVS LMSDLEGNTK SRVRLLVLVP PSKPECGIEG
160 170 180 190 200
ETIIGNNIQL TCQSKEGSPT PQYSWKRYNI LNQEQPLAQP ASGQPVSLKN
210 220 230 240 250
ISTDTSGYYI CTSSNEEGTQ FCNITVAVRS PSMNVALYVG IAVGVVAALI
260 270 280 290 300
IIGIIIYCCC CRGKDDNTED KEDARPNREA YEEPPEQLRE LSREREEEDD
310
YRQEEQRSTG RESPDHLDQ
Length:319
Mass (Da):35,632
Last modified:May 1, 1997 - v1
Checksum:i9BFC7AAF45C2408E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02007920D → N. Corresponds to variant dbSNP:rs2274531Ensembl.1
Natural variantiVAR_049874165K → N. Corresponds to variant dbSNP:rs2228399Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79725 mRNA Translation: AAC50957.1
AK312833 mRNA Translation: BAG35687.1
AL158837 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90783.1
BC069705 mRNA Translation: AAH69705.1
BC069723 mRNA Translation: AAH69723.1
BC069745 mRNA Translation: AAH69745.1
BC069761 mRNA Translation: AAH69761.1
BC069789 mRNA Translation: AAH69789.1
BC074830 mRNA Translation: AAH74830.1
BC074876 mRNA Translation: AAH74876.1
BC107164 mRNA Translation: AAI07165.1
BC107165 mRNA Translation: AAI07166.1
CCDSiCCDS1258.1
RefSeqiNP_005805.1, NM_005814.2
UniGeneiHs.651244

Genome annotation databases

EnsembliENST00000367868; ENSP00000356842; ENSG00000143167
GeneIDi10223
KEGGihsa:10223
UCSCiuc001gea.2 human

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiGPA33_HUMAN
AccessioniPrimary (citable) accession number: Q99795
Secondary accession number(s): Q5VZP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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