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Q99795 (GPA33_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell surface A33 antigen
Alternative name(s):
Glycoprotein A33
Gene names
Name:GPA33
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in cell-cell recognition and signaling.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.

Post-translational modification

N-glycosylated, contains approximately 8 kDa of N-linked carbohydrate. Ref.6

Palmitoylated. Ref.6

Sequence similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 319298Cell surface A33 antigen
PRO_0000014770

Regions

Topological domain22 – 235214Extracellular Potential
Transmembrane236 – 25621Helical; Potential
Topological domain257 – 31963Cytoplasmic Potential
Domain22 – 134113Ig-like V-type
Domain140 – 22788Ig-like C2-type
Compositional bias258 – 2614Poly-Cys

Amino acid modifications

Glycosylation1121N-linked (GlcNAc...) Ref.6
Glycosylation2001N-linked (GlcNAc...) Potential
Glycosylation2231N-linked (GlcNAc...) Potential
Disulfide bond43 ↔ 117 Potential
Disulfide bond146 ↔ 222 Potential
Disulfide bond162 ↔ 211 Potential

Natural variations

Natural variant201D → N.
Corresponds to variant rs2274531 [ dbSNP | Ensembl ].
VAR_020079
Natural variant1651K → N.
Corresponds to variant rs16858376 [ dbSNP | Ensembl ].
VAR_049874

Sequences

Sequence LengthMass (Da)Tools
Q99795 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 9BFC7AAF45C2408E

FASTA31935,632
        10         20         30         40         50         60 
MVGKMWPVLW TLCAVRVTVD AISVETPQDV LRASQGKSVT LPCTYHTSTS SREGLIQWDK 

        70         80         90        100        110        120 
LLLTHTERVV IWPFSNKNYI HGELYKNRVS ISNNAEQSDA SITIDQLTMA DNGTYECSVS 

       130        140        150        160        170        180 
LMSDLEGNTK SRVRLLVLVP PSKPECGIEG ETIIGNNIQL TCQSKEGSPT PQYSWKRYNI 

       190        200        210        220        230        240 
LNQEQPLAQP ASGQPVSLKN ISTDTSGYYI CTSSNEEGTQ FCNITVAVRS PSMNVALYVG 

       250        260        270        280        290        300 
IAVGVVAALI IIGIIIYCCC CRGKDDNTED KEDARPNREA YEEPPEQLRE LSREREEEDD 

       310 
YRQEEQRSTG RESPDHLDQ 

« Hide

References

« Hide 'large scale' references
[1]"The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily."
Heath J.K., White S.J., Johnstone C.N., Catimel B., Simpson R.J., Moritz R.L., Tu G.-F., Ji H., Whitehead R.H., Groenen L.C., Scott A.M., Ritter G., Cohen L., Welt S., Old L.J., Nice E.C., Burgess A.W.
Proc. Natl. Acad. Sci. U.S.A. 94:469-474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Colon carcinoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[6]"Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium."
Ritter G., Cohen L.S., Nice E.C., Catimel B., Burgess A.W., Moritz R.L., Ji H., Heath J.K., White S.J., Welt S., Old L.J., Simpson R.J.
Biochem. Biophys. Res. Commun. 236:682-686(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-112, PALMITOYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U79725 mRNA. Translation: AAC50957.1.
AK312833 mRNA. Translation: BAG35687.1.
AL158837 Genomic DNA. Translation: CAH69957.1.
CH471067 Genomic DNA. Translation: EAW90783.1.
BC069705 mRNA. Translation: AAH69705.1.
BC069723 mRNA. Translation: AAH69723.1.
BC069745 mRNA. Translation: AAH69745.1.
BC069761 mRNA. Translation: AAH69761.1.
BC069789 mRNA. Translation: AAH69789.1.
BC074830 mRNA. Translation: AAH74830.1.
BC074876 mRNA. Translation: AAH74876.1.
BC107164 mRNA. Translation: AAI07165.1.
BC107165 mRNA. Translation: AAI07166.1.
RefSeqNP_005805.1. NM_005814.1.
UniGeneHs.651244.

3D structure databases

ProteinModelPortalQ99795.
SMRQ99795. Positions 27-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115517. 1 interaction.
MINTMINT-5001643.
STRING9606.ENSP00000356842.

PTM databases

PhosphoSiteQ99795.

Polymorphism databases

DMDM2842765.

Proteomic databases

PaxDbQ99795.
PeptideAtlasQ99795.
PRIDEQ99795.

Protocols and materials databases

DNASU10223.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367868; ENSP00000356842; ENSG00000143167.
GeneID10223.
KEGGhsa:10223.
UCSCuc001gea.1. human.

Organism-specific databases

CTD10223.
GeneCardsGC01M167022.
HGNCHGNC:4445. GPA33.
HPACAB025943.
HPA018858.
MIM602171. gene.
neXtProtNX_Q99795.
PharmGKBPA28826.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44728.
HOGENOMHOG000112779.
HOVERGENHBG051792.
InParanoidQ99795.
KOK06790.
OMASPSMNVA.
OrthoDBEOG7MH0Z1.
PhylomeDBQ99795.
TreeFamTF330875.

Gene expression databases

ArrayExpressQ99795.
BgeeQ99795.
CleanExHS_GPA33.
GenevestigatorQ99795.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00408. IGc2. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPA33.
GenomeRNAi10223.
NextBio38708.
PROQ99795.
SOURCESearch...

Entry information

Entry nameGPA33_HUMAN
AccessionPrimary (citable) accession number: Q99795
Secondary accession number(s): Q5VZP6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM