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Protein

Cell surface A33 antigen

Gene

GPA33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell-cell recognition and signaling.

GO - Molecular functioni

  • receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface A33 antigen
Alternative name(s):
Glycoprotein A33
Gene namesi
Name:GPA33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4445. GPA33.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 235214ExtracellularSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 31963CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell-cell junction Source: GO_Central
  • cell surface Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28826.

Polymorphism and mutation databases

BioMutaiGPA33.
DMDMi2842765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 319298Cell surface A33 antigenPRO_0000014770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 117PROSITE-ProRule annotation
Glycosylationi112 – 1121N-linked (GlcNAc...)1 Publication
Disulfide bondi146 ↔ 222PROSITE-ProRule annotation
Disulfide bondi162 ↔ 211PROSITE-ProRule annotation
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence analysis
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated, contains approximately 8 kDa of N-linked carbohydrate.1 Publication
Palmitoylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ99795.
PaxDbiQ99795.
PeptideAtlasiQ99795.
PRIDEiQ99795.

PTM databases

iPTMnetiQ99795.
PhosphoSiteiQ99795.
SwissPalmiQ99795.

Expressioni

Tissue specificityi

Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.

Gene expression databases

BgeeiQ99795.
CleanExiHS_GPA33.
ExpressionAtlasiQ99795. baseline and differential.
GenevisibleiQ99795. HS.

Organism-specific databases

HPAiCAB025943.
HPA018858.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-4289554,EBI-752420

Protein-protein interaction databases

BioGridi115517. 2 interactions.
IntActiQ99795. 1 interaction.
MINTiMINT-5001643.
STRINGi9606.ENSP00000356842.

Structurei

3D structure databases

ProteinModelPortaliQ99795.
SMRiQ99795. Positions 27-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 134113Ig-like V-typeAdd
BLAST
Domaini140 – 22788Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 2614Poly-Cys

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWKU. Eukaryota.
ENOG410YJEV. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000112779.
HOVERGENiHBG051792.
InParanoidiQ99795.
KOiK06790.
OMAiSPSMNVA.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ99795.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGKMWPVLW TLCAVRVTVD AISVETPQDV LRASQGKSVT LPCTYHTSTS
60 70 80 90 100
SREGLIQWDK LLLTHTERVV IWPFSNKNYI HGELYKNRVS ISNNAEQSDA
110 120 130 140 150
SITIDQLTMA DNGTYECSVS LMSDLEGNTK SRVRLLVLVP PSKPECGIEG
160 170 180 190 200
ETIIGNNIQL TCQSKEGSPT PQYSWKRYNI LNQEQPLAQP ASGQPVSLKN
210 220 230 240 250
ISTDTSGYYI CTSSNEEGTQ FCNITVAVRS PSMNVALYVG IAVGVVAALI
260 270 280 290 300
IIGIIIYCCC CRGKDDNTED KEDARPNREA YEEPPEQLRE LSREREEEDD
310
YRQEEQRSTG RESPDHLDQ
Length:319
Mass (Da):35,632
Last modified:May 1, 1997 - v1
Checksum:i9BFC7AAF45C2408E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201D → N.
Corresponds to variant rs2274531 [ dbSNP | Ensembl ].
VAR_020079
Natural varianti165 – 1651K → N.
Corresponds to variant rs2228399 [ dbSNP | Ensembl ].
VAR_049874

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79725 mRNA. Translation: AAC50957.1.
AK312833 mRNA. Translation: BAG35687.1.
AL158837 Genomic DNA. Translation: CAH69957.1.
CH471067 Genomic DNA. Translation: EAW90783.1.
BC069705 mRNA. Translation: AAH69705.1.
BC069723 mRNA. Translation: AAH69723.1.
BC069745 mRNA. Translation: AAH69745.1.
BC069761 mRNA. Translation: AAH69761.1.
BC069789 mRNA. Translation: AAH69789.1.
BC074830 mRNA. Translation: AAH74830.1.
BC074876 mRNA. Translation: AAH74876.1.
BC107164 mRNA. Translation: AAI07165.1.
BC107165 mRNA. Translation: AAI07166.1.
CCDSiCCDS1258.1.
RefSeqiNP_005805.1. NM_005814.2.
UniGeneiHs.651244.

Genome annotation databases

EnsembliENST00000367868; ENSP00000356842; ENSG00000143167.
GeneIDi10223.
KEGGihsa:10223.
UCSCiuc001gea.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79725 mRNA. Translation: AAC50957.1.
AK312833 mRNA. Translation: BAG35687.1.
AL158837 Genomic DNA. Translation: CAH69957.1.
CH471067 Genomic DNA. Translation: EAW90783.1.
BC069705 mRNA. Translation: AAH69705.1.
BC069723 mRNA. Translation: AAH69723.1.
BC069745 mRNA. Translation: AAH69745.1.
BC069761 mRNA. Translation: AAH69761.1.
BC069789 mRNA. Translation: AAH69789.1.
BC074830 mRNA. Translation: AAH74830.1.
BC074876 mRNA. Translation: AAH74876.1.
BC107164 mRNA. Translation: AAI07165.1.
BC107165 mRNA. Translation: AAI07166.1.
CCDSiCCDS1258.1.
RefSeqiNP_005805.1. NM_005814.2.
UniGeneiHs.651244.

3D structure databases

ProteinModelPortaliQ99795.
SMRiQ99795. Positions 27-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115517. 2 interactions.
IntActiQ99795. 1 interaction.
MINTiMINT-5001643.
STRINGi9606.ENSP00000356842.

PTM databases

iPTMnetiQ99795.
PhosphoSiteiQ99795.
SwissPalmiQ99795.

Polymorphism and mutation databases

BioMutaiGPA33.
DMDMi2842765.

Proteomic databases

MaxQBiQ99795.
PaxDbiQ99795.
PeptideAtlasiQ99795.
PRIDEiQ99795.

Protocols and materials databases

DNASUi10223.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367868; ENSP00000356842; ENSG00000143167.
GeneIDi10223.
KEGGihsa:10223.
UCSCiuc001gea.2. human.

Organism-specific databases

CTDi10223.
GeneCardsiGPA33.
HGNCiHGNC:4445. GPA33.
HPAiCAB025943.
HPA018858.
MIMi602171. gene.
neXtProtiNX_Q99795.
PharmGKBiPA28826.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWKU. Eukaryota.
ENOG410YJEV. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000112779.
HOVERGENiHBG051792.
InParanoidiQ99795.
KOiK06790.
OMAiSPSMNVA.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ99795.
TreeFamiTF330875.

Miscellaneous databases

ChiTaRSiGPA33. human.
GeneWikiiGPA33.
GenomeRNAii10223.
PROiQ99795.
SOURCEiSearch...

Gene expression databases

BgeeiQ99795.
CleanExiHS_GPA33.
ExpressionAtlasiQ99795. baseline and differential.
GenevisibleiQ99795. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Colon carcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium."
    Ritter G., Cohen L.S., Nice E.C., Catimel B., Burgess A.W., Moritz R.L., Ji H., Heath J.K., White S.J., Welt S., Old L.J., Simpson R.J.
    Biochem. Biophys. Res. Commun. 236:682-686(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-112, PALMITOYLATION.

Entry informationi

Entry nameiGPA33_HUMAN
AccessioniPrimary (citable) accession number: Q99795
Secondary accession number(s): Q5VZP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.