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Q99788

- CML1_HUMAN

UniProt

Q99788 - CML1_HUMAN

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Protein
Chemokine-like receptor 1
Gene
CMKLR1, CHEMR23, DEZ
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).4 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB
  2. chemokine receptor activity Source: ProtInc
  3. protein binding Source: UniProtKB
  4. receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. chemokine-mediated signaling pathway Source: GOC
  3. chemotaxis Source: UniProtKB
  4. immune response Source: ProtInc
  5. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  6. negative regulation of interleukin-12 production Source: UniProtKB
  7. positive regulation of fat cell differentiation Source: UniProtKB
  8. positive regulation of macrophage chemotaxis Source: DFLAT
  9. regulation of calcium-mediated signaling Source: UniProtKB
  10. skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine-like receptor 1
Alternative name(s):
G-protein coupled receptor ChemR23
G-protein coupled receptor DEZ
Gene namesi
Name:CMKLR1
Synonyms:CHEMR23, DEZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:2121. CMKLR1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141Extracellular Reviewed prediction
Add
BLAST
Transmembranei42 – 6423Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini65 – 7511Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei76 – 9722Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini98 – 11417Extracellular Reviewed prediction
Add
BLAST
Transmembranei115 – 13521Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini136 – 15419Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei155 – 17622Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini177 – 22448Extracellular Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini246 – 26116Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei262 – 28221Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini283 – 30018Extracellular Reviewed prediction
Add
BLAST
Transmembranei301 – 32020Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini321 – 37353Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Chemokine-like receptor 1
PRO_0000069307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi112 ↔ 189 Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ99788.

PTM databases

PhosphoSiteiQ99788.

Expressioni

Tissue specificityi

Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.6 Publications

Developmental stagei

Expressed during bone development.

Inductioni

Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells.3 Publications

Gene expression databases

ArrayExpressiQ99788.
BgeeiQ99788.
CleanExiHS_CMKLR1.
GenevestigatoriQ99788.

Organism-specific databases

HPAiHPA047865.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311733.

Structurei

3D structure databases

ProteinModelPortaliQ99788.
SMRiQ99788. Positions 33-324.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiQ99788.
KOiK04245.
OMAiACYLTIV.
OrthoDBiEOG7SR4MM.
PhylomeDBiQ99788.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000355. Chemokine_rcpt.
IPR002258. DEZorph_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01126. DEZORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q99788-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRMEDEDYNT SISYGDEYPD YLDSIVVLED LSPLEARVTR IFLVVVYSIV    50
CFLGILGNGL VIIIATFKMK KTVNMVWFLN LAVADFLFNV FLPIHITYAA 100
MDYHWVFGTA MCKISNFLLI HNMFTSVFLL TIISSDRCIS VLLPVWSQNH 150
RSVRLAYMAC MVIWVLAFFL SSPSLVFRDT ANLHGKISCF NNFSLSTPGS 200
SSWPTHSQMD PVGYSRHMVV TVTRFLCGFL VPVLIITACY LTIVCKLQRN 250
RLAKTKKPFK IIVTIIITFF LCWCPYHTLN LLELHHTAMP GSVFSLGLPL 300
ATALAIANSC MNPILYVFMG QDFKKFKVAL FSRLVNALSE DTGHSSYPSH 350
RSFTKMSSMN ERTSMNERET GML 373

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Length:373
Mass (Da):42,322
Last modified:November 16, 2001 - v2
Checksum:i5244B9738EC93834
GO
Isoform B (identifier: Q99788-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Show »
Length:371
Mass (Da):42,035
Checksum:i9A4E7AB541FB2898
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 22Missing in isoform B.
VSP_001985

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481Q → H in AAC51258. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79526 mRNA. Translation: AAC51258.1.
U79527 mRNA. Translation: AAC51259.1.
Y14838 Genomic DNA. Translation: CAA75112.1.
AB065871 Genomic DNA. Translation: BAC06089.1.
AY497547 mRNA. Translation: AAR90850.1.
AK291800 mRNA. Translation: BAF84489.1.
BT019556 mRNA. Translation: AAV38363.1.
BT019557 mRNA. Translation: AAV38364.1.
AC009729 Genomic DNA. No translation available.
AC063957 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97810.1.
CH471054 Genomic DNA. Translation: EAW97811.1.
BC106927 mRNA. Translation: AAI06928.1.
BC106928 mRNA. Translation: AAI06929.1.
CCDSiCCDS41829.1. [Q99788-2]
CCDS44965.1. [Q99788-1]
RefSeqiNP_001135815.1. NM_001142343.1. [Q99788-1]
NP_001135816.1. NM_001142344.1. [Q99788-1]
NP_001135817.1. NM_001142345.1. [Q99788-1]
NP_004063.1. NM_004072.2. [Q99788-2]
UniGeneiHs.197143.

Genome annotation databases

EnsembliENST00000312143; ENSP00000311733; ENSG00000174600. [Q99788-1]
ENST00000397688; ENSP00000380803; ENSG00000174600. [Q99788-2]
ENST00000412676; ENSP00000401293; ENSG00000174600. [Q99788-1]
ENST00000550402; ENSP00000449716; ENSG00000174600. [Q99788-1]
ENST00000552995; ENSP00000447579; ENSG00000174600. [Q99788-2]
GeneIDi1240.
KEGGihsa:1240.
UCSCiuc001tmv.3. human. [Q99788-1]

Polymorphism databases

DMDMi17380487.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79526 mRNA. Translation: AAC51258.1 .
U79527 mRNA. Translation: AAC51259.1 .
Y14838 Genomic DNA. Translation: CAA75112.1 .
AB065871 Genomic DNA. Translation: BAC06089.1 .
AY497547 mRNA. Translation: AAR90850.1 .
AK291800 mRNA. Translation: BAF84489.1 .
BT019556 mRNA. Translation: AAV38363.1 .
BT019557 mRNA. Translation: AAV38364.1 .
AC009729 Genomic DNA. No translation available.
AC063957 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97810.1 .
CH471054 Genomic DNA. Translation: EAW97811.1 .
BC106927 mRNA. Translation: AAI06928.1 .
BC106928 mRNA. Translation: AAI06929.1 .
CCDSi CCDS41829.1. [Q99788-2 ]
CCDS44965.1. [Q99788-1 ]
RefSeqi NP_001135815.1. NM_001142343.1. [Q99788-1 ]
NP_001135816.1. NM_001142344.1. [Q99788-1 ]
NP_001135817.1. NM_001142345.1. [Q99788-1 ]
NP_004063.1. NM_004072.2. [Q99788-2 ]
UniGenei Hs.197143.

3D structure databases

ProteinModelPortali Q99788.
SMRi Q99788. Positions 33-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000311733.

Chemistry

ChEMBLi CHEMBL3540.
GuidetoPHARMACOLOGYi 79.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q99788.

Polymorphism databases

DMDMi 17380487.

Proteomic databases

PRIDEi Q99788.

Protocols and materials databases

DNASUi 1240.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312143 ; ENSP00000311733 ; ENSG00000174600 . [Q99788-1 ]
ENST00000397688 ; ENSP00000380803 ; ENSG00000174600 . [Q99788-2 ]
ENST00000412676 ; ENSP00000401293 ; ENSG00000174600 . [Q99788-1 ]
ENST00000550402 ; ENSP00000449716 ; ENSG00000174600 . [Q99788-1 ]
ENST00000552995 ; ENSP00000447579 ; ENSG00000174600 . [Q99788-2 ]
GeneIDi 1240.
KEGGi hsa:1240.
UCSCi uc001tmv.3. human. [Q99788-1 ]

Organism-specific databases

CTDi 1240.
GeneCardsi GC12M108681.
HGNCi HGNC:2121. CMKLR1.
HPAi HPA047865.
MIMi 602351. gene.
neXtProti NX_Q99788.
PharmGKBi PA26640.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150376.
HOGENOMi HOG000234122.
HOVERGENi HBG107927.
InParanoidi Q99788.
KOi K04245.
OMAi ACYLTIV.
OrthoDBi EOG7SR4MM.
PhylomeDBi Q99788.
TreeFami TF330976.

Miscellaneous databases

GeneWikii CMKLR1.
GenomeRNAii 1240.
NextBioi 5061.
PROi Q99788.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99788.
Bgeei Q99788.
CleanExi HS_CMKLR1.
Genevestigatori Q99788.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000355. Chemokine_rcpt.
IPR002258. DEZorph_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01126. DEZORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development."
    Methner A., Hermey G., Schinke B., Hermans-Borgmeyer I.
    Biochem. Biophys. Res. Commun. 233:336-342(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
  2. "ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains."
    Samson M., Edinger A.L., Stordeur P., Rucker J., Verhasselt V., Sharron M., Govaerts C., Mollereau C., Vassart G., Doms R.W., Parmentier M.
    Eur. J. Immunol. 28:1689-1700(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B), FUNCTION AS HIV-1 AND SIV CORECEPTORS.
  3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B).
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Tissue: Kidney.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Placenta.
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
  7. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
  10. "Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors."
    Gantz I., Konda Y., Yang Y.K., Miller D.E., Dierick H.A., Yamada T.
    Cytogenet. Cell Genet. 74:286-290(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23."
    Meder W., Wendland M., Busmann A., Kutzleb C., Spodsberg N., John H., Richter R., Schleuder D., Meyer M., Forssmann W.G.
    FEBS Lett. 555:495-499(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.
  12. "Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids."
    Wittamer V., Franssen J.D., Vulcano M., Mirjolet J.F., Le Poul E., Migeotte I., Brezillon S., Tyldesley R., Blanpain C., Detheux M., Mantovani A., Sozzani S., Vassart G., Parmentier M., Communi D.
    J. Exp. Med. 198:977-985(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, LIGAND-BINDING, INDUCTION.
  13. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  14. "Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin."
    Vermi W., Riboldi E., Wittamer V., Gentili F., Luini W., Marrelli S., Vecchi A., Franssen J.D., Communi D., Massardi L., Sironi M., Mantovani A., Parmentier M., Facchetti F., Sozzani S.
    J. Exp. Med. 201:509-515(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
  15. "Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1."
    Arita M., Bianchini F., Aliberti J., Sher A., Chiang N., Hong S., Yang R., Petasis N.A., Serhan C.N.
    J. Exp. Med. 201:713-722(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING, INDUCTION, FUNCTION, TISSUE SPECIFICITY.
  16. "Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands."
    Zabel B.A., Ohyama T., Zuniga L., Kim J.Y., Johnston B., Allen S.J., Guido D.G., Handel T.M., Butcher E.C.
    Exp. Hematol. 34:1106-1114(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  17. "Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes."
    Takahashi M., Takahashi Y., Takahashi K., Zolotaryov F.N., Hong K.S., Kitazawa R., Iida K., Okimura Y., Kaji H., Kitazawa S., Kasuga M., Chihara K.
    FEBS Lett. 582:573-578(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  18. "Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis."
    Kaur J., Adya R., Tan B.K., Chen J., Randeva H.S.
    Biochem. Biophys. Res. Commun. 391:1762-1768(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION, FUNCTION.

Entry informationi

Entry nameiCML1_HUMAN
AccessioniPrimary (citable) accession number: Q99788
Secondary accession number(s): A8K6Y5
, O75748, Q3KP37, Q5U0H0, Q99789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 16, 2001
Last modified: July 9, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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