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Q99788 (CML1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chemokine-like receptor 1
Alternative name(s):
G-protein coupled receptor ChemR23
G-protein coupled receptor DEZ
Gene names
Name:CMKLR1
Synonyms:CHEMR23, DEZ
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Ref.2 Ref.14 Ref.15 Ref.18

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.14 Ref.16.

Tissue specificity

Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes. Ref.10 Ref.12 Ref.14 Ref.15 Ref.17 Ref.18

Developmental stage

Expressed during bone development.

Induction

Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells. Ref.12 Ref.15 Ref.18

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay Ref.12. Source: UniProtKB

chemokine-mediated signaling pathway

Traceable author statement PubMed 9425281. Source: GOC

chemotaxis

Inferred from direct assay Ref.12. Source: UniProtKB

immune response

Traceable author statement PubMed 9425281. Source: ProtInc

negative regulation of NF-kappaB transcription factor activity

Inferred from direct assay Ref.15. Source: UniProtKB

negative regulation of interleukin-12 production

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of fat cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of macrophage chemotaxis

Inferred from mutant phenotype PubMed 19443732. Source: DFLAT

regulation of calcium-mediated signaling

Inferred from direct assay Ref.12. Source: UniProtKB

skeletal system development

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral component of membrane

Non-traceable author statement Ref.2. Source: UniProtKB

integral component of plasma membrane

Traceable author statement PubMed 9425281. Source: ProtInc

plasma membrane

Inferred from direct assay Ref.12. Source: UniProtKB

   Molecular_functionG-protein coupled receptor activity

Non-traceable author statement Ref.2. Source: UniProtKB

chemokine receptor activity

Traceable author statement PubMed 9425281. Source: ProtInc

receptor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q99788-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform B (identifier: Q99788-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373Chemokine-like receptor 1
PRO_0000069307

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6423Helical; Name=1; Potential
Topological domain65 – 7511Cytoplasmic Potential
Transmembrane76 – 9722Helical; Name=2; Potential
Topological domain98 – 11417Extracellular Potential
Transmembrane115 – 13521Helical; Name=3; Potential
Topological domain136 – 15419Cytoplasmic Potential
Transmembrane155 – 17622Helical; Name=4; Potential
Topological domain177 – 22448Extracellular Potential
Transmembrane225 – 24521Helical; Name=5; Potential
Topological domain246 – 26116Cytoplasmic Potential
Transmembrane262 – 28221Helical; Name=6; Potential
Topological domain283 – 30018Extracellular Potential
Transmembrane301 – 32020Helical; Name=7; Potential
Topological domain321 – 37353Cytoplasmic Potential

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 189 Potential

Natural variations

Alternative sequence1 – 22Missing in isoform B.
VSP_001985

Experimental info

Sequence conflict2481Q → H in AAC51258. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified November 16, 2001. Version 2.
Checksum: 5244B9738EC93834

FASTA37342,322
        10         20         30         40         50         60 
MRMEDEDYNT SISYGDEYPD YLDSIVVLED LSPLEARVTR IFLVVVYSIV CFLGILGNGL 

        70         80         90        100        110        120 
VIIIATFKMK KTVNMVWFLN LAVADFLFNV FLPIHITYAA MDYHWVFGTA MCKISNFLLI 

       130        140        150        160        170        180 
HNMFTSVFLL TIISSDRCIS VLLPVWSQNH RSVRLAYMAC MVIWVLAFFL SSPSLVFRDT 

       190        200        210        220        230        240 
ANLHGKISCF NNFSLSTPGS SSWPTHSQMD PVGYSRHMVV TVTRFLCGFL VPVLIITACY 

       250        260        270        280        290        300 
LTIVCKLQRN RLAKTKKPFK IIVTIIITFF LCWCPYHTLN LLELHHTAMP GSVFSLGLPL 

       310        320        330        340        350        360 
ATALAIANSC MNPILYVFMG QDFKKFKVAL FSRLVNALSE DTGHSSYPSH RSFTKMSSMN 

       370 
ERTSMNERET GML 

« Hide

Isoform B [UniParc].

Checksum: 9A4E7AB541FB2898
Show »

FASTA37142,035

References

« Hide 'large scale' references
[1]"A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development."
Methner A., Hermey G., Schinke B., Hermans-Borgmeyer I.
Biochem. Biophys. Res. Commun. 233:336-342(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[2]"ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains."
Samson M., Edinger A.L., Stordeur P., Rucker J., Verhasselt V., Sharron M., Govaerts C., Mollereau C., Vassart G., Doms R.W., Parmentier M.
Eur. J. Immunol. 28:1689-1700(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B), FUNCTION AS HIV-1 AND SIV CORECEPTORS.
[3]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B).
[4]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
King M.M., Aronstam R.S., Sharma S.V.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Tissue: Kidney.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Tissue: Placenta.
[6]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
[7]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
[10]"Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors."
Gantz I., Konda Y., Yang Y.K., Miller D.E., Dierick H.A., Yamada T.
Cytogenet. Cell Genet. 74:286-290(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[11]"Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23."
Meder W., Wendland M., Busmann A., Kutzleb C., Spodsberg N., John H., Richter R., Schleuder D., Meyer M., Forssmann W.G.
FEBS Lett. 555:495-499(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND-BINDING.
[12]"Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids."
Wittamer V., Franssen J.D., Vulcano M., Mirjolet J.F., Le Poul E., Migeotte I., Brezillon S., Tyldesley R., Blanpain C., Detheux M., Mantovani A., Sozzani S., Vassart G., Parmentier M., Communi D.
J. Exp. Med. 198:977-985(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, LIGAND-BINDING, INDUCTION.
[13]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[14]"Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin."
Vermi W., Riboldi E., Wittamer V., Gentili F., Luini W., Marrelli S., Vecchi A., Franssen J.D., Communi D., Massardi L., Sironi M., Mantovani A., Parmentier M., Facchetti F., Sozzani S.
J. Exp. Med. 201:509-515(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
[15]"Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1."
Arita M., Bianchini F., Aliberti J., Sher A., Chiang N., Hong S., Yang R., Petasis N.A., Serhan C.N.
J. Exp. Med. 201:713-722(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND-BINDING, INDUCTION, FUNCTION, TISSUE SPECIFICITY.
[16]"Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands."
Zabel B.A., Ohyama T., Zuniga L., Kim J.Y., Johnston B., Allen S.J., Guido D.G., Handel T.M., Butcher E.C.
Exp. Hematol. 34:1106-1114(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[17]"Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes."
Takahashi M., Takahashi Y., Takahashi K., Zolotaryov F.N., Hong K.S., Kitazawa R., Iida K., Okimura Y., Kaji H., Kitazawa S., Kasuga M., Chihara K.
FEBS Lett. 582:573-578(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[18]"Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis."
Kaur J., Adya R., Tan B.K., Chen J., Randeva H.S.
Biochem. Biophys. Res. Commun. 391:1762-1768(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U79526 mRNA. Translation: AAC51258.1.
U79527 mRNA. Translation: AAC51259.1.
Y14838 Genomic DNA. Translation: CAA75112.1.
AB065871 Genomic DNA. Translation: BAC06089.1.
AY497547 mRNA. Translation: AAR90850.1.
AK291800 mRNA. Translation: BAF84489.1.
BT019556 mRNA. Translation: AAV38363.1.
BT019557 mRNA. Translation: AAV38364.1.
AC009729 Genomic DNA. No translation available.
AC063957 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97810.1.
CH471054 Genomic DNA. Translation: EAW97811.1.
BC106927 mRNA. Translation: AAI06928.1.
BC106928 mRNA. Translation: AAI06929.1.
RefSeqNP_001135815.1. NM_001142343.1.
NP_001135816.1. NM_001142344.1.
NP_001135817.1. NM_001142345.1.
NP_004063.1. NM_004072.2.
UniGeneHs.197143.

3D structure databases

ProteinModelPortalQ99788.
SMRQ99788. Positions 16-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000311733.

Chemistry

ChEMBLCHEMBL3540.
GuidetoPHARMACOLOGY79.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ99788.

Polymorphism databases

DMDM17380487.

Proteomic databases

PRIDEQ99788.

Protocols and materials databases

DNASU1240.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312143; ENSP00000311733; ENSG00000174600. [Q99788-1]
ENST00000397688; ENSP00000380803; ENSG00000174600. [Q99788-2]
ENST00000412676; ENSP00000401293; ENSG00000174600. [Q99788-1]
ENST00000550402; ENSP00000449716; ENSG00000174600. [Q99788-1]
ENST00000552995; ENSP00000447579; ENSG00000174600. [Q99788-2]
GeneID1240.
KEGGhsa:1240.
UCSCuc001tmv.3. human. [Q99788-1]

Organism-specific databases

CTD1240.
GeneCardsGC12M108681.
HGNCHGNC:2121. CMKLR1.
HPAHPA047865.
MIM602351. gene.
neXtProtNX_Q99788.
PharmGKBPA26640.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150376.
HOGENOMHOG000234122.
HOVERGENHBG107927.
InParanoidQ99788.
KOK04245.
OMAACYLTIV.
OrthoDBEOG7SR4MM.
PhylomeDBQ99788.
TreeFamTF330976.

Gene expression databases

ArrayExpressQ99788.
BgeeQ99788.
CleanExHS_CMKLR1.
GenevestigatorQ99788.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000355. Chemokine_rcpt.
IPR002258. DEZorph_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01126. DEZORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCMKLR1.
GenomeRNAi1240.
NextBio5061.
PROQ99788.
SOURCESearch...

Entry information

Entry nameCML1_HUMAN
AccessionPrimary (citable) accession number: Q99788
Secondary accession number(s): A8K6Y5 expand/collapse secondary AC list , O75748, Q3KP37, Q5U0H0, Q99789
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 16, 2001
Last modified: April 16, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries