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Q99788

- CML1_HUMAN

UniProt

Q99788 - CML1_HUMAN

Protein

Chemokine-like receptor 1

Gene

CMKLR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (16 Nov 2001)
      Previous versions | rss
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    Functioni

    Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).4 Publications

    GO - Molecular functioni

    1. chemokine receptor activity Source: ProtInc
    2. G-protein coupled receptor activity Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. receptor activity Source: ProtInc

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: GOC
    2. chemotaxis Source: UniProtKB
    3. G-protein coupled receptor signaling pathway Source: UniProtKB
    4. immune response Source: ProtInc
    5. negative regulation of interleukin-12 production Source: UniProtKB
    6. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
    7. positive regulation of fat cell differentiation Source: UniProtKB
    8. positive regulation of macrophage chemotaxis Source: DFLAT
    9. regulation of calcium-mediated signaling Source: UniProtKB
    10. skeletal system development Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chemokine-like receptor 1
    Alternative name(s):
    G-protein coupled receptor ChemR23
    G-protein coupled receptor DEZ
    Gene namesi
    Name:CMKLR1
    Synonyms:CHEMR23, DEZ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:2121. CMKLR1.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26640.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Chemokine-like receptor 1PRO_0000069307Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 189PROSITE-ProRule annotation
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ99788.

    PTM databases

    PhosphoSiteiQ99788.

    Expressioni

    Tissue specificityi

    Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.6 Publications

    Developmental stagei

    Expressed during bone development.

    Inductioni

    Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells.3 Publications

    Gene expression databases

    ArrayExpressiQ99788.
    BgeeiQ99788.
    CleanExiHS_CMKLR1.
    GenevestigatoriQ99788.

    Organism-specific databases

    HPAiHPA047865.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000311733.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99788.
    SMRiQ99788. Positions 33-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 7511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 22448ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini246 – 26116CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini283 – 30018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini321 – 37353CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6423Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 9722Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17622Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei301 – 32020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150376.
    HOGENOMiHOG000234122.
    HOVERGENiHBG107927.
    InParanoidiQ99788.
    KOiK04245.
    OMAiACYLTIV.
    OrthoDBiEOG7SR4MM.
    PhylomeDBiQ99788.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000355. Chemokine_rcpt.
    IPR002258. DEZorph_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01126. DEZORPHANR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q99788-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRMEDEDYNT SISYGDEYPD YLDSIVVLED LSPLEARVTR IFLVVVYSIV    50
    CFLGILGNGL VIIIATFKMK KTVNMVWFLN LAVADFLFNV FLPIHITYAA 100
    MDYHWVFGTA MCKISNFLLI HNMFTSVFLL TIISSDRCIS VLLPVWSQNH 150
    RSVRLAYMAC MVIWVLAFFL SSPSLVFRDT ANLHGKISCF NNFSLSTPGS 200
    SSWPTHSQMD PVGYSRHMVV TVTRFLCGFL VPVLIITACY LTIVCKLQRN 250
    RLAKTKKPFK IIVTIIITFF LCWCPYHTLN LLELHHTAMP GSVFSLGLPL 300
    ATALAIANSC MNPILYVFMG QDFKKFKVAL FSRLVNALSE DTGHSSYPSH 350
    RSFTKMSSMN ERTSMNERET GML 373

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Length:373
    Mass (Da):42,322
    Last modified:November 16, 2001 - v2
    Checksum:i5244B9738EC93834
    GO
    Isoform B (identifier: Q99788-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2: Missing.

    Show »
    Length:371
    Mass (Da):42,035
    Checksum:i9A4E7AB541FB2898
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti248 – 2481Q → H in AAC51258. (PubMed:9603476)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 22Missing in isoform B. 3 PublicationsVSP_001985

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79526 mRNA. Translation: AAC51258.1.
    U79527 mRNA. Translation: AAC51259.1.
    Y14838 Genomic DNA. Translation: CAA75112.1.
    AB065871 Genomic DNA. Translation: BAC06089.1.
    AY497547 mRNA. Translation: AAR90850.1.
    AK291800 mRNA. Translation: BAF84489.1.
    BT019556 mRNA. Translation: AAV38363.1.
    BT019557 mRNA. Translation: AAV38364.1.
    AC009729 Genomic DNA. No translation available.
    AC063957 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97810.1.
    CH471054 Genomic DNA. Translation: EAW97811.1.
    BC106927 mRNA. Translation: AAI06928.1.
    BC106928 mRNA. Translation: AAI06929.1.
    CCDSiCCDS41829.1. [Q99788-2]
    CCDS44965.1. [Q99788-1]
    RefSeqiNP_001135815.1. NM_001142343.1. [Q99788-1]
    NP_001135816.1. NM_001142344.1. [Q99788-1]
    NP_001135817.1. NM_001142345.1. [Q99788-1]
    NP_004063.1. NM_004072.2. [Q99788-2]
    UniGeneiHs.197143.

    Genome annotation databases

    EnsembliENST00000312143; ENSP00000311733; ENSG00000174600. [Q99788-1]
    ENST00000412676; ENSP00000401293; ENSG00000174600. [Q99788-1]
    ENST00000550402; ENSP00000449716; ENSG00000174600. [Q99788-1]
    ENST00000552995; ENSP00000447579; ENSG00000174600. [Q99788-2]
    GeneIDi1240.
    KEGGihsa:1240.
    UCSCiuc001tmv.3. human. [Q99788-1]

    Polymorphism databases

    DMDMi17380487.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79526 mRNA. Translation: AAC51258.1 .
    U79527 mRNA. Translation: AAC51259.1 .
    Y14838 Genomic DNA. Translation: CAA75112.1 .
    AB065871 Genomic DNA. Translation: BAC06089.1 .
    AY497547 mRNA. Translation: AAR90850.1 .
    AK291800 mRNA. Translation: BAF84489.1 .
    BT019556 mRNA. Translation: AAV38363.1 .
    BT019557 mRNA. Translation: AAV38364.1 .
    AC009729 Genomic DNA. No translation available.
    AC063957 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97810.1 .
    CH471054 Genomic DNA. Translation: EAW97811.1 .
    BC106927 mRNA. Translation: AAI06928.1 .
    BC106928 mRNA. Translation: AAI06929.1 .
    CCDSi CCDS41829.1. [Q99788-2 ]
    CCDS44965.1. [Q99788-1 ]
    RefSeqi NP_001135815.1. NM_001142343.1. [Q99788-1 ]
    NP_001135816.1. NM_001142344.1. [Q99788-1 ]
    NP_001135817.1. NM_001142345.1. [Q99788-1 ]
    NP_004063.1. NM_004072.2. [Q99788-2 ]
    UniGenei Hs.197143.

    3D structure databases

    ProteinModelPortali Q99788.
    SMRi Q99788. Positions 33-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000311733.

    Chemistry

    ChEMBLi CHEMBL3540.
    GuidetoPHARMACOLOGYi 79.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q99788.

    Polymorphism databases

    DMDMi 17380487.

    Proteomic databases

    PRIDEi Q99788.

    Protocols and materials databases

    DNASUi 1240.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312143 ; ENSP00000311733 ; ENSG00000174600 . [Q99788-1 ]
    ENST00000412676 ; ENSP00000401293 ; ENSG00000174600 . [Q99788-1 ]
    ENST00000550402 ; ENSP00000449716 ; ENSG00000174600 . [Q99788-1 ]
    ENST00000552995 ; ENSP00000447579 ; ENSG00000174600 . [Q99788-2 ]
    GeneIDi 1240.
    KEGGi hsa:1240.
    UCSCi uc001tmv.3. human. [Q99788-1 ]

    Organism-specific databases

    CTDi 1240.
    GeneCardsi GC12M108681.
    HGNCi HGNC:2121. CMKLR1.
    HPAi HPA047865.
    MIMi 602351. gene.
    neXtProti NX_Q99788.
    PharmGKBi PA26640.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150376.
    HOGENOMi HOG000234122.
    HOVERGENi HBG107927.
    InParanoidi Q99788.
    KOi K04245.
    OMAi ACYLTIV.
    OrthoDBi EOG7SR4MM.
    PhylomeDBi Q99788.
    TreeFami TF330976.

    Miscellaneous databases

    GeneWikii CMKLR1.
    GenomeRNAii 1240.
    NextBioi 5061.
    PROi Q99788.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99788.
    Bgeei Q99788.
    CleanExi HS_CMKLR1.
    Genevestigatori Q99788.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000355. Chemokine_rcpt.
    IPR002258. DEZorph_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01126. DEZORPHANR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development."
      Methner A., Hermey G., Schinke B., Hermans-Borgmeyer I.
      Biochem. Biophys. Res. Commun. 233:336-342(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
    2. "ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains."
      Samson M., Edinger A.L., Stordeur P., Rucker J., Verhasselt V., Sharron M., Govaerts C., Mollereau C., Vassart G., Doms R.W., Parmentier M.
      Eur. J. Immunol. 28:1689-1700(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B), FUNCTION AS HIV-1 AND SIV CORECEPTORS.
    3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B).
    4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Tissue: Kidney.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Tissue: Placenta.
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    7. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    10. "Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors."
      Gantz I., Konda Y., Yang Y.K., Miller D.E., Dierick H.A., Yamada T.
      Cytogenet. Cell Genet. 74:286-290(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23."
      Meder W., Wendland M., Busmann A., Kutzleb C., Spodsberg N., John H., Richter R., Schleuder D., Meyer M., Forssmann W.G.
      FEBS Lett. 555:495-499(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND-BINDING.
    12. "Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids."
      Wittamer V., Franssen J.D., Vulcano M., Mirjolet J.F., Le Poul E., Migeotte I., Brezillon S., Tyldesley R., Blanpain C., Detheux M., Mantovani A., Sozzani S., Vassart G., Parmentier M., Communi D.
      J. Exp. Med. 198:977-985(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, LIGAND-BINDING, INDUCTION.
    13. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    14. "Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin."
      Vermi W., Riboldi E., Wittamer V., Gentili F., Luini W., Marrelli S., Vecchi A., Franssen J.D., Communi D., Massardi L., Sironi M., Mantovani A., Parmentier M., Facchetti F., Sozzani S.
      J. Exp. Med. 201:509-515(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
    15. "Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1."
      Arita M., Bianchini F., Aliberti J., Sher A., Chiang N., Hong S., Yang R., Petasis N.A., Serhan C.N.
      J. Exp. Med. 201:713-722(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND-BINDING, INDUCTION, FUNCTION, TISSUE SPECIFICITY.
    16. "Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands."
      Zabel B.A., Ohyama T., Zuniga L., Kim J.Y., Johnston B., Allen S.J., Guido D.G., Handel T.M., Butcher E.C.
      Exp. Hematol. 34:1106-1114(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    17. "Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes."
      Takahashi M., Takahashi Y., Takahashi K., Zolotaryov F.N., Hong K.S., Kitazawa R., Iida K., Okimura Y., Kaji H., Kitazawa S., Kasuga M., Chihara K.
      FEBS Lett. 582:573-578(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    18. "Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis."
      Kaur J., Adya R., Tan B.K., Chen J., Randeva H.S.
      Biochem. Biophys. Res. Commun. 391:1762-1768(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION, FUNCTION.

    Entry informationi

    Entry nameiCML1_HUMAN
    AccessioniPrimary (citable) accession number: Q99788
    Secondary accession number(s): A8K6Y5
    , O75748, Q3KP37, Q5U0H0, Q99789
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3