Q99788 (CML1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chemokine-like receptor 1

Alternative name(s):
G-protein coupled receptor ChemR23
G-protein coupled receptor DEZ

Gene names

Name:	CMKLR1
Synonyms:	CHEMR23, DEZ

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Ref.2 Ref.14 Ref.15 Ref.17
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.14 Ref.16.
Tissue specificity	Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Ref.10 Ref.12 Ref.14 Ref.15 Ref.17
Developmental stage	Expressed during bone development.
Induction	Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells. Ref.12 Ref.15 Ref.17
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from direct assay Ref.12. Source: UniProtKB immune response Traceable author statement PubMed 9425281. Source: ProtInc negative regulation of NF-kappaB transcription factor activity Inferred from direct assay Ref.15. Source: UniProtKB negative regulation of interleukin-12 production Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of macrophage chemotaxis Inferred from mutant phenotype PubMed 19443732. Source: DFLAT regulation of calcium-mediated signaling Inferred from direct assay Ref.12. Source: UniProtKB skeletal system development Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement PubMed 9425281. Source: ProtInc
Molecular_function	chemokine receptor activity Traceable author statement PubMed 9425281. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q99788-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform B (identifier: Q99788-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Chemokine-like receptor 1		PRO_0000069307
Regions
	Topological domain	1 – 41	41	Extracellular Potential
	Transmembrane	42 – 64	23	Helical; Name=1; Potential
	Topological domain	65 – 75	11	Cytoplasmic Potential
	Transmembrane	76 – 97	22	Helical; Name=2; Potential
	Topological domain	98 – 114	17	Extracellular Potential
	Transmembrane	115 – 135	21	Helical; Name=3; Potential
	Topological domain	136 – 154	19	Cytoplasmic Potential
	Transmembrane	155 – 176	22	Helical; Name=4; Potential
	Topological domain	177 – 224	48	Extracellular Potential
	Transmembrane	225 – 245	21	Helical; Name=5; Potential
	Topological domain	246 – 261	16	Cytoplasmic Potential
	Transmembrane	262 – 282	21	Helical; Name=6; Potential
	Topological domain	283 – 300	18	Extracellular Potential
	Transmembrane	301 – 320	20	Helical; Name=7; Potential
	Topological domain	321 – 373	53	Cytoplasmic Potential
Amino acid modifications
	Modified residue	339	1	Phosphoserine By similarity
	Modified residue	342	1	Phosphothreonine By similarity
	Modified residue	349	1	Phosphoserine By similarity
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Disulfide bond	112 ↔ 189		Potential
Natural variations
	Alternative sequence	1 – 2	2	Missing in isoform B.		VSP_001985
Experimental info
	Sequence conflict	248	1	Q → H in AAC51258. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified November 16, 2001. Version 2. Checksum: 5244B9738EC93834	FASTA	373	42,322
	10 20 30 40 50 60 MRMEDEDYNT SISYGDEYPD YLDSIVVLED LSPLEARVTR IFLVVVYSIV CFLGILGNGL 70 80 90 100 110 120 VIIIATFKMK KTVNMVWFLN LAVADFLFNV FLPIHITYAA MDYHWVFGTA MCKISNFLLI 130 140 150 160 170 180 HNMFTSVFLL TIISSDRCIS VLLPVWSQNH RSVRLAYMAC MVIWVLAFFL SSPSLVFRDT 190 200 210 220 230 240 ANLHGKISCF NNFSLSTPGS SSWPTHSQMD PVGYSRHMVV TVTRFLCGFL VPVLIITACY 250 260 270 280 290 300 LTIVCKLQRN RLAKTKKPFK IIVTIIITFF LCWCPYHTLN LLELHHTAMP GSVFSLGLPL 310 320 330 340 350 360 ATALAIANSC MNPILYVFMG QDFKKFKVAL FSRLVNALSE DTGHSSYPSH RSFTKMSSMN 370 ERTSMNERET GML
	Isoform B [UniParc]. Checksum: 9A4E7AB541FB2898	FASTA	371	42,035
	10 20 30 40 50 60 MEDEDYNTSI SYGDEYPDYL DSIVVLEDLS PLEARVTRIF LVVVYSIVCF LGILGNGLVI 70 80 90 100 110 120 IIATFKMKKT VNMVWFLNLA VADFLFNVFL PIHITYAAMD YHWVFGTAMC KISNFLLIHN 130 140 150 160 170 180 MFTSVFLLTI ISSDRCISVL LPVWSQNHRS VRLAYMACMV IWVLAFFLSS PSLVFRDTAN 190 200 210 220 230 240 LHGKISCFNN FSLSTPGSSS WPTHSQMDPV GYSRHMVVTV TRFLCGFLVP VLIITACYLT 250 260 270 280 290 300 IVCKLQRNRL AKTKKPFKII VTIIITFFLC WCPYHTLNLL ELHHTAMPGS VFSLGLPLAT 310 320 330 340 350 360 ALAIANSCMN PILYVFMGQD FKKFKVALFS RLVNALSEDT GHSSYPSHRS FTKMSSMNER 370 TSMNERETGM L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development." Methner A., Hermey G., Schinke B., Hermans-Borgmeyer I. Biochem. Biophys. Res. Commun. 233:336-342(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[2]	"ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains." Samson M., Edinger A.L., Stordeur P., Rucker J., Verhasselt V., Sharron M., Govaerts C., Mollereau C., Vassart G., Doms R.W., Parmentier M. Eur. J. Immunol. 28:1689-1700(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B), FUNCTION AS HIV-1 AND SIV CORECEPTORS.
[3]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B).
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." King M.M., Aronstam R.S., Sharma S.V. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). Tissue: Kidney.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Placenta.
[6]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
[7]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
[10]	"Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors." Gantz I., Konda Y., Yang Y.K., Miller D.E., Dierick H.A., Yamada T. Cytogenet. Cell Genet. 74:286-290(1996) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23." Meder W., Wendland M., Busmann A., Kutzleb C., Spodsberg N., John H., Richter R., Schleuder D., Meyer M., Forssmann W.G. FEBS Lett. 555:495-499(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LIGAND-BINDING.
[12]	"Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids." Wittamer V., Franssen J.D., Vulcano M., Mirjolet J.F., Le Poul E., Migeotte I., Brezillon S., Tyldesley R., Blanpain C., Detheux M., Mantovani A., Sozzani S., Vassart G., Parmentier M., Communi D. J. Exp. Med. 198:977-985(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, LIGAND-BINDING, INDUCTION.
[13]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[14]	"Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin." Vermi W., Riboldi E., Wittamer V., Gentili F., Luini W., Marrelli S., Vecchi A., Franssen J.D., Communi D., Massardi L., Sironi M., Mantovani A., Parmentier M., Facchetti F., Sozzani S. J. Exp. Med. 201:509-515(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
[15]	"Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1." Arita M., Bianchini F., Aliberti J., Sher A., Chiang N., Hong S., Yang R., Petasis N.A., Serhan C.N. J. Exp. Med. 201:713-722(2005) [PubMed] [Europe PMC] [Abstract] Cited for: LIGAND-BINDING, INDUCTION, FUNCTION, TISSUE SPECIFICITY.
[16]	"Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands." Zabel B.A., Ohyama T., Zuniga L., Kim J.Y., Johnston B., Allen S.J., Guido D.G., Handel T.M., Butcher E.C. Exp. Hematol. 34:1106-1114(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[17]	"Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis." Kaur J., Adya R., Tan B.K., Chen J., Randeva H.S. Biochem. Biophys. Res. Commun. 391:1762-1768(2010) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INDUCTION, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U79526 mRNA. Translation: AAC51258.1. U79527 mRNA. Translation: AAC51259.1. Y14838 Genomic DNA. Translation: CAA75112.1. AB065871 Genomic DNA. Translation: BAC06089.1. AY497547 mRNA. Translation: AAR90850.1. AK291800 mRNA. Translation: BAF84489.1. BT019556 mRNA. Translation: AAV38363.1. BT019557 mRNA. Translation: AAV38364.1. AC009729 Genomic DNA. No translation available. AC063957 Genomic DNA. No translation available. CH471054 Genomic DNA. Translation: EAW97810.1. CH471054 Genomic DNA. Translation: EAW97811.1. BC106927 mRNA. Translation: AAI06928.1. BC106928 mRNA. Translation: AAI06929.1.
IPI	IPI00017843. IPI00215678.
RefSeq	NP_001135815.1. NM_001142343.1. NP_001135816.1. NM_001142344.1. NP_001135817.1. NM_001142345.1. NP_004063.1. NM_004072.2.
UniGene	Hs.197143.
3D structure databases
ProteinModelPortal	Q99788.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000311733.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q99788.
Polymorphism databases
DMDM	17380487.
Proteomic databases
PRIDE	Q99788.
Protocols and materials databases
DNASU	1240.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312143; ENSP00000311733; ENSG00000174600. ENST00000397688; ENSP00000380803; ENSG00000174600. ENST00000412676; ENSP00000401293; ENSG00000174600. ENST00000550402; ENSP00000449716; ENSG00000174600. ENST00000552995; ENSP00000447579; ENSG00000174600.
GeneID	1240.
KEGG	hsa:1240.
UCSC	uc001tmv.3. human.
Organism-specific databases
CTD	1240.
GeneCards	GC12M108681.
HGNC	HGNC:2121. CMKLR1.
HPA	HPA047865.
MIM	602351. gene.
neXtProt	NX_Q99788.
PharmGKB	PA26640.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150376.
HOGENOM	HOG000234122.
HOVERGEN	HBG107927.
InParanoid	Q99788.
KO	K04245.
OMA	ACYLTIV.
OrthoDB	EOG4SXNCW.
Gene expression databases
ArrayExpress	Q99788.
Bgee	Q99788.
CleanEx	HS_CMKLR1.
Genevestigator	Q99788.
GermOnline	ENSG00000174600. Homo sapiens.
Family and domain databases
InterPro	IPR002258. DEZorph_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01126. DEZORPHANR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL3540.
GenomeRNAi	1240.
NextBio	5061.
SOURCE	Search...

Entry information

Entry name

CML1_HUMAN

Accession

Primary (citable) accession number: Q99788
Secondary accession number(s): A8K6Y5 , O75748, Q3KP37, Q5U0H0, Q99789

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 16, 2001
Last modified:	May 1, 2013
This is version 120 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.