Q99784 (NOE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Noelin

Alternative name(s):
Neuronal olfactomedin-related ER localized protein
Olfactomedin-1

Gene names

Name:	OLFM1
Synonyms:	NOE1, NOEL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play an important role in regulating the production of neural crest cells by the neural tube By similarity.
Subunit structure	Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM1. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing By similarity.
Subcellular location	Secreted Potential. Cell junction › synapse By similarity.
Sequence similarities	Contains 1 olfactomedin-like domain.

Ontologies

Keywords
Cellular component	Cell junction Secreted Synapse
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nervous system development Traceable author statement Ref.1. Source: ProtInc protein oligomerization Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW extracellular space Inferred from electronic annotation. Source: Compara synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DISC1	Q9NRI5	3	EBI-1105073,EBI-529989

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q99784-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99784-2)

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: A → G
     154-485: Missing.

Isoform 3 (identifier: Q99784-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: MSVPLLKIGV...GGGTLDRSTG → MPGRWRWQRDMHPARKLLSLLFLILMGTELTQ

Isoform 4 (identifier: Q99784-4)

Also known as: AMY;

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: MSVPLLKIGV...GGGTLDRSTG → MPGRWRWQRDMHPARKLLSLLFLILMGTELTQ
     153-153: A → G
     154-485: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 485	469	Noelin		PRO_0000020074
Regions
	Domain	226 – 478	253	Olfactomedin-like
	Coiled coil	87 – 225	139	Potential
Amino acid modifications
	Glycosylation	33	1	N-linked (GlcNAc...) Potential
	Glycosylation	103	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	187	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	288	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	307	1	N-linked (GlcNAc...) Potential
	Glycosylation	394	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	431	1	N-linked (GlcNAc...) Potential
	Glycosylation	473	1	N-linked (GlcNAc...) Potential
	Disulfide bond	227 ↔ 409		By similarity
Natural variations
	Alternative sequence	1 – 50	50	MSVPL…DRSTG → MPGRWRWQRDMHPARKLLSL LFLILMGTELTQ in isoform 3 and isoform 4.		VSP_003759
	Alternative sequence	153	1	A → G in isoform 2 and isoform 4.		VSP_003760
	Alternative sequence	154 – 485	332	Missing in isoform 2 and isoform 4.		VSP_003761

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 23, 2008. Version 4. Checksum: D94BBDDAC60CF674	FASTA	485	55,343
	10 20 30 40 50 60 MSVPLLKIGV VLSTMAMITN WMSQTLPSLV GLNTTKLSAA GGGTLDRSTG VLPTNPEESW 70 80 90 100 110 120 QVYSSAQDSE GRCICTVVAP QQTMCSRDAR TKQLRQLLEK VQNMSQSIEV LDRRTQRDLQ 130 140 150 160 170 180 YVEKMENQMK GLESKFKQVE ESHKQHLARQ FKAIKAKMDE LRPLIPVLEE YKADAKLVLQ 190 200 210 220 230 240 FKEEVQNLTS VLNELQEEIG AYDYDELQSR VSNLEERLRA CMQKLACGKL TGISDPVTVK 250 260 270 280 290 300 TSGSRFGSWM TDPLAPEGDN RVWYMDGYHN NRFVREYKSM VDFMNTDNFT SHRLPHPWSG 310 320 330 340 350 360 TGQVVYNGSI YFNKFQSHII IRFDLKTETI LKTRSLDYAG YNNMYHYAWG GHSDIDLMVD 370 380 390 400 410 420 ESGLWAVYAT NQNAGNIVVS RLDPVSLQTL QTWNTSYPKR SAGEAFIICG TLYVTNGYSG 430 440 450 460 470 480 GTKVHYAYQT NASTYEYIDI PFQNKYSHIS MLDYNPKDRA LYAWNNGHQI LYNVTLFHVI RSDEL
	Isoform 2 [UniParc]. Checksum: 3B18DC0207992A74	FASTA	153	17,160
	10 20 30 40 50 60 MSVPLLKIGV VLSTMAMITN WMSQTLPSLV GLNTTKLSAA GGGTLDRSTG VLPTNPEESW 70 80 90 100 110 120 QVYSSAQDSE GRCICTVVAP QQTMCSRDAR TKQLRQLLEK VQNMSQSIEV LDRRTQRDLQ 130 140 150 YVEKMENQMK GLESKFKQVE ESHKQHLARQ FKG
	Isoform 3 [UniParc]. Checksum: 93D8EA9AD73562B6	FASTA	467	54,117
	10 20 30 40 50 60 MPGRWRWQRD MHPARKLLSL LFLILMGTEL TQVLPTNPEE SWQVYSSAQD SEGRCICTVV 70 80 90 100 110 120 APQQTMCSRD ARTKQLRQLL EKVQNMSQSI EVLDRRTQRD LQYVEKMENQ MKGLESKFKQ 130 140 150 160 170 180 VEESHKQHLA RQFKAIKAKM DELRPLIPVL EEYKADAKLV LQFKEEVQNL TSVLNELQEE 190 200 210 220 230 240 IGAYDYDELQ SRVSNLEERL RACMQKLACG KLTGISDPVT VKTSGSRFGS WMTDPLAPEG 250 260 270 280 290 300 DNRVWYMDGY HNNRFVREYK SMVDFMNTDN FTSHRLPHPW SGTGQVVYNG SIYFNKFQSH 310 320 330 340 350 360 IIIRFDLKTE TILKTRSLDY AGYNNMYHYA WGGHSDIDLM VDESGLWAVY ATNQNAGNIV 370 380 390 400 410 420 VSRLDPVSLQ TLQTWNTSYP KRSAGEAFII CGTLYVTNGY SGGTKVHYAY QTNASTYEYI 430 440 450 460 DIPFQNKYSH ISMLDYNPKD RALYAWNNGH QILYNVTLFH VIRSDEL
	Isoform 4 (AMY) [UniParc]. Checksum: 8F6A30B160351055	FASTA	135	15,934
	10 20 30 40 50 60 MPGRWRWQRD MHPARKLLSL LFLILMGTEL TQVLPTNPEE SWQVYSSAQD SEGRCICTVV 70 80 90 100 110 120 APQQTMCSRD ARTKQLRQLL EKVQNMSQSI EVLDRRTQRD LQYVEKMENQ MKGLESKFKQ 130 VEESHKQHLA RQFKG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles." Yokoyama M., Nishi Y., Yoshii J., Okubo K., Matsubara K. DNA Res. 3:311-320(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Eye.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-485 (ISOFORM 3).
[5]	"Large-scale concatenation cDNA sequencing." Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A. Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-485 (ISOFORM 1). Tissue: Brain.
[6]	"Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders." Mukhopadhyay A., Talukdar S., Bhattacharjee A., Ray K. Mol. Vis. 10:304-314(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-103; ASN-187; ASN-288 AND ASN-394, MASS SPECTROMETRY. Tissue: Plasma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D82343 mRNA. Translation: BAA11554.1. AK290478 mRNA. Translation: BAF83167.1. BC011741 mRNA. Translation: AAH11741.2. BC008763 mRNA. Translation: AAH08763.2. BT007146 mRNA. Translation: AAP35810.1. U79299 mRNA. Translation: AAB50225.1. AF035301 mRNA. Translation: AAB88184.1. BK001427 Genomic DNA. Translation: DAA01547.1.
IPI	IPI00017841. IPI00419820. IPI00419822. IPI00472517.
PIR	JC5272.
RefSeq	NP_006325.1. NM_006334.3. NP_055094.1. NM_014279.4.
UniGene	Hs.522484.
3D structure databases
ProteinModelPortal	Q99784.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99784. 2 interactions.
STRING	9606.ENSP00000252854.
PTM databases
PhosphoSite	Q99784.
Polymorphism databases
DMDM	206729935.
Proteomic databases
PaxDb	Q99784.
PRIDE	Q99784.
Protocols and materials databases
DNASU	10439.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252854; ENSP00000252854; ENSG00000130558. ENST00000277415; ENSP00000277415; ENSG00000130558. ENST00000371793; ENSP00000360858; ENSG00000130558. ENST00000392991; ENSP00000376717; ENSG00000130558.
GeneID	10439.
KEGG	hsa:10439.
UCSC	uc010nar.3. human.
Organism-specific databases
CTD	10439.
GeneCards	GC09P137967.
HGNC	HGNC:17187. OLFM1.
MIM	605366. gene.
neXtProt	NX_Q99784.
PharmGKB	PA31915.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG283888.
HOGENOM	HOG000232069.
HOVERGEN	HBG006513.
InParanoid	Q99784.
OMA	MVDFMNT.
PhylomeDB	Q99784.
Gene expression databases
ArrayExpress	Q99784.
Bgee	Q99784.
CleanEx	HS_OLFM1.
Genevestigator	Q99784.
GermOnline	ENSG00000130558. Homo sapiens.
Family and domain databases
InterPro	IPR022082. Noelin-1. IPR003112. Olfac-like. IPR011047. Quinonprotein_ADH-like_supfam. [Graphical view]
Pfam	PF12308. Noelin-1. 1 hit. PF02191. OLF. 1 hit. [Graphical view]
SMART	SM00284. OLF. 1 hit. [Graphical view]
SUPFAM	SSF50998. Quin_alc_DH_like. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. PS51132. OLF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	OLFM1. human.
GenomeRNAi	10439.
NextBio	39567.
SOURCE	Search...

Entry information

Entry name

NOE1_HUMAN

Accession

Primary (citable) accession number: Q99784
Secondary accession number(s): Q53XZ8 , Q6IMJ4, Q969S7, Q99452

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	September 23, 2008
Last modified:	April 3, 2013
This is version 127 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.