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Protein

Noelin

Gene

OLFM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Noelin
Alternative name(s):
Neuronal olfactomedin-related ER localized protein
Olfactomedin-1
Gene namesi
Name:OLFM1
Synonyms:NOE1, NOEL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17187. OLFM1.

Subcellular locationi

  • Secreted By similarity
  • Cell junctionsynapse By similarity
  • Endoplasmic reticulum By similarity
  • Cell projectionaxon By similarity
  • Perikaryon By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Endoplasmic reticulum, Secreted, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi10439.
OpenTargetsiENSG00000130558.
PharmGKBiPA31915.

Polymorphism and mutation databases

DMDMi206729935.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002007417 – 485NoelinAdd BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)1 Publication1
Glycosylationi187N-linked (GlcNAc...)1 Publication1
Disulfide bondi221InterchainBy similarity
Disulfide bondi227 ↔ 409PROSITE-ProRule annotationBy similarity
Glycosylationi288N-linked (GlcNAc...)1 Publication1
Glycosylationi307N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)1 Publication1
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Glycosylationi473N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ99784.
PaxDbiQ99784.
PeptideAtlasiQ99784.
PRIDEiQ99784.

PTM databases

iPTMnetiQ99784.
PhosphoSitePlusiQ99784.

Expressioni

Gene expression databases

BgeeiENSG00000130558.
CleanExiHS_OLFM1.
ExpressionAtlasiQ99784. baseline and differential.
GenevisibleiQ99784. HS.

Organism-specific databases

HPAiHPA057444.

Interactioni

Subunit structurei

Homotetramer; disulfide-linked. Dimer of dimers, giving rise to a V-shaped homotretramer. Isoform 1 and isoform 3 interact with RTN4R. Identified in a complex with RTN4R and LINGO1. Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM1. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity). Interacts with OLFM2 (PubMed:21228389).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI53EBI-1105073,EBI-529989

Protein-protein interaction databases

BioGridi115706. 13 interactors.
IntActiQ99784. 5 interactors.
STRINGi9606.ENSP00000252854.

Structurei

Secondary structure

1485
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi229 – 233Combined sources5
Beta strandi245 – 251Combined sources7
Beta strandi262 – 266Combined sources5
Beta strandi268 – 279Combined sources12
Helixi280 – 285Combined sources6
Beta strandi290 – 301Combined sources12
Beta strandi304 – 306Combined sources3
Beta strandi309 – 314Combined sources6
Beta strandi317 – 324Combined sources8
Turni325 – 328Combined sources4
Beta strandi329 – 335Combined sources7
Beta strandi342 – 345Combined sources4
Beta strandi356 – 360Combined sources5
Beta strandi363 – 369Combined sources7
Turni371 – 375Combined sources5
Beta strandi376 – 382Combined sources7
Turni384 – 386Combined sources3
Beta strandi389 – 398Combined sources10
Helixi399 – 401Combined sources3
Beta strandi405 – 408Combined sources4
Beta strandi411 – 416Combined sources6
Beta strandi418 – 421Combined sources4
Beta strandi423 – 429Combined sources7
Turni430 – 433Combined sources4
Beta strandi434 – 441Combined sources8
Beta strandi449 – 455Combined sources7
Turni456 – 459Combined sources4
Beta strandi460 – 477Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XATX-ray2.11A218-485[»]
ProteinModelPortaliQ99784.
SMRiQ99784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 478Olfactomedin-likePROSITE-ProRule annotationAdd BLAST253

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 225Sequence analysisAdd BLAST139

Domaini

The protein contains a globular N-terminal tetramerization domain, a long stalk formed by the coiled coil region and a C-terminal olfactomedin-like domain. Interactions between dimers are mediated by the coiled coil region. The dimers interact mostly via the N-terminal tetramerization domain, giving rise to a V-shaped overall architecture of the tetramer.By similarity

Sequence similaritiesi

Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410INP5. Eukaryota.
ENOG41100WH. LUCA.
GeneTreeiENSGT00760000119005.
HOGENOMiHOG000232069.
HOVERGENiHBG006513.
InParanoidiQ99784.
OMAiQILQTWN.
OrthoDBiEOG091G05HN.
PhylomeDBiQ99784.
TreeFamiTF315964.

Family and domain databases

InterProiIPR031217. Noelin.
IPR022082. Noelin_dom.
IPR003112. Olfac-like_dom.
IPR011044. Quino_amine_DH_bsu.
[Graphical view]
PANTHERiPTHR23192:SF34. PTHR23192:SF34. 1 hit.
PfamiPF12308. Noelin-1. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51132. OLF. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q99784-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVPLLKIGV VLSTMAMITN WMSQTLPSLV GLNTTKLSAA GGGTLDRSTG
60 70 80 90 100
VLPTNPEESW QVYSSAQDSE GRCICTVVAP QQTMCSRDAR TKQLRQLLEK
110 120 130 140 150
VQNMSQSIEV LDRRTQRDLQ YVEKMENQMK GLESKFKQVE ESHKQHLARQ
160 170 180 190 200
FKAIKAKMDE LRPLIPVLEE YKADAKLVLQ FKEEVQNLTS VLNELQEEIG
210 220 230 240 250
AYDYDELQSR VSNLEERLRA CMQKLACGKL TGISDPVTVK TSGSRFGSWM
260 270 280 290 300
TDPLAPEGDN RVWYMDGYHN NRFVREYKSM VDFMNTDNFT SHRLPHPWSG
310 320 330 340 350
TGQVVYNGSI YFNKFQSHII IRFDLKTETI LKTRSLDYAG YNNMYHYAWG
360 370 380 390 400
GHSDIDLMVD ESGLWAVYAT NQNAGNIVVS RLDPVSLQTL QTWNTSYPKR
410 420 430 440 450
SAGEAFIICG TLYVTNGYSG GTKVHYAYQT NASTYEYIDI PFQNKYSHIS
460 470 480
MLDYNPKDRA LYAWNNGHQI LYNVTLFHVI RSDEL
Length:485
Mass (Da):55,343
Last modified:September 23, 2008 - v4
Checksum:iD94BBDDAC60CF674
GO
Isoform 2 (identifier: Q99784-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: A → G
     154-485: Missing.

Show »
Length:153
Mass (Da):17,160
Checksum:i3B18DC0207992A74
GO
Isoform 3 (identifier: Q99784-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: MSVPLLKIGV...GGGTLDRSTG → MPGRWRWQRDMHPARKLLSLLFLILMGTELTQ

Show »
Length:467
Mass (Da):54,117
Checksum:i93D8EA9AD73562B6
GO
Isoform 4 (identifier: Q99784-4) [UniParc]FASTAAdd to basket
Also known as: AMY

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: MSVPLLKIGV...GGGTLDRSTG → MPGRWRWQRDMHPARKLLSLLFLILMGTELTQ
     153-153: A → G
     154-485: Missing.

Show »
Length:135
Mass (Da):15,934
Checksum:i8F6A30B160351055
GO
Isoform 5 (identifier: Q99784-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLSAAGGGTLDRSTG → MGEAPGREGRGPCPQLESPRRRR

Note: No experimental confirmation available.
Show »
Length:458
Mass (Da):52,815
Checksum:iDFD8A706766D5244
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127N → T in BAC04756 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0037591 – 50MSVPL…DRSTG → MPGRWRWQRDMHPARKLLSL LFLILMGTELTQ in isoform 3 and isoform 4. 3 PublicationsAdd BLAST50
Alternative sequenceiVSP_0556251 – 50MSVPL…DRSTG → MGEAPGREGRGPCPQLESPR RRR in isoform 5. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_003760153A → G in isoform 2 and isoform 4. 1 Publication1
Alternative sequenceiVSP_003761154 – 485Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST332

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82343 mRNA. Translation: BAA11554.1.
AK096304 mRNA. Translation: BAC04756.1.
AK290478 mRNA. Translation: BAF83167.1.
AL159992 Genomic DNA. No translation available.
AL390778 Genomic DNA. No translation available.
BC008763 mRNA. Translation: AAH08763.2.
BC011741 mRNA. Translation: AAH11741.2.
BT007146 mRNA. Translation: AAP35810.1.
U79299 mRNA. Translation: AAB50225.1.
AF035301 mRNA. Translation: AAB88184.1.
BK001427 Genomic DNA. Translation: DAA01546.1.
BK001427 Genomic DNA. Translation: DAA01547.1.
CCDSiCCDS65183.1. [Q99784-5]
CCDS65184.1. [Q99784-1]
CCDS6986.1. [Q99784-3]
CCDS6987.1. [Q99784-4]
PIRiJC5272.
RefSeqiNP_001269540.1. NM_001282611.1. [Q99784-1]
NP_001269541.1. NM_001282612.1. [Q99784-5]
NP_006325.1. NM_006334.3. [Q99784-4]
NP_055094.1. NM_014279.4. [Q99784-3]
UniGeneiHs.522484.

Genome annotation databases

EnsembliENST00000252854; ENSP00000252854; ENSG00000130558. [Q99784-3]
ENST00000277415; ENSP00000277415; ENSG00000130558. [Q99784-4]
ENST00000371793; ENSP00000360858; ENSG00000130558. [Q99784-1]
ENST00000371796; ENSP00000360861; ENSG00000130558. [Q99784-5]
ENST00000392991; ENSP00000376717; ENSG00000130558. [Q99784-2]
GeneIDi10439.
KEGGihsa:10439.
UCSCiuc004cfk.5. human. [Q99784-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82343 mRNA. Translation: BAA11554.1.
AK096304 mRNA. Translation: BAC04756.1.
AK290478 mRNA. Translation: BAF83167.1.
AL159992 Genomic DNA. No translation available.
AL390778 Genomic DNA. No translation available.
BC008763 mRNA. Translation: AAH08763.2.
BC011741 mRNA. Translation: AAH11741.2.
BT007146 mRNA. Translation: AAP35810.1.
U79299 mRNA. Translation: AAB50225.1.
AF035301 mRNA. Translation: AAB88184.1.
BK001427 Genomic DNA. Translation: DAA01546.1.
BK001427 Genomic DNA. Translation: DAA01547.1.
CCDSiCCDS65183.1. [Q99784-5]
CCDS65184.1. [Q99784-1]
CCDS6986.1. [Q99784-3]
CCDS6987.1. [Q99784-4]
PIRiJC5272.
RefSeqiNP_001269540.1. NM_001282611.1. [Q99784-1]
NP_001269541.1. NM_001282612.1. [Q99784-5]
NP_006325.1. NM_006334.3. [Q99784-4]
NP_055094.1. NM_014279.4. [Q99784-3]
UniGeneiHs.522484.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XATX-ray2.11A218-485[»]
ProteinModelPortaliQ99784.
SMRiQ99784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115706. 13 interactors.
IntActiQ99784. 5 interactors.
STRINGi9606.ENSP00000252854.

PTM databases

iPTMnetiQ99784.
PhosphoSitePlusiQ99784.

Polymorphism and mutation databases

DMDMi206729935.

Proteomic databases

MaxQBiQ99784.
PaxDbiQ99784.
PeptideAtlasiQ99784.
PRIDEiQ99784.

Protocols and materials databases

DNASUi10439.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252854; ENSP00000252854; ENSG00000130558. [Q99784-3]
ENST00000277415; ENSP00000277415; ENSG00000130558. [Q99784-4]
ENST00000371793; ENSP00000360858; ENSG00000130558. [Q99784-1]
ENST00000371796; ENSP00000360861; ENSG00000130558. [Q99784-5]
ENST00000392991; ENSP00000376717; ENSG00000130558. [Q99784-2]
GeneIDi10439.
KEGGihsa:10439.
UCSCiuc004cfk.5. human. [Q99784-1]

Organism-specific databases

CTDi10439.
DisGeNETi10439.
GeneCardsiOLFM1.
HGNCiHGNC:17187. OLFM1.
HPAiHPA057444.
MIMi605366. gene.
neXtProtiNX_Q99784.
OpenTargetsiENSG00000130558.
PharmGKBiPA31915.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INP5. Eukaryota.
ENOG41100WH. LUCA.
GeneTreeiENSGT00760000119005.
HOGENOMiHOG000232069.
HOVERGENiHBG006513.
InParanoidiQ99784.
OMAiQILQTWN.
OrthoDBiEOG091G05HN.
PhylomeDBiQ99784.
TreeFamiTF315964.

Miscellaneous databases

ChiTaRSiOLFM1. human.
GeneWikiiOLFM1.
GenomeRNAii10439.
PROiQ99784.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130558.
CleanExiHS_OLFM1.
ExpressionAtlasiQ99784. baseline and differential.
GenevisibleiQ99784. HS.

Family and domain databases

InterProiIPR031217. Noelin.
IPR022082. Noelin_dom.
IPR003112. Olfac-like_dom.
IPR011044. Quino_amine_DH_bsu.
[Graphical view]
PANTHERiPTHR23192:SF34. PTHR23192:SF34. 1 hit.
PfamiPF12308. Noelin-1. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51132. OLF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOE1_HUMAN
AccessioniPrimary (citable) accession number: Q99784
Secondary accession number(s): Q53XZ8
, Q6IMJ4, Q6IMJ5, Q8N8R0, Q969S7, Q99452
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 159 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.