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Q99766

- ATP5S_HUMAN

UniProt

Q99766 - ATP5S_HUMAN

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Protein

ATP synthase subunit s, mitochondrial

Gene

ATP5S

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Magnesium; via carbonyl oxygenBy similarity
Metal bindingi108 – 1081MagnesiumBy similarity

GO - Molecular functioni

  1. hydrogen ion transmembrane transporter activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP biosynthetic process Source: UniProtKB-KW
  2. hydrogen ion transmembrane transport Source: GOC
  3. proton transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_6759. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit s, mitochondrial
Alternative name(s):
ATP synthase-coupling factor B
Short name:
FB
Mitochondrial ATP synthase regulatory component factor B
Gene namesi
Name:ATP5S
Synonyms:ATPW
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:18799. ATP5S.

Subcellular locationi

Mitochondrion By similarity. Mitochondrion inner membrane By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. proton-transporting ATP synthase complex, coupling factor F(o) Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040MitochondrionAdd
BLAST
Chaini41 – 215175ATP synthase subunit s, mitochondrialPRO_0000002538Add
BLAST

Proteomic databases

MaxQBiQ99766.
PaxDbiQ99766.
PRIDEiQ99766.

PTM databases

PhosphoSiteiQ99766.

Expressioni

Gene expression databases

BgeeiQ99766.
CleanExiHS_ATP5S.
ExpressionAtlasiQ99766. baseline and differential.
GenevestigatoriQ99766.

Organism-specific databases

HPAiHPA046967.

Interactioni

Subunit structurei

Homotetramer. Associates with ATP synthase (By similarity).By similarity

Protein-protein interaction databases

IntActiQ99766. 1 interaction.
STRINGi9606.ENSP00000308334.

Structurei

3D structure databases

ProteinModelPortaliQ99766.
SMRiQ99766. Positions 41-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati77 – 10226LRR 1Add
BLAST
Repeati103 – 13129LRR 2Add
BLAST
Repeati132 – 15625LRR 3Add
BLAST
Repeati157 – 18832LRR 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7676N-terminal domainAdd
BLAST

Sequence similaritiesi

Belongs to the ATP synthase subunit s family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transit peptide

Phylogenomic databases

eggNOGiNOG307162.
GeneTreeiENSGT00530000063680.
HOGENOMiHOG000230741.
HOVERGENiHBG050615.
InParanoidiQ99766.
KOiK07554.
OMAiCAFKPMA.
OrthoDBiEOG7GJ6FJ.
PhylomeDBiQ99766.
TreeFamiTF315274.

Family and domain databases

InterProiIPR026063. ATP_synthase_s.
[Graphical view]
PANTHERiPTHR13382. PTHR13382. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99766-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCCAVSEQRL TCADQMMPFG KISQQLCGVK KLPWSCDSRY FWGWLNAVFN
60 70 80 90 100
KVDYDRIRDV GPDRAASEWL LRCGAMVRYH GQERWQKDYN HLPTGPLDKY
110 120 130 140 150
KIQAIDATDS CIMSIGFDHM EGLEHVEKIR LCKCHYIEDD CLLRLSQLEN
160 170 180 190 200
LQKTILEMEI ISCGNITDKG IIALRHLRNL KYLLLSDLPG VREKENLVQA
210
FKTALPSLEL KLQLK
Length:215
Mass (Da):24,866
Last modified:November 30, 2010 - v3
Checksum:iDFDCDE6D81E5DC62
GO
Isoform 2 (identifier: Q99766-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-136: EGLEHVEKIRLCKCHY → GNYPIVLLIENADDLQ
     137-215: Missing.

Show »
Length:136
Mass (Da):15,685
Checksum:iC69A8CD2A7720FCC
GO
Isoform 3 (identifier: Q99766-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-127: GLEHVE → TSNICC
     128-215: Missing.

Show »
Length:127
Mass (Da):14,667
Checksum:i7C0681D95BD6EABB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181P → L.5 Publications
Corresponds to variant rs2275592 [ dbSNP | Ensembl ].
VAR_060296

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei121 – 13616EGLEH…CKCHY → GNYPIVLLIENADDLQ in isoform 2. 1 PublicationVSP_040059Add
BLAST
Alternative sequencei122 – 1276GLEHVE → TSNICC in isoform 3. 1 PublicationVSP_040060
Alternative sequencei128 – 21588Missing in isoform 3. 1 PublicationVSP_040061Add
BLAST
Alternative sequencei137 – 21579Missing in isoform 2. 1 PublicationVSP_040062Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79253 mRNA. Translation: AAB50202.1.
AY052377 mRNA. Translation: AAL13058.1.
AK290008 mRNA. Translation: BAF82697.1.
AL359397 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65718.1.
CH471078 Genomic DNA. Translation: EAW65722.1.
BC011549 mRNA. Translation: AAH11549.1.
CCDSiCCDS32075.1. [Q99766-1]
CCDS32076.1. [Q99766-3]
CCDS45102.1. [Q99766-2]
RefSeqiNP_001003803.1. NM_001003803.2. [Q99766-1]
NP_001003805.1. NM_001003805.2. [Q99766-3]
NP_056499.2. NM_015684.3. [Q99766-2]
UniGeneiHs.438489.

Genome annotation databases

EnsembliENST00000245448; ENSP00000245448; ENSG00000125375. [Q99766-3]
ENST00000311459; ENSP00000308334; ENSG00000125375. [Q99766-1]
ENST00000426751; ENSP00000389246; ENSG00000125375. [Q99766-2]
GeneIDi27109.
KEGGihsa:27109.
UCSCiuc001wxv.3. human. [Q99766-2]
uc001wxw.2. human. [Q99766-1]
uc001wxx.2. human. [Q99766-3]

Polymorphism databases

DMDMi313104249.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79253 mRNA. Translation: AAB50202.1 .
AY052377 mRNA. Translation: AAL13058.1 .
AK290008 mRNA. Translation: BAF82697.1 .
AL359397 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65718.1 .
CH471078 Genomic DNA. Translation: EAW65722.1 .
BC011549 mRNA. Translation: AAH11549.1 .
CCDSi CCDS32075.1. [Q99766-1 ]
CCDS32076.1. [Q99766-3 ]
CCDS45102.1. [Q99766-2 ]
RefSeqi NP_001003803.1. NM_001003803.2. [Q99766-1 ]
NP_001003805.1. NM_001003805.2. [Q99766-3 ]
NP_056499.2. NM_015684.3. [Q99766-2 ]
UniGenei Hs.438489.

3D structure databases

ProteinModelPortali Q99766.
SMRi Q99766. Positions 41-215.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99766. 1 interaction.
STRINGi 9606.ENSP00000308334.

PTM databases

PhosphoSitei Q99766.

Polymorphism databases

DMDMi 313104249.

Proteomic databases

MaxQBi Q99766.
PaxDbi Q99766.
PRIDEi Q99766.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000245448 ; ENSP00000245448 ; ENSG00000125375 . [Q99766-3 ]
ENST00000311459 ; ENSP00000308334 ; ENSG00000125375 . [Q99766-1 ]
ENST00000426751 ; ENSP00000389246 ; ENSG00000125375 . [Q99766-2 ]
GeneIDi 27109.
KEGGi hsa:27109.
UCSCi uc001wxv.3. human. [Q99766-2 ]
uc001wxw.2. human. [Q99766-1 ]
uc001wxx.2. human. [Q99766-3 ]

Organism-specific databases

CTDi 27109.
GeneCardsi GC14P050782.
HGNCi HGNC:18799. ATP5S.
HPAi HPA046967.
neXtProti NX_Q99766.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307162.
GeneTreei ENSGT00530000063680.
HOGENOMi HOG000230741.
HOVERGENi HBG050615.
InParanoidi Q99766.
KOi K07554.
OMAi CAFKPMA.
OrthoDBi EOG7GJ6FJ.
PhylomeDBi Q99766.
TreeFami TF315274.

Enzyme and pathway databases

Reactomei REACT_6759. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

ChiTaRSi ATP5S. human.
GeneWikii ATP5S.
GenomeRNAii 27109.
NextBioi 49778.
PROi Q99766.

Gene expression databases

Bgeei Q99766.
CleanExi HS_ATP5S.
ExpressionAtlasi Q99766. baseline and differential.
Genevestigatori Q99766.

Family and domain databases

InterProi IPR026063. ATP_synthase_s.
[Graphical view ]
PANTHERi PTHR13382. PTHR13382. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale concatenation cDNA sequencing."
    Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-18.
    Tissue: Brain.
  2. "Factor B and the mitochondrial ATP synthase complex."
    Belogrudov G.I., Hatefi Y.
    J. Biol. Chem. 277:6097-6103(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, SUBUNIT, VARIANT LEU-18.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-18.
    Tissue: Hippocampus.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-18.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-18.
    Tissue: Uterus.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATP5S_HUMAN
AccessioniPrimary (citable) accession number: Q99766
Secondary accession number(s): A8K1U3
, D9N156, Q8WWX3, Q96F77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3