Reviewed, UniProtKB/Swiss-Prot Q99766 (ATP5S_HUMAN)

Names and origin

Protein names

Recommended name:
    ATP synthase subunit s, mitochondrial
Alternative name(s):
    ATP synthase-coupling factor B
    Mitochondrial ATP synthase regulatory component factor B

Gene names

Name:	ATP5S
Synonyms:	ATPW

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase.
Subunit structure	Monomer. Associates with ATP synthase By similarity.
Subcellular location	Mitochondrion By similarity. Mitochondrion inner membrane By similarity.
Sequence similarities	Belongs to the ATP synthase subunit s family.
Caution	It is uncertain whether Met-1 or Met-16 is the initiator.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proton transport Non-traceable author statement. Source: UniProtKB
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrogen ion transmembrane transporter activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 40	40	Mitochondrion
	Chain	41 – 215	175	ATP synthase subunit s, mitochondrial		PRO_0000002538
Natural variations
	Natural variant	18	1	L → P: dbSNP rs2275592.		VAR_060296
Experimental info
	Sequence conflict	121 – 136	16	EGLEH…CKCHY → GNYPIVLLIENADDLQ in AAB50202. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q99766-1 [UniParc]. Last modified May 10, 2002. Version 2. Checksum: F692E8419A82E029	FASTA	215	24,882
	10 20 30 40 50 60 MCCAVSEQRL TCADQMMLFG KISQQLCGVK KLPWSCDSRY FWGWLNAVFN KVDYDRIRDV 70 80 90 100 110 120 GPDRAASEWL LRCGAMVRYH GQERWQKDYN HLPTGPLDKY KIQAIDATDS CIMSIGFDHM 130 140 150 160 170 180 EGLEHVEKIR LCKCHYIEDD CLLRLSQLEN LQKTILEMEI ISCGNITDKG IIALRHLRNL 190 200 210 KYLLLSDLPG VREKENLVQA FKTALPSLEL KLQLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Factor B and the mitochondrial ATP synthase complex." Belogrudov G.I., Hatefi Y. J. Biol. Chem. 277:6097-6103(2002) [PubMed: 11744738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, SUBUNIT.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Large-scale concatenation cDNA sequencing." Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A. Genome Res. 7:353-358(1997) [PubMed: 9110174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-136. Tissue: Brain.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY052377 mRNA. Translation: AAL13058.1. AK290008 mRNA. Translation: BAF82697.1. CH471078 Genomic DNA. Translation: EAW65722.1. U79253 mRNA. Translation: AAB50202.1.
IPI	IPI00017816.
RefSeq	NP_001003803.1. NP_056499.2.
UniGene	Hs.256034 Hs.438489
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q99766.
Genome annotation databases
Ensembl	ENST00000311459; ENSP00000308334; ENSG00000125375; Homo sapiens. [Genome view]
GeneID	27109.
KEGG	hsa:27109.
UCSC	uc001wxw.1. human.
Organism-specific databases
CTD	27109.
GeneCards	GC14P049848.
H-InvDB	HIX0011641.
HGNC	HGNC:18799. ATP5S.
PharmGKB	PA134991095.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q99766.
Gene expression databases
ArrayExpress	Q99766.
Bgee	Q99766.
CleanEx	HS_ATP5S.
Genevestigator	Q99766.
GermOnline	ENSG00000125375. Homo sapiens.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

ATP5S_HUMAN

Accession

Primary (citable) accession number: Q99766
Secondary accession number(s): A8K1U3, Q8WWX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 10, 2002
Last modified:	November 24, 2009
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.