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Q99766

- ATP5S_HUMAN

UniProt

Q99766 - ATP5S_HUMAN

Protein

ATP synthase subunit s, mitochondrial

Gene

ATP5S

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi74 – 741Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi108 – 1081MagnesiumBy similarity

    GO - Molecular functioni

    1. hydrogen ion transmembrane transporter activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP biosynthetic process Source: UniProtKB-KW
    2. hydrogen ion transmembrane transport Source: GOC
    3. proton transport Source: UniProtKB

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_6759. Formation of ATP by chemiosmotic coupling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit s, mitochondrial
    Alternative name(s):
    ATP synthase-coupling factor B
    Short name:
    FB
    Mitochondrial ATP synthase regulatory component factor B
    Gene namesi
    Name:ATP5S
    Synonyms:ATPW
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:18799. ATP5S.

    Subcellular locationi

    Mitochondrion By similarity. Mitochondrion inner membrane By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. proton-transporting ATP synthase complex, coupling factor F(o) Source: UniProtKB-KW

    Keywords - Cellular componenti

    CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4040MitochondrionAdd
    BLAST
    Chaini41 – 215175ATP synthase subunit s, mitochondrialPRO_0000002538Add
    BLAST

    Proteomic databases

    MaxQBiQ99766.
    PaxDbiQ99766.
    PRIDEiQ99766.

    PTM databases

    PhosphoSiteiQ99766.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99766.
    BgeeiQ99766.
    CleanExiHS_ATP5S.
    GenevestigatoriQ99766.

    Organism-specific databases

    HPAiHPA046967.

    Interactioni

    Subunit structurei

    Homotetramer. Associates with ATP synthase By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ99766. 1 interaction.
    STRINGi9606.ENSP00000308334.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99766.
    SMRiQ99766. Positions 41-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati77 – 10226LRR 1Add
    BLAST
    Repeati103 – 13129LRR 2Add
    BLAST
    Repeati132 – 15625LRR 3Add
    BLAST
    Repeati157 – 18832LRR 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 7676N-terminal domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ATP synthase subunit s family.Curated
    Contains 4 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Transit peptide

    Phylogenomic databases

    eggNOGiNOG307162.
    HOGENOMiHOG000230741.
    HOVERGENiHBG050615.
    KOiK07554.
    OMAiCAFKPMA.
    OrthoDBiEOG7GJ6FJ.
    PhylomeDBiQ99766.
    TreeFamiTF315274.

    Family and domain databases

    InterProiIPR026063. ATP_synthase_s.
    [Graphical view]
    PANTHERiPTHR13382. PTHR13382. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99766-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCCAVSEQRL TCADQMMPFG KISQQLCGVK KLPWSCDSRY FWGWLNAVFN    50
    KVDYDRIRDV GPDRAASEWL LRCGAMVRYH GQERWQKDYN HLPTGPLDKY 100
    KIQAIDATDS CIMSIGFDHM EGLEHVEKIR LCKCHYIEDD CLLRLSQLEN 150
    LQKTILEMEI ISCGNITDKG IIALRHLRNL KYLLLSDLPG VREKENLVQA 200
    FKTALPSLEL KLQLK 215
    Length:215
    Mass (Da):24,866
    Last modified:November 30, 2010 - v3
    Checksum:iDFDCDE6D81E5DC62
    GO
    Isoform 2 (identifier: Q99766-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         121-136: EGLEHVEKIRLCKCHY → GNYPIVLLIENADDLQ
         137-215: Missing.

    Show »
    Length:136
    Mass (Da):15,685
    Checksum:iC69A8CD2A7720FCC
    GO
    Isoform 3 (identifier: Q99766-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         122-127: GLEHVE → TSNICC
         128-215: Missing.

    Show »
    Length:127
    Mass (Da):14,667
    Checksum:i7C0681D95BD6EABB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181P → L.5 Publications
    Corresponds to variant rs2275592 [ dbSNP | Ensembl ].
    VAR_060296

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei121 – 13616EGLEH…CKCHY → GNYPIVLLIENADDLQ in isoform 2. 1 PublicationVSP_040059Add
    BLAST
    Alternative sequencei122 – 1276GLEHVE → TSNICC in isoform 3. 1 PublicationVSP_040060
    Alternative sequencei128 – 21588Missing in isoform 3. 1 PublicationVSP_040061Add
    BLAST
    Alternative sequencei137 – 21579Missing in isoform 2. 1 PublicationVSP_040062Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79253 mRNA. Translation: AAB50202.1.
    AY052377 mRNA. Translation: AAL13058.1.
    AK290008 mRNA. Translation: BAF82697.1.
    AL359397 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65718.1.
    CH471078 Genomic DNA. Translation: EAW65722.1.
    BC011549 mRNA. Translation: AAH11549.1.
    CCDSiCCDS32075.1. [Q99766-1]
    CCDS32076.1. [Q99766-3]
    CCDS45102.1. [Q99766-2]
    RefSeqiNP_001003803.1. NM_001003803.2. [Q99766-1]
    NP_001003805.1. NM_001003805.2. [Q99766-3]
    NP_056499.2. NM_015684.3. [Q99766-2]
    UniGeneiHs.438489.

    Genome annotation databases

    EnsembliENST00000245448; ENSP00000245448; ENSG00000125375. [Q99766-3]
    ENST00000311459; ENSP00000308334; ENSG00000125375. [Q99766-1]
    ENST00000426751; ENSP00000389246; ENSG00000125375. [Q99766-2]
    GeneIDi27109.
    KEGGihsa:27109.
    UCSCiuc001wxv.3. human. [Q99766-2]
    uc001wxw.2. human. [Q99766-1]
    uc001wxx.2. human. [Q99766-3]

    Polymorphism databases

    DMDMi313104249.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79253 mRNA. Translation: AAB50202.1 .
    AY052377 mRNA. Translation: AAL13058.1 .
    AK290008 mRNA. Translation: BAF82697.1 .
    AL359397 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65718.1 .
    CH471078 Genomic DNA. Translation: EAW65722.1 .
    BC011549 mRNA. Translation: AAH11549.1 .
    CCDSi CCDS32075.1. [Q99766-1 ]
    CCDS32076.1. [Q99766-3 ]
    CCDS45102.1. [Q99766-2 ]
    RefSeqi NP_001003803.1. NM_001003803.2. [Q99766-1 ]
    NP_001003805.1. NM_001003805.2. [Q99766-3 ]
    NP_056499.2. NM_015684.3. [Q99766-2 ]
    UniGenei Hs.438489.

    3D structure databases

    ProteinModelPortali Q99766.
    SMRi Q99766. Positions 41-215.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99766. 1 interaction.
    STRINGi 9606.ENSP00000308334.

    PTM databases

    PhosphoSitei Q99766.

    Polymorphism databases

    DMDMi 313104249.

    Proteomic databases

    MaxQBi Q99766.
    PaxDbi Q99766.
    PRIDEi Q99766.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000245448 ; ENSP00000245448 ; ENSG00000125375 . [Q99766-3 ]
    ENST00000311459 ; ENSP00000308334 ; ENSG00000125375 . [Q99766-1 ]
    ENST00000426751 ; ENSP00000389246 ; ENSG00000125375 . [Q99766-2 ]
    GeneIDi 27109.
    KEGGi hsa:27109.
    UCSCi uc001wxv.3. human. [Q99766-2 ]
    uc001wxw.2. human. [Q99766-1 ]
    uc001wxx.2. human. [Q99766-3 ]

    Organism-specific databases

    CTDi 27109.
    GeneCardsi GC14P050782.
    HGNCi HGNC:18799. ATP5S.
    HPAi HPA046967.
    neXtProti NX_Q99766.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307162.
    HOGENOMi HOG000230741.
    HOVERGENi HBG050615.
    KOi K07554.
    OMAi CAFKPMA.
    OrthoDBi EOG7GJ6FJ.
    PhylomeDBi Q99766.
    TreeFami TF315274.

    Enzyme and pathway databases

    Reactomei REACT_6759. Formation of ATP by chemiosmotic coupling.

    Miscellaneous databases

    ChiTaRSi ATP5S. human.
    GeneWikii ATP5S.
    GenomeRNAii 27109.
    NextBioi 49778.
    PROi Q99766.

    Gene expression databases

    ArrayExpressi Q99766.
    Bgeei Q99766.
    CleanExi HS_ATP5S.
    Genevestigatori Q99766.

    Family and domain databases

    InterProi IPR026063. ATP_synthase_s.
    [Graphical view ]
    PANTHERi PTHR13382. PTHR13382. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale concatenation cDNA sequencing."
      Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
      Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-18.
      Tissue: Brain.
    2. "Factor B and the mitochondrial ATP synthase complex."
      Belogrudov G.I., Hatefi Y.
      J. Biol. Chem. 277:6097-6103(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, SUBUNIT, VARIANT LEU-18.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-18.
      Tissue: Hippocampus.
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-18.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-18.
      Tissue: Uterus.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATP5S_HUMAN
    AccessioniPrimary (citable) accession number: Q99766
    Secondary accession number(s): A8K1U3
    , D9N156, Q8WWX3, Q96F77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-16 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3