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Q99766 (ATP5S_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP synthase subunit s, mitochondrial
Alternative name(s):
ATP synthase-coupling factor B
Short name=FB
Mitochondrial ATP synthase regulatory component factor B
Gene names
Name:ATP5S
Synonyms:ATPW
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway By similarity.

Subunit structure

Homotetramer. Associates with ATP synthase By similarity. Ref.2

Subcellular location

Mitochondrion By similarity. Mitochondrion inner membrane By similarity.

Sequence similarities

Belongs to the ATP synthase subunit s family.

Contains 4 LRR (leucine-rich) repeats.

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q99766-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q99766-2)

The sequence of this isoform differs from the canonical sequence as follows:
     121-136: EGLEHVEKIRLCKCHY → GNYPIVLLIENADDLQ
     137-215: Missing.
Isoform 3 (identifier: Q99766-3)

The sequence of this isoform differs from the canonical sequence as follows:
     122-127: GLEHVE → TSNICC
     128-215: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4040Mitochondrion
Chain41 – 215175ATP synthase subunit s, mitochondrial
PRO_0000002538

Regions

Repeat77 – 10226LRR 1
Repeat103 – 13129LRR 2
Repeat132 – 15625LRR 3
Repeat157 – 18832LRR 4
Region1 – 7676N-terminal domain

Sites

Metal binding741Magnesium; via carbonyl oxygen By similarity
Metal binding1081Magnesium By similarity

Natural variations

Alternative sequence121 – 13616EGLEH…CKCHY → GNYPIVLLIENADDLQ in isoform 2.
VSP_040059
Alternative sequence122 – 1276GLEHVE → TSNICC in isoform 3.
VSP_040060
Alternative sequence128 – 21588Missing in isoform 3.
VSP_040061
Alternative sequence137 – 21579Missing in isoform 2.
VSP_040062
Natural variant181P → L. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6
Corresponds to variant rs2275592 [ dbSNP | Ensembl ].
VAR_060296

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: DFDCDE6D81E5DC62

FASTA21524,866
        10         20         30         40         50         60 
MCCAVSEQRL TCADQMMPFG KISQQLCGVK KLPWSCDSRY FWGWLNAVFN KVDYDRIRDV 

        70         80         90        100        110        120 
GPDRAASEWL LRCGAMVRYH GQERWQKDYN HLPTGPLDKY KIQAIDATDS CIMSIGFDHM 

       130        140        150        160        170        180 
EGLEHVEKIR LCKCHYIEDD CLLRLSQLEN LQKTILEMEI ISCGNITDKG IIALRHLRNL 

       190        200        210 
KYLLLSDLPG VREKENLVQA FKTALPSLEL KLQLK 

« Hide

Isoform 2 [UniParc].

Checksum: C69A8CD2A7720FCC
Show »

FASTA13615,685
Isoform 3 [UniParc].

Checksum: 7C0681D95BD6EABB
Show »

FASTA12714,667

References

« Hide 'large scale' references
[1]"Large-scale concatenation cDNA sequencing."
Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-18.
Tissue: Brain.
[2]"Factor B and the mitochondrial ATP synthase complex."
Belogrudov G.I., Hatefi Y.
J. Biol. Chem. 277:6097-6103(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, SUBUNIT, VARIANT LEU-18.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-18.
Tissue: Hippocampus.
[4]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-18.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-18.
Tissue: Uterus.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U79253 mRNA. Translation: AAB50202.1.
AY052377 mRNA. Translation: AAL13058.1.
AK290008 mRNA. Translation: BAF82697.1.
AL359397 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65718.1.
CH471078 Genomic DNA. Translation: EAW65722.1.
BC011549 mRNA. Translation: AAH11549.1.
CCDSCCDS32075.1. [Q99766-1]
CCDS32076.1. [Q99766-3]
CCDS45102.1. [Q99766-2]
RefSeqNP_001003803.1. NM_001003803.2. [Q99766-1]
NP_001003805.1. NM_001003805.2. [Q99766-3]
NP_056499.2. NM_015684.3. [Q99766-2]
UniGeneHs.438489.

3D structure databases

ProteinModelPortalQ99766.
SMRQ99766. Positions 41-215.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ99766. 1 interaction.
STRING9606.ENSP00000308334.

PTM databases

PhosphoSiteQ99766.

Polymorphism databases

DMDM313104249.

Proteomic databases

MaxQBQ99766.
PaxDbQ99766.
PRIDEQ99766.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000245448; ENSP00000245448; ENSG00000125375. [Q99766-3]
ENST00000311459; ENSP00000308334; ENSG00000125375. [Q99766-1]
ENST00000426751; ENSP00000389246; ENSG00000125375. [Q99766-2]
GeneID27109.
KEGGhsa:27109.
UCSCuc001wxv.3. human. [Q99766-2]
uc001wxw.2. human. [Q99766-1]
uc001wxx.2. human. [Q99766-3]

Organism-specific databases

CTD27109.
GeneCardsGC14P050782.
HGNCHGNC:18799. ATP5S.
HPAHPA046967.
neXtProtNX_Q99766.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG307162.
HOGENOMHOG000230741.
HOVERGENHBG050615.
KOK07554.
OMACAFKPMA.
OrthoDBEOG7GJ6FJ.
PhylomeDBQ99766.
TreeFamTF315274.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressQ99766.
BgeeQ99766.
CleanExHS_ATP5S.
GenevestigatorQ99766.

Family and domain databases

InterProIPR026063. ATP_synthase_s.
[Graphical view]
PANTHERPTHR13382. PTHR13382. 1 hit.
ProtoNetSearch...

Other

ChiTaRSATP5S. human.
GeneWikiATP5S.
GenomeRNAi27109.
NextBio49778.
PROQ99766.

Entry information

Entry nameATP5S_HUMAN
AccessionPrimary (citable) accession number: Q99766
Secondary accession number(s): A8K1U3 expand/collapse secondary AC list , D9N156, Q8WWX3, Q96F77
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM