Q99747 (SNAG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-soluble NSF attachment protein
Short name=SNAP-gamma

Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein gamma

Gene names

Name:	NAPG
Synonyms:	SNAPG

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subunit structure	Binds RIP11. Interacts with VTI1A By similarity. Ref.3
Subcellular location	Membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the SNAP family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular membrane fusion Traceable author statement. Source: ProtInc intra-Golgi vesicle-mediated transport Traceable author statement. Source: ProtInc intracellular protein transport Inferred from electronic annotation. Source: InterPro protein complex assembly Non-traceable author statement Ref.3. Source: UniProtKB protein stabilization Non-traceable author statement Ref.3. Source: UniProtKB
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell membrane fraction Non-traceable author statement Ref.3. Source: UniProtKB mitochondrion Inferred from direct assay Ref.3. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Gamma-soluble NSF attachment protein		PRO_0000219063
Amino acid modifications
	Modified residue	284	1	Phosphoserine By similarity
	Modified residue	307	1	Phosphotyrosine Ref.4
Natural variations
	Natural variant	92	1	P → S. Corresponds to variant rs16974765 [ dbSNP | Ensembl ].		VAR_052027
	Natural variant	281	1	K → N. Corresponds to variant rs2305370 [ dbSNP | Ensembl ].		VAR_020129
Experimental info
	Sequence conflict	147	1	E → D in AAH01889. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q99747 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: C37D73C1AEFD48C8	FASTA	312	34,746
	10 20 30 40 50 60 MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ FEQAKDACLR 70 80 90 100 110 120 EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK ASMMYLENGT PDTAAMALER 130 140 150 160 170 180 AGKLIENVDP EKAVQLYQQT ANVFENEERL RQAVELLGKA SRLLVRGRRF DEAALSIQKE 190 200 210 220 230 240 KNIYKEIENY PTCYKKTIAQ VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE 250 260 270 280 290 300 GYDQQDQDQV SDVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGVTATAA 310 DEEEDEYSGG LC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery." Lemons P.P., Chen D., Bernstein A.M., Bennett M.K., Whiteheart S.W. Blood 90:1490-1500(1997) [PubMed: 9269766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria." Chen D., Xu W., He P., Medrano E.E., Whiteheart S.W. J. Biol. Chem. 276:13127-13135(2001) [PubMed: 11278501] [Abstract] Cited for: INTERACTION WITH RIP11.
[4]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-307, MASS SPECTROMETRY.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U78107 mRNA. Translation: AAB69753.1. BC001889 mRNA. Translation: AAH01889.1.
IPI	IPI00293817.
RefSeq	NP_003817.1. NM_003826.2.
UniGene	Hs.464622.
3D structure databases
ProteinModelPortal	Q99747.
SMR	Q99747. Positions 2-276.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99747. 1 interaction.
STRING	Q99747.
PTM databases
PhosphoSite	Q99747.
Polymorphism databases
DMDM	3024632.
2D gel databases
OGP	Q99747.
Proteomic databases
PRIDE	Q99747.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322897; ENSP00000324628; ENSG00000134265.
GeneID	8774.
KEGG	hsa:8774.
UCSC	uc002kon.1. human.
Organism-specific databases
CTD	8774.
GeneCards	GC18P010516.
H-InvDB	HIX0014333.
HGNC	HGNC:7642. NAPG.
HPA	HPA008208. HPA011389.
MIM	603216. gene.
neXtProt	NX_Q99747.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000010109.
HOGENOM	HBG387031.
HOVERGEN	HBG001648.
InParanoid	Q99747.
OMA	FHAAKAY.
OrthoDB	EOG4QNMWK.
PhylomeDB	Q99747.
Gene expression databases
ArrayExpress	Q99747.
Bgee	Q99747.
CleanEx	HS_NAPG.
Genevestigator	Q99747.
GermOnline	ENSG00000134265. Homo sapiens.
Family and domain databases
InterPro	IPR000744. NSF_attach. IPR011990. TPR-like_helical. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
PANTHER	PTHR13768. NSF_attach. 1 hit.
ProtoNet	Search...
Other
NextBio	32900.
SOURCE	Search...

Entry information

Entry name

SNAG_HUMAN

Accession

Primary (citable) accession number: Q99747
Secondary accession number(s): Q9BUV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 1, 1997
Last modified:	January 25, 2012
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.