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Protein

Gamma-soluble NSF attachment protein

Gene

NAPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • intra-Golgi vesicle-mediated transport Source: ProtInc
  • membrane fusion Source: ProtInc
  • protein-containing complex assembly Source: UniProtKB
  • protein stabilization Source: UniProtKB

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-soluble NSF attachment protein
Short name:
SNAP-gamma
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein gamma
Gene namesi
Name:NAPG
Synonyms:SNAPG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000134265.12
HGNCiHGNC:7642 NAPG
MIMi603216 gene
neXtProtiNX_Q99747

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8774
OpenTargetsiENSG00000134265
PharmGKBiPA31445

Polymorphism and mutation databases

BioMutaiNAPG
DMDMi3024632

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190631 – 312Gamma-soluble NSF attachment proteinAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284PhosphoserineBy similarity1
Modified residuei287PhosphothreonineBy similarity1
Modified residuei308PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99747
MaxQBiQ99747
PaxDbiQ99747
PeptideAtlasiQ99747
PRIDEiQ99747

2D gel databases

OGPiQ99747

PTM databases

iPTMnetiQ99747
PhosphoSitePlusiQ99747
SwissPalmiQ99747

Expressioni

Gene expression databases

BgeeiENSG00000134265
CleanExiHS_NAPG
ExpressionAtlasiQ99747 baseline and differential
GenevisibleiQ99747 HS

Organism-specific databases

HPAiHPA008208
HPA011389

Interactioni

Subunit structurei

Binds RIP11. Interacts with VTI1A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114304, 40 interactors
CORUMiQ99747
IntActiQ99747, 6 interactors
STRINGi9606.ENSP00000324628

Structurei

3D structure databases

ProteinModelPortaliQ99747
SMRiQ99747
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1585 Eukaryota
ENOG410ZYD7 LUCA
GeneTreeiENSGT00390000010109
HOGENOMiHOG000007747
HOVERGENiHBG001648
InParanoidiQ99747
KOiK21198
OMAiPYEQAGM
OrthoDBiEOG091G0GNK
PhylomeDBiQ99747
TreeFamiTF312872

Family and domain databases

CDDicd15832 SNAP, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR000744 NSF_attach
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13768 PTHR13768, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99747-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ
60 70 80 90 100
FEQAKDACLR EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK
110 120 130 140 150
ASMMYLENGT PDTAAMALER AGKLIENVDP EKAVQLYQQT ANVFENEERL
160 170 180 190 200
RQAVELLGKA SRLLVRGRRF DEAALSIQKE KNIYKEIENY PTCYKKTIAQ
210 220 230 240 250
VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE GYDQQDQDQV
260 270 280 290 300
SDVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGVTATAA
310
DEEEDEYSGG LC
Length:312
Mass (Da):34,746
Last modified:May 1, 1997 - v1
Checksum:iC37D73C1AEFD48C8
GO
Isoform 2 (identifier: Q99747-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):25,662
Checksum:i1243534338B3B8D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147E → D in AAH01889 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05202792P → S. Corresponds to variant dbSNP:rs2228300Ensembl.1
Natural variantiVAR_020129281K → N. Corresponds to variant dbSNP:rs2305370Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563551 – 82Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78107 mRNA Translation: AAB69753.1
AK294038 mRNA Translation: BAG57390.1
AP001099 Genomic DNA No translation available.
BC001889 mRNA Translation: AAH01889.1
CCDSiCCDS45827.1 [Q99747-1]
RefSeqiNP_003817.1, NM_003826.2 [Q99747-1]
XP_011524058.1, XM_011525756.2 [Q99747-2]
UniGeneiHs.464622

Genome annotation databases

EnsembliENST00000322897; ENSP00000324628; ENSG00000134265 [Q99747-1]
GeneIDi8774
KEGGihsa:8774
UCSCiuc002kon.4 human [Q99747-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNAG_HUMAN
AccessioniPrimary (citable) accession number: Q99747
Secondary accession number(s): B4DFC9, Q9BUV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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