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Protein

Gamma-soluble NSF attachment protein

Gene

NAPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • intra-Golgi vesicle-mediated transport Source: ProtInc
  • membrane fusion Source: ProtInc
  • protein complex assembly Source: UniProtKB
  • protein stabilization Source: UniProtKB

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-6811438. Intra-Golgi traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-soluble NSF attachment protein
Short name:
SNAP-gamma
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein gamma
Gene namesi
Name:NAPG
Synonyms:SNAPG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000134265.12.
HGNCiHGNC:7642. NAPG.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8774.
OpenTargetsiENSG00000134265.
PharmGKBiPA31445.

Polymorphism and mutation databases

BioMutaiNAPG.
DMDMi3024632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190631 – 312Gamma-soluble NSF attachment proteinAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284PhosphoserineBy similarity1
Modified residuei287PhosphothreonineBy similarity1
Modified residuei308PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99747.
MaxQBiQ99747.
PaxDbiQ99747.
PeptideAtlasiQ99747.
PRIDEiQ99747.

2D gel databases

OGPiQ99747.

PTM databases

iPTMnetiQ99747.
PhosphoSitePlusiQ99747.
SwissPalmiQ99747.

Expressioni

Gene expression databases

BgeeiENSG00000134265.
CleanExiHS_NAPG.
ExpressionAtlasiQ99747. baseline and differential.
GenevisibleiQ99747. HS.

Organism-specific databases

HPAiHPA008208.
HPA011389.

Interactioni

Subunit structurei

Binds RIP11. Interacts with VTI1A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114304. 40 interactors.
CORUMiQ99747.
IntActiQ99747. 4 interactors.
STRINGi9606.ENSP00000324628.

Structurei

3D structure databases

ProteinModelPortaliQ99747.
SMRiQ99747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1585. Eukaryota.
ENOG410ZYD7. LUCA.
GeneTreeiENSGT00390000010109.
HOGENOMiHOG000007747.
HOVERGENiHBG001648.
InParanoidiQ99747.
KOiK21198.
OMAiPYEQAGM.
OrthoDBiEOG091G0GNK.
PhylomeDBiQ99747.
TreeFamiTF312872.

Family and domain databases

CDDicd15832. SNAP. 1 hit.
Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
PANTHERiPTHR13768. PTHR13768. 1 hit.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99747-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ
60 70 80 90 100
FEQAKDACLR EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK
110 120 130 140 150
ASMMYLENGT PDTAAMALER AGKLIENVDP EKAVQLYQQT ANVFENEERL
160 170 180 190 200
RQAVELLGKA SRLLVRGRRF DEAALSIQKE KNIYKEIENY PTCYKKTIAQ
210 220 230 240 250
VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE GYDQQDQDQV
260 270 280 290 300
SDVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGVTATAA
310
DEEEDEYSGG LC
Length:312
Mass (Da):34,746
Last modified:May 1, 1997 - v1
Checksum:iC37D73C1AEFD48C8
GO
Isoform 2 (identifier: Q99747-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):25,662
Checksum:i1243534338B3B8D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147E → D in AAH01889 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05202792P → S. Corresponds to variant dbSNP:rs16974765Ensembl.1
Natural variantiVAR_020129281K → N. Corresponds to variant dbSNP:rs2305370Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563551 – 82Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78107 mRNA. Translation: AAB69753.1.
AK294038 mRNA. Translation: BAG57390.1.
AP001099 Genomic DNA. No translation available.
BC001889 mRNA. Translation: AAH01889.1.
CCDSiCCDS45827.1. [Q99747-1]
RefSeqiNP_003817.1. NM_003826.2. [Q99747-1]
XP_011524058.1. XM_011525756.2. [Q99747-2]
UniGeneiHs.464622.

Genome annotation databases

EnsembliENST00000322897; ENSP00000324628; ENSG00000134265. [Q99747-1]
GeneIDi8774.
KEGGihsa:8774.
UCSCiuc002kon.4. human. [Q99747-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNAG_HUMAN
AccessioniPrimary (citable) accession number: Q99747
Secondary accession number(s): B4DFC9, Q9BUV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: September 27, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families