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Q99743

- NPAS2_HUMAN

UniProt

Q99743 - NPAS2_HUMAN

Protein

Neuronal PAS domain-containing protein 2

Gene

NPAS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes.5 Publications

    Cofactori

    Binds heme.

    Enzyme regulationi

    Carbon monoxide (CO) and the redox state of the cell can modulate the transcriptional activity of the NPAS2-ARNTL/BMAL1 heterodimer. NADH and NADPH enhance the DNA-binding activity of the heterodimer whereas CO binds the heme group in NPAS2 and inhibits the DNA-binding activity of the heterodimer By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi119 – 1191Iron (heme B axial ligand)By similarity
    Metal bindingi171 – 1711Iron (heme B axial ligand)By similarity

    GO - Molecular functioni

    1. core promoter binding Source: UniProtKB
    2. DNA binding Source: UniProtKB
    3. Hsp90 protein binding Source: BHF-UCL
    4. metal ion binding Source: UniProtKB-KW
    5. protein binding Source: UniProtKB
    6. sequence-specific DNA binding transcription factor activity Source: ProtInc
    7. signal transducer activity Source: InterPro

    GO - Biological processi

    1. cellular lipid metabolic process Source: Reactome
    2. cellular response to DNA damage stimulus Source: UniProtKB-KW
    3. central nervous system development Source: ProtInc
    4. circadian regulation of gene expression Source: UniProtKB
    5. circadian sleep/wake cycle Source: Ensembl
    6. locomotor rhythm Source: Ensembl
    7. negative regulation of cell death Source: UniProtKB
    8. positive regulation of DNA repair Source: UniProtKB
    9. positive regulation of transcription, DNA-templated Source: UniProtKB
    10. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    11. regulation of response to DNA damage stimulus Source: UniProtKB
    12. response to redox state Source: UniProtKB
    13. small molecule metabolic process Source: Reactome
    14. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Biological rhythms, DNA damage, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_116145. PPARA activates gene expression.
    REACT_118659. RORA activates circadian gene expression.
    REACT_118789. REV-ERBA represses gene expression.
    REACT_24941. Circadian Clock.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal PAS domain-containing protein 2
    Short name:
    Neuronal PAS2
    Alternative name(s):
    Basic-helix-loop-helix-PAS protein MOP4
    Class E basic helix-loop-helix protein 9
    Short name:
    bHLHe9
    Member of PAS protein 4
    PAS domain-containing protein 4
    Gene namesi
    Name:NPAS2
    Synonyms:BHLHE9, MOP4, PASD4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:7895. NPAS2.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleus Source: UniProtKB
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    MIMi608516. phenotype.
    PharmGKBiPA31696.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824Neuronal PAS domain-containing protein 2PRO_0000127406Add
    BLAST

    Proteomic databases

    PaxDbiQ99743.
    PRIDEiQ99743.

    PTM databases

    PhosphoSiteiQ99743.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99743.
    BgeeiQ99743.
    CleanExiHS_NPAS2.
    GenevestigatoriQ99743.

    Organism-specific databases

    HPAiHPA019674.

    Interactioni

    Subunit structurei

    Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ARNTL/BMAL1 and this heterodimerization is required for E-box-dependent transactivation. Interacts with NCOA3, KAT2B, CREBBP and EP300.1 Publication

    Protein-protein interaction databases

    BioGridi110923. 13 interactions.
    DIPiDIP-60821N.
    IntActiQ99743. 8 interactions.
    STRINGi9606.ENSP00000338283.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99743.
    SMRiQ99743. Positions 6-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 5951bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini82 – 15271PAS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini237 – 30771PAS 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini311 – 35444PACAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 6161Sufficient for heterodimer formation with ARNTL/BMAL1, E-box binding and for the effect of NADPHBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG300360.
    HOVERGENiHBG050997.
    InParanoidiQ99743.
    KOiK09026.
    PhylomeDBiQ99743.
    TreeFamiTF324568.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR001067. Nuc_translocat.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view]
    PRINTSiPR00785. NCTRNSLOCATR.
    SMARTiSM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    PS50112. PAS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99743-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEDEKDRAK RASRNKSEKK RRDQFNVLIK ELSSMLPGNT RKMDKTTVLE    50
    KVIGFLQKHN EVSAQTEICD IQQDWKPSFL SNEEFTQLML EALDGFIIAV 100
    TTDGSIIYVS DSITPLLGHL PSDVMDQNLL NFLPEQEHSE VYKILSSHML 150
    VTDSPSPEYL KSDSDLEFYC HLLRGSLNPK EFPTYEYIKF VGNFRSYNNV 200
    PSPSCNGFDN TLSRPCRVPL GKEVCFIATV RLATPQFLKE MCIVDEPLEE 250
    FTSRHSLEWK FLFLDHRAPP IIGYLPFEVL GTSGYDYYHI DDLELLARCH 300
    QHLMQFGKGK SCCYRFLTKG QQWIWLQTHY YITYHQWNSK PEFIVCTHSV 350
    VSYADVRVER RQELALEDPP SEALHSSALK DKGSSLEPRQ HFNTLDVGAS 400
    GLNTSHSPSA SSRSSHKSSH TAMSEPTSTP TKLMAEASTP ALPRSATLPQ 450
    ELPVPGLSQA ATMPAPLPSP SSCDLTQQLL PQTVLQSTPA PMAQFSAQFS 500
    MFQTIKDQLE QRTRILQANI RWQQEELHKI QEQLCLVQDS NVQMFLQQPA 550
    VSLSFSSTQR PEAQQQLQQR SAAVTQPQLG AGPQLPGQIS SAQVTSQHLL 600
    RESSVISTQG PKPMRSSQLM QSSGRSGSSL VSPFSSATAA LPPSLNLTTP 650
    ASTSQDASQC QPSPDFSHDR QLRLLLSQPI QPMMPGSCDA RQPSEVSRTG 700
    RQVKYAQSQT VFQNPDAHPA NSSSAPMPVL LMGQAVLHPS FPASQPSPLQ 750
    PAQARQQPPQ HYLQVQAPTS LHSEQQDSLL LSTYSQQPGT LGYPQPPPAQ 800
    PQPLRPPRRV SSLSESSGLQ QPPR 824
    Length:824
    Mass (Da):91,791
    Last modified:November 2, 2010 - v3
    Checksum:i679919FCDD3AFDEB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti51 – 511K → E in AAC51211. (PubMed:9079689)Curated
    Sequence conflicti164 – 1641S → G in AAC51211. (PubMed:9079689)Curated
    Sequence conflicti308 – 3081K → T in AAB47250. (PubMed:9012850)Curated

    Polymorphismi

    Variants in NPAS2 show a susceptibility to seasonal affective disorder (SAD) [MIMi:608516]. SAD is a depressive condition resulting from seasonal changes, and with diurnal preference.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti394 – 3941T → A Associated with non-Hodgkin's lymphoma and breast cancer risk. 5 Publications
    Corresponds to variant rs2305160 [ dbSNP | Ensembl ].
    VAR_029078
    Natural varianti471 – 4711S → L Susceptibility to seasonal affective disorder (SAD) and diurnal preference. 1 Publication
    Corresponds to variant rs11541353 [ dbSNP | Ensembl ].
    VAR_029079

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77970 mRNA. Translation: AAB47250.1.
    AC016738 Genomic DNA. Translation: AAY14822.1.
    AC092168 Genomic DNA. No translation available.
    AC106891 Genomic DNA. Translation: AAX88966.1.
    BC051351 mRNA. Translation: AAH51351.2.
    BC072383 mRNA. Translation: AAH72383.1.
    U51625 mRNA. Translation: AAC51211.1.
    CCDSiCCDS2048.1.
    RefSeqiNP_002509.2. NM_002518.3.
    UniGeneiHs.156832.
    Hs.705895.

    Genome annotation databases

    EnsembliENST00000335681; ENSP00000338283; ENSG00000170485.
    GeneIDi4862.
    KEGGihsa:4862.
    UCSCiuc002tap.1. human.

    Polymorphism databases

    DMDMi311033423.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77970 mRNA. Translation: AAB47250.1 .
    AC016738 Genomic DNA. Translation: AAY14822.1 .
    AC092168 Genomic DNA. No translation available.
    AC106891 Genomic DNA. Translation: AAX88966.1 .
    BC051351 mRNA. Translation: AAH51351.2 .
    BC072383 mRNA. Translation: AAH72383.1 .
    U51625 mRNA. Translation: AAC51211.1 .
    CCDSi CCDS2048.1.
    RefSeqi NP_002509.2. NM_002518.3.
    UniGenei Hs.156832.
    Hs.705895.

    3D structure databases

    ProteinModelPortali Q99743.
    SMRi Q99743. Positions 6-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110923. 13 interactions.
    DIPi DIP-60821N.
    IntActi Q99743. 8 interactions.
    STRINGi 9606.ENSP00000338283.

    PTM databases

    PhosphoSitei Q99743.

    Polymorphism databases

    DMDMi 311033423.

    Proteomic databases

    PaxDbi Q99743.
    PRIDEi Q99743.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335681 ; ENSP00000338283 ; ENSG00000170485 .
    GeneIDi 4862.
    KEGGi hsa:4862.
    UCSCi uc002tap.1. human.

    Organism-specific databases

    CTDi 4862.
    GeneCardsi GC02P101436.
    H-InvDB HIX0200274.
    HGNCi HGNC:7895. NPAS2.
    HPAi HPA019674.
    MIMi 603347. gene.
    608516. phenotype.
    neXtProti NX_Q99743.
    PharmGKBi PA31696.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300360.
    HOVERGENi HBG050997.
    InParanoidi Q99743.
    KOi K09026.
    PhylomeDBi Q99743.
    TreeFami TF324568.

    Enzyme and pathway databases

    Reactomei REACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_116145. PPARA activates gene expression.
    REACT_118659. RORA activates circadian gene expression.
    REACT_118789. REV-ERBA represses gene expression.
    REACT_24941. Circadian Clock.

    Miscellaneous databases

    ChiTaRSi NPAS2. human.
    GeneWikii NPAS2.
    GenomeRNAii 4862.
    NextBioi 18730.
    PROi Q99743.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99743.
    Bgeei Q99743.
    CleanExi HS_NPAS2.
    Genevestigatori Q99743.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR001067. Nuc_translocat.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view ]
    PRINTSi PR00785. NCTRNSLOCATR.
    SMARTi SM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    PS50112. PAS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system."
      Zhou Y.-D., Barnard M., Tian H., Li X., Ring H.Z., Francke U., Shelton J., Richardson J., Russell D.W., McKnight S.L.
      Proc. Natl. Acad. Sci. U.S.A. 94:713-718(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-394 AND LEU-471.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-394.
      Tissue: Lung.
    4. "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway."
      Hogenesch J.B., Chan W.K., Jackiw V.H., Brown R.C., Gu Y.-Z., Pray-Grant M., Perdew G.H., Bradfield C.A.
      J. Biol. Chem. 272:8581-8593(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-626, VARIANT ALA-394.
    5. "NPAS2: an analog of clock operative in the mammalian forebrain."
      Reick M., Garcia J.A., Dudley C., McKnight S.L.
      Science 293:506-509(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors."
      Rutter J., Reick M., Wu L.C., McKnight S.L.
      Science 293:510-514(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING.
    7. "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."
      Curtis A.M., Seo S.B., Westgate E.J., Rudic R.D., Smyth E.M., Chakravarti D., FitzGerald G.A., McNamara P.
      J. Biol. Chem. 279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH NCOA3; KAT2B; CREBBP AND EP300.
    8. "Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood."
      Hampp G., Ripperger J.A., Houben T., Schmutz I., Blex C., Perreau-Lenz S., Brunk I., Spanagel R., Ahnert-Hilger G., Meijer J.H., Albrecht U.
      Curr. Biol. 18:678-683(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response."
      Hoffman A.E., Zheng T., Ba Y., Zhu Y.
      Mol. Cancer Res. 6:1461-1468(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Metabolism and the circadian clock converge."
      Eckel-Mahan K., Sassone-Corsi P.
      Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    11. Cited for: ASSOCIATION OF VARIANT LEU-471 WITH SAD.
    12. "Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma."
      Zhu Y., Leaderer D., Guss C., Brown H.N., Zhang Y., Boyle P., Stevens R.G., Hoffman A., Qin Q., Han X., Zheng T.
      Int. J. Cancer 120:432-435(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ALA-394.
    13. "Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk."
      Zhu Y., Stevens R.G., Leaderer D., Hoffman A., Holford T., Zhang Y., Brown H.N., Zheng T.
      Breast Cancer Res. Treat. 107:421-425(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ALA-394.

    Entry informationi

    Entry nameiNPAS2_HUMAN
    AccessioniPrimary (citable) accession number: Q99743
    Secondary accession number(s): Q4ZFV9
    , Q53SQ3, Q86V96, Q99629
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 141 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3