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Q99743

- NPAS2_HUMAN

UniProt

Q99743 - NPAS2_HUMAN

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Protein
Neuronal PAS domain-containing protein 2
Gene
NPAS2, BHLHE9, MOP4, PASD4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes.5 Publications

Cofactori

Binds heme.

Enzyme regulationi

Carbon monoxide (CO) and the redox state of the cell can modulate the transcriptional activity of the NPAS2-ARNTL/BMAL1 heterodimer. NADH and NADPH enhance the DNA-binding activity of the heterodimer whereas CO binds the heme group in NPAS2 and inhibits the DNA-binding activity of the heterodimer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi119 – 1191Iron (heme B axial ligand) By similarity
Metal bindingi171 – 1711Iron (heme B axial ligand) By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. Hsp90 protein binding Source: BHF-UCL
  3. core promoter binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. protein binding Source: UniProtKB
  6. sequence-specific DNA binding transcription factor activity Source: ProtInc
  7. signal transducer activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cellular lipid metabolic process Source: Reactome
  2. cellular response to DNA damage stimulus Source: UniProtKB-KW
  3. central nervous system development Source: ProtInc
  4. circadian regulation of gene expression Source: UniProtKB
  5. circadian sleep/wake cycle Source: Ensembl
  6. locomotor rhythm Source: Ensembl
  7. negative regulation of cell death Source: UniProtKB
  8. positive regulation of DNA repair Source: UniProtKB
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. positive regulation of transcription, DNA-templated Source: UniProtKB
  11. regulation of response to DNA damage stimulus Source: UniProtKB
  12. response to redox state Source: UniProtKB
  13. small molecule metabolic process Source: Reactome
  14. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, DNA damage, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_116145. PPARA activates gene expression.
REACT_118659. RORA activates circadian gene expression.
REACT_118789. REV-ERBA represses gene expression.
REACT_24941. Circadian Clock.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal PAS domain-containing protein 2
Short name:
Neuronal PAS2
Alternative name(s):
Basic-helix-loop-helix-PAS protein MOP4
Class E basic helix-loop-helix protein 9
Short name:
bHLHe9
Member of PAS protein 4
PAS domain-containing protein 4
Gene namesi
Name:NPAS2
Synonyms:BHLHE9, MOP4, PASD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:7895. NPAS2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

MIMi608516. phenotype.
PharmGKBiPA31696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Neuronal PAS domain-containing protein 2
PRO_0000127406Add
BLAST

Proteomic databases

PaxDbiQ99743.
PRIDEiQ99743.

PTM databases

PhosphoSiteiQ99743.

Expressioni

Gene expression databases

ArrayExpressiQ99743.
BgeeiQ99743.
CleanExiHS_NPAS2.
GenevestigatoriQ99743.

Organism-specific databases

HPAiHPA019674.

Interactioni

Subunit structurei

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ARNTL/BMAL1 and this heterodimerization is required for E-box-dependent transactivation. Interacts with NCOA3, KAT2B, CREBBP and EP300.1 Publication

Protein-protein interaction databases

BioGridi110923. 13 interactions.
IntActiQ99743. 8 interactions.
STRINGi9606.ENSP00000338283.

Structurei

3D structure databases

ProteinModelPortaliQ99743.
SMRiQ99743. Positions 6-359.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 5951bHLH
Add
BLAST
Domaini82 – 15271PAS 1
Add
BLAST
Domaini237 – 30771PAS 2
Add
BLAST
Domaini311 – 35444PAC
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 6161Sufficient for heterodimer formation with ARNTL/BMAL1, E-box binding and for the effect of NADPH By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG300360.
HOVERGENiHBG050997.
InParanoidiQ99743.
KOiK09026.
PhylomeDBiQ99743.
TreeFamiTF324568.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00785. NCTRNSLOCATR.
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99743-1 [UniParc]FASTAAdd to Basket

« Hide

MDEDEKDRAK RASRNKSEKK RRDQFNVLIK ELSSMLPGNT RKMDKTTVLE    50
KVIGFLQKHN EVSAQTEICD IQQDWKPSFL SNEEFTQLML EALDGFIIAV 100
TTDGSIIYVS DSITPLLGHL PSDVMDQNLL NFLPEQEHSE VYKILSSHML 150
VTDSPSPEYL KSDSDLEFYC HLLRGSLNPK EFPTYEYIKF VGNFRSYNNV 200
PSPSCNGFDN TLSRPCRVPL GKEVCFIATV RLATPQFLKE MCIVDEPLEE 250
FTSRHSLEWK FLFLDHRAPP IIGYLPFEVL GTSGYDYYHI DDLELLARCH 300
QHLMQFGKGK SCCYRFLTKG QQWIWLQTHY YITYHQWNSK PEFIVCTHSV 350
VSYADVRVER RQELALEDPP SEALHSSALK DKGSSLEPRQ HFNTLDVGAS 400
GLNTSHSPSA SSRSSHKSSH TAMSEPTSTP TKLMAEASTP ALPRSATLPQ 450
ELPVPGLSQA ATMPAPLPSP SSCDLTQQLL PQTVLQSTPA PMAQFSAQFS 500
MFQTIKDQLE QRTRILQANI RWQQEELHKI QEQLCLVQDS NVQMFLQQPA 550
VSLSFSSTQR PEAQQQLQQR SAAVTQPQLG AGPQLPGQIS SAQVTSQHLL 600
RESSVISTQG PKPMRSSQLM QSSGRSGSSL VSPFSSATAA LPPSLNLTTP 650
ASTSQDASQC QPSPDFSHDR QLRLLLSQPI QPMMPGSCDA RQPSEVSRTG 700
RQVKYAQSQT VFQNPDAHPA NSSSAPMPVL LMGQAVLHPS FPASQPSPLQ 750
PAQARQQPPQ HYLQVQAPTS LHSEQQDSLL LSTYSQQPGT LGYPQPPPAQ 800
PQPLRPPRRV SSLSESSGLQ QPPR 824
Length:824
Mass (Da):91,791
Last modified:November 2, 2010 - v3
Checksum:i679919FCDD3AFDEB
GO

Polymorphismi

Variants in NPAS2 show a susceptibility to seasonal affective disorder (SAD) [MIMi:608516]. SAD is a depressive condition resulting from seasonal changes, and with diurnal preference.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti394 – 3941T → A Associated with non-Hodgkin's lymphoma and breast cancer risk. 5 Publications
Corresponds to variant rs2305160 [ dbSNP | Ensembl ].
VAR_029078
Natural varianti471 – 4711S → L Susceptibility to seasonal affective disorder (SAD) and diurnal preference. 2 Publications
Corresponds to variant rs11541353 [ dbSNP | Ensembl ].
VAR_029079

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511K → E in AAC51211. 1 Publication
Sequence conflicti164 – 1641S → G in AAC51211. 1 Publication
Sequence conflicti308 – 3081K → T in AAB47250. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77970 mRNA. Translation: AAB47250.1.
AC016738 Genomic DNA. Translation: AAY14822.1.
AC092168 Genomic DNA. No translation available.
AC106891 Genomic DNA. Translation: AAX88966.1.
BC051351 mRNA. Translation: AAH51351.2.
BC072383 mRNA. Translation: AAH72383.1.
U51625 mRNA. Translation: AAC51211.1.
CCDSiCCDS2048.1.
RefSeqiNP_002509.2. NM_002518.3.
UniGeneiHs.156832.
Hs.705895.

Genome annotation databases

EnsembliENST00000335681; ENSP00000338283; ENSG00000170485.
GeneIDi4862.
KEGGihsa:4862.
UCSCiuc002tap.1. human.

Polymorphism databases

DMDMi311033423.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77970 mRNA. Translation: AAB47250.1 .
AC016738 Genomic DNA. Translation: AAY14822.1 .
AC092168 Genomic DNA. No translation available.
AC106891 Genomic DNA. Translation: AAX88966.1 .
BC051351 mRNA. Translation: AAH51351.2 .
BC072383 mRNA. Translation: AAH72383.1 .
U51625 mRNA. Translation: AAC51211.1 .
CCDSi CCDS2048.1.
RefSeqi NP_002509.2. NM_002518.3.
UniGenei Hs.156832.
Hs.705895.

3D structure databases

ProteinModelPortali Q99743.
SMRi Q99743. Positions 6-359.
ModBasei Search...

Protein-protein interaction databases

BioGridi 110923. 13 interactions.
IntActi Q99743. 8 interactions.
STRINGi 9606.ENSP00000338283.

PTM databases

PhosphoSitei Q99743.

Polymorphism databases

DMDMi 311033423.

Proteomic databases

PaxDbi Q99743.
PRIDEi Q99743.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335681 ; ENSP00000338283 ; ENSG00000170485 .
GeneIDi 4862.
KEGGi hsa:4862.
UCSCi uc002tap.1. human.

Organism-specific databases

CTDi 4862.
GeneCardsi GC02P101436.
H-InvDB HIX0200274.
HGNCi HGNC:7895. NPAS2.
HPAi HPA019674.
MIMi 603347. gene.
608516. phenotype.
neXtProti NX_Q99743.
PharmGKBi PA31696.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300360.
HOVERGENi HBG050997.
InParanoidi Q99743.
KOi K09026.
PhylomeDBi Q99743.
TreeFami TF324568.

Enzyme and pathway databases

Reactomei REACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_116145. PPARA activates gene expression.
REACT_118659. RORA activates circadian gene expression.
REACT_118789. REV-ERBA represses gene expression.
REACT_24941. Circadian Clock.

Miscellaneous databases

ChiTaRSi NPAS2. human.
GeneWikii NPAS2.
GenomeRNAii 4862.
NextBioi 18730.
PROi Q99743.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99743.
Bgeei Q99743.
CleanExi HS_NPAS2.
Genevestigatori Q99743.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view ]
PRINTSi PR00785. NCTRNSLOCATR.
SMARTi SM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system."
    Zhou Y.-D., Barnard M., Tian H., Li X., Ring H.Z., Francke U., Shelton J., Richardson J., Russell D.W., McKnight S.L.
    Proc. Natl. Acad. Sci. U.S.A. 94:713-718(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-394 AND LEU-471.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-394.
    Tissue: Lung.
  4. "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway."
    Hogenesch J.B., Chan W.K., Jackiw V.H., Brown R.C., Gu Y.-Z., Pray-Grant M., Perdew G.H., Bradfield C.A.
    J. Biol. Chem. 272:8581-8593(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-626, VARIANT ALA-394.
  5. "NPAS2: an analog of clock operative in the mammalian forebrain."
    Reick M., Garcia J.A., Dudley C., McKnight S.L.
    Science 293:506-509(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors."
    Rutter J., Reick M., Wu L.C., McKnight S.L.
    Science 293:510-514(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  7. "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."
    Curtis A.M., Seo S.B., Westgate E.J., Rudic R.D., Smyth E.M., Chakravarti D., FitzGerald G.A., McNamara P.
    J. Biol. Chem. 279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH NCOA3; KAT2B; CREBBP AND EP300.
  8. "Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood."
    Hampp G., Ripperger J.A., Houben T., Schmutz I., Blex C., Perreau-Lenz S., Brunk I., Spanagel R., Ahnert-Hilger G., Meijer J.H., Albrecht U.
    Curr. Biol. 18:678-683(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response."
    Hoffman A.E., Zheng T., Ba Y., Zhu Y.
    Mol. Cancer Res. 6:1461-1468(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Metabolism and the circadian clock converge."
    Eckel-Mahan K., Sassone-Corsi P.
    Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. Cited for: ASSOCIATION OF VARIANT LEU-471 WITH SAD.
  12. "Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma."
    Zhu Y., Leaderer D., Guss C., Brown H.N., Zhang Y., Boyle P., Stevens R.G., Hoffman A., Qin Q., Han X., Zheng T.
    Int. J. Cancer 120:432-435(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ALA-394.
  13. "Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk."
    Zhu Y., Stevens R.G., Leaderer D., Hoffman A., Holford T., Zhang Y., Brown H.N., Zheng T.
    Breast Cancer Res. Treat. 107:421-425(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ALA-394.

Entry informationi

Entry nameiNPAS2_HUMAN
AccessioniPrimary (citable) accession number: Q99743
Secondary accession number(s): Q4ZFV9
, Q53SQ3, Q86V96, Q99629
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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