Reviewed,
UniProtKB/Swiss-Prot Q99741 (CDC6_HUMAN)
Last modified
June 16, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cell division control protein 6 homolog Alternative name(s): CDC6-related protein p62(cdc6) Short name=HsCDC6 Short name=HsCDC18 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 560 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Subunit structure | Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Ref.2 Ref.6 |
| Subcellular location | Nucleus. Cytoplasm. Note: The protein is nuclear in G1 and cytoplasmic in S-phase cells. Ref.2 |
| Sequence similarities | Belongs to the CDC6/cdc18 family. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CDKN1A | P38936 | 1 | EBI-374862,EBI-375077 | |
| CDKN2A | P42771 | 1 | EBI-374862,EBI-375053 | |
| CDT1 | Q9H211 | 2 | EBI-374862,EBI-456953 | |
| MCM10 | Q7L590 | 1 | EBI-374862,EBI-374912 | |
| MCM2 | P49736 | 1 | EBI-374862,EBI-374819 | |
| MCM3 | P25205 | 1 | EBI-374862,EBI-355153 | |
| ORC1L | Q13415 | 1 | EBI-374862,EBI-374847 | |
| ORC2L | Q13416 | 1 | EBI-374862,EBI-374957 | |
| ORC3L | Q9UBD5 | 1 | EBI-374862,EBI-374916 | |
| ORC5L | O43913 | 1 | EBI-374862,EBI-374928 | |
| ORC6L | Q9Y5N6 | 1 | EBI-374862,EBI-374840 | |
| RPS27A | P62988 | 1 | EBI-374862,EBI-413034 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 560 | 560 | Cell division control protein 6 homolog | PRO_0000150979 | |||||
Regions | |||||||||
| Nucleotide binding | 202 – 209 | 8 | ATP Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 45 | 1 | Phosphoserine Ref.7 Ref.8 | ||||||
| Modified residue | 54 | 1 | Phosphoserine Ref.7 | ||||||
| Modified residue | 166 | 1 | Phosphothreonine Ref.5 | ||||||
Natural variations | |||||||||
| Natural variant | 238 | 1 | T → A: dbSNP rs4135010. Ref.3 | VAR_019349 | |||||
| Natural variant | 295 | 1 | D → N: dbSNP rs4135012. Ref.3 | VAR_019350 | |||||
| Natural variant | 299 | 1 | T → M: dbSNP rs4135013. Ref.3 | VAR_019351 | |||||
| Natural variant | 378 | 1 | R → H: dbSNP rs4135016. Ref.3 | VAR_019352 | |||||
| Natural variant | 441 | 1 | V → I: dbSNP rs13706. Ref.3 Ref.4 | VAR_019353 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A human protein related to yeast Cdc6p." Williams R.S., Shohet R.V., Stillman B. Proc. Natl. Acad. Sci. U.S.A. 94:142-147(1997) [PubMed: 8990175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase." Saha P., Chen J., Thome K.C., Lawlis S.J., Hou Z.H., Hendricks M., Parvin J.D., Dutta A. Mol. Cell. Biol. 18:2758-2767(1998) [PubMed: 9566895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH PCNA; ORC1L AND CYCLIN-CDK. |
| [3] | NIEHS SNPs program Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-238; ASN-295; MET-299; HIS-378 AND ILE-441. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-441. Tissue: Brain. |
| [5] | "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-166, MASS SPECTROMETRY. Tissue: Epithelium. |
| [6] | "Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage." Hall J.R., Kow E., Nevis K.R., Lu C.K., Luce K.S., Zhong Q., Cook J.G. Mol. Biol. Cell 18:3340-3350(2007) [PubMed: 17567951] [Abstract] Cited for: INTERACTION WITH HUWE1. |
| [7] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-54, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| U77949 mRNA. Translation: AAB38317.1. AF022109 mRNA. Translation: AAC52071.1. AY150310 Genomic DNA. Translation: AAN10296.1. BC025232 mRNA. Translation: AAH25232.1. | |||||||||||||||||||
| IPI | IPI00014575. | ||||||||||||||||||
| RefSeq | NP_001245.1. | ||||||||||||||||||
| UniGene | Hs.405958 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| DIP | DIP:28154N. | ||||||||||||||||||
| IntAct | Q99741. 12 interactions. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | Q99741. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q99741. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENSG00000094804. Homo sapiens. [Contig view] | ||||||||||||||||||
| GeneID | 990. | ||||||||||||||||||
| KEGG | hsa:990. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| GeneCards | GC17P035697. | ||||||||||||||||||
| H-InvDB | HIX0013795. | ||||||||||||||||||
| HGNC | HGNC:1744. CDC6. | ||||||||||||||||||
| MIM | 602627. gene. | ||||||||||||||||||
| PharmGKB | PA134904022. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOGENOM | Q99741. | ||||||||||||||||||
| HOVERGEN | Q99741. | ||||||||||||||||||
| OMA | Q99741. LYEAYSN. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| Reactome | REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q99741. | ||||||||||||||||||
| Bgee | Q99741. | ||||||||||||||||||
| CleanEx | HS_CDC6. | ||||||||||||||||||
| GermOnline | ENSG00000094804. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR016314. Cdc6. IPR015163. Cdc6_C. [Graphical view] | ||||||||||||||||||
| Pfam | PF00004. AAA. 1 hit. PF09079. Cdc6_C. 1 hit. [Graphical view] | ||||||||||||||||||
| PIRSF | PIRSF001767. Cdc6. 1 hit. | ||||||||||||||||||
| SMART | SM00382. AAA. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 4156. | ||||||||||||||||||
| PMAP-CutDB | Q99741. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | CDC6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q99741 Secondary accession number(s): Q8TB30 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


