Cell division control protein 6 homolog

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Reviewed, UniProtKB/Swiss-Prot Q99741 (CDC6_HUMAN)

Last modified June 16, 2009. Version 72. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cell division control protein 6 homolog
Alternative name(s):
    CDC6-related protein
    p62(cdc6)
      Short name=HsCDC6
      Short name=HsCDC18

Gene names

Name:	CDC6
Synonyms:	CDC18L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Subunit structure	Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Ref.2 Ref.6
Subcellular location	Nucleus. Cytoplasm. Note: The protein is nuclear in G1 and cytoplasmic in S-phase cells. Ref.2
Sequence similarities	Belongs to the CDC6/cdc18 family.

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Ontologies

Keywords
Biological process	Cell cycle Cell division DNA replication Mitosis
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	DNA replication Inferred from Experiment. Source: Reactome DNA replication checkpoint Ref.2 Traceable author statement. Source: ProtInc cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell proliferation Ref.2 Traceable author statement. Source: ProtInc regulation of cyclin-dependent protein kinase activity Ref.2 Traceable author statement. Source: ProtInc traversing start control point of mitotic cell cycle Ref.2 Traceable author statement. Source: ProtInc
Cellular component	cytosol Inferred from Experiment. Source: Reactome nucleoplasm Inferred from Experiment. Source: Reactome
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
CDKN1A	P38936	1	EBI-374862,EBI-375077
CDKN2A	P42771	1	EBI-374862,EBI-375053
CDT1	Q9H211	2	EBI-374862,EBI-456953
MCM10	Q7L590	1	EBI-374862,EBI-374912
MCM2	P49736	1	EBI-374862,EBI-374819
MCM3	P25205	1	EBI-374862,EBI-355153
ORC1L	Q13415	1	EBI-374862,EBI-374847
ORC2L	Q13416	1	EBI-374862,EBI-374957
ORC3L	Q9UBD5	1	EBI-374862,EBI-374916
ORC5L	O43913	1	EBI-374862,EBI-374928
ORC6L	Q9Y5N6	1	EBI-374862,EBI-374840
RPS27A	P62988	1	EBI-374862,EBI-413034

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 560

560

Cell division control protein 6 homolog

PRO_0000150979

Regions

Nucleotide binding

202 – 209

ATP Potential

Amino acid modifications

Modified residue

Phosphoserine Ref.7 Ref.8

Modified residue

Phosphoserine Ref.7

Modified residue

166

Phosphothreonine Ref.5

Natural variations

Natural variant

238

T → A: dbSNP rs4135010. Ref.3

VAR_019349

Natural variant

295

D → N: dbSNP rs4135012. Ref.3

VAR_019350

Natural variant

299

T → M: dbSNP rs4135013. Ref.3

VAR_019351

Natural variant

378

R → H: dbSNP rs4135016. Ref.3

VAR_019352

Natural variant

441

V → I: dbSNP rs13706. Ref.3 Ref.4

VAR_019353

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Sequences

Sequence

Length

Mass (Da)

Tools

Q99741-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 3ED7DE4AF80CB017
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FASTA

560

62,720

        10         20         30         40         50         60 
MPQTRSQAQA TISFPKRKLS RALNKAKNSS DAKLEPTNVQ TVTCSPRVKA LPLSPRKRLG 

        70         80         90        100        110        120 
DDNLCNTPHL PPCSPPKQGK KENGPPHSHT LKGRRLVFDN QLTIKSPSKR ELAKVHQNKI 

       130        140        150        160        170        180 
LSSVRKSQEI TTNSEQRCPL KKESACVRLF KQEGTCYQQA KLVLNTAVPD RLPAREREMD 

       190        200        210        220        230        240 
VIRNFLREHI CGKKAGSLYL SGAPGTGKTA CLSRILQDLK KELKGFKTIM LNCMSLRTAQ 

       250        260        270        280        290        300 
AVFPAIAQEI CQEEVSRPAG KDMMRKLEKH MTAEKGPMIV LVLDEMDQLD SKGQDVLYTL 

       310        320        330        340        350        360 
FEWPWLSNSH LVLIGIANTL DLTDRILPRL QAREKCKPQL LNFPPYTRNQ IVTILQDRLN 

       370        380        390        400        410        420 
QVSRDQVLDN AAVQFCARKV SAVSGDVRKA LDVCRRAIEI VESDVKSQTI LKPLSECKSP 

       430        440        450        460        470        480 
SEPLIPKRVG LIHISQVISE VDGNRMTLSQ EGAQDSFPLQ QKILVCSLML LIRQLKIKEV 

       490        500        510        520        530        540 
TLGKLYEAYS KVCRKQQVAA VDQSECLSLS GLLEARGILG LKRNKETRLT KVFFKIEEKE 

       550        560 
IEHALKDKAL IGNILATGLP

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human protein related to yeast Cdc6p." Williams R.S., Shohet R.V., Stillman B. Proc. Natl. Acad. Sci. U.S.A. 94:142-147(1997) [PubMed: 8990175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase." Saha P., Chen J., Thome K.C., Lawlis S.J., Hou Z.H., Hendricks M., Parvin J.D., Dutta A. Mol. Cell. Biol. 18:2758-2767(1998) [PubMed: 9566895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH PCNA; ORC1L AND CYCLIN-CDK.
[3]	NIEHS SNPs program Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-238; ASN-295; MET-299; HIS-378 AND ILE-441.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-441. Tissue: Brain.
[5]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-166, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage." Hall J.R., Kow E., Nevis K.R., Lu C.K., Luce K.S., Zhong Q., Cook J.G. Mol. Biol. Cell 18:3340-3350(2007) [PubMed: 17567951] [Abstract] Cited for: INTERACTION WITH HUWE1.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-54, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, MASS SPECTROMETRY.
+	Additional computationally mapped references.

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Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

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Cross-references

Sequence databases

U77949 mRNA. Translation: AAB38317.1.
AF022109 mRNA. Translation: AAC52071.1.
AY150310 Genomic DNA. Translation: AAN10296.1.
BC025232 mRNA. Translation: AAH25232.1.

IPI

IPI00014575.

RefSeq

NP_001245.1.

UniGene

Hs.405958

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CCH	X-ray	1.70	E/F	89-100	[»]
2CCI	X-ray	2.70	F/I	74-100	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:28154N.

IntAct

Q99741. 12 interactions.

PTM databases

PhosphoSite

Q99741.

Proteomic databases

PRIDE

Q99741.

Genome annotation databases

Ensembl

ENSG00000094804. Homo sapiens. [Contig view]

GeneID

990.

KEGG

hsa:990.

Organism-specific databases

GeneCards

GC17P035697.

H-InvDB

HIX0013795.

HGNC

HGNC:1744. CDC6.

MIM

602627. gene.

PharmGKB

PA134904022.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q99741.

HOVERGEN

Q99741.

OMA

Q99741. LYEAYSN.

Enzyme and pathway databases

Reactome

REACT_152. Cell Cycle, Mitotic.
REACT_1538. Cell Cycle Checkpoints.
REACT_383. DNA Replication.

Gene expression databases

ArrayExpress

Q99741.

Bgee

Q99741.

CleanEx

HS_CDC6.

GermOnline

ENSG00000094804. Homo sapiens.

Family and domain databases

InterPro

IPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR016314. Cdc6.
IPR015163. Cdc6_C.
[Graphical view]

Pfam

PF00004. AAA. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]

PIRSF

PIRSF001767. Cdc6. 1 hit.

SMART

SM00382. AAA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

4156.

PMAP-CutDB

Q99741.

SOURCE

Search...

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Entry information

Entry name

CDC6_HUMAN

Accession

Primary (citable) accession number: Q99741
Secondary accession number(s): Q8TB30

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	May 1, 1997
Last modified:	June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents