Q99740 (Q99740_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Soluble protein Jagged EMBL AAC50909.1
Organism	Homo sapiens (Human) EMBL AAC50909.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	263 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	EGF-like domain RuleBase RU000458 SAAS SAAS018097 Repeat SAAS SAAS006209
PTM	Disulfide bond SAAS SAAS018097
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAC50909.1

Sequences

	Sequence		Length	Mass (Da)
	Q99740 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: E77235CBB360B620	FASTA	263	28,405
	10 20 30 40 50 60 ARNSSCLPNP CHNGGTCVVN GESFTCVCKE GWEGPICAQN TNDCSPHPCY NSGTCVDGDN 70 80 90 100 110 120 WYRCECAPGF AGPDCRININ ECQSSPCAFG ATCVDEINGY RCVCPPGHSG AKCQEVSGRP 130 140 150 160 170 180 CITMGSVIPD GAKWDDDCNT CQCLNGRIAC SKVWCGPRPC LLHKGHSECP SGQSCIPILD 190 200 210 220 230 240 DQCFVHPCTG VGECRSSSLQ PVKTKCTSDS YYQDNCANIT FTFNKEMMSP GLTTEHICSE 250 260 LRNLNILKIY GMMGTRSRKS LTK

References

[1]	"Jagged: a mammalian ligand that activates Notch1." Lindsell C.E., Shawber C.J., Boulter J., Weinmaster G. Cell 80:909-917(1995) [PubMed: 7697721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Umbilical vein EMBL AAC50909.1.
[2]	"An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro." Zimrin A.B., Pepper M.S., McMahon G.A., Nguyen F., Montesano R., Maciag T. J. Biol. Chem. 271:32499-32502(1996) [PubMed: 8955070] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Umbilical vein EMBL AAC50909.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U77914 mRNA. Translation: AAC50909.1.
IPI	IPI00383613.
RefSeq	NP_000205.1. NM_000214.2.
UniGene	Hs.224012. Hs.728907.
3D structure databases
HSSP	HSSP built from PDB template 1CCF based on UniProtKB P00743.
ProteinModelPortal	Q99740.
ModBase	Search...
Protein-protein interaction databases
STRING	Q99740.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	182.
KEGG	hsa:182.
Organism-specific databases
CTD	182.
Phylogenomic databases
GeneTree	ENSGT00600000084060.
Gene expression databases
ArrayExpress	Q99740.
Family and domain databases
InterPro	IPR006209. EGF. IPR006210. EGF-like. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR000742. EGF_3. IPR018097. EGF_Ca-bd_CS. IPR001007. VWF_C. [Graphical view]
KO	K06052.
Pfam	PF00008. EGF. 1 hit. [Graphical view]
SMART	SM00181. EGF. 1 hit. SM00179. EGF_CA. 2 hits. SM00214. VWC. 1 hit. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 2 hits. PS00022. EGF_1. 3 hits. PS01186. EGF_2. 2 hits. PS50026. EGF_3. 3 hits. PS01187. EGF_CA. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q99740_HUMAN

Accession

Primary (citable) accession number: Q99740

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	May 1, 1997
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.