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Protein
Submitted name:

Soluble protein Jagged

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Soluble protein JaggedImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29986.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ99740.
PRIDEiQ99740.

Expressioni

Gene expression databases

GenevisibleiQ99740. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000254958.

Structurei

3D structure databases

ProteinModelPortaliQ99740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 3837EGF-likeInterPro annotationAdd
BLAST
Domaini40 – 7637EGF-likeInterPro annotationAdd
BLAST
Domaini78 – 11437EGF-likeInterPro annotationAdd
BLAST

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
KOiK06052.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 1 hit.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ARNSSCLPNP CHNGGTCVVN GESFTCVCKE GWEGPICAQN TNDCSPHPCY
60 70 80 90 100
NSGTCVDGDN WYRCECAPGF AGPDCRININ ECQSSPCAFG ATCVDEINGY
110 120 130 140 150
RCVCPPGHSG AKCQEVSGRP CITMGSVIPD GAKWDDDCNT CQCLNGRIAC
160 170 180 190 200
SKVWCGPRPC LLHKGHSECP SGQSCIPILD DQCFVHPCTG VGECRSSSLQ
210 220 230 240 250
PVKTKCTSDS YYQDNCANIT FTFNKEMMSP GLTTEHICSE LRNLNILKIY
260
GMMGTRSRKS LTK
Length:263
Mass (Da):28,405
Last modified:May 1, 1997 - v1
Checksum:iE77235CBB360B620
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77914 mRNA. Translation: AAC50909.1.
RefSeqiNP_000205.1. NM_000214.2.
UniGeneiHs.224012.
Hs.626544.

Genome annotation databases

GeneIDi182.
KEGGihsa:182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77914 mRNA. Translation: AAC50909.1.
RefSeqiNP_000205.1. NM_000214.2.
UniGeneiHs.224012.
Hs.626544.

3D structure databases

ProteinModelPortaliQ99740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000254958.

Proteomic databases

PaxDbiQ99740.
PRIDEiQ99740.

Protocols and materials databases

DNASUi182.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi182.
KEGGihsa:182.

Organism-specific databases

CTDi182.
PharmGKBiPA29986.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
KOiK06052.

Miscellaneous databases

GenomeRNAii182.

Gene expression databases

GenevisibleiQ99740. HS.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 1 hit.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Jagged: a mammalian ligand that activates Notch1."
    Lindsell C.E., Shawber C.J., Boulter J., Weinmaster G.
    Cell 80:909-917(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Umbilical veinImported.
  2. "An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro."
    Zimrin A.B., Pepper M.S., McMahon G.A., Nguyen F., Montesano R., Maciag T.
    J. Biol. Chem. 271:32499-32502(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Umbilical veinImported.

Entry informationi

Entry nameiQ99740_HUMAN
AccessioniPrimary (citable) accession number: Q99740
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.