Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Microsomal glutathione S-transferase 2

Gene

MGST2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  • enzyme activator activity Source: InterPro
  • glutathione peroxidase activity Source: BHF-UCL
  • glutathione transferase activity Source: UniProtKB
  • leukotriene-C4 synthase activity Source: UniProtKB

GO - Biological processi

  • glutathione biosynthetic process Source: UniProtKB
  • glutathione derivative biosynthetic process Source: Reactome
  • leukotriene biosynthetic process Source: UniProtKB
  • lipid metabolic process Source: BHF-UCL
  • membrane lipid catabolic process Source: BHF-UCL
  • positive regulation of inflammatory response Source: BHF-UCL
  • response to lipopolysaccharide Source: Ensembl
  • response to organonitrogen compound Source: Ensembl
  • xenobiotic metabolic process Source: Reactome

Keywordsi

Molecular functionTransferase
Biological processLeukotriene biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-5423646 Aflatoxin activation and detoxification

Chemistry databases

SwissLipidsiSLP:000001464

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 2 (EC:2.5.1.18)
Short name:
Microsomal GST-2
Alternative name(s):
Microsomal GST-II
Gene namesi
Name:MGST2
Synonyms:GST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000085871.8
HGNCiHGNC:7063 MGST2
MIMi601733 gene
neXtProtiNX_Q99735

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi4258
OpenTargetsiENSG00000085871
PharmGKBiPA30792

Chemistry databases

ChEMBLiCHEMBL1743185
DrugBankiDB01008 Busulfan
DB00143 Glutathione

Polymorphism and mutation databases

BioMutaiMGST2
DMDMi2842764

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177401 – 147Microsomal glutathione S-transferase 2Add BLAST147

Proteomic databases

MaxQBiQ99735
PaxDbiQ99735
PeptideAtlasiQ99735
PRIDEiQ99735
TopDownProteomicsiQ99735-1 [Q99735-1]

PTM databases

iPTMnetiQ99735
PhosphoSitePlusiQ99735

Expressioni

Tissue specificityi

Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow.

Gene expression databases

BgeeiENSG00000085871
CleanExiHS_MGST2
GenevisibleiQ99735 HS

Organism-specific databases

HPAiHPA010707

Interactioni

Subunit structurei

Homotrimer.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110414, 6 interactors
IntActiQ99735, 7 interactors
MINTiQ99735
STRINGi9606.ENSP00000265498

Structurei

3D structure databases

ProteinModelPortaliQ99735
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX5K Eukaryota
ENOG41121Z4 LUCA
GeneTreeiENSGT00430000030964
HOGENOMiHOG000186087
HOVERGENiHBG105513
InParanoidiQ99735
KOiK00799
OMAiIFRAQQN
OrthoDBiEOG091G12NW
PhylomeDBiQ99735
TreeFamiTF105328

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR001446 5_LipOase_AP
IPR018295 FLAP/GST2/LTC4S_CS
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
PRINTSiPR00488 5LPOXGNASEAP
SUPFAMiSSF161084 SSF161084, 1 hit
PROSITEiView protein in PROSITE
PS01297 FLAP_GST2_LTC4S, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99735-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNSILLAA VSILSACQQS YFALQVGKAR LKYKVTPPAV TGSPEFERVF
60 70 80 90 100
RAQQNCVEFY PIFIITLWMA GWYFNQVFAT CLGLVYIYGR HLYFWGYSEA
110 120 130 140
AKKRITGFRL SLGILALLTL LGALGIANSF LDEYLDLNIA KKLRRQF
Length:147
Mass (Da):16,621
Last modified:May 1, 1997 - v1
Checksum:iD0E89B46885D16EF
GO
Isoform 2 (identifier: Q99735-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-147: QQNCVEFYPI...NIAKKLRRQF → HFCYLSGSGVHIWPSPILLGIFRSC

Note: No experimental confirmation available.
Show »
Length:77
Mass (Da):8,359
Checksum:iCABF1D4ECFAD2B79
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019997101A → V1 PublicationCorresponds to variant dbSNP:rs8192111Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04453853 – 147QQNCV…LRRQF → HFCYLSGSGVHIWPSPILLG IFRSC in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77604 mRNA Translation: AAC51768.1
CR407640 mRNA Translation: CAG28568.1
AY341028 Genomic DNA Translation: AAP88934.1 Sequence problems.
AC108053 Genomic DNA No translation available.
AC112236 Genomic DNA No translation available.
BC025416 mRNA Translation: AAH25416.1
BG519599 mRNA No translation available.
CCDSiCCDS3749.1 [Q99735-1]
CCDS56339.1 [Q99735-2]
RefSeqiNP_001191295.1, NM_001204366.1 [Q99735-1]
NP_001191297.1, NM_001204368.1 [Q99735-2]
NP_002404.1, NM_002413.4 [Q99735-1]
XP_016863700.1, XM_017008211.1 [Q99735-1]
XP_016863701.1, XM_017008212.1 [Q99735-1]
XP_016863702.1, XM_017008213.1 [Q99735-1]
UniGeneiHs.81874

Genome annotation databases

EnsembliENST00000265498; ENSP00000265498; ENSG00000085871 [Q99735-1]
ENST00000503816; ENSP00000423008; ENSG00000085871 [Q99735-1]
ENST00000506797; ENSP00000424278; ENSG00000085871 [Q99735-2]
ENST00000616265; ENSP00000482639; ENSG00000085871 [Q99735-1]
GeneIDi4258
KEGGihsa:4258
UCSCiuc003ihy.4 human [Q99735-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiMGST2_HUMAN
AccessioniPrimary (citable) accession number: Q99735
Secondary accession number(s): D6RBB5, Q7Z5B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health