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Protein

Nucleosome assembly protein 1-like 4

Gene

NAP1L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • unfolded protein binding Source: ProtInc

GO - Biological processi

  • nucleosome assembly Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 4
Alternative name(s):
Nucleosome assembly protein 2
Short name:
NAP-2
Gene namesi
Name:NAP1L4
Synonyms:NAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7640. NAP1L4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31442.

Polymorphism and mutation databases

BioMutaiNAP1L4.
DMDMi2498672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 375374Nucleosome assembly protein 1-like 4PRO_0000185658Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei5 – 51PhosphoserineCombined sources
Modified residuei7 – 71PhosphoserineCombined sources
Modified residuei12 – 121PhosphoserineCombined sources
Modified residuei51 – 511PhosphothreonineCombined sources
Modified residuei53 – 531PhosphoserineBy similarity
Modified residuei54 – 541PhosphoserineCombined sources
Modified residuei58 – 581PhosphothreonineCombined sources
Modified residuei105 – 1051N6-acetyllysineBy similarity
Modified residuei125 – 1251PhosphoserineCombined sources
Modified residuei146 – 1461N6-acetyllysineBy similarity
Modified residuei304 – 3041PhosphoserineCombined sources

Post-translational modificationi

Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human (By similarity).By similarityCurated

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99733.
MaxQBiQ99733.
PaxDbiQ99733.
PeptideAtlasiQ99733.
PRIDEiQ99733.

PTM databases

iPTMnetiQ99733.
PhosphoSiteiQ99733.
SwissPalmiQ99733.

Miscellaneous databases

PMAP-CutDBQ99733.

Expressioni

Tissue specificityi

Ubiquitous. Biallelically expressed in fetal and adult tissues. Highest levels in testis.

Gene expression databases

BgeeiENSG00000205531.
CleanExiHS_NAP1L4.
ExpressionAtlasiQ99733. baseline and differential.
GenevisibleiQ99733. HS.

Organism-specific databases

HPAiCAB011567.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
tatP046083EBI-2255116,EBI-6164389From a different organism.

GO - Molecular functioni

  • unfolded protein binding Source: ProtInc

Protein-protein interaction databases

BioGridi110757. 73 interactions.
IntActiQ99733. 33 interactions.
MINTiMINT-5001909.
STRINGi9606.ENSP00000369915.

Structurei

3D structure databases

ProteinModelPortaliQ99733.
SMRiQ99733. Positions 53-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi265 – 2717Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi126 – 1316Poly-Glu
Compositional biasi301 – 31010Asp/Glu-rich (acidic)
Compositional biasi347 – 37024Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1507. Eukaryota.
ENOG410XQN9. LUCA.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiQ99733.
KOiK11282.
OMAiDDADINP.
OrthoDBiEOG091G0HVV.
PhylomeDBiQ99733.
TreeFamiTF314349.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 2 hits.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99733-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADHSFSDGV PSDSVEAAKN ASNTEKLTDQ VMQNPRVLAA LQERLDNVPH
60 70 80 90 100
TPSSYIETLP KAVKRRINAL KQLQVRCAHI EAKFYEEVHD LERKYAALYQ
110 120 130 140 150
PLFDKRREFI TGDVEPTDAE SEWHSENEEE EKLAGDMKSK VVVTEKAAAT
160 170 180 190 200
AEEPDPKGIP EFWFTIFRNV DMLSELVQEY DEPILKHLQD IKVKFSDPGQ
210 220 230 240 250
PMSFVLEFHF EPNDYFTNSV LTKTYKMKSE PDKADPFSFE GPEIVDCDGC
260 270 280 290 300
TIDWKKGKNV TVKTIKKKQK HKGRGTVRTI TKQVPNESFF NFFNPLKASG
310 320 330 340 350
DGESLDEDSE FTLASDFEIG HFFRERIVPR AVLYFTGEAI EDDDNFEEGE
360 370
EGEEEELEGD EEGEDEDDAE INPKV
Length:375
Mass (Da):42,823
Last modified:May 1, 1997 - v1
Checksum:i788E1F9F5BC8FD45
GO
Isoform 2 (identifier: Q99733-2) [UniParc]FASTAAdd to basket
Also known as: NAP1L4b

The sequence of this isoform differs from the canonical sequence as follows:
     375-375: V → KEPSQPAECKQQ

Show »
Length:386
Mass (Da):44,079
Checksum:i4B758A68C22F9D9E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071R → K in BAG35491 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei375 – 3751V → KEPSQPAECKQQ in isoform 2. 1 PublicationVSP_053910

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77456 mRNA. Translation: AAC50870.1.
AB500094 mRNA. Translation: BAH95827.1.
AK312599 mRNA. Translation: BAG35491.1.
AC131971 Genomic DNA. No translation available.
BC022090 mRNA. Translation: AAH22090.1.
CCDSiCCDS41599.1. [Q99733-1]
RefSeqiNP_005960.1. NM_005969.3. [Q99733-1]
UniGeneiHs.731784.

Genome annotation databases

EnsembliENST00000380542; ENSP00000369915; ENSG00000205531. [Q99733-1]
ENST00000526115; ENSP00000436397; ENSG00000205531. [Q99733-2]
ENST00000616696; ENSP00000478654; ENSG00000273562. [Q99733-2]
ENST00000619695; ENSP00000483728; ENSG00000273562. [Q99733-1]
ENST00000620138; ENSP00000481412; ENSG00000205531. [Q99733-2]
ENST00000632791; ENSP00000487984; ENSG00000273562. [Q99733-2]
GeneIDi4676.
KEGGihsa:4676.
UCSCiuc001lxc.4. human. [Q99733-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77456 mRNA. Translation: AAC50870.1.
AB500094 mRNA. Translation: BAH95827.1.
AK312599 mRNA. Translation: BAG35491.1.
AC131971 Genomic DNA. No translation available.
BC022090 mRNA. Translation: AAH22090.1.
CCDSiCCDS41599.1. [Q99733-1]
RefSeqiNP_005960.1. NM_005969.3. [Q99733-1]
UniGeneiHs.731784.

3D structure databases

ProteinModelPortaliQ99733.
SMRiQ99733. Positions 53-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110757. 73 interactions.
IntActiQ99733. 33 interactions.
MINTiMINT-5001909.
STRINGi9606.ENSP00000369915.

PTM databases

iPTMnetiQ99733.
PhosphoSiteiQ99733.
SwissPalmiQ99733.

Polymorphism and mutation databases

BioMutaiNAP1L4.
DMDMi2498672.

Proteomic databases

EPDiQ99733.
MaxQBiQ99733.
PaxDbiQ99733.
PeptideAtlasiQ99733.
PRIDEiQ99733.

Protocols and materials databases

DNASUi4676.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380542; ENSP00000369915; ENSG00000205531. [Q99733-1]
ENST00000526115; ENSP00000436397; ENSG00000205531. [Q99733-2]
ENST00000616696; ENSP00000478654; ENSG00000273562. [Q99733-2]
ENST00000619695; ENSP00000483728; ENSG00000273562. [Q99733-1]
ENST00000620138; ENSP00000481412; ENSG00000205531. [Q99733-2]
ENST00000632791; ENSP00000487984; ENSG00000273562. [Q99733-2]
GeneIDi4676.
KEGGihsa:4676.
UCSCiuc001lxc.4. human. [Q99733-1]

Organism-specific databases

CTDi4676.
GeneCardsiNAP1L4.
HGNCiHGNC:7640. NAP1L4.
HPAiCAB011567.
MIMi601651. gene.
neXtProtiNX_Q99733.
PharmGKBiPA31442.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1507. Eukaryota.
ENOG410XQN9. LUCA.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiQ99733.
KOiK11282.
OMAiDDADINP.
OrthoDBiEOG091G0HVV.
PhylomeDBiQ99733.
TreeFamiTF314349.

Miscellaneous databases

ChiTaRSiNAP1L4. human.
GeneWikiiNAP1L4.
GenomeRNAii4676.
PMAP-CutDBQ99733.
PROiQ99733.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205531.
CleanExiHS_NAP1L4.
ExpressionAtlasiQ99733. baseline and differential.
GenevisibleiQ99733. HS.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 2 hits.
PfamiPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNP1L4_HUMAN
AccessioniPrimary (citable) accession number: Q99733
Secondary accession number(s): B2R6J4, F5HFY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.