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Protein

C-C motif chemokine 19

Gene

CCL19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.1 Publication

GO - Molecular functioni

  1. CCR10 chemokine receptor binding Source: BHF-UCL
  2. CCR7 chemokine receptor binding Source: BHF-UCL
  3. CCR chemokine receptor binding Source: UniProtKB
  4. chemokine activity Source: BHF-UCL
  5. chemokine receptor binding Source: UniProtKB

GO - Biological processi

  1. activation of JUN kinase activity Source: BHF-UCL
  2. cell communication Source: ProtInc
  3. cell maturation Source: BHF-UCL
  4. cellular calcium ion homeostasis Source: ProtInc
  5. dendritic cell chemotaxis Source: BHF-UCL
  6. establishment of T cell polarity Source: BHF-UCL
  7. immune response Source: ProtInc
  8. immunological synapse formation Source: BHF-UCL
  9. inflammatory response Source: BHF-UCL
  10. interleukin-12 secretion Source: BHF-UCL
  11. mature conventional dendritic cell differentiation Source: BHF-UCL
  12. myeloid dendritic cell chemotaxis Source: BHF-UCL
  13. negative regulation of leukocyte apoptotic process Source: BHF-UCL
  14. positive regulation of Cdc42 GTPase activity Source: BHF-UCL
  15. positive regulation of cell motility Source: BHF-UCL
  16. positive regulation of chemotaxis Source: BHF-UCL
  17. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
  18. positive regulation of dendritic cell dendrite assembly Source: BHF-UCL
  19. positive regulation of endocytosis Source: BHF-UCL
  20. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  21. positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
  22. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
  23. positive regulation of interleukin-12 production Source: BHF-UCL
  24. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
  25. positive regulation of JNK cascade Source: BHF-UCL
  26. positive regulation of neutrophil chemotaxis Source: BHF-UCL
  27. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
  28. positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
  29. positive regulation of protein kinase activity Source: BHF-UCL
  30. positive regulation of protein kinase B signaling Source: BHF-UCL
  31. positive regulation of Ras GTPase activity Source: BHF-UCL
  32. positive regulation of receptor-mediated endocytosis Source: BHF-UCL
  33. positive regulation of T cell proliferation Source: BHF-UCL
  34. positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
  35. positive regulation of tumor necrosis factor production Source: BHF-UCL
  36. regulation of cell projection assembly Source: BHF-UCL
  37. release of sequestered calcium ion into cytosol Source: BHF-UCL
  38. response to nitric oxide Source: BHF-UCL
  39. response to prostaglandin E Source: BHF-UCL
  40. response to virus Source: ProtInc
  41. T cell costimulation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 19
Alternative name(s):
Beta-chemokine exodus-3
CK beta-11
Epstein-Barr virus-induced molecule 1 ligand chemokine
Short name:
EBI1 ligand chemokine
Short name:
ELC
Macrophage inflammatory protein 3 beta
Short name:
MIP-3-beta
Small-inducible cytokine A19
Gene namesi
Name:CCL19
Synonyms:ELC, MIP3B, SCYA19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:10617. CCL19.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 9877C-C motif chemokine 19PRO_0000005214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 55By similarity
Disulfide bondi30 ↔ 71By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ99731.
PRIDEiQ99731.

PTM databases

PhosphoSiteiQ99731.

Expressioni

Tissue specificityi

Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.

Gene expression databases

BgeeiQ99731.
CleanExiHS_CCL19.
ExpressionAtlasiQ99731. baseline and differential.
GenevestigatoriQ99731.

Interactioni

Protein-protein interaction databases

BioGridi112266. 3 interactions.
DIPiDIP-5857N.
MINTiMINT-123917.
STRINGi9606.ENSP00000308815.

Structurei

3D structure databases

ProteinModelPortaliQ99731.
SMRiQ99731. Positions 29-87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39607.
GeneTreeiENSGT00730000111353.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ99731.
KOiK05512.
OrthoDBiEOG7X3QV0.
PhylomeDBiQ99731.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL
60 70 80 90
IKDGCRVPAV VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS
Length:98
Mass (Da):10,993
Last modified:May 1, 1997 - v1
Checksum:i0D2516DB2EB1C81B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77180 mRNA. Translation: AAC50944.1.
AB000887 mRNA. Translation: BAA20383.1.
U88321 mRNA. Translation: AAC23905.1.
AJ223410 Genomic DNA. Translation: CAA11307.1.
BC027968 mRNA. Translation: AAH27968.1.
CCDSiCCDS6570.1.
RefSeqiNP_006265.1. NM_006274.2.
UniGeneiHs.50002.

Genome annotation databases

EnsembliENST00000311925; ENSP00000308815; ENSG00000172724.
GeneIDi6363.
KEGGihsa:6363.
UCSCiuc003zvn.3. human.

Polymorphism databases

DMDMi2842763.

Cross-referencesi

Web resourcesi

Wikipedia

CCL19 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77180 mRNA. Translation: AAC50944.1.
AB000887 mRNA. Translation: BAA20383.1.
U88321 mRNA. Translation: AAC23905.1.
AJ223410 Genomic DNA. Translation: CAA11307.1.
BC027968 mRNA. Translation: AAH27968.1.
CCDSiCCDS6570.1.
RefSeqiNP_006265.1. NM_006274.2.
UniGeneiHs.50002.

3D structure databases

ProteinModelPortaliQ99731.
SMRiQ99731. Positions 29-87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112266. 3 interactions.
DIPiDIP-5857N.
MINTiMINT-123917.
STRINGi9606.ENSP00000308815.

PTM databases

PhosphoSiteiQ99731.

Polymorphism databases

DMDMi2842763.

Proteomic databases

PaxDbiQ99731.
PRIDEiQ99731.

Protocols and materials databases

DNASUi6363.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311925; ENSP00000308815; ENSG00000172724.
GeneIDi6363.
KEGGihsa:6363.
UCSCiuc003zvn.3. human.

Organism-specific databases

CTDi6363.
GeneCardsiGC09M034692.
HGNCiHGNC:10617. CCL19.
MIMi602227. gene.
neXtProtiNX_Q99731.
PharmGKBiPA35550.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39607.
GeneTreeiENSGT00730000111353.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ99731.
KOiK05512.
OrthoDBiEOG7X3QV0.
PhylomeDBiQ99731.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiCCL19.
GenomeRNAii6363.
NextBioi24724.
PROiQ99731.
SOURCEiSearch...

Gene expression databases

BgeeiQ99731.
CleanExiHS_CCL19.
ExpressionAtlasiQ99731. baseline and differential.
GenevestigatoriQ99731.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta."
    Rossi D.L., Vicari A.P., Franz-Bacon K., McClanahan T.K., Zlotnik A.
    J. Immunol. 158:1033-1036(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7."
    Yoshida R., Imai T., Hieshima K., Kusuda J., Baba M., Kitaura M., Nishimura M., Kakizaki M., Nomiyama H., Yoshie O.
    J. Biol. Chem. 272:13803-13809(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Fetal lung.
  3. "DCCL chemokines represent a novel beta chemokine subfamily."
    Hromas R.A., Gray P., Klemsz M., Fife K., Broxmeyer H.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Reiterer P., Bernhardt G., Lipp M.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Spleen.
  6. "CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells."
    Kim C.H., Pelus L.M., White J.R., Applebaum E., Johanson K., Broxmeyer H.E.
    J. Immunol. 160:2418-2424(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
    Watts A.O., Verkaar F., van der Lee M.M., Timmerman C.A., Kuijer M., van Offenbeek J., van Lith L.H., Smit M.J., Leurs R., Zaman G.J., Vischer H.F.
    J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECEPTOR INTERACTION.

Entry informationi

Entry nameiCCL19_HUMAN
AccessioniPrimary (citable) accession number: Q99731
Secondary accession number(s): O00697, O00736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: February 4, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.