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Q99731 (CCL19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 19
Alternative name(s):
Beta-chemokine exodus-3
CK beta-11
Epstein-Barr virus-induced molecule 1 ligand chemokine
Short name=EBI1 ligand chemokine
Short name=ELC
Macrophage inflammatory protein 3 beta
Short name=MIP-3-beta
Small-inducible cytokine A19
Gene names
Name:CCL19
Synonyms:ELC, MIP3B, SCYA19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. Ref.6

Subcellular location

Secreted.

Tissue specificity

Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processT cell costimulation

Inferred from sequence or structural similarity. Source: BHF-UCL

activation of JUN kinase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

cell communication

Traceable author statement Ref.2. Source: ProtInc

cell maturation

Inferred from sequence or structural similarity. Source: BHF-UCL

cellular calcium ion homeostasis

Traceable author statement Ref.2. Source: ProtInc

dendritic cell chemotaxis

Inferred from direct assay PubMed 15778365. Source: BHF-UCL

establishment of T cell polarity

Inferred from direct assay PubMed 12729902. Source: BHF-UCL

immune response

Traceable author statement PubMed 10861057. Source: ProtInc

immunological synapse formation

Inferred from sequence or structural similarity. Source: BHF-UCL

inflammatory response

Non-traceable author statement PubMed 14592837. Source: BHF-UCL

interleukin-12 secretion

Inferred from sequence or structural similarity. Source: BHF-UCL

mature dendritic cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

myeloid dendritic cell chemotaxis

Inferred from direct assay PubMed 14592837. Source: BHF-UCL

negative regulation of leukocyte apoptotic process

Inferred from direct assay PubMed 15059845. Source: BHF-UCL

positive regulation of Cdc42 GTPase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of ERK1 and ERK2 cascade

Inferred from direct assay PubMed 15778365. Source: BHF-UCL

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from direct assay PubMed 15059845. Source: BHF-UCL

positive regulation of JNK cascade

Inferred from direct assay PubMed 15778365. Source: BHF-UCL

positive regulation of NF-kappaB import into nucleus

Inferred from direct assay PubMed 15059845. Source: BHF-UCL

positive regulation of Ras GTPase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T cell proliferation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T-helper 1 cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of cell motility

Inferred from direct assay PubMed 15778365. Source: BHF-UCL

positive regulation of chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of dendritic cell antigen processing and presentation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of dendritic cell dendrite assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of endocytosis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of glycoprotein biosynthetic process

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interleukin-1 beta secretion

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interleukin-12 production

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of neutrophil chemotaxis

Inferred from direct assay PubMed 21051556. Source: BHF-UCL

positive regulation of phosphatidylinositol 3-kinase activity

Inferred from direct assay PubMed 15059845PubMed 15778365. Source: BHF-UCL

positive regulation of protein kinase B signaling

Inferred from direct assay PubMed 15059845PubMed 15778365. Source: BHF-UCL

positive regulation of protein kinase activity

Inferred from direct assay PubMed 14592837PubMed 15059845. Source: BHF-UCL

positive regulation of receptor-mediated endocytosis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of tumor necrosis factor production

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of cell projection assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

release of sequestered calcium ion into cytosol

Inferred from direct assay PubMed 14592837. Source: BHF-UCL

response to nitric oxide

Inferred from direct assay PubMed 16249377. Source: BHF-UCL

response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

response to prostaglandin E

Inferred from direct assay PubMed 14592837. Source: BHF-UCL

response to virus

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionCCR chemokine receptor binding

Inferred from physical interaction PubMed 20002784. Source: UniProtKB

CCR10 chemokine receptor binding

Inferred from direct assay PubMed 10706668. Source: BHF-UCL

CCR7 chemokine receptor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

chemokine activity

Inferred from direct assay PubMed 15778365. Source: BHF-UCL

chemokine receptor binding

Inferred from direct assay Ref.7. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 9877C-C motif chemokine 19
PRO_0000005214

Amino acid modifications

Disulfide bond29 ↔ 55 By similarity
Disulfide bond30 ↔ 71 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99731 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 0D2516DB2EB1C81B

FASTA9810,993
        10         20         30         40         50         60 
MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL IKDGCRVPAV 

        70         80         90 
VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS 

« Hide

References

« Hide 'large scale' references
[1]"Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta."
Rossi D.L., Vicari A.P., Franz-Bacon K., McClanahan T.K., Zlotnik A.
J. Immunol. 158:1033-1036(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7."
Yoshida R., Imai T., Hieshima K., Kusuda J., Baba M., Kitaura M., Nishimura M., Kakizaki M., Nomiyama H., Yoshie O.
J. Biol. Chem. 272:13803-13809(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Fetal lung.
[3]"DCCL chemokines represent a novel beta chemokine subfamily."
Hromas R.A., Gray P., Klemsz M., Fife K., Broxmeyer H.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]Reiterer P., Bernhardt G., Lipp M.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas and Spleen.
[6]"CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells."
Kim C.H., Pelus L.M., White J.R., Applebaum E., Johanson K., Broxmeyer H.E.
J. Immunol. 160:2418-2424(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
Watts A.O., Verkaar F., van der Lee M.M., Timmerman C.A., Kuijer M., van Offenbeek J., van Lith L.H., Smit M.J., Leurs R., Zaman G.J., Vischer H.F.
J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: RECEPTOR INTERACTION.
+Additional computationally mapped references.

Web resources

Wikipedia

CCL19 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U77180 mRNA. Translation: AAC50944.1.
AB000887 mRNA. Translation: BAA20383.1.
U88321 mRNA. Translation: AAC23905.1.
AJ223410 Genomic DNA. Translation: CAA11307.1.
BC027968 mRNA. Translation: AAH27968.1.
CCDSCCDS6570.1.
RefSeqNP_006265.1. NM_006274.2.
UniGeneHs.50002.

3D structure databases

ProteinModelPortalQ99731.
SMRQ99731. Positions 29-87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112266. 3 interactions.
DIPDIP-5857N.
MINTMINT-123917.
STRING9606.ENSP00000308815.

PTM databases

PhosphoSiteQ99731.

Polymorphism databases

DMDM2842763.

Proteomic databases

PaxDbQ99731.
PRIDEQ99731.

Protocols and materials databases

DNASU6363.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311925; ENSP00000308815; ENSG00000172724.
GeneID6363.
KEGGhsa:6363.
UCSCuc003zvn.3. human.

Organism-specific databases

CTD6363.
GeneCardsGC09M034692.
HGNCHGNC:10617. CCL19.
MIM602227. gene.
neXtProtNX_Q99731.
PharmGKBPA35550.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39607.
HOGENOMHOG000036685.
HOVERGENHBG017871.
KOK05512.
OrthoDBEOG7X3QV0.
PhylomeDBQ99731.
TreeFamTF334888.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ99731.
BgeeQ99731.
CleanExHS_CCL19.
GenevestigatorQ99731.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCCL19.
GenomeRNAi6363.
NextBio24724.
PROQ99731.
SOURCESearch...

Entry information

Entry nameCCL19_HUMAN
AccessionPrimary (citable) accession number: Q99731
Secondary accession number(s): O00697, O00736
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM