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Q99731

- CCL19_HUMAN

UniProt

Q99731 - CCL19_HUMAN

Protein

C-C motif chemokine 19

Gene

CCL19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.1 Publication

    GO - Molecular functioni

    1. CCR10 chemokine receptor binding Source: BHF-UCL
    2. CCR7 chemokine receptor binding Source: BHF-UCL
    3. CCR chemokine receptor binding Source: UniProtKB
    4. chemokine activity Source: BHF-UCL
    5. chemokine receptor binding Source: UniProtKB

    GO - Biological processi

    1. activation of JUN kinase activity Source: BHF-UCL
    2. cell communication Source: ProtInc
    3. cell maturation Source: BHF-UCL
    4. cellular calcium ion homeostasis Source: ProtInc
    5. dendritic cell chemotaxis Source: BHF-UCL
    6. establishment of T cell polarity Source: BHF-UCL
    7. immune response Source: ProtInc
    8. immunological synapse formation Source: BHF-UCL
    9. inflammatory response Source: BHF-UCL
    10. interleukin-12 secretion Source: BHF-UCL
    11. mature dendritic cell differentiation Source: BHF-UCL
    12. myeloid dendritic cell chemotaxis Source: BHF-UCL
    13. negative regulation of leukocyte apoptotic process Source: BHF-UCL
    14. positive regulation of Cdc42 GTPase activity Source: BHF-UCL
    15. positive regulation of cell motility Source: BHF-UCL
    16. positive regulation of chemotaxis Source: BHF-UCL
    17. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
    18. positive regulation of dendritic cell dendrite assembly Source: BHF-UCL
    19. positive regulation of endocytosis Source: BHF-UCL
    20. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
    21. positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
    22. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
    23. positive regulation of interleukin-12 production Source: BHF-UCL
    24. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
    25. positive regulation of JNK cascade Source: BHF-UCL
    26. positive regulation of neutrophil chemotaxis Source: BHF-UCL
    27. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
    28. positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
    29. positive regulation of protein kinase activity Source: BHF-UCL
    30. positive regulation of protein kinase B signaling Source: BHF-UCL
    31. positive regulation of Ras GTPase activity Source: BHF-UCL
    32. positive regulation of receptor-mediated endocytosis Source: BHF-UCL
    33. positive regulation of T cell proliferation Source: BHF-UCL
    34. positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
    35. positive regulation of tumor necrosis factor production Source: BHF-UCL
    36. regulation of cell projection assembly Source: BHF-UCL
    37. release of sequestered calcium ion into cytosol Source: BHF-UCL
    38. response to nitric oxide Source: BHF-UCL
    39. response to organic cyclic compound Source: Ensembl
    40. response to prostaglandin E Source: BHF-UCL
    41. response to virus Source: ProtInc
    42. T cell costimulation Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 19
    Alternative name(s):
    Beta-chemokine exodus-3
    CK beta-11
    Epstein-Barr virus-induced molecule 1 ligand chemokine
    Short name:
    EBI1 ligand chemokine
    Short name:
    ELC
    Macrophage inflammatory protein 3 beta
    Short name:
    MIP-3-beta
    Small-inducible cytokine A19
    Gene namesi
    Name:CCL19
    Synonyms:ELC, MIP3B, SCYA19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:10617. CCL19.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35550.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 9877C-C motif chemokine 19PRO_0000005214Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 55By similarity
    Disulfide bondi30 ↔ 71By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ99731.
    PRIDEiQ99731.

    PTM databases

    PhosphoSiteiQ99731.

    Expressioni

    Tissue specificityi

    Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.

    Gene expression databases

    ArrayExpressiQ99731.
    BgeeiQ99731.
    CleanExiHS_CCL19.
    GenevestigatoriQ99731.

    Interactioni

    Protein-protein interaction databases

    BioGridi112266. 3 interactions.
    DIPiDIP-5857N.
    MINTiMINT-123917.
    STRINGi9606.ENSP00000308815.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99731.
    SMRiQ99731. Positions 29-87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39607.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    KOiK05512.
    OrthoDBiEOG7X3QV0.
    PhylomeDBiQ99731.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99731-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL   50
    IKDGCRVPAV VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS 98
    Length:98
    Mass (Da):10,993
    Last modified:May 1, 1997 - v1
    Checksum:i0D2516DB2EB1C81B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77180 mRNA. Translation: AAC50944.1.
    AB000887 mRNA. Translation: BAA20383.1.
    U88321 mRNA. Translation: AAC23905.1.
    AJ223410 Genomic DNA. Translation: CAA11307.1.
    BC027968 mRNA. Translation: AAH27968.1.
    CCDSiCCDS6570.1.
    RefSeqiNP_006265.1. NM_006274.2.
    UniGeneiHs.50002.

    Genome annotation databases

    EnsembliENST00000311925; ENSP00000308815; ENSG00000172724.
    GeneIDi6363.
    KEGGihsa:6363.
    UCSCiuc003zvn.3. human.

    Polymorphism databases

    DMDMi2842763.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL19 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77180 mRNA. Translation: AAC50944.1 .
    AB000887 mRNA. Translation: BAA20383.1 .
    U88321 mRNA. Translation: AAC23905.1 .
    AJ223410 Genomic DNA. Translation: CAA11307.1 .
    BC027968 mRNA. Translation: AAH27968.1 .
    CCDSi CCDS6570.1.
    RefSeqi NP_006265.1. NM_006274.2.
    UniGenei Hs.50002.

    3D structure databases

    ProteinModelPortali Q99731.
    SMRi Q99731. Positions 29-87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112266. 3 interactions.
    DIPi DIP-5857N.
    MINTi MINT-123917.
    STRINGi 9606.ENSP00000308815.

    PTM databases

    PhosphoSitei Q99731.

    Polymorphism databases

    DMDMi 2842763.

    Proteomic databases

    PaxDbi Q99731.
    PRIDEi Q99731.

    Protocols and materials databases

    DNASUi 6363.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311925 ; ENSP00000308815 ; ENSG00000172724 .
    GeneIDi 6363.
    KEGGi hsa:6363.
    UCSCi uc003zvn.3. human.

    Organism-specific databases

    CTDi 6363.
    GeneCardsi GC09M034692.
    HGNCi HGNC:10617. CCL19.
    MIMi 602227. gene.
    neXtProti NX_Q99731.
    PharmGKBi PA35550.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39607.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    KOi K05512.
    OrthoDBi EOG7X3QV0.
    PhylomeDBi Q99731.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii CCL19.
    GenomeRNAii 6363.
    NextBioi 24724.
    PROi Q99731.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99731.
    Bgeei Q99731.
    CleanExi HS_CCL19.
    Genevestigatori Q99731.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta."
      Rossi D.L., Vicari A.P., Franz-Bacon K., McClanahan T.K., Zlotnik A.
      J. Immunol. 158:1033-1036(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7."
      Yoshida R., Imai T., Hieshima K., Kusuda J., Baba M., Kitaura M., Nishimura M., Kakizaki M., Nomiyama H., Yoshie O.
      J. Biol. Chem. 272:13803-13809(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Fetal lung.
    3. "DCCL chemokines represent a novel beta chemokine subfamily."
      Hromas R.A., Gray P., Klemsz M., Fife K., Broxmeyer H.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Reiterer P., Bernhardt G., Lipp M.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas and Spleen.
    6. "CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells."
      Kim C.H., Pelus L.M., White J.R., Applebaum E., Johanson K., Broxmeyer H.E.
      J. Immunol. 160:2418-2424(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
      Watts A.O., Verkaar F., van der Lee M.M., Timmerman C.A., Kuijer M., van Offenbeek J., van Lith L.H., Smit M.J., Leurs R., Zaman G.J., Vischer H.F.
      J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECEPTOR INTERACTION.

    Entry informationi

    Entry nameiCCL19_HUMAN
    AccessioniPrimary (citable) accession number: Q99731
    Secondary accession number(s): O00697, O00736
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3