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Protein

C-C motif chemokine 19

Gene

CCL19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.1 Publication

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: BHF-UCL
  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172724-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 19
Alternative name(s):
Beta-chemokine exodus-3
CK beta-11
Epstein-Barr virus-induced molecule 1 ligand chemokine
Short name:
EBI1 ligand chemokine
Short name:
ELC
Macrophage inflammatory protein 3 beta
Short name:
MIP-3-beta
Small-inducible cytokine A19
Gene namesi
Name:CCL19
Synonyms:ELC, MIP3B, SCYA19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10617. CCL19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6363.
OpenTargetsiENSG00000172724.
PharmGKBiPA35550.

Polymorphism and mutation databases

BioMutaiCCL19.
DMDMi2842763.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000000521422 – 98C-C motif chemokine 19Add BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 55By similarity
Disulfide bondi30 ↔ 71By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ99731.
PeptideAtlasiQ99731.
PRIDEiQ99731.

PTM databases

PhosphoSitePlusiQ99731.

Expressioni

Tissue specificityi

Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.

Gene expression databases

BgeeiENSG00000172724.
CleanExiHS_CCL19.
ExpressionAtlasiQ99731. baseline and differential.
GenevisibleiQ99731. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TNFAIP6P980662EBI-11711510,EBI-11700693

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: BHF-UCL
  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112266. 2 interactors.
DIPiDIP-5857N.
IntActiQ99731. 2 interactors.
MINTiMINT-123917.
STRINGi9606.ENSP00000308815.

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 29Combined sources4
Beta strandi42 – 49Combined sources8
Turni51 – 53Combined sources3
Beta strandi59 – 64Combined sources6
Beta strandi69 – 72Combined sources4
Beta strandi74 – 76Combined sources3
Helixi77 – 90Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MP1NMR-A22-98[»]
ProteinModelPortaliQ99731.
SMRiQ99731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4UG. Eukaryota.
ENOG410ZG6G. LUCA.
GeneTreeiENSGT00730000111353.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ99731.
KOiK05512.
PhylomeDBiQ99731.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL
60 70 80 90
IKDGCRVPAV VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS
Length:98
Mass (Da):10,993
Last modified:May 1, 1997 - v1
Checksum:i0D2516DB2EB1C81B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77180 mRNA. Translation: AAC50944.1.
AB000887 mRNA. Translation: BAA20383.1.
U88321 mRNA. Translation: AAC23905.1.
AJ223410 Genomic DNA. Translation: CAA11307.1.
BC027968 mRNA. Translation: AAH27968.1.
CCDSiCCDS6570.1.
RefSeqiNP_006265.1. NM_006274.2.
UniGeneiHs.50002.

Genome annotation databases

EnsembliENST00000311925; ENSP00000308815; ENSG00000172724.
GeneIDi6363.
KEGGihsa:6363.
UCSCiuc003zvn.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

CCL19 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77180 mRNA. Translation: AAC50944.1.
AB000887 mRNA. Translation: BAA20383.1.
U88321 mRNA. Translation: AAC23905.1.
AJ223410 Genomic DNA. Translation: CAA11307.1.
BC027968 mRNA. Translation: AAH27968.1.
CCDSiCCDS6570.1.
RefSeqiNP_006265.1. NM_006274.2.
UniGeneiHs.50002.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MP1NMR-A22-98[»]
ProteinModelPortaliQ99731.
SMRiQ99731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112266. 2 interactors.
DIPiDIP-5857N.
IntActiQ99731. 2 interactors.
MINTiMINT-123917.
STRINGi9606.ENSP00000308815.

PTM databases

PhosphoSitePlusiQ99731.

Polymorphism and mutation databases

BioMutaiCCL19.
DMDMi2842763.

Proteomic databases

PaxDbiQ99731.
PeptideAtlasiQ99731.
PRIDEiQ99731.

Protocols and materials databases

DNASUi6363.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311925; ENSP00000308815; ENSG00000172724.
GeneIDi6363.
KEGGihsa:6363.
UCSCiuc003zvn.4. human.

Organism-specific databases

CTDi6363.
DisGeNETi6363.
GeneCardsiCCL19.
HGNCiHGNC:10617. CCL19.
MIMi602227. gene.
neXtProtiNX_Q99731.
OpenTargetsiENSG00000172724.
PharmGKBiPA35550.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4UG. Eukaryota.
ENOG410ZG6G. LUCA.
GeneTreeiENSGT00730000111353.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ99731.
KOiK05512.
PhylomeDBiQ99731.
TreeFamiTF334888.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172724-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiCCL19.
GenomeRNAii6363.
PROiQ99731.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172724.
CleanExiHS_CCL19.
ExpressionAtlasiQ99731. baseline and differential.
GenevisibleiQ99731. HS.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL19_HUMAN
AccessioniPrimary (citable) accession number: Q99731
Secondary accession number(s): O00697, O00736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.