Q99731 (CCL19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 19

Alternative name(s):
Beta-chemokine exodus-3
CK beta-11
Epstein-Barr virus-induced molecule 1 ligand chemokine
Short name=EBI1 ligand chemokine
Short name=ELC
Macrophage inflammatory protein 3 beta
Short name=MIP-3-beta
Small-inducible cytokine A19

Gene names

Name:	CCL19
Synonyms:	ELC, MIP3B, SCYA19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Ref.6
Subcellular location	Secreted.
Tissue specificity	Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	T cell costimulation Inferred from sequence or structural similarity. Source: BHF-UCL activation of JUN kinase activity Inferred from sequence or structural similarity. Source: BHF-UCL cell maturation Inferred from sequence or structural similarity. Source: BHF-UCL establishment of T cell polarity Inferred from direct assay PubMed 12729902. Source: BHF-UCL immune response Traceable author statement PubMed 10861057. Source: ProtInc immunological synapse formation Inferred from sequence or structural similarity. Source: BHF-UCL inflammatory response Non-traceable author statement PubMed 14592837. Source: BHF-UCL interleukin-12 secretion Inferred from sequence or structural similarity. Source: BHF-UCL mature dendritic cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL myeloid dendritic cell chemotaxis Inferred from direct assay PubMed 14592837. Source: BHF-UCL negative regulation of leukocyte apoptotic process Inferred from direct assay PubMed 15059845. Source: BHF-UCL positive regulation of Cdc42 GTPase activity Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of ERK1 and ERK2 cascade Inferred from direct assay PubMed 15778365. Source: BHF-UCL positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay PubMed 15059845. Source: BHF-UCL positive regulation of JNK cascade Inferred from direct assay PubMed 15778365. Source: BHF-UCL positive regulation of NF-kappaB import into nucleus Inferred from direct assay PubMed 15059845. Source: BHF-UCL positive regulation of T cell proliferation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of T-helper 1 cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of dendritic cell antigen processing and presentation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of dendritic cell dendrite assembly Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of glycoprotein biosynthetic process Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of interleukin-1 beta secretion Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of interleukin-12 production Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of neutrophil chemotaxis Inferred from direct assay PubMed 21051556. Source: BHF-UCL positive regulation of phosphatidylinositol 3-kinase activity Inferred from direct assay PubMed 15059845PubMed 15778365. Source: BHF-UCL positive regulation of protein kinase B signaling cascade Inferred from direct assay PubMed 15059845PubMed 15778365. Source: BHF-UCL positive regulation of receptor-mediated endocytosis Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of tumor necrosis factor production Inferred from sequence or structural similarity. Source: BHF-UCL release of sequestered calcium ion into cytosol Inferred from direct assay PubMed 14592837. Source: BHF-UCL response to nitric oxide Inferred from direct assay PubMed 16249377. Source: BHF-UCL response to organic cyclic compound Inferred from electronic annotation. Source: Compara response to prostaglandin E stimulus Inferred from direct assay PubMed 14592837. Source: BHF-UCL response to virus Traceable author statement Ref.2. Source: ProtInc
Cellular_component	extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	CCR10 chemokine receptor binding Inferred from direct assay PubMed 10706668. Source: BHF-UCL CCR7 chemokine receptor binding Inferred from sequence or structural similarity. Source: BHF-UCL chemokine activity Inferred from direct assay PubMed 15778365. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21
	Chain	22 – 98	77	C-C motif chemokine 19		PRO_0000005214
Amino acid modifications
	Disulfide bond	29 ↔ 55		By similarity
	Disulfide bond	30 ↔ 71		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q99731 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 0D2516DB2EB1C81B	FASTA	98	10,993
	10 20 30 40 50 60 MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL IKDGCRVPAV 70 80 90 VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta." Rossi D.L., Vicari A.P., Franz-Bacon K., McClanahan T.K., Zlotnik A. J. Immunol. 158:1033-1036(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7." Yoshida R., Imai T., Hieshima K., Kusuda J., Baba M., Kitaura M., Nishimura M., Kakizaki M., Nomiyama H., Yoshie O. J. Biol. Chem. 272:13803-13809(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Fetal lung.
[3]	"DCCL chemokines represent a novel beta chemokine subfamily." Hromas R.A., Gray P., Klemsz M., Fife K., Broxmeyer H. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	Reiterer P., Bernhardt G., Lipp M. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Spleen.
[6]	"CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells." Kim C.H., Pelus L.M., White J.R., Applebaum E., Johanson K., Broxmeyer H.E. J. Immunol. 160:2418-2424(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Web resources

Wikipedia

CCL19 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U77180 mRNA. Translation: AAC50944.1. AB000887 mRNA. Translation: BAA20383.1. U88321 mRNA. Translation: AAC23905.1. AJ223410 Genomic DNA. Translation: CAA11307.1. BC027968 mRNA. Translation: AAH27968.1.
IPI	IPI00017761.
RefSeq	NP_006265.1. NM_006274.2.
UniGene	Hs.50002.
3D structure databases
ProteinModelPortal	Q99731.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5857N.
STRING	9606.ENSP00000308815.
PTM databases
PhosphoSite	Q99731.
Polymorphism databases
DMDM	2842763.
Proteomic databases
PaxDb	Q99731.
PRIDE	Q99731.
Protocols and materials databases
DNASU	6363.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311925; ENSP00000308815; ENSG00000172724.
GeneID	6363.
KEGG	hsa:6363.
UCSC	uc003zvn.3. human.
Organism-specific databases
CTD	6363.
GeneCards	GC09M034692.
HGNC	HGNC:10617. CCL19.
MIM	602227. gene.
neXtProt	NX_Q99731.
PharmGKB	PA35550.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39607.
HOGENOM	HOG000036685.
HOVERGEN	HBG017871.
KO	K05512.
OrthoDB	EOG4H465J.
PhylomeDB	Q99731.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q99731.
Bgee	Q99731.
CleanEx	HS_CCL19.
Genevestigator	Q99731.
GermOnline	ENSG00000172724. Homo sapiens.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6363.
NextBio	24724.
SOURCE	Search...

Entry information

Entry name

CCL19_HUMAN

Accession

Primary (citable) accession number: Q99731
Secondary accession number(s): O00697, O00736

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.