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Protein

Heterogeneous nuclear ribonucleoprotein A/B

Gene

HNRNPAB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

GO - Molecular functioni

  • mRNA binding Source: ProtInc
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32041-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A/B
Short name:
hnRNP A/B
Alternative name(s):
APOBEC1-binding protein 1
Short name:
ABBP-1
Gene namesi
Name:HNRNPAB
Synonyms:ABBP1, HNRPAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:5034. HNRNPAB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3182.
OpenTargetsiENSG00000197451.
PharmGKBiPA162391196.

Polymorphism and mutation databases

BioMutaiHNRNPAB.
DMDMi158523286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814921 – 332Heterogeneous nuclear ribonucleoprotein A/BAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineCombined sources1
Modified residuei215N6-acetyllysineBy similarity1
Modified residuei242PhosphoserineCombined sources1
Modified residuei245Dimethylated arginine; alternate1 Publication1
Modified residuei245Omega-N-methylarginine; alternate1 Publication1
Modified residuei250Omega-N-methylarginineBy similarity1
Modified residuei253Omega-N-methylarginineBy similarity1
Modified residuei318N6-acetyllysineBy similarity1
Modified residuei322Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei322Dimethylated arginine; alternateCombined sources1
Modified residuei322Omega-N-methylarginine; alternateCombined sources1
Isoform 3 (identifier: Q99729-3)
Modified residuei250Omega-N-methylarginineCombined sources1
Modified residuei253Omega-N-methylarginineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei271N6-acetyllysineCombined sources1
Isoform 4 (identifier: Q99729-4)
Modified residuei251Omega-N-methylarginineCombined sourcesCurated1
Modified residuei254Omega-N-methylarginineCombined sourcesCurated1
Modified residuei256PhosphoserineCombined sourcesCurated1
Modified residuei272N6-acetyllysineCombined sourcesCurated1

Post-translational modificationi

Dimethylation at Arg-322 is probably asymmetric.

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ99729.
PaxDbiQ99729.
PeptideAtlasiQ99729.
PRIDEiQ99729.

2D gel databases

SWISS-2DPAGEQ99729.

PTM databases

iPTMnetiQ99729.
PhosphoSitePlusiQ99729.
SwissPalmiQ99729.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000197451.
CleanExiHS_HNRNPAB.
ExpressionAtlasiQ99729. baseline and differential.
GenevisibleiQ99729. HS.

Organism-specific databases

HPAiHPA046688.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SF1Q156374EBI-1044873,EBI-744603

Protein-protein interaction databases

BioGridi109423. 96 interactors.
DIPiDIP-50394N.
IntActiQ99729. 49 interactors.
MINTiMINT-4537784.
STRINGi9606.ENSP00000351108.

Structurei

Secondary structure

1332
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi70 – 74Combined sources5
Helixi82 – 89Combined sources8
Turni90 – 92Combined sources3
Beta strandi95 – 102Combined sources8
Turni104 – 106Combined sources3
Beta strandi109 – 119Combined sources11
Helixi121 – 128Combined sources8
Beta strandi132 – 134Combined sources3
Beta strandi137 – 143Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S7RX-ray2.15A/B59-144[»]
ProteinModelPortaliQ99729.
SMRiQ99729.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99729.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 154RRM 1PROSITE-ProRule annotationAdd BLAST86
Domaini153 – 233RRM 2PROSITE-ProRule annotationAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi241 – 324Gly-richAdd BLAST84

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234441.
HOVERGENiHBG002295.
InParanoidiQ99729.
KOiK13044.
OMAiAAEEQPM.
OrthoDBiEOG091G1CPI.
PhylomeDBiQ99729.
TreeFamiTF314808.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012956. CARG-binding_factor_N.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF08143. CBFNT. 1 hit.
PF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99729-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN
60 70 80 90 100
QNGAEGDQIN ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI
110 120 130 140 150
KMDPNTGRSR GFGFILFKDA ASVEKVLDQK EHRLDGRVID PKKAMAMKKD
160 170 180 190 200
PVKKIFVGGL NPESPTEEKI REYFGEFGEI EAIELPMDPK LNKRRGFVFI
210 220 230 240 250
TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY GSGGRGNRNR
260 270 280 290 300
GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY
310 320 330
YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY
Length:332
Mass (Da):36,225
Last modified:September 11, 2007 - v2
Checksum:iF824A7E08D15268A
GO
Isoform 2 (identifier: Q99729-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-32: ASRGRGW → GESPAGAG
     164-165: SP → A

Show »
Length:332
Mass (Da):35,968
Checksum:iF710B690D495500D
GO
Isoform 3 (identifier: Q99729-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-32: ASRGRGW → GESPAGAG
     164-165: SP → A
     264-310: Missing.

Show »
Length:285
Mass (Da):30,588
Checksum:i3E4F386C2F5B9705
GO
Isoform 4 (identifier: Q99729-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-32: ASRGRGW → GESPAGAG
     264-310: Missing.

Show »
Length:286
Mass (Da):30,701
Checksum:iAA24BA3F6A0BAD62
GO

Sequence cautioni

Isoform 4 : The sequence AAA36575 differs from that shown. Reason: Frameshift at several positions.Combined sourcesCurated
The sequence AAC50956 differs from that shown. Reason: Frameshift at positions 296, 307 and 330.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00782626 – 32ASRGRGW → GESPAGAG in isoform 2, isoform 3 and isoform 4. 3 Publications7
Alternative sequenceiVSP_007828164 – 165SP → A in isoform 2 and isoform 3. 2 Publications2
Alternative sequenceiVSP_007829264 – 310Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65028 mRNA. Translation: AAA36575.1. Frameshift.
U76713 mRNA. Translation: AAC50956.1. Frameshift.
AK054600 mRNA. Translation: BAG51397.1.
AK097657 mRNA. Translation: BAC05134.1.
CH471165 Genomic DNA. Translation: EAW53843.1.
CH471165 Genomic DNA. Translation: EAW53844.1.
CH471165 Genomic DNA. Translation: EAW53845.1.
BC001616 mRNA. Translation: AAH01616.1.
BC002625 mRNA. Translation: AAH02625.1.
BC004561 mRNA. Translation: AAH04561.1.
BC009359 mRNA. Translation: AAH09359.1.
BC036708 mRNA. Translation: AAH36708.1.
CCDSiCCDS34309.1. [Q99729-2]
CCDS34310.1. [Q99729-3]
PIRiS17563.
RefSeqiNP_004490.2. NM_004499.3. [Q99729-3]
NP_112556.2. NM_031266.2. [Q99729-2]
UniGeneiHs.591731.
Hs.715055.

Genome annotation databases

EnsembliENST00000355836; ENSP00000348093; ENSG00000197451. [Q99729-3]
ENST00000358344; ENSP00000351108; ENSG00000197451. [Q99729-2]
ENST00000504898; ENSP00000425031; ENSG00000197451. [Q99729-2]
ENST00000506259; ENSP00000427465; ENSG00000197451. [Q99729-3]
GeneIDi3182.
KEGGihsa:3182.
UCSCiuc003miu.4. human. [Q99729-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65028 mRNA. Translation: AAA36575.1. Frameshift.
U76713 mRNA. Translation: AAC50956.1. Frameshift.
AK054600 mRNA. Translation: BAG51397.1.
AK097657 mRNA. Translation: BAC05134.1.
CH471165 Genomic DNA. Translation: EAW53843.1.
CH471165 Genomic DNA. Translation: EAW53844.1.
CH471165 Genomic DNA. Translation: EAW53845.1.
BC001616 mRNA. Translation: AAH01616.1.
BC002625 mRNA. Translation: AAH02625.1.
BC004561 mRNA. Translation: AAH04561.1.
BC009359 mRNA. Translation: AAH09359.1.
BC036708 mRNA. Translation: AAH36708.1.
CCDSiCCDS34309.1. [Q99729-2]
CCDS34310.1. [Q99729-3]
PIRiS17563.
RefSeqiNP_004490.2. NM_004499.3. [Q99729-3]
NP_112556.2. NM_031266.2. [Q99729-2]
UniGeneiHs.591731.
Hs.715055.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S7RX-ray2.15A/B59-144[»]
ProteinModelPortaliQ99729.
SMRiQ99729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109423. 96 interactors.
DIPiDIP-50394N.
IntActiQ99729. 49 interactors.
MINTiMINT-4537784.
STRINGi9606.ENSP00000351108.

PTM databases

iPTMnetiQ99729.
PhosphoSitePlusiQ99729.
SwissPalmiQ99729.

Polymorphism and mutation databases

BioMutaiHNRNPAB.
DMDMi158523286.

2D gel databases

SWISS-2DPAGEQ99729.

Proteomic databases

MaxQBiQ99729.
PaxDbiQ99729.
PeptideAtlasiQ99729.
PRIDEiQ99729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355836; ENSP00000348093; ENSG00000197451. [Q99729-3]
ENST00000358344; ENSP00000351108; ENSG00000197451. [Q99729-2]
ENST00000504898; ENSP00000425031; ENSG00000197451. [Q99729-2]
ENST00000506259; ENSP00000427465; ENSG00000197451. [Q99729-3]
GeneIDi3182.
KEGGihsa:3182.
UCSCiuc003miu.4. human. [Q99729-1]

Organism-specific databases

CTDi3182.
DisGeNETi3182.
GeneCardsiHNRNPAB.
HGNCiHGNC:5034. HNRNPAB.
HPAiHPA046688.
MIMi602688. gene.
neXtProtiNX_Q99729.
OpenTargetsiENSG00000197451.
PharmGKBiPA162391196.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234441.
HOVERGENiHBG002295.
InParanoidiQ99729.
KOiK13044.
OMAiAAEEQPM.
OrthoDBiEOG091G1CPI.
PhylomeDBiQ99729.
TreeFamiTF314808.

Enzyme and pathway databases

BioCyciZFISH:G66-32041-MONOMER.

Miscellaneous databases

ChiTaRSiHNRNPAB. human.
EvolutionaryTraceiQ99729.
GeneWikiiHNRPAB.
GenomeRNAii3182.
PROiQ99729.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197451.
CleanExiHS_HNRNPAB.
ExpressionAtlasiQ99729. baseline and differential.
GenevisibleiQ99729. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012956. CARG-binding_factor_N.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF08143. CBFNT. 1 hit.
PF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROAA_HUMAN
AccessioniPrimary (citable) accession number: Q99729
Secondary accession number(s): B3KNN5
, D3DWP7, Q04150, Q8N7U3, Q9BQ99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.