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Q99726

- ZNT3_HUMAN

UniProt

Q99726 - ZNT3_HUMAN

Protein

Zinc transporter 3

Gene

SLC30A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Involved in accumulation of zinc in synaptic vesicles.By similarity

    GO - Molecular functioni

    1. zinc transporting ATPase activity Source: ProtInc

    GO - Biological processi

    1. positive regulation of transport Source: Ensembl
    2. regulation of sequestering of zinc ion Source: BHF-UCL
    3. transmembrane transport Source: Reactome
    4. transport Source: ProtInc
    5. zinc ion transmembrane transport Source: GOC

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

    Protein family/group databases

    TCDBi2.A.4.3.2. the cation diffusion facilitator (cdf) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 3
    Short name:
    ZnT-3
    Alternative name(s):
    Solute carrier family 30 member 3
    Gene namesi
    Name:SLC30A3
    Synonyms:ZNT3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11014. SLC30A3.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: BHF-UCL
    3. endosome Source: ProtInc
    4. integral component of plasma membrane Source: ProtInc
    5. late endosome Source: BHF-UCL
    6. membrane Source: ProtInc
    7. neuron projection Source: UniProtKB
    8. synaptic vesicle Source: ProtInc
    9. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35884.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Zinc transporter 3PRO_0000206096Add
    BLAST

    Proteomic databases

    MaxQBiQ99726.
    PaxDbiQ99726.
    PRIDEiQ99726.

    PTM databases

    PhosphoSiteiQ99726.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99726.
    BgeeiQ99726.
    CleanExiHS_SLC30A3.
    GenevestigatoriQ99726.

    Organism-specific databases

    HPAiHPA060505.

    Interactioni

    Protein-protein interaction databases

    BioGridi113562. 1 interaction.
    STRINGi9606.ENSP00000233535.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99726.
    SMRiQ99726. Positions 76-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 1059VacuolarSequence Analysis
    Topological domaini127 – 14519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini167 – 17711VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini199 – 23537CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 2648VacuolarSequence Analysis
    Topological domaini286 – 388103CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    HOGENOMiHOG000079023.
    HOVERGENiHBG003345.
    InParanoidiQ99726.
    KOiK14690.
    OMAiCREPPQA.
    OrthoDBiEOG7S4X68.
    PhylomeDBiQ99726.
    TreeFamiTF313382.

    Family and domain databases

    Gene3Di1.20.1510.10. 1 hit.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99726-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM    50
    PFHHCHRDPL PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL 100
    AIMTDAAHLL ADVGSMMGSL FSLWLSTRPA TRTMTFGWHR SETLGALASV 150
    VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM LLTASIAVCA NLLMAFVLHQ 200
    AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL GDLLQSFGVL 250
    AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV 300
    GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA 350
    EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPPQA 388
    Length:388
    Mass (Da):41,945
    Last modified:November 25, 2008 - v2
    Checksum:iD73DE65F46860FD8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti223 – 2231E → Q in AAB39732. (PubMed:8962159)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U76010 mRNA. Translation: AAB39732.1.
    AK313600 mRNA. Translation: BAG36366.1.
    AC013413 Genomic DNA. Translation: AAY24294.1.
    BC028358 mRNA. Translation: AAH28358.1.
    CCDSiCCDS1743.1.
    RefSeqiNP_003450.2. NM_003459.4.
    UniGeneiHs.467981.

    Genome annotation databases

    EnsembliENST00000233535; ENSP00000233535; ENSG00000115194.
    GeneIDi7781.
    KEGGihsa:7781.
    UCSCiuc002rjk.3. human.

    Polymorphism databases

    DMDMi215273923.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U76010 mRNA. Translation: AAB39732.1 .
    AK313600 mRNA. Translation: BAG36366.1 .
    AC013413 Genomic DNA. Translation: AAY24294.1 .
    BC028358 mRNA. Translation: AAH28358.1 .
    CCDSi CCDS1743.1.
    RefSeqi NP_003450.2. NM_003459.4.
    UniGenei Hs.467981.

    3D structure databases

    ProteinModelPortali Q99726.
    SMRi Q99726. Positions 76-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113562. 1 interaction.
    STRINGi 9606.ENSP00000233535.

    Protein family/group databases

    TCDBi 2.A.4.3.2. the cation diffusion facilitator (cdf) family.

    PTM databases

    PhosphoSitei Q99726.

    Polymorphism databases

    DMDMi 215273923.

    Proteomic databases

    MaxQBi Q99726.
    PaxDbi Q99726.
    PRIDEi Q99726.

    Protocols and materials databases

    DNASUi 7781.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233535 ; ENSP00000233535 ; ENSG00000115194 .
    GeneIDi 7781.
    KEGGi hsa:7781.
    UCSCi uc002rjk.3. human.

    Organism-specific databases

    CTDi 7781.
    GeneCardsi GC02M027476.
    H-InvDB HIX0001914.
    HGNCi HGNC:11014. SLC30A3.
    HPAi HPA060505.
    MIMi 602878. gene.
    neXtProti NX_Q99726.
    PharmGKBi PA35884.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1230.
    HOGENOMi HOG000079023.
    HOVERGENi HBG003345.
    InParanoidi Q99726.
    KOi K14690.
    OMAi CREPPQA.
    OrthoDBi EOG7S4X68.
    PhylomeDBi Q99726.
    TreeFami TF313382.

    Enzyme and pathway databases

    Reactomei REACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

    Miscellaneous databases

    GeneWikii SLC30A3.
    GenomeRNAii 7781.
    NextBioi 30125.
    PROi Q99726.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99726.
    Bgeei Q99726.
    CleanExi HS_SLC30A3.
    Genevestigatori Q99726.

    Family and domain databases

    Gene3Di 1.20.1510.10. 1 hit.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Temporal cortex.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiZNT3_HUMAN
    AccessioniPrimary (citable) accession number: Q99726
    Secondary accession number(s): Q8TC03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3