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Q99726

- ZNT3_HUMAN

UniProt

Q99726 - ZNT3_HUMAN

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Protein
Zinc transporter 3
Gene
SLC30A3, ZNT3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in accumulation of zinc in synaptic vesicles By similarity.

GO - Molecular functioni

  1. zinc transporting ATPase activity Source: ProtInc

GO - Biological processi

  1. positive regulation of transport Source: Ensembl
  2. regulation of sequestering of zinc ion Source: BHF-UCL
  3. transmembrane transport Source: Reactome
  4. transport Source: ProtInc
  5. zinc ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.3.2. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 3
Short name:
ZnT-3
Alternative name(s):
Solute carrier family 30 member 3
Gene namesi
Name:SLC30A3
Synonyms:ZNT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11014. SLC30A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei76 – 9621Helical; Reviewed prediction
Add
BLAST
Topological domaini97 – 1059Vacuolar Reviewed prediction
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Topological domaini127 – 14519Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST
Topological domaini167 – 17711Vacuolar Reviewed prediction
Add
BLAST
Transmembranei178 – 19821Helical; Reviewed prediction
Add
BLAST
Topological domaini199 – 23537Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei236 – 25621Helical; Reviewed prediction
Add
BLAST
Topological domaini257 – 2648Vacuolar Reviewed prediction
Transmembranei265 – 28521Helical; Reviewed prediction
Add
BLAST
Topological domaini286 – 388103Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: BHF-UCL
  3. endosome Source: ProtInc
  4. integral component of plasma membrane Source: ProtInc
  5. late endosome Source: BHF-UCL
  6. membrane Source: ProtInc
  7. neuron projection Source: UniProtKB
  8. synaptic vesicle Source: ProtInc
  9. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Zinc transporter 3
PRO_0000206096Add
BLAST

Proteomic databases

MaxQBiQ99726.
PaxDbiQ99726.
PRIDEiQ99726.

PTM databases

PhosphoSiteiQ99726.

Expressioni

Gene expression databases

ArrayExpressiQ99726.
BgeeiQ99726.
CleanExiHS_SLC30A3.
GenevestigatoriQ99726.

Organism-specific databases

HPAiHPA060505.

Interactioni

Protein-protein interaction databases

BioGridi113562. 1 interaction.
STRINGi9606.ENSP00000233535.

Structurei

3D structure databases

ProteinModelPortaliQ99726.
SMRiQ99726. Positions 76-172.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ99726.
KOiK14690.
OMAiCREPPQA.
OrthoDBiEOG7S4X68.
PhylomeDBiQ99726.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99726-1 [UniParc]FASTAAdd to Basket

« Hide

MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM    50
PFHHCHRDPL PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL 100
AIMTDAAHLL ADVGSMMGSL FSLWLSTRPA TRTMTFGWHR SETLGALASV 150
VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM LLTASIAVCA NLLMAFVLHQ 200
AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL GDLLQSFGVL 250
AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV 300
GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA 350
EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPPQA 388
Length:388
Mass (Da):41,945
Last modified:November 25, 2008 - v2
Checksum:iD73DE65F46860FD8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231E → Q in AAB39732. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U76010 mRNA. Translation: AAB39732.1.
AK313600 mRNA. Translation: BAG36366.1.
AC013413 Genomic DNA. Translation: AAY24294.1.
BC028358 mRNA. Translation: AAH28358.1.
CCDSiCCDS1743.1.
RefSeqiNP_003450.2. NM_003459.4.
UniGeneiHs.467981.

Genome annotation databases

EnsembliENST00000233535; ENSP00000233535; ENSG00000115194.
GeneIDi7781.
KEGGihsa:7781.
UCSCiuc002rjk.3. human.

Polymorphism databases

DMDMi215273923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U76010 mRNA. Translation: AAB39732.1 .
AK313600 mRNA. Translation: BAG36366.1 .
AC013413 Genomic DNA. Translation: AAY24294.1 .
BC028358 mRNA. Translation: AAH28358.1 .
CCDSi CCDS1743.1.
RefSeqi NP_003450.2. NM_003459.4.
UniGenei Hs.467981.

3D structure databases

ProteinModelPortali Q99726.
SMRi Q99726. Positions 76-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113562. 1 interaction.
STRINGi 9606.ENSP00000233535.

Protein family/group databases

TCDBi 2.A.4.3.2. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSitei Q99726.

Polymorphism databases

DMDMi 215273923.

Proteomic databases

MaxQBi Q99726.
PaxDbi Q99726.
PRIDEi Q99726.

Protocols and materials databases

DNASUi 7781.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000233535 ; ENSP00000233535 ; ENSG00000115194 .
GeneIDi 7781.
KEGGi hsa:7781.
UCSCi uc002rjk.3. human.

Organism-specific databases

CTDi 7781.
GeneCardsi GC02M027476.
H-InvDB HIX0001914.
HGNCi HGNC:11014. SLC30A3.
HPAi HPA060505.
MIMi 602878. gene.
neXtProti NX_Q99726.
PharmGKBi PA35884.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1230.
HOGENOMi HOG000079023.
HOVERGENi HBG003345.
InParanoidi Q99726.
KOi K14690.
OMAi CREPPQA.
OrthoDBi EOG7S4X68.
PhylomeDBi Q99726.
TreeFami TF313382.

Enzyme and pathway databases

Reactomei REACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

GeneWikii SLC30A3.
GenomeRNAii 7781.
NextBioi 30125.
PROi Q99726.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99726.
Bgeei Q99726.
CleanExi HS_SLC30A3.
Genevestigatori Q99726.

Family and domain databases

Gene3Di 1.20.1510.10. 1 hit.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Temporal cortex.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZNT3_HUMAN
AccessioniPrimary (citable) accession number: Q99726
Secondary accession number(s): Q8TC03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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