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Protein

Zinc transporter 3

Gene

SLC30A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in accumulation of zinc in synaptic vesicles.By similarity

GO - Molecular functioni

  • zinc transporting ATPase activity Source: ProtInc

GO - Biological processi

  • positive regulation of transport Source: Ensembl
  • regulation of sequestering of zinc ion Source: BHF-UCL
  • transmembrane transport Source: Reactome
  • transport Source: ProtInc
  • zinc II ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.3.2. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 3
Short name:
ZnT-3
Alternative name(s):
Solute carrier family 30 member 3
Gene namesi
Name:SLC30A3
Synonyms:ZNT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11014. SLC30A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Topological domaini97 – 1059VacuolarSequence Analysis
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Topological domaini127 – 14519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Topological domaini167 – 17711VacuolarSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Topological domaini199 – 23537CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Topological domaini257 – 2648VacuolarSequence Analysis
Transmembranei265 – 28521HelicalSequence AnalysisAdd
BLAST
Topological domaini286 – 388103CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: BHF-UCL
  • endosome Source: ProtInc
  • integral component of plasma membrane Source: ProtInc
  • late endosome Source: BHF-UCL
  • membrane Source: ProtInc
  • neuron projection Source: UniProtKB
  • synaptic vesicle Source: ProtInc
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35884.

Polymorphism and mutation databases

BioMutaiSLC30A3.
DMDMi215273923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Zinc transporter 3PRO_0000206096Add
BLAST

Proteomic databases

MaxQBiQ99726.
PaxDbiQ99726.
PRIDEiQ99726.

PTM databases

PhosphoSiteiQ99726.

Expressioni

Gene expression databases

BgeeiQ99726.
CleanExiHS_SLC30A3.
ExpressionAtlasiQ99726. baseline and differential.
GenevisibleiQ99726. HS.

Organism-specific databases

HPAiHPA060505.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NAALADL2Q58DX53EBI-10294651,EBI-10178964

Protein-protein interaction databases

BioGridi113562. 2 interactions.
IntActiQ99726. 1 interaction.
STRINGi9606.ENSP00000233535.

Structurei

3D structure databases

ProteinModelPortaliQ99726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ99726.
KOiK14690.
OMAiCREPPQA.
OrthoDBiEOG7S4X68.
PhylomeDBiQ99726.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM
60 70 80 90 100
PFHHCHRDPL PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL
110 120 130 140 150
AIMTDAAHLL ADVGSMMGSL FSLWLSTRPA TRTMTFGWHR SETLGALASV
160 170 180 190 200
VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM LLTASIAVCA NLLMAFVLHQ
210 220 230 240 250
AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL GDLLQSFGVL
260 270 280 290 300
AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV
310 320 330 340 350
GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA
360 370 380
EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPPQA
Length:388
Mass (Da):41,945
Last modified:November 25, 2008 - v2
Checksum:iD73DE65F46860FD8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231E → Q in AAB39732 (PubMed:8962159).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76010 mRNA. Translation: AAB39732.1.
AK313600 mRNA. Translation: BAG36366.1.
AC013413 Genomic DNA. Translation: AAY24294.1.
BC028358 mRNA. Translation: AAH28358.1.
CCDSiCCDS1743.1.
RefSeqiNP_003450.2. NM_003459.4.
UniGeneiHs.467981.

Genome annotation databases

EnsembliENST00000233535; ENSP00000233535; ENSG00000115194.
GeneIDi7781.
KEGGihsa:7781.
UCSCiuc002rjk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76010 mRNA. Translation: AAB39732.1.
AK313600 mRNA. Translation: BAG36366.1.
AC013413 Genomic DNA. Translation: AAY24294.1.
BC028358 mRNA. Translation: AAH28358.1.
CCDSiCCDS1743.1.
RefSeqiNP_003450.2. NM_003459.4.
UniGeneiHs.467981.

3D structure databases

ProteinModelPortaliQ99726.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113562. 2 interactions.
IntActiQ99726. 1 interaction.
STRINGi9606.ENSP00000233535.

Protein family/group databases

TCDBi2.A.4.3.2. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSiteiQ99726.

Polymorphism and mutation databases

BioMutaiSLC30A3.
DMDMi215273923.

Proteomic databases

MaxQBiQ99726.
PaxDbiQ99726.
PRIDEiQ99726.

Protocols and materials databases

DNASUi7781.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233535; ENSP00000233535; ENSG00000115194.
GeneIDi7781.
KEGGihsa:7781.
UCSCiuc002rjk.3. human.

Organism-specific databases

CTDi7781.
GeneCardsiGC02M027476.
H-InvDBHIX0001914.
HGNCiHGNC:11014. SLC30A3.
HPAiHPA060505.
MIMi602878. gene.
neXtProtiNX_Q99726.
PharmGKBiPA35884.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ99726.
KOiK14690.
OMAiCREPPQA.
OrthoDBiEOG7S4X68.
PhylomeDBiQ99726.
TreeFamiTF313382.

Enzyme and pathway databases

ReactomeiREACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

GeneWikiiSLC30A3.
GenomeRNAii7781.
NextBioi30125.
PROiQ99726.
SOURCEiSearch...

Gene expression databases

BgeeiQ99726.
CleanExiHS_SLC30A3.
ExpressionAtlasiQ99726. baseline and differential.
GenevisibleiQ99726. HS.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Temporal cortex.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZNT3_HUMAN
AccessioniPrimary (citable) accession number: Q99726
Secondary accession number(s): Q8TC03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: June 24, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.