Q99726 (ZNT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc transporter 3
Short name=ZnT-3

Alternative name(s):
Solute carrier family 30 member 3

Gene names

Name:	SLC30A3
Synonyms:	ZNT3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in accumulation of zinc in synaptic vesicles By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein Probable. Cell junction › synapse › synaptosome By similarity.
Sequence similarities	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport Zinc transport
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse Synaptosome
Domain	Transmembrane Transmembrane helix
Ligand	Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transport Inferred from electronic annotation. Source: Compara regulation of sequestering of zinc ion Inferred from direct assay PubMed 17349999. Source: BHF-UCL
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc late endosome Inferred from direct assay PubMed 17349999. Source: BHF-UCL neuron projection Inferred from sequence or structural similarity. Source: UniProtKB synaptic vesicle Traceable author statement Ref.1. Source: ProtInc synaptic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	zinc transporting ATPase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Zinc transporter 3		PRO_0000206096
Regions
	Topological domain	1 – 75	75	Cytoplasmic Potential
	Transmembrane	76 – 96	21	Helical; Potential
	Topological domain	97 – 105	9	Vacuolar Potential
	Transmembrane	106 – 126	21	Helical; Potential
	Topological domain	127 – 145	19	Cytoplasmic Potential
	Transmembrane	146 – 166	21	Helical; Potential
	Topological domain	167 – 177	11	Vacuolar Potential
	Transmembrane	178 – 198	21	Helical; Potential
	Topological domain	199 – 235	37	Cytoplasmic Potential
	Transmembrane	236 – 256	21	Helical; Potential
	Topological domain	257 – 264	8	Vacuolar Potential
	Transmembrane	265 – 285	21	Helical; Potential
	Topological domain	286 – 388	103	Cytoplasmic Potential
Amino acid modifications
	Modified residue	38	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	223	1	E → Q in AAB39732. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q99726 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: D73DE65F46860FD8	FASTA	388	41,945
	10 20 30 40 50 60 MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM PFHHCHRDPL 70 80 90 100 110 120 PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL AIMTDAAHLL ADVGSMMGSL 130 140 150 160 170 180 FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM 190 200 210 220 230 240 LLTASIAVCA NLLMAFVLHQ AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL 250 260 270 280 290 300 GDLLQSFGVL AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV 310 320 330 340 350 360 GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA EASSRLYSRF 370 380 GFSSCTLQVE QYQPEMAQCL RCQEPPQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ZnT-3, a putative transporter of zinc into synaptic vesicles." Palmiter R.D., Cole T.B., Quaife C.J., Findley S.D. Proc. Natl. Acad. Sci. U.S.A. 93:14934-14939(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Temporal cortex.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U76010 mRNA. Translation: AAB39732.1. AK313600 mRNA. Translation: BAG36366.1. AC013413 Genomic DNA. Translation: AAY24294.1. BC028358 mRNA. Translation: AAH28358.1.
IPI	IPI00293793.
RefSeq	NP_003450.2. NM_003459.4.
UniGene	Hs.467981.
3D structure databases
ProteinModelPortal	Q99726.
SMR	Q99726. Positions 76-171.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000233535.
Protein family/group databases
TCDB	2.A.4.3.2. cation diffusion facilitator (CDF) family.
PTM databases
PhosphoSite	Q99726.
Polymorphism databases
DMDM	215273923.
Proteomic databases
PaxDb	Q99726.
PRIDE	Q99726.
Protocols and materials databases
DNASU	7781.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000233535; ENSP00000233535; ENSG00000115194.
GeneID	7781.
KEGG	hsa:7781.
UCSC	uc002rjk.3. human.
Organism-specific databases
CTD	7781.
GeneCards	GC02M027476.
H-InvDB	HIX0001914.
HGNC	HGNC:11014. SLC30A3.
MIM	602878. gene.
neXtProt	NX_Q99726.
PharmGKB	PA35884.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1230.
HOGENOM	HOG000079023.
HOVERGEN	HBG003345.
InParanoid	Q99726.
KO	K14690.
OMA	HSRFGFS.
OrthoDB	EOG4VQ9PF.
PhylomeDB	Q99726.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q99726.
Bgee	Q99726.
CleanEx	HS_SLC30A3.
Genevestigator	Q99726.
GermOnline	ENSG00000115194. Homo sapiens.
Family and domain databases
InterPro	IPR002524. Cation_efflux. [Graphical view]
PANTHER	PTHR11562. PTHR11562. 1 hit.
Pfam	PF01545. Cation_efflux. 1 hit. [Graphical view]
TIGRFAMs	TIGR01297. CDF. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	7781.
NextBio	30125.
SOURCE	Search...

Entry information

Entry name

ZNT3_HUMAN

Accession

Primary (citable) accession number: Q99726
Secondary accession number(s): Q8TC03

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.