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Q99720 (SGMR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sigma non-opioid intracellular receptor 1
Alternative name(s):
Aging-associated gene 8 protein
SR31747-binding protein
Short name=SR-BP
Sigma 1-type opioid receptor
Short name=SIG-1R
Short name=Sigma1-receptor
Short name=Sigma1R
Short name=hSigmaR1
Gene names
Name:SIGMAR1
Synonyms:OPRS1, SRBP
ORF Names:AAG8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Ref.2 Ref.17

Subunit structure

Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists. Interacts with KCNA4 By similarity.

Subcellular location

Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projectiongrowth cone. Note: Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. Ref.2 Ref.13

Tissue specificity

Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. Ref.1 Ref.2 Ref.16

Involvement in disease

Amyotrophic lateral sclerosis 16, juvenile (ALS16) [MIM:614373]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20

Miscellaneous

Depletion by RNAi inhibits growth and survival signaling cascades and induces cell death. The antagonist rimcazole produces the same effect.

Sequence similarities

Belongs to the ERG2 family.

Ontologies

Keywords
   Biological processLipid transport
Transport
   Cellular componentCell junction
Cell membrane
Cell projection
Endoplasmic reticulum
Lipid droplet
Membrane
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseAmyotrophic lateral sclerosis
Disease mutation
Neurodegeneration
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell death

Inferred from electronic annotation. Source: UniProtKB-KW

lipid transport

Inferred from electronic annotation. Source: UniProtKB-KW

nervous system development

Inferred from electronic annotation. Source: Ensembl

regulation of neuron apoptotic process

Inferred from mutant phenotype Ref.20. Source: UniProtKB

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-SubCell

endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

growth cone

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

lipid particle

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear envelope

Inferred from direct assay Ref.2. Source: UniProtKB

nuclear inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiondrug binding

Traceable author statement Ref.1. Source: ProtInc

opioid receptor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q99720-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q99720-2)

The sequence of this isoform differs from the canonical sequence as follows:
     31-50: Missing.
Isoform 3 (identifier: Q99720-3)

Also known as: Sigma-R1A;

The sequence of this isoform differs from the canonical sequence as follows:
     118-148: Missing.
Isoform 4 (identifier: Q99720-4)

The sequence of this isoform differs from the canonical sequence as follows:
     103-106: YVLL → ALLG
     107-223: Missing.
Isoform 5 (identifier: Q99720-5)

The sequence of this isoform differs from the canonical sequence as follows:
     31-52: Missing.
     63-76: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Sigma non-opioid intracellular receptor 1
PRO_0000268652

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 3021Helical; Potential
Topological domain31 – 8050Extracellular Potential
Transmembrane81 – 10121Helical; Potential
Topological domain102 – 223122Cytoplasmic Potential
Region2 – 87Targeting to lipid droplets By similarity
Region118 – 14831Mediates ligand-binding

Natural variations

Alternative sequence31 – 5222Missing in isoform 5.
VSP_021981
Alternative sequence31 – 5020Missing in isoform 2.
VSP_021982
Alternative sequence63 – 7614Missing in isoform 5.
VSP_021983
Alternative sequence103 – 1064YVLL → ALLG in isoform 4.
VSP_021984
Alternative sequence107 – 223117Missing in isoform 4.
VSP_021985
Alternative sequence118 – 14831Missing in isoform 3.
VSP_021986
Natural variant21Q → P. Ref.19
Corresponds to variant rs1800866 [ dbSNP | Ensembl ].
VAR_029750
Natural variant1021E → Q in ALS16; the mutation decreases the viability of motor neurons; the mutant protein is shifted to lower density membranes and forms detergent-resistant complexes; there is an almost 2-fold increase in apoptosis in response to stress compared to controls. Ref.20
VAR_067311
Natural variant2111R → Q. Ref.19
Corresponds to variant rs192644838 [ dbSNP | Ensembl ].
VAR_029751

Experimental info

Mutagenesis1231E → G: No effect on ligand-binding. Ref.15
Mutagenesis1261D → G: Reduces ligand-binding. No effect on subcellular localization. Ref.15
Mutagenesis1381E → G: No effect on ligand-binding. Ref.15
Mutagenesis1441E → G: No effect on ligand-binding. Ref.15
Mutagenesis1501E → G: No effect on ligand-binding. Ref.15
Mutagenesis1581E → G: No effect on ligand-binding. Ref.15
Mutagenesis1631E → G: No effect on ligand-binding. Ref.15
Mutagenesis1721E → G: Reduces ligand-binding. No effect on subcellular localization. Ref.15
Mutagenesis1881D → G: No effect on ligand-binding. Ref.15
Mutagenesis1951D → G: No effect on ligand-binding. Ref.15
Mutagenesis2131E → G: No effect on ligand-binding. Ref.15
Sequence conflict1511T → A in AAF64280. Ref.4
Sequence conflict1681T → A in ABG29111. Ref.6
Sequence conflict2081R → W in AAV33304. Ref.5
Sequence conflict2181L → I in ABG29111. Ref.6
Sequence conflict2191F → S in BAD96619. Ref.9

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 0C498636BEB1C443

FASTA22325,128
        10         20         30         40         50         60 
MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA GLDHELAFSR 

        70         80         90        100        110        120 
LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL SEYVLLFGTA LGSRGHSGRY 

       130        140        150        160        170        180 
WAEISDTIIS GTFHQWREGT TKSEVFYPGE TVVHGPGEAT AVEWGPNTWM VEYGRGVIPS 

       190        200        210        220 
TLAFALADTV FSTQDFLTLF YTLRSYARGL RLELTTYLFG QDP 

« Hide

Isoform 2 [UniParc].

Checksum: 755BFC0F9182D947
Show »

FASTA20322,803
Isoform 3 (Sigma-R1A) [UniParc].

Checksum: 9E0C6A120A89126F
Show »

FASTA19221,483
Isoform 4 [UniParc].

Checksum: 8A4FDBFAFF6DAEEE
Show »

FASTA10611,992
Isoform 5 [UniParc].

Checksum: E50731B80FB98FBF
Show »

FASTA18721,013

References

« Hide 'large scale' references
[1]"Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)."
Kekuda R., Prasad P.D., Fei Y.-J., Leibach F.H., Ganapathy V.
Biochem. Biophys. Res. Commun. 229:553-558(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Choriocarcinoma.
[2]"Purification and characterization of the human SR 31747A-binding protein. A nuclear membrane protein related to yeast sterol isomerase."
Jbilo O., Vidal H., Paul R., De Nys N., Bensaid M., Silve S., Carayon P., Davi D., Galiegue S., Bourrie B., Guillemot J.-C., Ferrara P., Loison G., Maffrand J.-P., Le Fur G., Casellas P.
J. Biol. Chem. 272:27107-27115(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 40-47; 48-60; 61-64; 120-133 AND 212-222, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Lymphoblast.
[3]"Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene."
Prasad P.D., Li H.W., Fei Y.-J., Ganapathy M.E., Fujita T., Plumley L.H., Yang-Feng T.L., Leibach F.H., Ganapathy V.
J. Neurochem. 70:443-451(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]Wang L.-M., Shelness G.S., Childers S.R., Mach R.H., Wheeler K.T.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
Tissue: Mammary gland.
[5]"Identification of a human aging-associated gene."
Kim J.W.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"A new splice variant of sigma-1 identified in human breast cancer biopsy sample."
Zhang J., Aft R.L., Zhang F., Mach R.H.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4).
Tissue: Mammary cancer.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
Tissue: Thyroid.
[8]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[9]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[10]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
Tissue: Brain and Muscle.
[13]"Colocalization of sterol isomerase and sigma(1) receptor at endoplasmic reticulum and nuclear envelope level."
Dussossoy D., Carayon P., Belugou S., Feraut D., Bord A., Goubet C., Roque C., Vidal H., Combes T., Loison G., Casellas P.
Eur. J. Biochem. 263:377-386(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[14]"Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line."
Ganapathy M.E., Prasad P.D., Huang W., Seth P., Leibach F.H., Ganapathy V.
J. Pharmacol. Exp. Ther. 289:251-260(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION (ISOFORM 3).
[15]"Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor."
Seth P., Ganapathy M.E., Conway S.J., Bridges C.D., Smith S.B., Casellas P., Ganapathy V.
Biochim. Biophys. Acta 1540:59-67(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF GLU-123; ASP-126; GLU-138; GLU-144; GLU-150; GLU-158; GLU-163; GLU-172; ASP-188; ASP-195 AND GLU-213.
[16]"Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina."
Ola M.S., Moore P., El-Sherbeny A., Roon P., Agarwal N., Sarthy V.P., Casellas P., Ganapathy V., Smith S.B.
Brain Res. Mol. Brain Res. 95:86-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[17]"Silencing of sigma-1 receptor induces cell death in human lens cells."
Wang L., Duncan G.
Exp. Cell Res. 312:1439-1446(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[18]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]"Lack of association between sigma receptor gene variants and schizophrenia."
Satoh F., Miyatake R., Furukawa A., Suwaki H.
Psychiatry Clin. Neurosci. 58:359-363(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PRO-2 AND GLN-211.
[20]"A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis."
Al-Saif A., Al-Mohanna F., Bohlega S.
Ann. Neurol. 70:913-919(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ALS16 GLN-102, CHARACTERIZATION OF VARIANT ALS16 GLN-102.
+Additional computationally mapped references.

Web resources

Wikipedia

Sigma-1 receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U75283 mRNA. Translation: AAB50402.1.
U79528 mRNA. Translation: AAB51238.1.
AF001977, AF001976 Genomic DNA. Translation: AAC04507.1.
AF226604 mRNA. Translation: AAF64280.1.
AY633611 mRNA. Translation: AAV33304.1.
DQ644568 mRNA. Translation: ABG29111.1.
DQ647702 mRNA. Translation: ABG36559.1.
DQ656583 mRNA. Translation: ABG46369.1.
AK098451 mRNA. Translation: BAC05307.1.
CR457075 mRNA. Translation: CAG33356.1.
AK222899 mRNA. Translation: BAD96619.1.
AL450283 Genomic DNA. Translation: CAI14185.1.
CH471071 Genomic DNA. Translation: EAW58431.1.
CH471071 Genomic DNA. Translation: EAW58434.1.
BC004899 mRNA. Translation: AAH04899.1.
BC007839 mRNA. Translation: AAH07839.1.
PIRJC5266.
RefSeqNP_001269134.1. NM_001282205.1.
NP_001269135.1. NM_001282206.1.
NP_001269136.1. NM_001282207.1.
NP_001269137.1. NM_001282208.1.
NP_001269138.1. NM_001282209.1.
NP_005857.1. NM_005866.3.
NP_671513.1. NM_147157.2.
UniGeneHs.522087.

3D structure databases

ProteinModelPortalQ99720.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115569. 6 interactions.
IntActQ99720. 2 interactions.

Chemistry

BindingDBQ99720.
ChEMBLCHEMBL287.
DrugBankDB00514. Dextromethorphan.
GuidetoPHARMACOLOGY2552.

PTM databases

PhosphoSiteQ99720.

Polymorphism databases

DMDM74752153.

Proteomic databases

PaxDbQ99720.
PRIDEQ99720.

Protocols and materials databases

DNASU10280.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000277010; ENSP00000277010; ENSG00000147955. [Q99720-1]
ENST00000353468; ENSP00000434453; ENSG00000147955. [Q99720-4]
ENST00000477726; ENSP00000420022; ENSG00000147955. [Q99720-3]
GeneID10280.
KEGGhsa:10280.
UCSCuc003zuz.3. human. [Q99720-1]
uc003zva.4. human. [Q99720-2]

Organism-specific databases

CTD10280.
GeneCardsGC09M034634.
H-InvDBHIX0008000.
HIX0169361.
HGNCHGNC:8157. SIGMAR1.
HPACAB013470.
HPA018002.
HPA024071.
MIM601978. gene.
614373. phenotype.
neXtProtNX_Q99720.
Orphanet300605. Juvenile amyotrophic lateral sclerosis.
PharmGKBPA164725706.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG296707.
HOVERGENHBG058220.
InParanoidQ99720.
OMAFYTLRAY.
PhylomeDBQ99720.
TreeFamTF300106.

Gene expression databases

ArrayExpressQ99720.
BgeeQ99720.
GenevestigatorQ99720.

Family and domain databases

InterProIPR006716. ERG2_sigma1_rcpt-like.
IPR028545. SIGMAR1.
[Graphical view]
PANTHERPTHR32416:SF0. PTHR32416:SF0. 1 hit.
PfamPF04622. ERG2_Sigma1R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSIGMAR1. human.
GeneWikiSigma-1_receptor.
GenomeRNAi10280.
NextBio38946.
PROQ99720.
SOURCESearch...

Entry information

Entry nameSGMR1_HUMAN
AccessionPrimary (citable) accession number: Q99720
Secondary accession number(s): D3DRM7 expand/collapse secondary AC list , O00673, O00725, Q0Z9W6, Q153Z1, Q2TSD1, Q53GN2, Q7Z653, Q8N7H3, Q9NYX0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 1, 1997
Last modified: March 19, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM