Reviewed, UniProtKB/Swiss-Prot Q99720 (OPRS1_HUMAN)

Names and origin

Protein names

Recommended name:
    Sigma 1-type opioid receptor
      Short name=Sigma1-receptor
      Short name=Sigma1R
      Short name=SIG-1R
      Short name=hSigmaR1
Alternative name(s):
    SR31747-binding protein
      Short name=SR-BP
    Aging-associated gene 8 protein

Gene names

Name:	OPRS1
Synonyms:	SIGMAR1, SRBP
ORF Names:	AAG8

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Ref.2 Ref.16
Subcellular location	Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection › growth cone. Note: Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. Ref.2 Ref.12
Tissue specificity	Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. Ref.2 Ref.1 Ref.15
Miscellaneous	Depletion of OPRS1 by RNAi inhibits growth and survival signaling cascades and induces cell death. The OSPR1 antagonist rimcazole produces the same effect.
Sequence similarities	Belongs to the ERG2 family.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Cell junction Cell membrane Cell projection Endoplasmic reticulum Lipid droplet Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
Molecular function	Receptor
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	ergosterol biosynthetic process Inferred from electronic annotation. Source: InterPro lipid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell growth cone Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc monolayer-surrounded lipid storage body Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	C-8 sterol isomerase activity Inferred from electronic annotation. Source: InterPro drug binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q99720-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99720-2)

The sequence of this isoform differs from the canonical sequence as follows:
     31-50: Missing.

Isoform 3 (identifier: Q99720-3)

Also known as: Sigma-R1A;

The sequence of this isoform differs from the canonical sequence as follows:
     118-148: Missing.

Isoform 4 (identifier: Q99720-4)

The sequence of this isoform differs from the canonical sequence as follows:
     103-106: YVLL → ALLG
     107-223: Missing.

Isoform 5 (identifier: Q99720-5)

The sequence of this isoform differs from the canonical sequence as follows:
     31-52: Missing.
     63-76: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Sigma 1-type opioid receptor		PRO_0000268652
Regions
	Topological domain	1 – 9	9	Cytoplasmic Potential
	Transmembrane	10 – 30	21	Potential
	Topological domain	31 – 80	50	Extracellular Potential
	Transmembrane	81 – 101	21	Potential
	Topological domain	102 – 223	122	Cytoplasmic Potential
	Region	2 – 8	7	Targeting to lipid droplets By similarity
	Region	118 – 148	31	Mediates ligand-binding
Natural variations
	Alternative sequence	31 – 52	22	Missing in isoform 5.		VSP_021981
	Alternative sequence	31 – 50	20	Missing in isoform 2.		VSP_021982
	Alternative sequence	63 – 76	14	Missing in isoform 5.		VSP_021983
	Alternative sequence	103 – 106	4	YVLL → ALLG in isoform 4.		VSP_021984
	Alternative sequence	107 – 223	117	Missing in isoform 4.		VSP_021985
	Alternative sequence	118 – 148	31	Missing in isoform 3.		VSP_021986
	Natural variant	2	1	Q → P: dbSNP rs1800866. Ref.17		VAR_029750
	Natural variant	211	1	R → Q		VAR_029751
Experimental info
	Mutagenesis	123	1	E → G: No effect on ligand-binding. Ref.14
	Mutagenesis	126	1	D → G: Reduces ligand-binding. No effect on subcellular localization. Ref.14
	Mutagenesis	138	1	E → G: No effect on ligand-binding. Ref.14
	Mutagenesis	144	1	E → G: No effect on ligand-binding. Ref.14
	Mutagenesis	150	1	E → G: No effect on ligand-binding. Ref.14
	Mutagenesis	158	1	E → G: No effect on ligand-binding. Ref.14
	Mutagenesis	163	1	E → G: No effect on ligand-binding. Ref.14
	Mutagenesis	172	1	E → G: Reduces ligand-binding. No effect on subcellular localization. Ref.14
	Mutagenesis	188	1	D → G: No effect on ligand-binding. Ref.14
	Mutagenesis	195	1	D → G: No effect on ligand-binding. Ref.14
	Mutagenesis	213	1	E → G: No effect on ligand-binding. Ref.14
	Sequence conflict	151	1	T → A in AAF64280. Ref.4
	Sequence conflict	168	1	T → A in ABG29111. Ref.6
	Sequence conflict	208	1	R → W in AAV33304. Ref.5
	Sequence conflict	218	1	L → I in ABG29111. Ref.6
	Sequence conflict	219	1	F → S in BAD96619. Ref.9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 0C498636BEB1C443	FASTA	223	25,128
	10 20 30 40 50 60 MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA GLDHELAFSR 70 80 90 100 110 120 LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL SEYVLLFGTA LGSRGHSGRY 130 140 150 160 170 180 WAEISDTIIS GTFHQWREGT TKSEVFYPGE TVVHGPGEAT AVEWGPNTWM VEYGRGVIPS 190 200 210 220 TLAFALADTV FSTQDFLTLF YTLRSYARGL RLELTTYLFG QDP
	Isoform 2. Checksum: 755BFC0F9182D947	FASTA	203	22,803
	10 20 30 40 50 60 MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GLDHELAFSR LIVELRRLHP GHVLPDEELQ 70 80 90 100 110 120 WVFVNAGGWM GAMCLLHASL SEYVLLFGTA LGSRGHSGRY WAEISDTIIS GTFHQWREGT 130 140 150 160 170 180 TKSEVFYPGE TVVHGPGEAT AVEWGPNTWM VEYGRGVIPS TLAFALADTV FSTQDFLTLF 190 200 YTLRSYARGL RLELTTYLFG QDP
	Isoform 3 (Sigma-R1A). Checksum: 9E0C6A120A89126F	FASTA	192	21,483
	10 20 30 40 50 60 MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA GLDHELAFSR 70 80 90 100 110 120 LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL SEYVLLFGTA LGSRGHSGET 130 140 150 160 170 180 VVHGPGEATA VEWGPNTWMV EYGRGVIPST LAFALADTVF STQDFLTLFY TLRSYARGLR 190 LELTTYLFGQ DP
	Isoform 4. Checksum: 8A4FDBFAFF6DAEEE	FASTA	106	11,992
	10 20 30 40 50 60 MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA GLDHELAFSR 70 80 90 100 LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL SEALLG
	Isoform 5. Checksum: E50731B80FB98FBF	FASTA	187	21,013
	10 20 30 40 50 60 MQWAVGRRWA WAALLLAVAA VLTQVVWLWL DHELAFSRLI EELQWVFVNA GGWMGAMCLL 70 80 90 100 110 120 HASLSEYVLL FGTALGSRGH SGRYWAEISD TIISGTFHQW REGTTKSEVF YPGETVVHGP 130 140 150 160 170 180 GEATAVEWGP NTWMVEYGRG VIPSTLAFAL ADTVFSTQDF LTLFYTLRSY ARGLRLELTT YLFGQDP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)." Kekuda R., Prasad P.D., Fei Y.-J., Leibach F.H., Ganapathy V. Biochem. Biophys. Res. Commun. 229:553-558(1996) [PubMed: 8954936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Choriocarcinoma.
[2]	"Purification and characterization of the human SR 31747A-binding protein. A nuclear membrane protein related to yeast sterol isomerase." Jbilo O., Vidal H., Paul R., De Nys N., Bensaid M., Silve S., Carayon P., Davi D., Galiegue S., Bourrie B., Guillemot J.-C., Ferrara P., Loison G., Maffrand J.-P., Le Fur G., Casellas P. J. Biol. Chem. 272:27107-27115(1997) [PubMed: 9341151] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 40-47; 48-60; 61-64; 120-133 AND 212-222, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Lymphoblast.
[3]	"Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene." Prasad P.D., Li H.W., Fei Y.-J., Ganapathy M.E., Fujita T., Plumley L.H., Yang-Feng T.L., Leibach F.H., Ganapathy V. J. Neurochem. 70:443-451(1998) [PubMed: 9453537] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	Wang L.-M., Shelness G.S., Childers S.R., Mach R.H., Wheeler K.T. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Mammary gland.
[5]	"Identification of a human aging-associated gene." Kim J.W. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"A new splice variant of sigma-1 identified in human breast cancer biopsy sample." Zhang J., Aft R.L., Zhang F., Mach R.H. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Mammary cancer.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Thyroid.
[8]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[9]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[10]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Brain and Muscle.
[12]	"Colocalization of sterol isomerase and sigma(1) receptor at endoplasmic reticulum and nuclear envelope level." Dussossoy D., Carayon P., Belugou S., Feraut D., Bord A., Goubet C., Roque C., Vidal H., Combes T., Loison G., Casellas P. Eur. J. Biochem. 263:377-386(1999) [PubMed: 10406945] [Abstract] Cited for: SUBCELLULAR LOCATION.
[13]	"Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line." Ganapathy M.E., Prasad P.D., Huang W., Seth P., Leibach F.H., Ganapathy V. J. Pharmacol. Exp. Ther. 289:251-260(1999) [PubMed: 10087012] [Abstract] Cited for: CHARACTERIZATION (ISOFORM 3).
[14]	"Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor." Seth P., Ganapathy M.E., Conway S.J., Bridges C.D., Smith S.B., Casellas P., Ganapathy V. Biochim. Biophys. Acta 1540:59-67(2001) [PubMed: 11476895] [Abstract] Cited for: MUTAGENESIS OF GLU-123; ASP-126; GLU-138; GLU-144; GLU-150; GLU-158; GLU-163; GLU-172; ASP-188; ASP-195 AND GLU-213.
[15]	"Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina." Ola M.S., Moore P., El-Sherbeny A., Roon P., Agarwal N., Sarthy V.P., Casellas P., Ganapathy V., Smith S.B. Brain Res. Mol. Brain Res. 95:86-95(2001) [PubMed: 11687279] [Abstract] Cited for: TISSUE SPECIFICITY.
[16]	"Silencing of sigma-1 receptor induces cell death in human lens cells." Wang L., Duncan G. Exp. Cell Res. 312:1439-1446(2006) [PubMed: 16472803] [Abstract] Cited for: FUNCTION.
[17]	"Lack of association between sigma receptor gene variants and schizophrenia." Satoh F., Miyatake R., Furukawa A., Suwaki H. Psychiatry Clin. Neurosci. 58:359-363(2004) [PubMed: 15298647] [Abstract] Cited for: VARIANTS PRO-2 AND GLN-211.
+	Additional computationally mapped references.

Web resources

Wikipedia

Sigma-1 receptor entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U75283 mRNA. Translation: AAB50402.1. U79528 mRNA. Translation: AAB51238.1. AF001977, AF001976 Genomic DNA. Translation: AAC04507.1. AF226604 mRNA. Translation: AAF64280.1. AY633611 mRNA. Translation: AAV33304.1. DQ644568 mRNA. Translation: ABG29111.1. DQ647702 mRNA. Translation: ABG36559.1. DQ656583 mRNA. Translation: ABG46369.1. AK098451 mRNA. Translation: BAC05307.1. CR457075 mRNA. Translation: CAG33356.1. AK222899 mRNA. Translation: BAD96619.1. AL450283 Genomic DNA. Translation: CAI14185.1. BC004899 mRNA. Translation: AAH04899.1. BC007839 mRNA. Translation: AAH07839.1.
IPI	IPI00004267. IPI00167206. IPI00218268. IPI00376226. IPI00816436.
PIR	JC5266.
RefSeq	NP_005857.1. NP_671513.1.
UniGene	Hs.522087
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q99720.
Proteomic databases
PRIDE	Q99720.
Genome annotation databases
Ensembl	ENST00000277010; ENSP00000277010; ENSG00000147955; Homo sapiens. [Genome view]
GeneID	10280.
KEGG	hsa:10280.
UCSC	uc003zvb.1. human. uc003zvc.1. human.
Organism-specific databases
CTD	10280.
GeneCards	GC09M034625.
HGNC	HGNC:8157. OPRS1.
HPA	CAB013470. HPA018002. HPA024071.
MIM	601978. gene.
PharmGKB	PA31946.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q99720.
InParanoid	Q99720.
OMA	FYTLRAY.
PhylomeDB	Q99720.
Gene expression databases
ArrayExpress	Q99720.
Bgee	Q99720.
Genevestigator	Q99720.
GermOnline	ENSG00000147955. Homo sapiens.
Family and domain databases
InterPro	IPR006716. ERG2_sigma1_rcpt-like. [Graphical view]
Pfam	PF04622. ERG2_Sigma1R. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00514. Dextromethorphan.
NextBio	38946.
SOURCE	Search...

Entry information

Entry name

OPRS1_HUMAN

Accession

Primary (citable) accession number: Q99720
Secondary accession number(s): O00673 , O00725, Q0Z9W6, Q153Z1, Q2TSD1, Q53GN2, Q7Z653, Q8N7H3, Q9NYX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	May 1, 1997
Last modified:	January 19, 2010
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.