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Protein

Septin-5

Gene

SEPT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85GTPBy similarity1
Binding sitei111GTP; via amide nitrogenBy similarity1
Binding sitei248GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei263GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 58GTPBy similarity8
Nucleotide bindingi190 – 198GTPBy similarity9

GO - Molecular functioni

  • GTPase activity Source: ParkinsonsUK-UCL
  • GTP binding Source: UniProtKB-KW
  • structural molecule activity Source: ProtInc

GO - Biological processi

  • cytokinesis Source: ProtInc
  • regulation of exocytosis Source: UniProtKB
  • regulation of synaptic vesicle exocytosis Source: ParkinsonsUK-UCL
  • synaptic vesicle targeting Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33708-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-5
Alternative name(s):
Cell division control-related protein 1
Short name:
CDCrel-1
Peanut-like protein 1
Gene namesi
Name:SEPT5
Synonyms:PNUTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:9164. SEPT5.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: Ensembl
  • cytoskeleton Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
  • synaptic vesicle Source: UniProtKB
  • terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi5413.
OpenTargetsiENSG00000184702.
PharmGKBiPA33486.

Polymorphism and mutation databases

BioMutaiSEPT5.
DMDMi6685760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735211 – 369Septin-5Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphothreonineBy similarity1
Modified residuei168Omega-N-methylarginineBy similarity1
Modified residuei225PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei336PhosphothreonineBy similarity1

Post-translational modificationi

In platelets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate and collagen.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ99719.
PaxDbiQ99719.
PeptideAtlasiQ99719.
PRIDEiQ99719.

2D gel databases

UCD-2DPAGEQ99719.

PTM databases

iPTMnetiQ99719.
PhosphoSitePlusiQ99719.
SwissPalmiQ99719.

Expressioni

Tissue specificityi

Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000184702.
CleanExiHS_SEPT5.
ExpressionAtlasiQ99719. baseline and differential.
GenevisibleiQ99719. HS.

Organism-specific databases

HPAiCAB016120.
HPA029095.
HPA063885.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT2 and SEPT5. In platelets, associated with a complex containing STX4. Interacts with PARK2. This interaction leads to SEPT5 ubiquitination and degradation (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA2BP433564EBI-373345,EBI-5650739
SEPT1Q8WYJ67EBI-373345,EBI-693002
SEPT10B5ME973EBI-373345,EBI-10176098
SEPT10Q9P0V93EBI-373345,EBI-3943788
SEPT11Q9NVA28EBI-373345,EBI-957999
SEPT2Q150193EBI-373345,EBI-741220
SEPT6Q141413EBI-373345,EBI-745901

Protein-protein interaction databases

BioGridi111414. 24 interactors.
DIPiDIP-31201N.
IntActiQ99719. 14 interactors.
MINTiMINT-6943161.
STRINGi9606.ENSP00000391311.

Structurei

3D structure databases

ProteinModelPortaliQ99719.
SMRiQ99719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 314Septin-type GAdd BLAST274

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili338 – 369Sequence analysisAdd BLAST32

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ99719.
KOiK04557.
PhylomeDBiQ99719.
TreeFamiTF101079.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99719-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA
60 70 80 90 100
GESGLGKSTL VHSLFLTDLY KDRKLLSAEE RISQTVEILK HTVDIEEKGV
110 120 130 140 150
KLKLTIVDTP GFGDAVNNTE CWKPITDYVD QQFEQYFRDE SGLNRKNIQD
160 170 180 190 200
NRVHCCLYFI SPFGHGLRPV DVGFMKALHE KVNIVPLIAK ADCLVPSEIR
210 220 230 240 250
KLKERIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE SAPFAVIGSN
260 270 280 290 300
TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC
310 320 330 340 350
DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDAE TEKLIRMKDE
360
ELRRMQEMLQ RMKQQMQDQ
Length:369
Mass (Da):42,777
Last modified:May 1, 1997 - v1
Checksum:i47054765DEA10D33
GO
Isoform 2 (identifier: Q99719-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSTGLRYKSKLATPEDKQ → MDSLAAPQDRLVEQLLSPRTQAQRRLK
     272-369: VENQAHCDFV...QRMKQQMQDQ → GALRLREAAQ...PAAAHPGRRD

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):39,332
Checksum:i380EACD6A7BFE814
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224D → N in CAA72332 (PubMed:9385360).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0426891 – 18MSTGL…PEDKQ → MDSLAAPQDRLVEQLLSPRT QAQRRLK in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_042690272 – 369VENQA…QMQDQ → GALRLREAAQHAHPHAYARP QGRDVRRALRELPRALHPAD DQQTDPGQPHGEPHPDPAAA HPGRRD in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74628 mRNA. Translation: AAB93438.1.
Y11593 mRNA. Translation: CAA72332.1.
AF006988 Genomic DNA. Translation: AAC39779.1.
CR456545 mRNA. Translation: CAG30431.1.
AK056273 mRNA. Translation: BAB71133.1.
AC000093 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX03032.1.
BC025261 mRNA. Translation: AAH25261.1.
CCDSiCCDS13764.1. [Q99719-1]
CCDS56224.1. [Q99719-2]
RefSeqiNP_001009939.1. NM_001009939.2. [Q99719-2]
NP_002679.2. NM_002688.5. [Q99719-1]
UniGeneiHs.728762.

Genome annotation databases

EnsembliENST00000438754; ENSP00000394541; ENSG00000184702. [Q99719-2]
ENST00000455784; ENSP00000391311; ENSG00000184702. [Q99719-1]
GeneIDi5413.
KEGGihsa:5413.
UCSCiuc002zpw.2. human. [Q99719-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74628 mRNA. Translation: AAB93438.1.
Y11593 mRNA. Translation: CAA72332.1.
AF006988 Genomic DNA. Translation: AAC39779.1.
CR456545 mRNA. Translation: CAG30431.1.
AK056273 mRNA. Translation: BAB71133.1.
AC000093 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX03032.1.
BC025261 mRNA. Translation: AAH25261.1.
CCDSiCCDS13764.1. [Q99719-1]
CCDS56224.1. [Q99719-2]
RefSeqiNP_001009939.1. NM_001009939.2. [Q99719-2]
NP_002679.2. NM_002688.5. [Q99719-1]
UniGeneiHs.728762.

3D structure databases

ProteinModelPortaliQ99719.
SMRiQ99719.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111414. 24 interactors.
DIPiDIP-31201N.
IntActiQ99719. 14 interactors.
MINTiMINT-6943161.
STRINGi9606.ENSP00000391311.

PTM databases

iPTMnetiQ99719.
PhosphoSitePlusiQ99719.
SwissPalmiQ99719.

Polymorphism and mutation databases

BioMutaiSEPT5.
DMDMi6685760.

2D gel databases

UCD-2DPAGEQ99719.

Proteomic databases

EPDiQ99719.
PaxDbiQ99719.
PeptideAtlasiQ99719.
PRIDEiQ99719.

Protocols and materials databases

DNASUi5413.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438754; ENSP00000394541; ENSG00000184702. [Q99719-2]
ENST00000455784; ENSP00000391311; ENSG00000184702. [Q99719-1]
GeneIDi5413.
KEGGihsa:5413.
UCSCiuc002zpw.2. human. [Q99719-1]

Organism-specific databases

CTDi5413.
DisGeNETi5413.
GeneCardsiSEPT5.
H-InvDBHIX0016241.
HGNCiHGNC:9164. SEPT5.
HPAiCAB016120.
HPA029095.
HPA063885.
MIMi602724. gene.
neXtProtiNX_Q99719.
OpenTargetsiENSG00000184702.
PharmGKBiPA33486.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ99719.
KOiK04557.
PhylomeDBiQ99719.
TreeFamiTF101079.

Enzyme and pathway databases

BioCyciZFISH:G66-33708-MONOMER.

Miscellaneous databases

ChiTaRSiSEPT5. human.
GeneWikiiSEPT5.
GenomeRNAii5413.
PROiQ99719.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184702.
CleanExiHS_SEPT5.
ExpressionAtlasiQ99719. baseline and differential.
GenevisibleiQ99719. HS.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT5_HUMAN
AccessioniPrimary (citable) accession number: Q99719
Secondary accession number(s): O15251, Q96MY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In a heterologous system, SEPT5 overexpression has been shown to exert dopamine-dependent neurotoxicity. As wild-type PARK2, but not familial-linked PARK2 mutants, ubiquitinates mouse SEPT5 and promotes its degradation, it has been sugested that a deficiency in SEPT5 degradation may contribute to the development of early onset Parkinson disease 2 (PARK2).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.