Reviewed, UniProtKB/Swiss-Prot Q99719 (SEPT5_HUMAN)

Names and origin

Protein names

Recommended name:
    Septin-5
Alternative name(s):
    Peanut-like protein 1
    Cell division control-related protein 1
      Short name=CDCrel-1

Gene names

Name:	SEPT5
Synonyms:	PNUTL1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in cytokinesis Potential.
Subunit structure	May assemble into a multicomponent structure.
Sequence similarities	Belongs to the septin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Ref.3 Traceable author statement. Source: ProtInc synaptic vesicle targeting Traceable author statement. Source: UniProtKB
Cellular component	plasma membrane Inferred from direct assay. Source: UniProtKB septin complex Inferred from electronic annotation. Source: InterPro synaptic vesicle Inferred from direct assay. Source: UniProtKB
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Ref.2 Traceable author statement. Source: ProtInc structural molecule activity Ref.3 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSM8	O95777	1	EBI-373345,EBI-347779
SEPT11	Q9NVA2	3	EBI-373345,EBI-957999
SEPT8	Q92599	2	EBI-373345,EBI-958021

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	Septin-5		PRO_0000173521
Regions
	Nucleotide binding	51 – 58	8	GTP By similarity
	Nucleotide binding	192 – 198	7	GTP By similarity
	Coiled coil	338 – 369	32	Potential
Sites
	Binding site	248	1	GTP; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	265	1	GTP By similarity
Amino acid modifications
	Modified residue	225	1	Phosphoserine Ref.7
	Modified residue	327	1	Phosphoserine By similarity
	Modified residue	336	1	Phosphothreonine By similarity
Experimental info
	Sequence conflict	224	1	D → N in CAA72332. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q99719-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 47054765DEA10D33	FASTA	369	42,777
	10 20 30 40 50 60 MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL 70 80 90 100 110 120 VHSLFLTDLY KDRKLLSAEE RISQTVEILK HTVDIEEKGV KLKLTIVDTP GFGDAVNNTE 130 140 150 160 170 180 CWKPITDYVD QQFEQYFRDE SGLNRKNIQD NRVHCCLYFI SPFGHGLRPV DVGFMKALHE 190 200 210 220 230 240 KVNIVPLIAK ADCLVPSEIR KLKERIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE 250 260 270 280 290 300 SAPFAVIGSN TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC 310 320 330 340 350 360 DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDAE TEKLIRMKDE ELRRMQEMLQ RMKQQMQDQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alternative expression of platelet glycoprotein Ib(beta) mRNA from an adjacent 5' gene with an imperfect polyadenylation signal sequence." Zieger B., Hashimoto Y., Ware J. J. Clin. Invest. 99:520-525(1997) [PubMed: 9022087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11." McKie J., Sutherland H., Harvey E., Kim U.J., Scambler P.J. Hum. Genet. 101:6-12(1997) [PubMed: 9385360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[3]	"Structure and expression of the human septin gene HCDCREL-1." Yagi M., Zieger B., Roth G.J., Ware J. Gene 212:229-236(1998) [PubMed: 9611266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[4]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 23-36; 42-71; 82-90; 182-190; 297-308 AND 325-343, MASS SPECTROMETRY. Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
[7]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, MASS SPECTROMETRY. Tissue: Platelet.
[8]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	U74628 mRNA. Translation: AAB93438.1. Y11593 mRNA. Translation: CAA72332.1. AF006988 Genomic DNA. Translation: AAC39779.1. CR456545 mRNA. Translation: CAG30431.1. BC025261 mRNA. Translation: AAH25261.1.
IPI	IPI00017731.
RefSeq	NP_002679.2.
UniGene	Hs.283743
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99719. 5 interactions.
PTM databases
PhosphoSite	Q99719.
Proteomic databases
PRIDE	Q99719.
Genome annotation databases
Ensembl	ENSG00000184702. Homo sapiens. [Contig view]
GeneID	5413.
KEGG	hsa:5413.
UCSC	uc002zpv.1. human.
Organism-specific databases
GeneCards	GC22P018077.
H-InvDB	HIX0016241.
HGNC	HGNC:9164. SEPT5.
HPA	CAB016120.
MIM	602724. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q99719.
Gene expression databases
ArrayExpress	Q99719.
Bgee	Q99719.
CleanEx	HS_SEPT5.
GermOnline	ENSG00000184702. Homo sapiens.
Family and domain databases
InterPro	IPR000038. Cell_Div_GTP_bd. IPR016491. Septin. [Graphical view]
PANTHER	PTHR18884. Cell_Div_GTP_bd. 1 hit.
Pfam	PF00735. Septin. 1 hit. [Graphical view]
PIRSF	PIRSF006698. Septin. 1 hit.
ProDom	PD002565. GTP_Cell_Div. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	20957.
SOURCE	Search...

Entry information

Entry name

SEPT5_HUMAN

Accession

Primary (citable) accession number: Q99719
Secondary accession number(s): O15251

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1997
Last modified:	July 7, 2009
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)