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Q99715

- COCA1_HUMAN

UniProt

Q99715 - COCA1_HUMAN

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Protein

Collagen alpha-1(XII) chain

Gene
COL12A1, COL12A1L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix By similarity.

GO - Molecular functioni

  1. extracellular matrix structural constituent conferring tensile strength Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. collagen catabolic process Source: Reactome
  3. collagen fibril organization Source: UniProtKB
  4. extracellular matrix disassembly Source: Reactome
  5. extracellular matrix organization Source: Reactome
  6. skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_150401. Collagen degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XII) chain
Gene namesi
Name:COL12A1
Synonyms:COL12A1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:2188. COL12A1.

Subcellular locationi

GO - Cellular componenti

  1. collagen type XII trimer Source: UniProtKB
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular region Source: Reactome
  4. extracellular space Source: BHF-UCL
  5. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 30633040Collagen alpha-1(XII) chainPRO_0000005783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi700 – 7001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi798 – 7981O-linked (Xyl...) (chondroitin sulfate) Reviewed prediction
Glycosylationi889 – 8891O-linked (Xyl...) (chondroitin sulfate) Reviewed prediction
Glycosylationi981 – 9811O-linked (Xyl...) (chondroitin sulfate) Reviewed prediction
Glycosylationi1763 – 17631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2206 – 22061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2528 – 25281N-linked (GlcNAc...)1 Publication
Glycosylationi2679 – 26791N-linked (GlcNAc...)1 Publication
Modified residuei2944 – 294414-hydroxyproline By similarity
Modified residuei2947 – 294714-hydroxyproline By similarity
Modified residuei2950 – 295014-hydroxyproline By similarity
Modified residuei2959 – 295914-hydroxyproline By similarity
Modified residuei2965 – 296514-hydroxyproline By similarity
Modified residuei2968 – 296814-hydroxyproline By similarity
Modified residuei2971 – 297114-hydroxyproline By similarity
Modified residuei2983 – 298314-hydroxyproline By similarity
Modified residuei3000 – 300014-hydroxyproline By similarity
Modified residuei3003 – 300314-hydroxyproline By similarity
Modified residuei3014 – 301414-hydroxyproline By similarity
Modified residuei3023 – 302314-hydroxyproline By similarity
Modified residuei3026 – 302614-hydroxyproline By similarity
Modified residuei3029 – 302914-hydroxyproline By similarity

Post-translational modificationi

The triple-helical tail is stabilized by disulfide bonds at each end By similarity.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates By similarity.
Isoform 1 O-glycosylation; glycosaminoglycan of chondroitin-sulfate type By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ99715.
PaxDbiQ99715.
PRIDEiQ99715.

PTM databases

PhosphoSiteiQ99715.

Expressioni

Tissue specificityi

Found in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, kidney and a squamous cell carcinoma cell line. Isoform 1 is also present in the corneal epithelial Bowman's membrane (BM) and the interfibrillar matrix of the corneal stroma, but it is not detected in the limbal BM.1 Publication

Gene expression databases

ArrayExpressiQ99715.
BgeeiQ99715.
CleanExiHS_COL12A1.
GenevestigatoriQ99715.

Organism-specific databases

HPAiHPA009143.

Interactioni

Subunit structurei

Trimer of identical chains each containing 190 kDa of non-triple-helical sequences.

Protein-protein interaction databases

BioGridi107700. 1 interaction.
IntActiQ99715. 6 interactions.
STRINGi9606.ENSP00000325146.

Structurei

3D structure databases

ProteinModelPortaliQ99715.
SMRiQ99715. Positions 25-1179, 1196-1367, 1385-2310, 2317-2724.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11791Fibronectin type-III 1Add
BLAST
Domaini140 – 316177VWFA 1Add
BLAST
Domaini336 – 42691Fibronectin type-III 2Add
BLAST
Domaini440 – 616177VWFA 2Add
BLAST
Domaini634 – 72289Fibronectin type-III 3Add
BLAST
Domaini725 – 81692Fibronectin type-III 4Add
BLAST
Domaini817 – 90589Fibronectin type-III 5Add
BLAST
Domaini907 – 99892Fibronectin type-III 6Add
BLAST
Domaini999 – 108789Fibronectin type-III 7Add
BLAST
Domaini1089 – 117991Fibronectin type-III 8Add
BLAST
Domaini1199 – 1371173VWFA 3Add
BLAST
Domaini1387 – 147690Fibronectin type-III 9Add
BLAST
Domaini1477 – 156791Fibronectin type-III 10Add
BLAST
Domaini1568 – 165891Fibronectin type-III 11Add
BLAST
Domaini1659 – 175496Fibronectin type-III 12Add
BLAST
Domaini1755 – 184995Fibronectin type-III 13Add
BLAST
Domaini1850 – 193586Fibronectin type-III 14Add
BLAST
Domaini1936 – 202691Fibronectin type-III 15Add
BLAST
Domaini2027 – 211791Fibronectin type-III 16Add
BLAST
Domaini2118 – 220689Fibronectin type-III 17Add
BLAST
Domaini2207 – 229488Fibronectin type-III 18Add
BLAST
Domaini2323 – 2496174VWFA 4Add
BLAST
Domaini2520 – 2712193Laminin G-likeAdd
BLAST
Domaini2747 – 279852Collagen-like 1Add
BLAST
Domaini2802 – 285251Collagen-like 2Add
BLAST
Domaini2853 – 289846Collagen-like 3Add
BLAST
Domaini2941 – 299050Collagen-like 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2451 – 2746296Nonhelical region (NC3)Add
BLAST
Regioni2747 – 2898152Triple-helical region (COL2) with 1 imperfectionAdd
BLAST
Regioni2899 – 294143Nonhelical region (NC2)Add
BLAST
Regioni2942 – 3044103Triple-helical region (COL1) with 2 imperfectionsAdd
BLAST
Regioni3045 – 306319Nonhelical region (NC1)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi862 – 8643Cell attachment site Reviewed prediction
Motifi2779 – 27813Cell attachment site Reviewed prediction
Motifi2895 – 28973Cell attachment site Reviewed prediction

Sequence similaritiesi

Contains 4 VWFA domains.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG051060.
InParanoidiQ99715.
KOiK08132.
OMAiNRFNQML.
PhylomeDBiQ99715.
TreeFamiTF329914.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.10. 18 hits.
3.40.50.410. 4 hits.
InterProiIPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR001791. Laminin_G.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 4 hits.
PF00041. fn3. 18 hits.
PF00092. VWA. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 18 hits.
SM00210. TSPN. 1 hit.
SM00327. VWA. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 4 hits.
PROSITEiPS50853. FN3. 18 hits.
PS50234. VWFA. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: The final tissue form of collagen XII may contain homotrimers of either isoform 1 or isoform 2 or any combination of isoform 1 and isoform 2.

Isoform 1 (identifier: Q99715-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MRSRLPPALA ALGAALLLSS IEAEVDPPSD LNFKIIDENT VHMSWAKPVD     50
PIVGYRITVD PTTDGPTKEF TLSASTTETL LSELVPETEY VVTITSYDEV 100
EESVPVIGQL TIQTGSSTKP VEKKPGKTEI QKCSVSAWTD LVFLVDGSWS 150
VGRNNFKYIL DFIAALVSAF DIGEEKTRVG VVQYSSDTRT EFNLNQYYQR 200
DELLAAIKKI PYKGGNTMTG DAIDYLVKNT FTESAGARVG FPKVAIIITD 250
GKSQDEVEIP ARELRNVGVE VFSLGIKAAD AKELKQIAST PSLNHVFNVA 300
NFDAIVDIQN EIISQVCSGV DEQLGELVSG EEVVEPPSNL IAMEVSSKYV 350
KLNWNPSPSP VTGYKVILTP MTAGSRQHAL SVGPQTTTLS VRDLSADTEY 400
QISVSAMKGM TSSEPISIME KTQPMKVQVE CSRGVDIKAD IVFLVDGSYS 450
IGIANFVKVR AFLEVLVKSF EISPNRVQIS LVQYSRDPHT EFTLKKFTKV 500
EDIIEAINTF PYRGGSTNTG KAMTYVREKI FVPSKGSRSN VPKVMILITD 550
GKSSDAFRDP AIKLRNSDVE IFAVGVKDAV RSELEAIASP PAETHVFTVE 600
DFDAFQRISF ELTQSICLRI EQELAAIKKK AYVPPKDLSF SEVTSYGFKT 650
NWSPAGENVF SYHITYKEAA GDDEVTVVEP ASSTSVVLSS LKPETLYLVN 700
VTAEYEDGFS IPLAGEETTE EVKGAPRNLK VTDETTDSFK ITWTQAPGRV 750
LRYRIIYRPV AGGESREVTT PPNQRRRTLE NLIPDTKYEV SVIPEYFSGP 800
GTPLTGNAAT EEVRGNPRDL RVSDPTTSTM KLSWSGAPGK VKQYLVTYTP 850
VAGGETQEVT VRGDTTNTVL QGLKEGTQYA LSVTALYASG AGDALFGEGT 900
TLEERGSPQD LVTKDITDTS IGAYWTSAPG MVRGYRVSWK SLYDDVDTGE 950
KNLPEDAIHT MIENLQPETK YRISVFATYS SGEGEPLTGD ATTELSQDSK 1000
TLKVDEETEN TMRVTWKPAP GKVVNYRVVY RPHGRGKQMV AKVPPTVTST 1050
VLKRLQPQTT YDITVLPIYK MGEGKLRQGS GTTASRFKSP RNLKTSDPTM 1100
SSFRVTWEPA PGEVKGYKVT FHPTGDDRRL GELVVGPYDN TVVLEELRAG 1150
TTYKVNVFGM FDGGESSPLV GQEMTTLSDT TVMPILSSGM ECLTRAEADI 1200
VLLVDGSWSI GRANFRTVRS FISRIVEVFD IGPKRVQIAL AQYSGDPRTE 1250
WQLNAHRDKK SLLQAVANLP YKGGNTLTGM ALNFIRQQNF RTQAGMRPRA 1300
RKIGVLITDG KSQDDVEAPS KKLKDEGVEL FAIGIKNADE VELKMIATDP 1350
DDTHAYNVAD FESLSRIVDD LTINLCNSVK GPGDLEAPSN LVISERTHRS 1400
FRVSWTPPSD SVDRYKVEYY PVSGGKRQEF YVSRMETSTV LKDLKPETEY 1450
VVNVYSVVED EYSEPLKGTE KTLPVPVVSL NIYDVGPTTM HVQWQPVGGA 1500
TGYILSYKPV KDTEPTRPKE VRLGPTVNDM QLTDLVPNTE YAVTVQAVLH 1550
DLTSEPVTVR EVTLPLPRPQ DLKLRDVTHS TMNVFWEPVP GKVRKYIVRY 1600
KTPEEDVKEV EVDRSETSTS LKDLFSQTLY TVSVSAVHDE GESPPVTAQE 1650
TTRPVPAPTN LKITEVTSEG FRGTWDHGAS DVSLYRITWA PFGSSDKMET 1700
ILNGDENTLV FENLNPNTIY EVSITAIYPD ESESDDLIGS ERTLPILTTQ 1750
APKSGPRNLQ VYNATSNSLT VKWDPASGRV QKYRITYQPS TGEGNEQTTT 1800
IGGRQNSVVL QKLKPDTPYT ITVSSLYPDG EGGRMTGRGK TKPLNTVRNL 1850
RVYDPSTSTL NVRWDHAEGN PRQYKLFYAP AAGGPEELVP IPGNTNYAIL 1900
RNLQPDTSYT VTVVPVYTEG DGGRTSDTGR TLMRGLARNV QVYNPTPNSL 1950
DVRWDPAPGP VLQYRVVYSP VDGTRPSESI VVPGNTRMVH LERLIPDTLY 2000
SVNLVALYSD GEGNPSPAQG RTLPRSGPRN LRVFGETTNS LSVAWDHADG 2050
PVQQYRIIYS PTVGDPIDEY TTVPGRRNNV ILQPLQPDTP YKITVIAVYE 2100
DGDGGHLTGN GRTVGLLPPQ NIHISDEWYT RFRVSWDPSP SPVLGYKIVY 2150
KPVGSNEPME AFVGEMTSYT LHNLNPSTTY DVNVYAQYDS GLSVPLTDQG 2200
TTLYLNVTDL KTYQIGWDTF CVKWSPHRAA TSYRLKLSPA DGTRGQEITV 2250
RGSETSHCFT GLSPDTDYGV TVFVQTPNLE GPGVSVKEHT TVKPTEAPTE 2300
PPTPPPPPTI PPARDVCKGA KADIVFLTDA SWSIGDDNFN KVVKFIFNTV 2350
GGFDEISPAG IQVSFVQYSD EVKSEFKLNT YNDKALALGA LQNIRYRGGN 2400
TRTGKALTFI KEKVLTWESG MRKNVPKVLV VVTDGRSQDE VKKAALVIQQ 2450
SGFSVFVVGV ADVDYNELAN IASKPSERHV FIVDDFESFE KIEDNLITFV 2500
CETATSSCPL IYLDGYTSPG FKMLEAYNLT EKNFASVQGV SLESGSFPSY 2550
SAYRIQKNAF VNQPTADLHP NGLPPSYTII LLFRLLPETP SDPFAIWQIT 2600
DRDYKPQVGV IADPSSKTLS FFNKDTRGEV QTVTFDTEEV KTLFYGSFHK 2650
VHIVVTSKSV KIYIDCYEII EKDIKEAGNI TTDGYEILGK LLKGERKSAA 2700
FQIQSFDIVC SPVWTSRDRC CDIPSRRDEG KCPAFPNSCT CTQDSVGPPG 2750
PPGPAGGPGA KGPRGERGIS GAIGPPGPRG DIGPPGPQGP PGPQGPNGLS 2800
IPGEQGRQGM KGDAGEPGLP GRTGTPGLPG PPGPMGPPGD RGFTGKDGAM 2850
GPRGPPGPPG SPGSPGVTGP SGKPGKPGDH GRPGPSGLKG EKGDRGDIAS 2900
QNMMRAVARQ VCEQLISGQM NRFNQMLNQI PNDYQSSRNQ PGPPGPPGPP 2950
GSAGARGEPG PGGRPGFPGT PGMQGPPGER GLPGEKGERG TGSSGPRGLP 3000
GPPGPQGESR TGPPGSTGSR GPPGPPGRPG NSGIRGPPGP PGYCDSSQCA 3050
SIPYNGQGYP GSG 3063
Length:3,063
Mass (Da):333,147
Last modified:May 1, 2007 - v2
Checksum:iEA38CAFECE8393D2
GO
Isoform 2 (identifier: Q99715-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     25-1188: Missing.

Show »
Length:1,899
Mass (Da):205,491
Checksum:iECFB9F5436FF7B24
GO
Isoform 4 (identifier: Q99715-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2651-2726: Missing.

Show »
Length:2,987
Mass (Da):324,570
Checksum:iE5EEB57CBFB556E2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti461 – 4611A → P.
Corresponds to variant rs34730529 [ dbSNP | Ensembl ].
VAR_048768
Natural varianti1738 – 17381I → T.
Corresponds to variant rs240736 [ dbSNP | Ensembl ].
VAR_048769
Natural varianti2021 – 20211R → Q.
Corresponds to variant rs34438461 [ dbSNP | Ensembl ].
VAR_061111
Natural varianti2160 – 21601E → V.
Corresponds to variant rs35523808 [ dbSNP | Ensembl ].
VAR_048770
Natural varianti2596 – 25961I → V.
Corresponds to variant rs35710072 [ dbSNP | Ensembl ].
VAR_048771
Natural varianti3048 – 30481Q → H.
Corresponds to variant rs57396313 [ dbSNP | Ensembl ].
VAR_061112
Natural varianti3058 – 30581G → S.1 Publication
Corresponds to variant rs970547 [ dbSNP | Ensembl ].
VAR_032059

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 11881164Missing in isoform 2. VSP_001149Add
BLAST
Alternative sequencei2651 – 272676Missing in isoform 4. VSP_024942Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471K → E in AAC51244. 1 Publication
Sequence conflicti441 – 4422IV → M in AAC01506. 1 Publication
Sequence conflicti581 – 5811R → D in AAC01506. 1 Publication
Sequence conflicti689 – 6891S → N in AAC01506. 1 Publication
Sequence conflicti743 – 7431W → S in AAC01506. 1 Publication
Sequence conflicti749 – 7491R → K in AAC01506. 1 Publication
Sequence conflicti753 – 7531Y → C in AAC51244. 1 Publication
Sequence conflicti813 – 8131V → G in AAC01506. 1 Publication
Sequence conflicti1355 – 13551A → D in AAC51244. 1 Publication
Sequence conflicti1690 – 16901A → G in AAC51244. 1 Publication
Sequence conflicti1729 – 17291P → A in AAC51244. 1 Publication
Sequence conflicti1949 – 19513SLD → RLG in AAC51244. 1 Publication
Sequence conflicti2614 – 26141P → S in AAB23937. 1 Publication
Sequence conflicti2647 – 26482SF → RK in AAB23937. 1 Publication
Sequence conflicti2848 – 28481G → S in AAC51244. 1 Publication
Sequence conflicti2858 – 28581P → R in AAC51244. 1 Publication
Sequence conflicti3035 – 30351R → Q in AAC51244. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73778 mRNA. Translation: AAC51244.1.
U73779 mRNA. Translation: AAD40483.1.
AL080250, AL096771, AL354664 Genomic DNA. Translation: CAI19898.1.
AL354664, AL080250, AL096771 Genomic DNA. Translation: CAH71310.1.
AL096771, AL354664, AL080250 Genomic DNA. Translation: CAI19908.1.
AF061871 Genomic DNA. Translation: AAC83578.1.
U68139 mRNA. Translation: AAC01506.1.
AH004088 Genomic DNA. Translation: AAB23937.2.
CCDSiCCDS43481.1. [Q99715-2]
CCDS43482.1. [Q99715-1]
PIRiA44479.
RefSeqiNP_004361.3. NM_004370.5. [Q99715-1]
NP_542376.2. NM_080645.2. [Q99715-2]
UniGeneiHs.101302.

Genome annotation databases

EnsembliENST00000322507; ENSP00000325146; ENSG00000111799. [Q99715-1]
ENST00000345356; ENSP00000305147; ENSG00000111799. [Q99715-2]
ENST00000416123; ENSP00000412864; ENSG00000111799. [Q99715-4]
GeneIDi1303.
KEGGihsa:1303.
UCSCiuc003phs.3. human. [Q99715-1]
uc003pht.3. human. [Q99715-2]

Polymorphism databases

DMDMi146345397.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73778 mRNA. Translation: AAC51244.1 .
U73779 mRNA. Translation: AAD40483.1 .
AL080250 , AL096771 , AL354664 Genomic DNA. Translation: CAI19898.1 .
AL354664 , AL080250 , AL096771 Genomic DNA. Translation: CAH71310.1 .
AL096771 , AL354664 , AL080250 Genomic DNA. Translation: CAI19908.1 .
AF061871 Genomic DNA. Translation: AAC83578.1 .
U68139 mRNA. Translation: AAC01506.1 .
AH004088 Genomic DNA. Translation: AAB23937.2 .
CCDSi CCDS43481.1. [Q99715-2 ]
CCDS43482.1. [Q99715-1 ]
PIRi A44479.
RefSeqi NP_004361.3. NM_004370.5. [Q99715-1 ]
NP_542376.2. NM_080645.2. [Q99715-2 ]
UniGenei Hs.101302.

3D structure databases

ProteinModelPortali Q99715.
SMRi Q99715. Positions 25-1179, 1196-1367, 1385-2310, 2317-2724.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107700. 1 interaction.
IntActi Q99715. 6 interactions.
STRINGi 9606.ENSP00000325146.

PTM databases

PhosphoSitei Q99715.

Polymorphism databases

DMDMi 146345397.

Proteomic databases

MaxQBi Q99715.
PaxDbi Q99715.
PRIDEi Q99715.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322507 ; ENSP00000325146 ; ENSG00000111799 . [Q99715-1 ]
ENST00000345356 ; ENSP00000305147 ; ENSG00000111799 . [Q99715-2 ]
ENST00000416123 ; ENSP00000412864 ; ENSG00000111799 . [Q99715-4 ]
GeneIDi 1303.
KEGGi hsa:1303.
UCSCi uc003phs.3. human. [Q99715-1 ]
uc003pht.3. human. [Q99715-2 ]

Organism-specific databases

CTDi 1303.
GeneCardsi GC06M075850.
H-InvDB HIX0006013.
HGNCi HGNC:2188. COL12A1.
HPAi HPA009143.
MIMi 120320. gene.
neXtProti NX_Q99715.
PharmGKBi PA26704.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG051060.
InParanoidi Q99715.
KOi K08132.
OMAi NRFNQML.
PhylomeDBi Q99715.
TreeFami TF329914.

Enzyme and pathway databases

Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_150401. Collagen degradation.

Miscellaneous databases

ChiTaRSi COL12A1. human.
GeneWikii Collagen,_type_XII,_alpha_1.
GenomeRNAii 1303.
NextBioi 5299.
PROi Q99715.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99715.
Bgeei Q99715.
CleanExi HS_COL12A1.
Genevestigatori Q99715.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
2.60.40.10. 18 hits.
3.40.50.410. 4 hits.
InterProi IPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR001791. Laminin_G.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01391. Collagen. 4 hits.
PF00041. fn3. 18 hits.
PF00092. VWA. 4 hits.
[Graphical view ]
SMARTi SM00060. FN3. 18 hits.
SM00210. TSPN. 1 hit.
SM00327. VWA. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 11 hits.
SSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 4 hits.
PROSITEi PS50853. FN3. 18 hits.
PS50234. VWFA. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13."
    Gerecke D.R., Olson P.F., Koch M., Knoll J.H.M., Taylor R., Hudson D.L., Champliaud M.-F., Olsen B.R., Burgeson R.E.
    Genomics 41:236-242(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 1280-1295; 1782-1801 AND 2906-2916, VARIANT SER-3058.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The chick and human collagen alpha1(XII) gene promoter -- activity of highly conserved regions around the first exon and in the first intron."
    Chiquet M., Mumenthaler U., Wittwer M., Jin W., Koch M.
    Eur. J. Biochem. 257:362-371(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
  4. "Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices."
    Wessel H., Anderson S., Fite D., Halvas E., Hempel J., SundarRaj N.
    Invest. Ophthalmol. Vis. Sci. 38:2408-2422(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 299-816 (ISOFORMS 1/4), TISSUE SPECIFICITY.
    Tissue: Cornea.
  5. "The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6."
    Oh S.P., Taylor R.W., Gerecke D.R., Rochelle J.M., Seldin M.F., Olsen B.R.
    Genomics 14:225-231(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2567-2755 (ISOFORM 4).
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2528 AND ASN-2679.
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOCA1_HUMAN
AccessioniPrimary (citable) accession number: Q99715
Secondary accession number(s): O43853
, Q15955, Q5VYK1, Q5VYK2, Q71UR3, Q99716
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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