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Q99712

- KCJ15_HUMAN

UniProt

Q99712 - KCJ15_HUMAN

Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

KCNJ15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei157 – 1571Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. potassium ion transport Source: ProtInc
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 15
    Alternative name(s):
    Inward rectifier K(+) channel Kir1.3
    Inward rectifier K(+) channel Kir4.2
    Potassium channel, inwardly rectifying subfamily J member 15
    Gene namesi
    Name:KCNJ15
    Synonyms:KCNJ14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:6261. KCNJ15.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30046.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375ATP-sensitive inward rectifier potassium channel 15PRO_0000154972Add
    BLAST

    Proteomic databases

    PaxDbiQ99712.
    PRIDEiQ99712.

    PTM databases

    PhosphoSiteiQ99712.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99712.
    BgeeiQ99712.
    CleanExiHS_KCNJ14.
    HS_KCNJ15.
    GenevestigatoriQ99712.

    Organism-specific databases

    HPAiHPA016702.

    Interactioni

    Subunit structurei

    Interacts with INADL.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    InadlQ63ZW74EBI-7082607,EBI-8366894From a different organism.

    Protein-protein interaction databases

    BioGridi109974. 2 interactions.
    IntActiQ99712. 2 interactions.
    MINTiMINT-103775.
    STRINGi9606.ENSP00000331698.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99712.
    SMRiQ99712. Positions 26-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6363CytoplasmicBy similarityAdd
    BLAST
    Topological domaini89 – 11325ExtracellularBy similarityAdd
    BLAST
    Topological domaini133 – 1419ExtracellularBy similarity
    Topological domaini164 – 375212CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei114 – 12512Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei126 – 1327Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8825Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei142 – 16322Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi127 – 1326Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289501.
    HOGENOMiHOG000237326.
    HOVERGENiHBG006178.
    InParanoidiQ99712.
    KOiK05008.
    OMAiCAVITKH.
    PhylomeDBiQ99712.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003270. K_chnl_inward-rec_Kir1.3.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF20. PTHR11767:SF20. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01323. KIR13CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99712-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY    50
    LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPGEP 100
    ISNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL 150
    VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVITKQN GKLCLVIQVA 200
    NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL 250
    PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY 300
    IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQQ 350
    LEEKYRQEDQ RERELRTLLL QQSNV 375
    Length:375
    Mass (Da):42,577
    Last modified:October 11, 2005 - v2
    Checksum:iCECCB4EDF827B24D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti235 – 2351V → A in CAA71734. (PubMed:9299242)Curated
    Sequence conflicti245 – 2451S → G in BAA13326. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301M → L.
    Corresponds to variant rs3746875 [ dbSNP | Ensembl ].
    VAR_025523
    Natural varianti71 – 711A → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036427
    Natural varianti98 – 981G → D.2 Publications
    Corresponds to variant rs2230033 [ dbSNP | Ensembl ].
    VAR_019728

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10745 mRNA. Translation: CAA71734.1.
    U73191 mRNA. Translation: AAC50922.1.
    D87291 mRNA. Translation: BAA13326.1.
    AP001434 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09683.1.
    CH471079 Genomic DNA. Translation: EAX09684.1.
    BC013327 mRNA. Translation: AAH13327.1.
    CCDSiCCDS13656.1.
    RefSeqiNP_001263364.1. NM_001276435.1.
    NP_001263365.1. NM_001276436.1.
    NP_001263366.1. NM_001276437.1.
    NP_001263367.1. NM_001276438.1.
    NP_001263368.1. NM_001276439.1.
    NP_002234.2. NM_002243.4.
    NP_733932.1. NM_170736.2.
    NP_733933.1. NM_170737.2.
    XP_005261032.1. XM_005260975.1.
    XP_005261033.1. XM_005260976.1.
    XP_006724065.1. XM_006724002.1.
    UniGeneiHs.411299.

    Genome annotation databases

    EnsembliENST00000328656; ENSP00000331698; ENSG00000157551.
    ENST00000398930; ENSP00000381904; ENSG00000157551.
    ENST00000398932; ENSP00000381905; ENSG00000157551.
    ENST00000398934; ENSP00000381907; ENSG00000157551.
    ENST00000398938; ENSP00000381911; ENSG00000157551.
    GeneIDi3772.
    KEGGihsa:3772.
    UCSCiuc002ywv.4. human.

    Polymorphism databases

    DMDMi77416869.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10745 mRNA. Translation: CAA71734.1 .
    U73191 mRNA. Translation: AAC50922.1 .
    D87291 mRNA. Translation: BAA13326.1 .
    AP001434 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09683.1 .
    CH471079 Genomic DNA. Translation: EAX09684.1 .
    BC013327 mRNA. Translation: AAH13327.1 .
    CCDSi CCDS13656.1.
    RefSeqi NP_001263364.1. NM_001276435.1.
    NP_001263365.1. NM_001276436.1.
    NP_001263366.1. NM_001276437.1.
    NP_001263367.1. NM_001276438.1.
    NP_001263368.1. NM_001276439.1.
    NP_002234.2. NM_002243.4.
    NP_733932.1. NM_170736.2.
    NP_733933.1. NM_170737.2.
    XP_005261032.1. XM_005260975.1.
    XP_005261033.1. XM_005260976.1.
    XP_006724065.1. XM_006724002.1.
    UniGenei Hs.411299.

    3D structure databases

    ProteinModelPortali Q99712.
    SMRi Q99712. Positions 26-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109974. 2 interactions.
    IntActi Q99712. 2 interactions.
    MINTi MINT-103775.
    STRINGi 9606.ENSP00000331698.

    PTM databases

    PhosphoSitei Q99712.

    Polymorphism databases

    DMDMi 77416869.

    Proteomic databases

    PaxDbi Q99712.
    PRIDEi Q99712.

    Protocols and materials databases

    DNASUi 3772.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328656 ; ENSP00000331698 ; ENSG00000157551 .
    ENST00000398930 ; ENSP00000381904 ; ENSG00000157551 .
    ENST00000398932 ; ENSP00000381905 ; ENSG00000157551 .
    ENST00000398934 ; ENSP00000381907 ; ENSG00000157551 .
    ENST00000398938 ; ENSP00000381911 ; ENSG00000157551 .
    GeneIDi 3772.
    KEGGi hsa:3772.
    UCSCi uc002ywv.4. human.

    Organism-specific databases

    CTDi 3772.
    GeneCardsi GC21P039529.
    HGNCi HGNC:6261. KCNJ15.
    HPAi HPA016702.
    MIMi 602106. gene.
    neXtProti NX_Q99712.
    PharmGKBi PA30046.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289501.
    HOGENOMi HOG000237326.
    HOVERGENi HBG006178.
    InParanoidi Q99712.
    KOi K05008.
    OMAi CAVITKH.
    PhylomeDBi Q99712.
    TreeFami TF313676.

    Enzyme and pathway databases

    Reactomei REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNJ15.
    GenomeRNAii 3772.
    NextBioi 14791.
    PROi Q99712.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99712.
    Bgeei Q99712.
    CleanExi HS_KCNJ14.
    HS_KCNJ15.
    Genevestigatori Q99712.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003270. K_chnl_inward-rec_Kir1.3.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF20. PTHR11767:SF20. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01323. KIR13CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1)."
      Gosset P., Ghezala G.A., Korn B., Yaspo M.-L., Poutska A., Lehrach H., Sinet P.-M., Creau N.
      Genomics 44:237-241(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)."
      Shuck M.E., Piser T.M., Bock J.H., Slightom J.L., Lee K.S., Bienkowski M.J.
      J. Biol. Chem. 272:586-593(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-98.
      Tissue: Kidney.
    3. Ohira M., Seki N., Nagase T., Suzuki E., Nomura N., Ohara O., Hattori M., Sakaki Y., Eki T., Murakami Y., Saito T., Ichikawa H., Ohki M.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-98.
      Tissue: Kidney.
    4. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    7. "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins."
      Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.
      Mol. Cell. Neurosci. 11:161-172(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INADL.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-71.

    Entry informationi

    Entry nameiKCJ15_HUMAN
    AccessioniPrimary (citable) accession number: Q99712
    Secondary accession number(s): D3DSH5
    , O00564, Q96L28, Q99446
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3