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Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

KCNJ15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei157Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • potassium ion import Source: GO_Central
  • potassium ion transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157551-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir1.3
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene namesi
Name:KCNJ15
Synonyms:KCNJ14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:6261. KCNJ15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicBy similarityAdd BLAST63
Transmembranei64 – 88Helical; Name=M1By similarityAdd BLAST25
Topological domaini89 – 113ExtracellularBy similarityAdd BLAST25
Intramembranei114 – 125Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei126 – 132Pore-formingBy similarity7
Topological domaini133 – 141ExtracellularBy similarity9
Transmembranei142 – 163Helical; Name=M2By similarityAdd BLAST22
Topological domaini164 – 375CytoplasmicBy similarityAdd BLAST212

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3772.
OpenTargetsiENSG00000157551.
PharmGKBiPA30046.

Chemistry databases

DrugBankiDB01392. Yohimbine.

Polymorphism and mutation databases

DMDMi77416869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549721 – 375ATP-sensitive inward rectifier potassium channel 15Add BLAST375

Proteomic databases

PaxDbiQ99712.
PeptideAtlasiQ99712.
PRIDEiQ99712.

PTM databases

PhosphoSitePlusiQ99712.

Expressioni

Gene expression databases

BgeeiENSG00000157551.
CleanExiHS_KCNJ14.
HS_KCNJ15.
ExpressionAtlasiQ99712. baseline and differential.
GenevisibleiQ99712. HS.

Organism-specific databases

HPAiHPA016702.

Interactioni

Subunit structurei

Interacts with PATJ.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
InadlQ63ZW74EBI-7082607,EBI-8366894From a different organism.

Protein-protein interaction databases

BioGridi109974. 1 interactor.
IntActiQ99712. 2 interactors.
MINTiMINT-103775.
STRINGi9606.ENSP00000331698.

Structurei

3D structure databases

ProteinModelPortaliQ99712.
SMRiQ99712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 132Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiQ99712.
KOiK05008.
OMAiCPLAIFT.
OrthoDBiEOG091G08HC.
PhylomeDBiQ99712.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY
60 70 80 90 100
LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPGEP
110 120 130 140 150
ISNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL
160 170 180 190 200
VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVITKQN GKLCLVIQVA
210 220 230 240 250
NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL
260 270 280 290 300
PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
310 320 330 340 350
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQQ
360 370
LEEKYRQEDQ RERELRTLLL QQSNV
Length:375
Mass (Da):42,577
Last modified:October 11, 2005 - v2
Checksum:iCECCB4EDF827B24D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235V → A in CAA71734 (PubMed:9299242).Curated1
Sequence conflicti245S → G in BAA13326 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02552330M → L.Corresponds to variant rs3746875dbSNPEnsembl.1
Natural variantiVAR_03642771A → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs199857043dbSNPEnsembl.1
Natural variantiVAR_01972898G → D.2 PublicationsCorresponds to variant rs2230033dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10745 mRNA. Translation: CAA71734.1.
U73191 mRNA. Translation: AAC50922.1.
D87291 mRNA. Translation: BAA13326.1.
AP001434 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09683.1.
CH471079 Genomic DNA. Translation: EAX09684.1.
BC013327 mRNA. Translation: AAH13327.1.
CCDSiCCDS13656.1.
RefSeqiNP_001263364.1. NM_001276435.1.
NP_001263365.1. NM_001276436.1.
NP_001263366.1. NM_001276437.1.
NP_001263367.1. NM_001276438.1.
NP_001263368.1. NM_001276439.1.
NP_002234.2. NM_002243.4.
NP_733932.1. NM_170736.2.
NP_733933.1. NM_170737.2.
XP_005261032.1. XM_005260975.2.
XP_006724065.1. XM_006724002.2.
XP_011527862.1. XM_011529560.2.
XP_011527863.1. XM_011529561.2.
XP_016883832.1. XM_017028343.1.
XP_016883833.1. XM_017028344.1.
XP_016883834.1. XM_017028345.1.
UniGeneiHs.411299.

Genome annotation databases

EnsembliENST00000328656; ENSP00000331698; ENSG00000157551.
ENST00000398930; ENSP00000381904; ENSG00000157551.
ENST00000398932; ENSP00000381905; ENSG00000157551.
ENST00000398934; ENSP00000381907; ENSG00000157551.
ENST00000398938; ENSP00000381911; ENSG00000157551.
ENST00000612702; ENSP00000484960; ENSG00000157551.
ENST00000613499; ENSP00000479100; ENSG00000157551.
GeneIDi3772.
KEGGihsa:3772.
UCSCiuc002ywv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10745 mRNA. Translation: CAA71734.1.
U73191 mRNA. Translation: AAC50922.1.
D87291 mRNA. Translation: BAA13326.1.
AP001434 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09683.1.
CH471079 Genomic DNA. Translation: EAX09684.1.
BC013327 mRNA. Translation: AAH13327.1.
CCDSiCCDS13656.1.
RefSeqiNP_001263364.1. NM_001276435.1.
NP_001263365.1. NM_001276436.1.
NP_001263366.1. NM_001276437.1.
NP_001263367.1. NM_001276438.1.
NP_001263368.1. NM_001276439.1.
NP_002234.2. NM_002243.4.
NP_733932.1. NM_170736.2.
NP_733933.1. NM_170737.2.
XP_005261032.1. XM_005260975.2.
XP_006724065.1. XM_006724002.2.
XP_011527862.1. XM_011529560.2.
XP_011527863.1. XM_011529561.2.
XP_016883832.1. XM_017028343.1.
XP_016883833.1. XM_017028344.1.
XP_016883834.1. XM_017028345.1.
UniGeneiHs.411299.

3D structure databases

ProteinModelPortaliQ99712.
SMRiQ99712.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109974. 1 interactor.
IntActiQ99712. 2 interactors.
MINTiMINT-103775.
STRINGi9606.ENSP00000331698.

Chemistry databases

DrugBankiDB01392. Yohimbine.

PTM databases

PhosphoSitePlusiQ99712.

Polymorphism and mutation databases

DMDMi77416869.

Proteomic databases

PaxDbiQ99712.
PeptideAtlasiQ99712.
PRIDEiQ99712.

Protocols and materials databases

DNASUi3772.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328656; ENSP00000331698; ENSG00000157551.
ENST00000398930; ENSP00000381904; ENSG00000157551.
ENST00000398932; ENSP00000381905; ENSG00000157551.
ENST00000398934; ENSP00000381907; ENSG00000157551.
ENST00000398938; ENSP00000381911; ENSG00000157551.
ENST00000612702; ENSP00000484960; ENSG00000157551.
ENST00000613499; ENSP00000479100; ENSG00000157551.
GeneIDi3772.
KEGGihsa:3772.
UCSCiuc002ywv.5. human.

Organism-specific databases

CTDi3772.
DisGeNETi3772.
GeneCardsiKCNJ15.
HGNCiHGNC:6261. KCNJ15.
HPAiHPA016702.
MIMi602106. gene.
neXtProtiNX_Q99712.
OpenTargetsiENSG00000157551.
PharmGKBiPA30046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiQ99712.
KOiK05008.
OMAiCPLAIFT.
OrthoDBiEOG091G08HC.
PhylomeDBiQ99712.
TreeFamiTF313676.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157551-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

ChiTaRSiKCNJ15. human.
GeneWikiiKCNJ15.
GenomeRNAii3772.
PROiQ99712.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157551.
CleanExiHS_KCNJ14.
HS_KCNJ15.
ExpressionAtlasiQ99712. baseline and differential.
GenevisibleiQ99712. HS.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCJ15_HUMAN
AccessioniPrimary (citable) accession number: Q99712
Secondary accession number(s): D3DSH5
, O00564, Q96L28, Q99446
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.