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Q99712

- KCJ15_HUMAN

UniProt

Q99712 - KCJ15_HUMAN

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Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

KCNJ15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei157 – 1571Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: ProtInc

GO - Biological processi

  1. potassium ion transmembrane transport Source: GOC
  2. potassium ion transport Source: ProtInc
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir1.3
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene namesi
Name:KCNJ15
Synonyms:KCNJ14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:6261. KCNJ15.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30046.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375ATP-sensitive inward rectifier potassium channel 15PRO_0000154972Add
BLAST

Proteomic databases

PaxDbiQ99712.
PRIDEiQ99712.

PTM databases

PhosphoSiteiQ99712.

Expressioni

Gene expression databases

BgeeiQ99712.
CleanExiHS_KCNJ14.
HS_KCNJ15.
ExpressionAtlasiQ99712. baseline and differential.
GenevestigatoriQ99712.

Organism-specific databases

HPAiHPA016702.

Interactioni

Subunit structurei

Interacts with INADL.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
InadlQ63ZW74EBI-7082607,EBI-8366894From a different organism.

Protein-protein interaction databases

BioGridi109974. 2 interactions.
IntActiQ99712. 2 interactions.
MINTiMINT-103775.
STRINGi9606.ENSP00000331698.

Structurei

3D structure databases

ProteinModelPortaliQ99712.
SMRiQ99712. Positions 26-355.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363CytoplasmicBy similarityAdd
BLAST
Topological domaini89 – 11325ExtracellularBy similarityAdd
BLAST
Topological domaini133 – 1419ExtracellularBy similarity
Topological domaini164 – 375212CytoplasmicBy similarityAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei114 – 12512Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei126 – 1327Pore-formingBy similarity

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8825Helical; Name=M1By similarityAdd
BLAST
Transmembranei142 – 16322Helical; Name=M2By similarityAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1326Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289501.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiQ99712.
KOiK05008.
OMAiCAVITKH.
PhylomeDBiQ99712.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99712-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY
60 70 80 90 100
LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPGEP
110 120 130 140 150
ISNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL
160 170 180 190 200
VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVITKQN GKLCLVIQVA
210 220 230 240 250
NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL
260 270 280 290 300
PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
310 320 330 340 350
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQQ
360 370
LEEKYRQEDQ RERELRTLLL QQSNV
Length:375
Mass (Da):42,577
Last modified:October 11, 2005 - v2
Checksum:iCECCB4EDF827B24D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351V → A in CAA71734. (PubMed:9299242)Curated
Sequence conflicti245 – 2451S → G in BAA13326. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301M → L.
Corresponds to variant rs3746875 [ dbSNP | Ensembl ].
VAR_025523
Natural varianti71 – 711A → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036427
Natural varianti98 – 981G → D.2 Publications
Corresponds to variant rs2230033 [ dbSNP | Ensembl ].
VAR_019728

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10745 mRNA. Translation: CAA71734.1.
U73191 mRNA. Translation: AAC50922.1.
D87291 mRNA. Translation: BAA13326.1.
AP001434 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09683.1.
CH471079 Genomic DNA. Translation: EAX09684.1.
BC013327 mRNA. Translation: AAH13327.1.
CCDSiCCDS13656.1.
RefSeqiNP_001263364.1. NM_001276435.1.
NP_001263365.1. NM_001276436.1.
NP_001263366.1. NM_001276437.1.
NP_001263367.1. NM_001276438.1.
NP_001263368.1. NM_001276439.1.
NP_002234.2. NM_002243.4.
NP_733932.1. NM_170736.2.
NP_733933.1. NM_170737.2.
XP_005261032.1. XM_005260975.1.
XP_005261033.1. XM_005260976.1.
XP_006724065.1. XM_006724002.1.
UniGeneiHs.411299.

Genome annotation databases

EnsembliENST00000328656; ENSP00000331698; ENSG00000157551.
ENST00000398930; ENSP00000381904; ENSG00000157551.
ENST00000398932; ENSP00000381905; ENSG00000157551.
ENST00000398934; ENSP00000381907; ENSG00000157551.
ENST00000398938; ENSP00000381911; ENSG00000157551.
ENST00000612702; ENSP00000484960; ENSG00000157551.
ENST00000613499; ENSP00000479100; ENSG00000157551.
GeneIDi3772.
KEGGihsa:3772.
UCSCiuc002ywv.4. human.

Polymorphism databases

DMDMi77416869.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10745 mRNA. Translation: CAA71734.1 .
U73191 mRNA. Translation: AAC50922.1 .
D87291 mRNA. Translation: BAA13326.1 .
AP001434 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09683.1 .
CH471079 Genomic DNA. Translation: EAX09684.1 .
BC013327 mRNA. Translation: AAH13327.1 .
CCDSi CCDS13656.1.
RefSeqi NP_001263364.1. NM_001276435.1.
NP_001263365.1. NM_001276436.1.
NP_001263366.1. NM_001276437.1.
NP_001263367.1. NM_001276438.1.
NP_001263368.1. NM_001276439.1.
NP_002234.2. NM_002243.4.
NP_733932.1. NM_170736.2.
NP_733933.1. NM_170737.2.
XP_005261032.1. XM_005260975.1.
XP_005261033.1. XM_005260976.1.
XP_006724065.1. XM_006724002.1.
UniGenei Hs.411299.

3D structure databases

ProteinModelPortali Q99712.
SMRi Q99712. Positions 26-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109974. 2 interactions.
IntActi Q99712. 2 interactions.
MINTi MINT-103775.
STRINGi 9606.ENSP00000331698.

Chemistry

DrugBanki DB01392. Yohimbine.

PTM databases

PhosphoSitei Q99712.

Polymorphism databases

DMDMi 77416869.

Proteomic databases

PaxDbi Q99712.
PRIDEi Q99712.

Protocols and materials databases

DNASUi 3772.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328656 ; ENSP00000331698 ; ENSG00000157551 .
ENST00000398930 ; ENSP00000381904 ; ENSG00000157551 .
ENST00000398932 ; ENSP00000381905 ; ENSG00000157551 .
ENST00000398934 ; ENSP00000381907 ; ENSG00000157551 .
ENST00000398938 ; ENSP00000381911 ; ENSG00000157551 .
ENST00000612702 ; ENSP00000484960 ; ENSG00000157551 .
ENST00000613499 ; ENSP00000479100 ; ENSG00000157551 .
GeneIDi 3772.
KEGGi hsa:3772.
UCSCi uc002ywv.4. human.

Organism-specific databases

CTDi 3772.
GeneCardsi GC21P039529.
HGNCi HGNC:6261. KCNJ15.
HPAi HPA016702.
MIMi 602106. gene.
neXtProti NX_Q99712.
PharmGKBi PA30046.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289501.
GeneTreei ENSGT00760000118842.
HOGENOMi HOG000237326.
HOVERGENi HBG006178.
InParanoidi Q99712.
KOi K05008.
OMAi CAVITKH.
PhylomeDBi Q99712.
TreeFami TF313676.

Enzyme and pathway databases

Reactomei REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.

Miscellaneous databases

GeneWikii KCNJ15.
GenomeRNAii 3772.
NextBioi 14791.
PROi Q99712.
SOURCEi Search...

Gene expression databases

Bgeei Q99712.
CleanExi HS_KCNJ14.
HS_KCNJ15.
ExpressionAtlasi Q99712. baseline and differential.
Genevestigatori Q99712.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1)."
    Gosset P., Ghezala G.A., Korn B., Yaspo M.-L., Poutska A., Lehrach H., Sinet P.-M., Creau N.
    Genomics 44:237-241(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)."
    Shuck M.E., Piser T.M., Bock J.H., Slightom J.L., Lee K.S., Bienkowski M.J.
    J. Biol. Chem. 272:586-593(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-98.
    Tissue: Kidney.
  3. Ohira M., Seki N., Nagase T., Suzuki E., Nomura N., Ohara O., Hattori M., Sakaki Y., Eki T., Murakami Y., Saito T., Ichikawa H., Ohki M.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-98.
    Tissue: Kidney.
  4. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  7. "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins."
    Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.
    Mol. Cell. Neurosci. 11:161-172(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INADL.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-71.

Entry informationi

Entry nameiKCJ15_HUMAN
AccessioniPrimary (citable) accession number: Q99712
Secondary accession number(s): D3DSH5
, O00564, Q96L28, Q99446
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3