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Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

KCNJ15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei157 – 1571Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

  • inward rectifier potassium channel activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir1.3
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene namesi
Name:KCNJ15
Synonyms:KCNJ14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:6261. KCNJ15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363CytoplasmicBy similarityAdd
BLAST
Transmembranei64 – 8825Helical; Name=M1By similarityAdd
BLAST
Topological domaini89 – 11325ExtracellularBy similarityAdd
BLAST
Intramembranei114 – 12512Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei126 – 1327Pore-formingBy similarity
Topological domaini133 – 1419ExtracellularBy similarity
Transmembranei142 – 16322Helical; Name=M2By similarityAdd
BLAST
Topological domaini164 – 375212CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30046.

Chemistry

DrugBankiDB01392. Yohimbine.

Polymorphism and mutation databases

DMDMi77416869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375ATP-sensitive inward rectifier potassium channel 15PRO_0000154972Add
BLAST

Proteomic databases

PaxDbiQ99712.
PRIDEiQ99712.

PTM databases

PhosphoSiteiQ99712.

Expressioni

Gene expression databases

BgeeiQ99712.
CleanExiHS_KCNJ14.
HS_KCNJ15.
ExpressionAtlasiQ99712. baseline and differential.
GenevisibleiQ99712. HS.

Organism-specific databases

HPAiHPA016702.

Interactioni

Subunit structurei

Interacts with INADL.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
InadlQ63ZW74EBI-7082607,EBI-8366894From a different organism.

Protein-protein interaction databases

BioGridi109974. 2 interactions.
IntActiQ99712. 2 interactions.
MINTiMINT-103775.
STRINGi9606.ENSP00000331698.

Structurei

3D structure databases

ProteinModelPortaliQ99712.
SMRiQ99712. Positions 26-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1326Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289501.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiQ99712.
KOiK05008.
OMAiCPLAIFT.
PhylomeDBiQ99712.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY
60 70 80 90 100
LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPGEP
110 120 130 140 150
ISNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL
160 170 180 190 200
VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVITKQN GKLCLVIQVA
210 220 230 240 250
NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL
260 270 280 290 300
PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
310 320 330 340 350
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQQ
360 370
LEEKYRQEDQ RERELRTLLL QQSNV
Length:375
Mass (Da):42,577
Last modified:October 11, 2005 - v2
Checksum:iCECCB4EDF827B24D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351V → A in CAA71734 (PubMed:9299242).Curated
Sequence conflicti245 – 2451S → G in BAA13326 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301M → L.
Corresponds to variant rs3746875 [ dbSNP | Ensembl ].
VAR_025523
Natural varianti71 – 711A → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036427
Natural varianti98 – 981G → D.2 Publications
Corresponds to variant rs2230033 [ dbSNP | Ensembl ].
VAR_019728

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10745 mRNA. Translation: CAA71734.1.
U73191 mRNA. Translation: AAC50922.1.
D87291 mRNA. Translation: BAA13326.1.
AP001434 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09683.1.
CH471079 Genomic DNA. Translation: EAX09684.1.
BC013327 mRNA. Translation: AAH13327.1.
CCDSiCCDS13656.1.
RefSeqiNP_001263364.1. NM_001276435.1.
NP_001263365.1. NM_001276436.1.
NP_001263366.1. NM_001276437.1.
NP_001263367.1. NM_001276438.1.
NP_001263368.1. NM_001276439.1.
NP_002234.2. NM_002243.4.
NP_733932.1. NM_170736.2.
NP_733933.1. NM_170737.2.
XP_005261032.1. XM_005260975.2.
XP_006724065.1. XM_006724002.2.
UniGeneiHs.411299.

Genome annotation databases

EnsembliENST00000328656; ENSP00000331698; ENSG00000157551.
ENST00000398930; ENSP00000381904; ENSG00000157551.
ENST00000398932; ENSP00000381905; ENSG00000157551.
ENST00000398934; ENSP00000381907; ENSG00000157551.
ENST00000398938; ENSP00000381911; ENSG00000157551.
ENST00000612702; ENSP00000484960; ENSG00000157551.
ENST00000613499; ENSP00000479100; ENSG00000157551.
GeneIDi3772.
KEGGihsa:3772.
UCSCiuc002ywv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10745 mRNA. Translation: CAA71734.1.
U73191 mRNA. Translation: AAC50922.1.
D87291 mRNA. Translation: BAA13326.1.
AP001434 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09683.1.
CH471079 Genomic DNA. Translation: EAX09684.1.
BC013327 mRNA. Translation: AAH13327.1.
CCDSiCCDS13656.1.
RefSeqiNP_001263364.1. NM_001276435.1.
NP_001263365.1. NM_001276436.1.
NP_001263366.1. NM_001276437.1.
NP_001263367.1. NM_001276438.1.
NP_001263368.1. NM_001276439.1.
NP_002234.2. NM_002243.4.
NP_733932.1. NM_170736.2.
NP_733933.1. NM_170737.2.
XP_005261032.1. XM_005260975.2.
XP_006724065.1. XM_006724002.2.
UniGeneiHs.411299.

3D structure databases

ProteinModelPortaliQ99712.
SMRiQ99712. Positions 26-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109974. 2 interactions.
IntActiQ99712. 2 interactions.
MINTiMINT-103775.
STRINGi9606.ENSP00000331698.

Chemistry

DrugBankiDB01392. Yohimbine.

PTM databases

PhosphoSiteiQ99712.

Polymorphism and mutation databases

DMDMi77416869.

Proteomic databases

PaxDbiQ99712.
PRIDEiQ99712.

Protocols and materials databases

DNASUi3772.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328656; ENSP00000331698; ENSG00000157551.
ENST00000398930; ENSP00000381904; ENSG00000157551.
ENST00000398932; ENSP00000381905; ENSG00000157551.
ENST00000398934; ENSP00000381907; ENSG00000157551.
ENST00000398938; ENSP00000381911; ENSG00000157551.
ENST00000612702; ENSP00000484960; ENSG00000157551.
ENST00000613499; ENSP00000479100; ENSG00000157551.
GeneIDi3772.
KEGGihsa:3772.
UCSCiuc002ywv.4. human.

Organism-specific databases

CTDi3772.
GeneCardsiGC21P039529.
HGNCiHGNC:6261. KCNJ15.
HPAiHPA016702.
MIMi602106. gene.
neXtProtiNX_Q99712.
PharmGKBiPA30046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG289501.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiQ99712.
KOiK05008.
OMAiCPLAIFT.
PhylomeDBiQ99712.
TreeFamiTF313676.

Enzyme and pathway databases

ReactomeiREACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.

Miscellaneous databases

ChiTaRSiKCNJ15. human.
GeneWikiiKCNJ15.
GenomeRNAii3772.
NextBioi14791.
PROiQ99712.
SOURCEiSearch...

Gene expression databases

BgeeiQ99712.
CleanExiHS_KCNJ14.
HS_KCNJ15.
ExpressionAtlasiQ99712. baseline and differential.
GenevisibleiQ99712. HS.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1)."
    Gosset P., Ghezala G.A., Korn B., Yaspo M.-L., Poutska A., Lehrach H., Sinet P.-M., Creau N.
    Genomics 44:237-241(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)."
    Shuck M.E., Piser T.M., Bock J.H., Slightom J.L., Lee K.S., Bienkowski M.J.
    J. Biol. Chem. 272:586-593(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-98.
    Tissue: Kidney.
  3. Ohira M., Seki N., Nagase T., Suzuki E., Nomura N., Ohara O., Hattori M., Sakaki Y., Eki T., Murakami Y., Saito T., Ichikawa H., Ohki M.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-98.
    Tissue: Kidney.
  4. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  7. "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins."
    Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.
    Mol. Cell. Neurosci. 11:161-172(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INADL.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-71.

Entry informationi

Entry nameiKCJ15_HUMAN
AccessioniPrimary (citable) accession number: Q99712
Secondary accession number(s): D3DSH5
, O00564, Q96L28, Q99446
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.