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Q99712 (IRK15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir1.3
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene names
Name:KCNJ15
Synonyms:KCNJ14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Subunit structure

Interacts with INADL. Ref.7

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandPotassium
   Molecular functionIon channel
Voltage-gated channel
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpotassium ion transport

Traceable author statement Ref.2. Source: ProtInc

synaptic transmission

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.2. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functioninward rectifier potassium channel activity

Traceable author statement Ref.2. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

InadlQ63ZW74EBI-7082607,EBI-8366894From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375ATP-sensitive inward rectifier potassium channel 15
PRO_0000154972

Regions

Topological domain1 – 6363Cytoplasmic By similarity
Transmembrane64 – 8825Helical; Name=M1; By similarity
Topological domain89 – 11325Extracellular By similarity
Intramembrane114 – 12512Helical; Pore-forming; Name=H5; By similarity
Intramembrane126 – 1327Pore-forming; By similarity
Topological domain133 – 1419Extracellular By similarity
Transmembrane142 – 16322Helical; Name=M2; By similarity
Topological domain164 – 375212Cytoplasmic By similarity
Motif127 – 1326Selectivity filter By similarity

Sites

Site1571Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

Natural variations

Natural variant301M → L.
Corresponds to variant rs3746875 [ dbSNP | Ensembl ].
VAR_025523
Natural variant711A → T in a breast cancer sample; somatic mutation. Ref.8
VAR_036427
Natural variant981G → D. Ref.2 Ref.3
Corresponds to variant rs2230033 [ dbSNP | Ensembl ].
VAR_019728

Experimental info

Sequence conflict2351V → A in CAA71734. Ref.1
Sequence conflict2451S → G in BAA13326. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q99712 [UniParc].

Last modified October 11, 2005. Version 2.
Checksum: CECCB4EDF827B24D

FASTA37542,577
        10         20         30         40         50         60 
MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID 

        70         80         90        100        110        120 
MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPGEP ISNHTPCIMK VDSLTGAFLF 

       130        140        150        160        170        180 
SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR PKKRAETIKF 

       190        200        210        220        230        240 
SHCAVITKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD 

       250        260        270        280        290        300 
SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY 

       310        320        330        340        350        360 
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQQ LEEKYRQEDQ 

       370 
RERELRTLLL QQSNV 

« Hide

References

« Hide 'large scale' references
[1]"A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1)."
Gosset P., Ghezala G.A., Korn B., Yaspo M.-L., Poutska A., Lehrach H., Sinet P.-M., Creau N.
Genomics 44:237-241(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)."
Shuck M.E., Piser T.M., Bock J.H., Slightom J.L., Lee K.S., Bienkowski M.J.
J. Biol. Chem. 272:586-593(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-98.
Tissue: Kidney.
[3]Ohira M., Seki N., Nagase T., Suzuki E., Nomura N., Ohara O., Hattori M., Sakaki Y., Eki T., Murakami Y., Saito T., Ichikawa H., Ohki M.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-98.
Tissue: Kidney.
[4]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[7]"CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins."
Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.
Mol. Cell. Neurosci. 11:161-172(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH INADL.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-71.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y10745 mRNA. Translation: CAA71734.1.
U73191 mRNA. Translation: AAC50922.1.
D87291 mRNA. Translation: BAA13326.1.
AP001434 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09683.1.
CH471079 Genomic DNA. Translation: EAX09684.1.
BC013327 mRNA. Translation: AAH13327.1.
RefSeqNP_001263364.1. NM_001276435.1.
NP_001263365.1. NM_001276436.1.
NP_001263366.1. NM_001276437.1.
NP_001263367.1. NM_001276438.1.
NP_001263368.1. NM_001276439.1.
NP_002234.2. NM_002243.4.
NP_733932.1. NM_170736.2.
NP_733933.1. NM_170737.2.
XP_005261032.1. XM_005260975.1.
XP_005261033.1. XM_005260976.1.
UniGeneHs.411299.

3D structure databases

ProteinModelPortalQ99712.
SMRQ99712. Positions 26-355.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109974. 2 interactions.
IntActQ99712. 2 interactions.
MINTMINT-103775.
STRING9606.ENSP00000331698.

PTM databases

PhosphoSiteQ99712.

Polymorphism databases

DMDM77416869.

Proteomic databases

PaxDbQ99712.
PRIDEQ99712.

Protocols and materials databases

DNASU3772.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328656; ENSP00000331698; ENSG00000157551.
ENST00000398930; ENSP00000381904; ENSG00000157551.
ENST00000398932; ENSP00000381905; ENSG00000157551.
ENST00000398934; ENSP00000381907; ENSG00000157551.
ENST00000398938; ENSP00000381911; ENSG00000157551.
GeneID3772.
KEGGhsa:3772.
UCSCuc002ywv.4. human.

Organism-specific databases

CTD3772.
GeneCardsGC21P039529.
HGNCHGNC:6261. KCNJ15.
HPAHPA016702.
MIM602106. gene.
neXtProtNX_Q99712.
PharmGKBPA30046.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG289501.
HOGENOMHOG000237326.
HOVERGENHBG006178.
InParanoidQ99712.
KOK05008.
OMAVRVANMR.
PhylomeDBQ99712.
TreeFamTF313676.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressQ99712.
BgeeQ99712.
CleanExHS_KCNJ14.
HS_KCNJ15.
GenevestigatorQ99712.

Family and domain databases

Gene3D2.60.40.1400. 1 hit.
InterProIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamPF01007. IRK. 1 hit.
[Graphical view]
PIRSFPIRSF005465. GIRK_kir. 1 hit.
PRINTSPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMSSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNJ15.
GenomeRNAi3772.
NextBio14791.
PROQ99712.
SOURCESearch...

Entry information

Entry nameIRK15_HUMAN
AccessionPrimary (citable) accession number: Q99712
Secondary accession number(s): D3DSH5 expand/collapse secondary AC list , O00564, Q96L28, Q99446
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM