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Protein

Killer cell immunoglobulin-like receptor 2DL4

Gene

KIR2DL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • cellular defense response Source: ProtInc
  • regulation of immune response Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL4
Alternative name(s):
CD158 antigen-like family member D
G9P
Killer cell inhibitory receptor 103AS
Short name:
KIR-103AS
MHC class I NK cell receptor KIR103AS
CD_antigen: CD158d
Gene namesi
Name:KIR2DL4
Synonyms:CD158D, KIR103AS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6332. KIR2DL4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 242221ExtracellularSequence AnalysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence AnalysisAdd
BLAST
Topological domaini264 – 377114CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30117.

Polymorphism and mutation databases

BioMutaiKIR2DL4.
DMDMi325511396.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 377356Killer cell immunoglobulin-like receptor 2DL4PRO_0000015081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 97By similarity
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi146 ↔ 195By similarity
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99706.
PRIDEiQ99706.

PTM databases

PhosphoSiteiQ99706.

Expressioni

Gene expression databases

BgeeiQ99706.
ExpressionAtlasiQ99706. baseline and differential.
GenevisibleiQ99706. HS.

Interactioni

Subunit structurei

Interacts with ARRB2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPMSQ930623EBI-10294579,EBI-740322
TRIP6Q156543EBI-10294579,EBI-742327

Protein-protein interaction databases

BioGridi110006. 5 interactions.
IntActiQ99706. 2 interactions.

Structurei

Secondary structure

1
377
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 376Combined sources
Beta strandi39 – 424Combined sources
Beta strandi47 – 526Combined sources
Beta strandi54 – 6714Combined sources
Helixi71 – 733Combined sources
Beta strandi76 – 849Combined sources
Helixi89 – 913Combined sources
Beta strandi93 – 1008Combined sources
Beta strandi102 – 1043Combined sources
Beta strandi115 – 1206Combined sources
Beta strandi127 – 1326Combined sources
Beta strandi134 – 1363Combined sources
Beta strandi141 – 15010Combined sources
Beta strandi153 – 1597Combined sources
Beta strandi162 – 1698Combined sources
Beta strandi171 – 1733Combined sources
Turni174 – 1763Combined sources
Beta strandi177 – 18610Combined sources
Beta strandi191 – 1988Combined sources
Beta strandi213 – 2175Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WYRX-ray2.80A/B24-218[»]
ProteinModelPortaliQ99706.
SMRiQ99706. Positions 30-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 10461Ig-like C2-type 1Add
BLAST
Domaini139 – 20264Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25862.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiQ99706.
KOiK07981.
OrthoDBiEOG7H792J.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99706-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMSPTVIIL ACLGFFLDQS VWAHVGGQDK PFCSAWPSAV VPQGGHVTLR
60 70 80 90 100
CHYRRGFNIF TLYKKDGVPV PELYNRIFWN SFLISPVTPA HAGTYRCRGF
110 120 130 140 150
HPHSPTEWSA PSNPLVIMVT GLYEKPSLTA RPGPTVRAGE NVTLSCSSQS
160 170 180 190 200
SFDIYHLSRE GEAHELRLPA VPSINGTFQA DFPLGPATHG ETYRCFGSFH
210 220 230 240 250
GSPYEWSDPS DPLPVSVTGN PSSSWPSPTE PSFKTGIARH LHAVIRYSVA
260 270 280 290 300
IILFTILPFF LLHRWCSKKK DAAVMNQEPA GHRTVNREDS DEQDPQEVTY
310 320 330 340 350
AQLDHCIFTQ RKITGPSQRS KRPSTDTSVC IELPNAEPRA LSPAHEHHSQ
360 370
ALMGSSRETT ALSQTQLASS NVPAAGI
Length:377
Mass (Da):41,487
Last modified:March 8, 2011 - v3
Checksum:i888B3297332D6C59
GO
Isoform 2 (identifier: Q99706-2) [UniParc]FASTAAdd to basket

Also known as: AST

The sequence of this isoform differs from the canonical sequence as follows:
     219-235: Missing.

Show »
Length:360
Mass (Da):39,699
Checksum:iA7E18C6F0DDBD526
GO
Isoform 3 (identifier: Q99706-3) [UniParc]FASTAAdd to basket

Also known as: AS

The sequence of this isoform differs from the canonical sequence as follows:
     236-270: Missing.

Show »
Length:342
Mass (Da):37,356
Checksum:i963B74BC0E5C7B64
GO
Isoform 4 (identifier: Q99706-4) [UniParc]FASTAAdd to basket

Also known as: ASD1

The sequence of this isoform differs from the canonical sequence as follows:
     219-235: Missing.
     236-270: Missing.

Show »
Length:325
Mass (Da):35,568
Checksum:iA07C525E18C55C79
GO
Isoform 5 (identifier: Q99706-5) [UniParc]FASTAAdd to basket

Also known as: ASD2

The sequence of this isoform differs from the canonical sequence as follows:
     219-235: Missing.
     236-270: Missing.
     271-288: Missing.

Show »
Length:307
Mass (Da):33,591
Checksum:i360E7C2058E1788E
GO
Isoform 6 (identifier: Q99706-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-121: Missing.
     219-235: Missing.
     236-270: Missing.

Show »
Length:230
Mass (Da):24,917
Checksum:i0FCFE3EE13BACBB7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471V → A in ABW73961 (PubMed:18082267).Curated
Sequence conflicti229 – 2291T → P in AAD24763 (Ref. 7) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531Y → C.3 Publications
Corresponds to variant rs618835 [ dbSNP | Ensembl ].
VAR_010307
Natural varianti87 – 871V → L.3 Publications
Corresponds to variant rs1057767 [ dbSNP | Ensembl ].
VAR_010308
Natural varianti138 – 1381A → T.5 Publications
Corresponds to variant rs1051454 [ dbSNP | Ensembl ].
VAR_010309
Natural varianti209 – 2091P → A.5 Publications
Corresponds to variant rs1051456 [ dbSNP | Ensembl ].
VAR_010310
Natural varianti271 – 2733DAA → MLL in allele KIR2DL4*0501.
VAR_064649
Natural varianti271 – 2711D → N.4 Publications
VAR_010311
Natural varianti274 – 377104Missing in allele KIR2DL4*0501.
VAR_065101Add
BLAST
Natural varianti371 – 3711N → H.4 Publications
Corresponds to variant rs1051460 [ dbSNP | Ensembl ].
VAR_010312

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei27 – 12195Missing in isoform 6. 1 PublicationVSP_002608Add
BLAST
Alternative sequencei219 – 23517Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 3 PublicationsVSP_002609Add
BLAST
Alternative sequencei236 – 27035Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsVSP_002610Add
BLAST
Alternative sequencei271 – 28818Missing in isoform 5. 1 PublicationVSP_002611Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71199 mRNA. Translation: AAB49756.1.
AF034771 mRNA. Translation: AAB95164.1.
AF034772 mRNA. Translation: AAB95165.1.
AF034773 mRNA. Translation: AAB95166.1.
U73394 mRNA. Translation: AAC51146.1.
AF003123
, AF003116, AF003117, AF003118, AF003119, AF003121, AF003122, AF003120 Genomic DNA. Translation: AAB61926.1.
AF002979 mRNA. Translation: AAB71387.1.
AF002980 mRNA. Translation: AAB71388.1.
AF002981 mRNA. Translation: AAB71389.1.
AF002982 mRNA. Translation: AAB71390.1.
EU194342 mRNA. Translation: ABW73961.1.
X97229 mRNA. Translation: CAA65868.1.
X99479 mRNA. Translation: CAA67842.1.
X99480 mRNA. Translation: CAA67843.1.
X99481 mRNA. Translation: CAA67844.1.
AF110035
, AF110032, AF110033, AF110034 Genomic DNA. Translation: AAD24763.1.
AC011501 Genomic DNA. No translation available.
AL133414 Genomic DNA. Translation: CAC40708.1.
CCDSiCCDS42619.1. [Q99706-3]
RefSeqiNP_001074239.1. NM_001080770.1. [Q99706-3]
NP_002246.5. NM_002255.5.
UniGeneiHs.661219.
Hs.743945.

Genome annotation databases

EnsembliENST00000345540; ENSP00000339634; ENSG00000189013. [Q99706-3]
ENST00000357494; ENSP00000350088; ENSG00000189013. [Q99706-4]
ENST00000396293; ENSP00000379588; ENSG00000189013. [Q99706-6]
ENST00000611022; ENSP00000484469; ENSG00000274232. [Q99706-3]
ENST00000612573; ENSP00000482206; ENSG00000275456.
ENST00000612660; ENSP00000479179; ENSG00000275317.
ENST00000613053; ENSP00000484389; ENSG00000277362.
ENST00000614653; ENSP00000478362; ENSG00000277750.
ENST00000614680; ENSP00000477984; ENSG00000273575. [Q99706-3]
ENST00000615232; ENSP00000479874; ENSG00000274232. [Q99706-6]
ENST00000615243; ENSP00000482454; ENSG00000274232. [Q99706-4]
ENST00000615970; ENSP00000477887; ENSG00000278271.
ENST00000616354; ENSP00000483782; ENSG00000278430.
ENST00000616384; ENSP00000479347; ENSG00000276044. [Q99706-3]
ENST00000618297; ENSP00000477886; ENSG00000278074.
ENST00000618358; ENSP00000483101; ENSG00000274609.
ENST00000618567; ENSP00000482383; ENSG00000276779.
ENST00000619637; ENSP00000478491; ENSG00000274955.
ENST00000619848; ENSP00000480801; ENSG00000277964.
ENST00000620484; ENSP00000477601; ENSG00000275317.
ENST00000620486; ENSP00000482452; ENSG00000278430.
ENST00000621182; ENSP00000479175; ENSG00000275699. [Q99706-3]
GeneIDi3805.
KEGGihsa:3805.
UCSCiuc002qhf.4. human. [Q99706-6]
uc002qhg.4. human. [Q99706-3]
uc002qhi.4. human. [Q99706-2]
uc002qhj.4. human. [Q99706-4]
uc010esd.4. human. [Q99706-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71199 mRNA. Translation: AAB49756.1.
AF034771 mRNA. Translation: AAB95164.1.
AF034772 mRNA. Translation: AAB95165.1.
AF034773 mRNA. Translation: AAB95166.1.
U73394 mRNA. Translation: AAC51146.1.
AF003123
, AF003116, AF003117, AF003118, AF003119, AF003121, AF003122, AF003120 Genomic DNA. Translation: AAB61926.1.
AF002979 mRNA. Translation: AAB71387.1.
AF002980 mRNA. Translation: AAB71388.1.
AF002981 mRNA. Translation: AAB71389.1.
AF002982 mRNA. Translation: AAB71390.1.
EU194342 mRNA. Translation: ABW73961.1.
X97229 mRNA. Translation: CAA65868.1.
X99479 mRNA. Translation: CAA67842.1.
X99480 mRNA. Translation: CAA67843.1.
X99481 mRNA. Translation: CAA67844.1.
AF110035
, AF110032, AF110033, AF110034 Genomic DNA. Translation: AAD24763.1.
AC011501 Genomic DNA. No translation available.
AL133414 Genomic DNA. Translation: CAC40708.1.
CCDSiCCDS42619.1. [Q99706-3]
RefSeqiNP_001074239.1. NM_001080770.1. [Q99706-3]
NP_002246.5. NM_002255.5.
UniGeneiHs.661219.
Hs.743945.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WYRX-ray2.80A/B24-218[»]
ProteinModelPortaliQ99706.
SMRiQ99706. Positions 30-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110006. 5 interactions.
IntActiQ99706. 2 interactions.

PTM databases

PhosphoSiteiQ99706.

Polymorphism and mutation databases

BioMutaiKIR2DL4.
DMDMi325511396.

Proteomic databases

PaxDbiQ99706.
PRIDEiQ99706.

Protocols and materials databases

DNASUi3805.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345540; ENSP00000339634; ENSG00000189013. [Q99706-3]
ENST00000357494; ENSP00000350088; ENSG00000189013. [Q99706-4]
ENST00000396293; ENSP00000379588; ENSG00000189013. [Q99706-6]
ENST00000611022; ENSP00000484469; ENSG00000274232. [Q99706-3]
ENST00000612573; ENSP00000482206; ENSG00000275456.
ENST00000612660; ENSP00000479179; ENSG00000275317.
ENST00000613053; ENSP00000484389; ENSG00000277362.
ENST00000614653; ENSP00000478362; ENSG00000277750.
ENST00000614680; ENSP00000477984; ENSG00000273575. [Q99706-3]
ENST00000615232; ENSP00000479874; ENSG00000274232. [Q99706-6]
ENST00000615243; ENSP00000482454; ENSG00000274232. [Q99706-4]
ENST00000615970; ENSP00000477887; ENSG00000278271.
ENST00000616354; ENSP00000483782; ENSG00000278430.
ENST00000616384; ENSP00000479347; ENSG00000276044. [Q99706-3]
ENST00000618297; ENSP00000477886; ENSG00000278074.
ENST00000618358; ENSP00000483101; ENSG00000274609.
ENST00000618567; ENSP00000482383; ENSG00000276779.
ENST00000619637; ENSP00000478491; ENSG00000274955.
ENST00000619848; ENSP00000480801; ENSG00000277964.
ENST00000620484; ENSP00000477601; ENSG00000275317.
ENST00000620486; ENSP00000482452; ENSG00000278430.
ENST00000621182; ENSP00000479175; ENSG00000275699. [Q99706-3]
GeneIDi3805.
KEGGihsa:3805.
UCSCiuc002qhf.4. human. [Q99706-6]
uc002qhg.4. human. [Q99706-3]
uc002qhi.4. human. [Q99706-2]
uc002qhj.4. human. [Q99706-4]
uc010esd.4. human. [Q99706-1]

Organism-specific databases

CTDi3805.
GeneCardsiGC19P055276.
HGNCiHGNC:6332. KIR2DL4.
MIMi604945. gene.
neXtProtiNX_Q99706.
PharmGKBiPA30117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25862.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiQ99706.
KOiK07981.
OrthoDBiEOG7H792J.
TreeFamiTF352669.

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiKIR2DL4.
GenomeRNAii3805.
NextBioi14949.
PROiQ99706.
SOURCEiSearch...

Gene expression databases

BgeeiQ99706.
ExpressionAtlasiQ99706. baseline and differential.
GenevisibleiQ99706. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains."
    Selvakumar A., Steffens U., Dupont B.
    Tissue Antigens 48:285-294(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-87; THR-138; ALA-209 AND HIS-371.
  2. "Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors."
    Valiante N.M., Uhrberg M., Shilling H.G., Lienert-Weidenbach K., Arnett K.L., D'Andrea A., Phillips J.H., Lanier L.L., Parham P.
    Immunity 7:739-751(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS CYS-53; THR-138; ALA-209; ASN-271 AND HIS-371.
  3. "Polymorphism and domain variability of human killer cell inhibitory receptors."
    Selvakumar A., Steffens U., Dupont B.
    Immunol. Rev. 155:183-196(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS LEU-87; THR-138; ALA-209 AND HIS-371.
  4. "Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103."
    Selvakumar A., Steffens U., Palanisamy N., Chaganti R.S.K., Dupont B.
    Tissue Antigens 49:564-573(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 3; 4 AND 5), VARIANTS LEU-87; THR-138; ALA-209; ASN-271 AND HIS-371.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE KIR2DL4*0501), VARIANT CYS-53.
  6. Biassoni R.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 6), VARIANTS THR-138; ALA-209 AND ASN-271.
    Tissue: Lymphoid tissue.
  7. "Exon deletion contributes to structural diversity of 2DL4 killer inhibitory receptors."
    Chan H.W., Salter R.D.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-53 AND ASN-271.
  8. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
    Yu M.-C., Su L.-L., Zou L., Liu Y., Wu N., Kong L., Zhuang Z.-H., Sun L., Liu H.P., Hu J.-H., Li D., Strominger J.L., Zang J.-W., Pei G., Ge B.-X.
    Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB2.

Entry informationi

Entry nameiKI2L4_HUMAN
AccessioniPrimary (citable) accession number: Q99706
Secondary accession number(s): A8W795
, O14621, O14622, O14623, O14624, O43534, P78400, P78401, Q8N738, Q99559, Q99560, Q99561, Q99562, Q9UQJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: March 8, 2011
Last modified: July 22, 2015
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.