ID MCHR1_HUMAN Reviewed; 353 AA. AC Q99705; B2RBX6; Q5R3J1; Q96S47; Q9BV08; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 24-JAN-2024, sequence version 3. DT 27-MAR-2024, entry version 191. DE RecName: Full=Melanin-concentrating hormone receptor 1 {ECO:0000305|PubMed:10421367}; DE Short=MCH receptor 1; DE Short=MCH-R1; DE Short=MCHR-1; DE AltName: Full=G-protein coupled receptor 24; DE AltName: Full=MCH-1R; DE Short=MCH1R; DE Short=MCHR; DE AltName: Full=SLC-1; DE AltName: Full=Somatostatin receptor-like protein; GN Name=MCHR1 {ECO:0000312|HGNC:HGNC:4479}; Synonyms=GPR24, SLC1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=10441476; DOI=10.1006/bbrc.1999.1104; RA Shimomura Y., Mori M., Sugo T., Ishibashi Y., Abe M., Kurokawa T., Onda H., RA Nishimura O., Sumino Y., Fujino M.; RT "Isolation and identification of melanin-concentrating hormone as the RT endogenous ligand of the SLC-1 receptor."; RL Biochem. Biophys. Res. Commun. 261:622-626(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS HIS-141; MET-236; GLN-248; SER-308 RP AND MET-342. RX PubMed=15941924; DOI=10.1530/eje.1.01917; RA Wermter A.-K., Reichwald K., Buech T., Geller F., Platzer C., Huse K., RA Hess C., Remschmidt H., Gudermann T., Preibisch G., Siegfried W., RA Goldschmidt H.-P., Li W.-D., Price R.A., Biebermann H., Krude H., RA Vollmert C., Wichmann H.-E., Illig T., Soerensen T.I.A., Astrup A., RA Larsen L.H., Pedersen O., Eberle D., Clement K., Blundell J., Wabitsch M., RA Schaefer H., Platzer M., Hinney A., Hebebrand J.; RT "Mutation analysis of the MCHR1 gene in human obesity."; RL Eur. J. Endocrinol. 152:851-862(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84; RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., RA Beare D.M., Dunham I.; RT "A genome annotation-driven approach to cloning the human ORFeome."; RL Genome Biol. 5:R84.1-R84.11(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RA King M.M., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction sequenced by RT the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., RA Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [10] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-353. RX PubMed=8977118; DOI=10.1016/s0014-5793(96)01160-x; RA Kolakowski L.F. Jr., Jung B.P., Nguyen T., Johnson M.P., Lynch K.R., RA Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.; RT "Characterization of a human gene related to genes encoding somatostatin RT receptors."; RL FEBS Lett. 398:253-258(1996). RN [11] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=10421367; DOI=10.1038/22313; RA Chambers J., Ames R.S., Bergsma D., Muir A., Fitzgerald L.R., Hervieu G., RA Dytko G.M., Foley J.J., Martin J., Liu W.S., Park J., Ellis C., Ganguly S., RA Konchar S., Cluderay J., Leslie R., Wilson S., Sarau H.M.; RT "Melanin-concentrating hormone is the cognate ligand for the orphan G- RT protein-coupled receptor SLC-1."; RL Nature 400:261-265(1999). RN [12] RP INTERACTION WITH NCDN. RX PubMed=16945926; DOI=10.1074/jbc.m602889200; RA Francke F., Ward R.J., Jenkins L., Kellett E., Richter D., Milligan G., RA Baechner D.; RT "Interaction of neurochondrin with the melanin-concentrating hormone RT receptor 1 interferes with G protein-coupled signal transduction but not RT agonist-mediated internalization."; RL J. Biol. Chem. 281:32496-32507(2006). RN [13] RP VARIANTS HIS-181 AND GLN-248. RX PubMed=15166293; DOI=10.1038/oby.2004.89; RA Gibson W.T., Pissios P., Trombly D.J., Luan J., Keogh J., Wareham N.J., RA Maratos-Flier E., O'Rahilly S., Farooqi I.S.; RT "Melanin-concentrating hormone receptor mutations and human obesity: RT functional analysis."; RL Obes. Res. 12:743-749(2004). RN [14] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=15340116; DOI=10.1038/oby.2004.167; RA Hawes B.E., Green B., O'Neill K., Fried S., Arreaza M.G., Qiu P., RA Simon J.S.; RT "Identification and characterization of single-nucleotide polymorphisms in RT MCH-R1 and MCH-R2."; RL Obes. Res. 12:1327-1334(2004). CC -!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to both G CC proteins that inhibit adenylyl cyclase and G proteins that activate CC phosphoinositide hydrolysis. {ECO:0000269|PubMed:10421367, CC ECO:0000269|PubMed:15340116}. CC -!- SUBUNIT: Interacts with NCDN. {ECO:0000269|PubMed:16945926}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:10421367, CC ECO:0000305|PubMed:15340116}; Multi-pass membrane protein CC {ECO:0000255}. CC -!- TISSUE SPECIFICITY: Highest level in brain, particularly in the frontal CC cortex and hypothalamus, lower levels in the liver and heart. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- SEQUENCE CAUTION: CC Sequence=AAC14587.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=AAH01736.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAH21146.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAO14670.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAP35371.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAS72373.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAB60890.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAG37373.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=CAG30383.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=EAW60388.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB063174; BAB60890.1; ALT_INIT; mRNA. DR EMBL; AF490537; AAO14670.1; ALT_INIT; mRNA. DR EMBL; CR456497; CAG30383.1; ALT_INIT; mRNA. DR EMBL; BT006725; AAP35371.1; ALT_INIT; mRNA. DR EMBL; AY562945; AAS72373.1; ALT_INIT; mRNA. DR EMBL; AK314857; BAG37373.1; ALT_INIT; mRNA. DR EMBL; Z86090; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471095; EAW60388.1; ALT_INIT; Genomic_DNA. DR EMBL; BC001736; AAH01736.1; ALT_INIT; mRNA. DR EMBL; BC021146; AAH21146.1; ALT_INIT; mRNA. DR EMBL; U71092; AAC14587.1; ALT_SEQ; Genomic_DNA. DR PIR; JC7080; JC7080. DR RefSeq; NP_005288.3; NM_005297.3. DR AlphaFoldDB; Q99705; -. DR SMR; Q99705; -. DR IntAct; Q99705; 1. DR STRING; 9606.ENSP00000249016; -. DR BindingDB; Q99705; -. DR ChEMBL; CHEMBL344; -. DR DrugBank; DB00502; Haloperidol. DR GuidetoPHARMACOLOGY; 280; -. DR TCDB; 9.A.14.13.6; the g-protein-coupled receptor (gpcr) family. DR GlyCosmos; Q99705; 3 sites, No reported glycans. DR GlyGen; Q99705; 3 sites. DR iPTMnet; Q99705; -. DR PhosphoSitePlus; Q99705; -. DR BioMuta; MCHR1; -. DR DMDM; 33860175; -. DR MassIVE; Q99705; -. DR PaxDb; 9606-ENSP00000249016; -. DR PeptideAtlas; Q99705; -. DR Antibodypedia; 300; 350 antibodies from 33 providers. DR DNASU; 2847; -. DR Ensembl; ENST00000249016.5; ENSP00000249016.5; ENSG00000128285.5. DR GeneID; 2847; -. DR KEGG; hsa:2847; -. DR MANE-Select; ENST00000249016.5; ENSP00000249016.5; NM_005297.4; NP_005288.4. DR UCSC; uc003ayz.4; human. DR AGR; HGNC:4479; -. DR CTD; 2847; -. DR DisGeNET; 2847; -. DR GeneCards; MCHR1; -. DR HGNC; HGNC:4479; MCHR1. DR HPA; ENSG00000128285; Tissue enhanced (brain, ovary). DR MIM; 601751; gene. DR neXtProt; NX_Q99705; -. DR OpenTargets; ENSG00000128285; -. DR PharmGKB; PA28867; -. DR VEuPathDB; HostDB:ENSG00000128285; -. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT00940000154272; -. DR HOGENOM; CLU_009579_8_1_1; -. DR InParanoid; Q99705; -. DR OMA; KSKFHGC; -. DR OrthoDB; 5393360at2759; -. DR PhylomeDB; Q99705; -. DR TreeFam; TF315737; -. DR PathwayCommons; Q99705; -. DR Reactome; R-HSA-375276; Peptide ligand-binding receptors. DR Reactome; R-HSA-416476; G alpha (q) signalling events. DR Reactome; R-HSA-418594; G alpha (i) signalling events. DR Reactome; R-HSA-5620922; BBSome-mediated cargo-targeting to cilium. DR SignaLink; Q99705; -. DR SIGNOR; Q99705; -. DR BioGRID-ORCS; 2847; 11 hits in 1140 CRISPR screens. DR ChiTaRS; MCHR1; human. DR GeneWiki; Melanin-concentrating_hormone_receptor_1; -. DR GenomeRNAi; 2847; -. DR Pharos; Q99705; Tchem. DR PRO; PR:Q99705; -. DR Proteomes; UP000005640; Chromosome 22. DR RNAct; Q99705; Protein. DR Bgee; ENSG00000128285; Expressed in endothelial cell and 114 other cell types or tissues. DR ExpressionAtlas; Q99705; baseline and differential. DR GO; GO:0060170; C:ciliary membrane; IEA:Ensembl. DR GO; GO:0005929; C:cilium; IDA:MGI. DR GO; GO:0043005; C:neuron projection; IBA:GO_Central. DR GO; GO:0097730; C:non-motile cilium; ISS:BHF-UCL. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central. DR GO; GO:0042562; F:hormone binding; IEA:Ensembl. DR GO; GO:0030273; F:melanin-concentrating hormone receptor activity; IEA:Ensembl. DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central. DR GO; GO:0008188; F:neuropeptide receptor activity; TAS:ProtInc. DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl. DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; TAS:ProtInc. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl. DR GO; GO:0007631; P:feeding behavior; TAS:ProtInc. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc. DR GO; GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc. DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central. DR GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc. DR CDD; cd15338; 7tmA_MCHR1; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR008361; MCH_rcpt. DR InterPro; IPR004047; MCHR1. DR PANTHER; PTHR24229:SF91; MELANIN-CONCENTRATING HORMONE RECEPTOR 1; 1. DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01507; MCH1RECEPTOR. DR PRINTS; PR01783; MCHRECEPTOR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; Q99705; HS. PE 1: Evidence at protein level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..353 FT /note="Melanin-concentrating hormone receptor 1" FT /id="PRO_0000069734" FT TOPO_DOM 1..44 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 45..67 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 68..79 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 80..102 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 103..116 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 117..139 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 140..158 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 159..181 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 182..209 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 210..232 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 233..252 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 253..275 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 276..289 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 290..312 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 313..353 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 1..29 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 9..29 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 13 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 16 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 23 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 116..194 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 34 FT /note="G -> R (in dbSNP:rs11914085)" FT /id="VAR_049417" FT VARIANT 141 FT /note="R -> H (in dbSNP:rs750210146)" FT /evidence="ECO:0000269|PubMed:15941924" FT /id="VAR_026655" FT VARIANT 181 FT /note="Y -> H" FT /evidence="ECO:0000269|PubMed:15166293" FT /id="VAR_026656" FT VARIANT 236 FT /note="T -> M (in dbSNP:rs550313335)" FT /evidence="ECO:0000269|PubMed:15941924" FT /id="VAR_026657" FT VARIANT 248 FT /note="R -> Q (in dbSNP:rs45439291)" FT /evidence="ECO:0000269|PubMed:15166293, FT ECO:0000269|PubMed:15941924" FT /id="VAR_026658" FT VARIANT 308 FT /note="P -> S (in dbSNP:rs539260735)" FT /evidence="ECO:0000269|PubMed:15941924" FT /id="VAR_026659" FT VARIANT 342 FT /note="T -> M (in dbSNP:rs149604804)" FT /evidence="ECO:0000269|PubMed:15941924" FT /id="VAR_026660" SQ SEQUENCE 353 AA; 38940 MW; 0C7D692C92667EDC CRC64; MDLEASLLPT GPNASNTSDG PDNLTSAGSP PRTGSISYIN IIMPSVFGTI CLLGIIGNST VIFAVVKKSK LHWCNNVPDI FIINLSVVDL LFLLGMPFMI HQLMGNGVWH FGETMCTLIT AMDANSQFTS TYILTAMAID RYLATVHPIS STKFRKPSVA TLVICLLWAL SFISITPVWL YARLIPFPGG AVGCGIRLPN PDTDLYWFTL YQFFLAFALP FVVITAAYVR ILQRMTSSVA PASQRSIRLR TKRVTRTAIA ICLVFFVCWA PYYVLQLTQL SISRPTLTFV YLYNAAISLG YANSCLNPFV YIVLCETFRK RLVLSVKPAA QGQLRAVSNA QTADEERTES KGT //