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Protein

Melanin-concentrating hormone receptor 1

Gene

MCHR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.1 Publication

Caution

It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • hormone binding Source: Ensembl
  • melanin-concentrating hormone receptor activity Source: GO_Central
  • neuropeptide receptor activity Source: ProtInc
  • protein C-terminus binding Source: Ensembl
  • signaling receptor binding Source: Ensembl

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
  • cell surface receptor signaling pathway Source: Ensembl
  • chemical synaptic transmission Source: GO_Central
  • feeding behavior Source: ProtInc
  • generation of precursor metabolites and energy Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • positive regulation of calcium ion transport Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
SIGNORiQ99705

Protein family/group databases

TCDBi9.A.14.13.6 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
SLC-1
Somatostatin receptor-like protein
Gene namesi
Name:MCHR1
Synonyms:GPR24, SLC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128285.4
HGNCiHGNC:4479 MCHR1
MIMi601751 gene
neXtProtiNX_Q99705

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 113ExtracellularSequence analysisAdd BLAST113
Transmembranei114 – 136Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini137 – 148CytoplasmicSequence analysisAdd BLAST12
Transmembranei149 – 171Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini172 – 185ExtracellularSequence analysisAdd BLAST14
Transmembranei186 – 208Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini209 – 227CytoplasmicSequence analysisAdd BLAST19
Transmembranei228 – 250Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini251 – 278ExtracellularSequence analysisAdd BLAST28
Transmembranei279 – 301Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini302 – 321CytoplasmicSequence analysisAdd BLAST20
Transmembranei322 – 344Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini345 – 358ExtracellularSequence analysisAdd BLAST14
Transmembranei359 – 381Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini382 – 422CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2847
OpenTargetsiENSG00000128285
PharmGKBiPA28867

Chemistry databases

ChEMBLiCHEMBL344
GuidetoPHARMACOLOGYi280

Polymorphism and mutation databases

BioMutaiMCHR1
DMDMi33860175

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697341 – 422Melanin-concentrating hormone receptor 1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99705
PeptideAtlasiQ99705
PRIDEiQ99705
ProteomicsDBi78416

PTM databases

iPTMnetiQ99705
PhosphoSitePlusiQ99705

Expressioni

Tissue specificityi

Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

Gene expression databases

BgeeiENSG00000128285
CleanExiHS_MCHR1
ExpressionAtlasiQ99705 baseline and differential
GenevisibleiQ99705 HS

Interactioni

Subunit structurei

Interacts with NCDN.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000249016

Chemistry databases

BindingDBiQ99705

Structurei

3D structure databases

ProteinModelPortaliQ99705
SMRiQ99705
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000000704
HOVERGENiHBG105726
InParanoidiQ99705
KOiK04320
OMAiTSTYILT
OrthoDBiEOG091G0HEN
PhylomeDBiQ99705
TreeFamiTF315737

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004047 MCH1_rcpt
IPR008361 MCH_rcpt
PANTHERiPTHR44627 PTHR44627, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01507 MCH1RECEPTOR
PR01783 MCHRECEPTOR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP
60 70 80 90 100
AWVEGSSARL WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP
110 120 130 140 150
RTGSISYINI IMPSVFGTIC LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF
160 170 180 190 200
IINLSVVDLL FLLGMPFMIH QLMGNGVWHF GETMCTLITA MDANSQFTST
210 220 230 240 250
YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS FISITPVWLY
260 270 280 290 300
ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI
310 320 330 340 350
LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS
360 370 380 390 400
ISRPTLTFVY LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ
410 420
GQLRAVSNAQ TADEERTESK GT
Length:422
Mass (Da):45,963
Last modified:August 15, 2003 - v2
Checksum:i3986919A18183818
GO

Sequence cautioni

The sequence AAC14587 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02665225T → M1 PublicationCorresponds to variant dbSNP:rs117372135Ensembl.1
Natural variantiVAR_02665328D → V1 PublicationCorresponds to variant dbSNP:rs112405400Ensembl.1
Natural variantiVAR_01622132N → D No significant functional differences. 7 PublicationsCorresponds to variant dbSNP:rs133072Ensembl.1
Natural variantiVAR_02665434G → R No changes in receptor binding or functional signaling. 1 Publication1
Natural variantiVAR_049417103G → R. Corresponds to variant dbSNP:rs11914085Ensembl.1
Natural variantiVAR_026655210R → H1 PublicationCorresponds to variant dbSNP:rs750210146Ensembl.1
Natural variantiVAR_026656250Y → H1 Publication1
Natural variantiVAR_026657305T → M1 PublicationCorresponds to variant dbSNP:rs550313335Ensembl.1
Natural variantiVAR_026658317R → Q2 PublicationsCorresponds to variant dbSNP:rs45439291Ensembl.1
Natural variantiVAR_026659377P → S1 PublicationCorresponds to variant dbSNP:rs539260735Ensembl.1
Natural variantiVAR_026660411T → M1 PublicationCorresponds to variant dbSNP:rs149604804Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063174 mRNA Translation: BAB60890.1
AF490537 mRNA Translation: AAO14670.1
CR456497 mRNA Translation: CAG30383.1
BT006725 mRNA Translation: AAP35371.1
AY562945 mRNA Translation: AAS72373.1
AK314857 mRNA Translation: BAG37373.1
Z86090 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60388.1
BC001736 mRNA Translation: AAH01736.1
BC021146 mRNA Translation: AAH21146.1
U71092 Genomic DNA Translation: AAC14587.1 Sequence problems.
CCDSiCCDS14004.1
PIRiJC7080
RefSeqiNP_005288.3, NM_005297.3
UniGeneiHs.248122

Genome annotation databases

EnsembliENST00000249016; ENSP00000249016; ENSG00000128285
GeneIDi2847
KEGGihsa:2847
UCSCiuc003ayz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMCHR1_HUMAN
AccessioniPrimary (citable) accession number: Q99705
Secondary accession number(s): B2RBX6
, Q5R3J1, Q96S47, Q9BV08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: June 20, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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