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Q99705 (MCHR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melanin-concentrating hormone receptor 1

Short name=MCH receptor 1
Short name=MCH-R1
Short name=MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name=MCH1R
Short name=MCHR
SLC-1
Somatostatin receptor-like protein
Gene names
Name:MCHR1
Synonyms:GPR24, SLC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Ref.11

Subunit structure

Interacts with NCDN. Ref.12

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.

Sequence caution

The sequence AAC14587.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 10421368. Source: ProtInc

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Traceable author statement Ref.11. Source: ProtInc

feeding behavior

Traceable author statement Ref.11. Source: ProtInc

generation of precursor metabolites and energy

Traceable author statement Ref.11. Source: ProtInc

positive regulation of calcium ion transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Traceable author statement Ref.11. Source: ProtInc

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.11. Source: ProtInc

nonmotile primary cilium

Inferred from sequence or structural similarity. Source: BHF-UCL

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionG-protein coupled receptor activity

Traceable author statement Ref.11. Source: ProtInc

hormone binding

Inferred from electronic annotation. Source: Ensembl

melanin-concentrating hormone receptor activity

Inferred from electronic annotation. Source: Ensembl

neuropeptide receptor activity

Traceable author statement PubMed 10860944. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Melanin-concentrating hormone receptor 1
PRO_0000069734

Regions

Topological domain1 – 113113Extracellular Potential
Transmembrane114 – 13623Helical; Name=1; Potential
Topological domain137 – 14812Cytoplasmic Potential
Transmembrane149 – 17123Helical; Name=2; Potential
Topological domain172 – 18514Extracellular Potential
Transmembrane186 – 20823Helical; Name=3; Potential
Topological domain209 – 22719Cytoplasmic Potential
Transmembrane228 – 25023Helical; Name=4; Potential
Topological domain251 – 27828Extracellular Potential
Transmembrane279 – 30123Helical; Name=5; Potential
Topological domain302 – 32120Cytoplasmic Potential
Transmembrane322 – 34423Helical; Name=6; Potential
Topological domain345 – 35814Extracellular Potential
Transmembrane359 – 38123Helical; Name=7; Potential
Topological domain382 – 42241Cytoplasmic Potential

Amino acid modifications

Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation851N-linked (GlcNAc...) Potential
Glycosylation921N-linked (GlcNAc...) Potential

Natural variations

Natural variant251T → M. Ref.2
Corresponds to variant rs117372135 [ dbSNP | Ensembl ].
VAR_026652
Natural variant281D → V. Ref.2
Corresponds to variant rs112405400 [ dbSNP | Ensembl ].
VAR_026653
Natural variant321N → D No significant functional differences. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.8 Ref.9
Corresponds to variant rs133072 [ dbSNP | Ensembl ].
VAR_016221
Natural variant341G → R No changes in receptor binding or functional signaling. Ref.14
VAR_026654
Natural variant1031G → R.
Corresponds to variant rs11914085 [ dbSNP | Ensembl ].
VAR_049417
Natural variant2101R → H. Ref.2
VAR_026655
Natural variant2501Y → H. Ref.13
VAR_026656
Natural variant3051T → M. Ref.2
VAR_026657
Natural variant3171R → Q. Ref.2 Ref.13
Corresponds to variant rs45439291 [ dbSNP | Ensembl ].
VAR_026658
Natural variant3771P → S. Ref.2
VAR_026659
Natural variant4111T → M. Ref.2
Corresponds to variant rs149604804 [ dbSNP | Ensembl ].
VAR_026660

Sequences

Sequence LengthMass (Da)Tools
Q99705 [UniParc].

Last modified August 15, 2003. Version 2.
Checksum: 3986919A18183818

FASTA42245,963
        10         20         30         40         50         60 
MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP AWVEGSSARL 

        70         80         90        100        110        120 
WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP RTGSISYINI IMPSVFGTIC 

       130        140        150        160        170        180 
LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF IINLSVVDLL FLLGMPFMIH QLMGNGVWHF 

       190        200        210        220        230        240 
GETMCTLITA MDANSQFTST YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS 

       250        260        270        280        290        300 
FISITPVWLY ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI 

       310        320        330        340        350        360 
LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS ISRPTLTFVY 

       370        380        390        400        410        420 
LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ GQLRAVSNAQ TADEERTESK 


GT 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor."
Shimomura Y., Mori M., Sugo T., Ishibashi Y., Abe M., Kurokawa T., Onda H., Nishimura O., Sumino Y., Fujino M.
Biochem. Biophys. Res. Commun. 261:622-626(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Mutation analysis of the MCHR1 gene in human obesity."
Wermter A.-K., Reichwald K., Buech T., Geller F., Platzer C., Huse K., Hess C., Remschmidt H., Gudermann T., Preibisch G., Siegfried W., Goldschmidt H.-P., Li W.-D., Price R.A., Biebermann H., Krude H., Vollmert C., Wichmann H.-E. expand/collapse author list , Illig T., Soerensen T.I.A., Astrup A., Larsen L.H., Pedersen O., Eberle D., Clement K., Blundell J., Wabitsch M., Schaefer H., Platzer M., Hinney A., Hebebrand J.
Eur. J. Endocrinol. 152:851-862(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-25; VAL-28; ASP-32; HIS-210; MET-305; GLN-317; SER-377 AND MET-411, CHARACTERIZATION OF VARIANT ASP-32.
[3]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
King M.M., Aronstam R.S., Sharma S.V.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
Tissue: Brain.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
Tissue: Brain.
[7]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-32.
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
Tissue: Brain.
[10]"Characterization of a human gene related to genes encoding somatostatin receptors."
Kolakowski L.F. Jr., Jung B.P., Nguyen T., Johnson M.P., Lynch K.R., Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.
FEBS Lett. 398:253-258(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-422.
[11]"Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1."
Chambers J., Ames R.S., Bergsma D., Muir A., Fitzgerald L.R., Hervieu G., Dytko G.M., Foley J.J., Martin J., Liu W.S., Park J., Ellis C., Ganguly S., Konchar S., Cluderay J., Leslie R., Wilson S., Sarau H.M.
Nature 400:261-265(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization."
Francke F., Ward R.J., Jenkins L., Kellett E., Richter D., Milligan G., Baechner D.
J. Biol. Chem. 281:32496-32507(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NCDN.
[13]"Melanin-concentrating hormone receptor mutations and human obesity: functional analysis."
Gibson W.T., Pissios P., Trombly D.J., Luan J., Keogh J., Wareham N.J., Maratos-Flier E., O'Rahilly S., Farooqi I.S.
Obes. Res. 12:743-749(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS HIS-250 AND GLN-317, CHARACTERIZATION OF VARIANT GLN-317.
[14]"Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2."
Hawes B.E., Green B., O'Neill K., Fried S., Arreaza M.G., Qiu P., Simon J.S.
Obes. Res. 12:1327-1334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ARG-34, CHARACTERIZATION OF VARIANT ARG-34.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB063174 mRNA. Translation: BAB60890.1.
AF490537 mRNA. Translation: AAO14670.1.
CR456497 mRNA. Translation: CAG30383.1.
BT006725 mRNA. Translation: AAP35371.1.
AY562945 mRNA. Translation: AAS72373.1.
AK314857 mRNA. Translation: BAG37373.1.
Z86090 Genomic DNA. Translation: CAI17933.1.
CH471095 Genomic DNA. Translation: EAW60388.1.
BC001736 mRNA. Translation: AAH01736.1.
BC021146 mRNA. Translation: AAH21146.1.
U71092 Genomic DNA. Translation: AAC14587.1. Sequence problems.
PIRJC7080.
RefSeqNP_005288.3. NM_005297.3.
UniGeneHs.248122.

3D structure databases

ProteinModelPortalQ99705.
SMRQ99705. Positions 101-389.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000249016.

Chemistry

BindingDBQ99705.
ChEMBLCHEMBL344.
GuidetoPHARMACOLOGY280.

Protein family/group databases

TCDB9.A.14.13.6. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteQ99705.

Polymorphism databases

DMDM33860175.

Proteomic databases

PaxDbQ99705.
PRIDEQ99705.

Protocols and materials databases

DNASU2847.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000249016; ENSP00000249016; ENSG00000128285.
GeneID2847.
KEGGhsa:2847.
UCSCuc003ayz.3. human.

Organism-specific databases

CTD2847.
GeneCardsGC22P041074.
HGNCHGNC:4479. MCHR1.
HPAHPA004149.
MIM601751. gene.
neXtProtNX_Q99705.
PharmGKBPA28867.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282817.
HOGENOMHOG000000704.
HOVERGENHBG105726.
InParanoidQ99705.
KOK04320.
OMAITPVWLY.
OrthoDBEOG7BKCVQ.
PhylomeDBQ99705.
TreeFamTF315737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ99705.
BgeeQ99705.
CleanExHS_MCHR1.
GenevestigatorQ99705.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMelanin-concentrating_hormone_receptor_1.
GenomeRNAi2847.
NextBio11231.
PROQ99705.
SOURCESearch...

Entry information

Entry nameMCHR1_HUMAN
AccessionPrimary (citable) accession number: Q99705
Secondary accession number(s): B2RBX6 expand/collapse secondary AC list , Q5R3J1, Q96S47, Q9BV08
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: April 16, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries