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Q99705

- MCHR1_HUMAN

UniProt

Q99705 - MCHR1_HUMAN

Protein

Melanin-concentrating hormone receptor 1

Gene

MCHR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (15 Aug 2003)
      Previous versions | rss
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    Functioni

    Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. hormone binding Source: Ensembl
    3. melanin-concentrating hormone receptor activity Source: Ensembl
    4. neuropeptide receptor activity Source: ProtInc

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
    2. feeding behavior Source: ProtInc
    3. generation of precursor metabolites and energy Source: ProtInc
    4. G-protein coupled receptor signaling pathway Source: ProtInc
    5. positive regulation of calcium ion transport Source: Ensembl
    6. positive regulation of cytosolic calcium ion concentration Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Protein family/group databases

    TCDBi9.A.14.13.6. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanin-concentrating hormone receptor 1
    Short name:
    MCH receptor 1
    Short name:
    MCH-R1
    Short name:
    MCHR-1
    Alternative name(s):
    G-protein coupled receptor 24
    MCH-1R
    Short name:
    MCH1R
    Short name:
    MCHR
    SLC-1
    Somatostatin receptor-like protein
    Gene namesi
    Name:MCHR1
    Synonyms:GPR24, SLC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:4479. MCHR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. nonmotile primary cilium Source: BHF-UCL
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28867.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Melanin-concentrating hormone receptor 1PRO_0000069734Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ99705.
    PRIDEiQ99705.

    PTM databases

    PhosphoSiteiQ99705.

    Expressioni

    Tissue specificityi

    Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

    Gene expression databases

    ArrayExpressiQ99705.
    BgeeiQ99705.
    CleanExiHS_MCHR1.
    GenevestigatoriQ99705.

    Organism-specific databases

    HPAiHPA004149.

    Interactioni

    Subunit structurei

    Interacts with NCDN.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000249016.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99705.
    SMRiQ99705. Positions 97-389.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 113113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 14812CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 18514ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 22719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 27828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini302 – 32120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini345 – 35814ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini382 – 42241CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei114 – 13623Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei149 – 17123Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei186 – 20823Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei228 – 25023Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei279 – 30123Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei322 – 34423Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei359 – 38123Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG282817.
    HOGENOMiHOG000000704.
    HOVERGENiHBG105726.
    InParanoidiQ99705.
    KOiK04320.
    OMAiITPVWLY.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiQ99705.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004047. MCH1_rcpt.
    IPR008361. MCH_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01507. MCH1RECEPTOR.
    PR01783. MCHRECEPTOR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99705-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP    50
    AWVEGSSARL WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP 100
    RTGSISYINI IMPSVFGTIC LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF 150
    IINLSVVDLL FLLGMPFMIH QLMGNGVWHF GETMCTLITA MDANSQFTST 200
    YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS FISITPVWLY 250
    ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI 300
    LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS 350
    ISRPTLTFVY LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ 400
    GQLRAVSNAQ TADEERTESK GT 422
    Length:422
    Mass (Da):45,963
    Last modified:August 15, 2003 - v2
    Checksum:i3986919A18183818
    GO

    Sequence cautioni

    The sequence AAC14587.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251T → M.1 Publication
    Corresponds to variant rs117372135 [ dbSNP | Ensembl ].
    VAR_026652
    Natural varianti28 – 281D → V.1 Publication
    Corresponds to variant rs112405400 [ dbSNP | Ensembl ].
    VAR_026653
    Natural varianti32 – 321N → D No significant functional differences. 7 Publications
    Corresponds to variant rs133072 [ dbSNP | Ensembl ].
    VAR_016221
    Natural varianti34 – 341G → R No changes in receptor binding or functional signaling. 1 Publication
    VAR_026654
    Natural varianti103 – 1031G → R.
    Corresponds to variant rs11914085 [ dbSNP | Ensembl ].
    VAR_049417
    Natural varianti210 – 2101R → H.1 Publication
    VAR_026655
    Natural varianti250 – 2501Y → H.1 Publication
    VAR_026656
    Natural varianti305 – 3051T → M.1 Publication
    VAR_026657
    Natural varianti317 – 3171R → Q.2 Publications
    Corresponds to variant rs45439291 [ dbSNP | Ensembl ].
    VAR_026658
    Natural varianti377 – 3771P → S.1 Publication
    VAR_026659
    Natural varianti411 – 4111T → M.1 Publication
    Corresponds to variant rs149604804 [ dbSNP | Ensembl ].
    VAR_026660

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB063174 mRNA. Translation: BAB60890.1.
    AF490537 mRNA. Translation: AAO14670.1.
    CR456497 mRNA. Translation: CAG30383.1.
    BT006725 mRNA. Translation: AAP35371.1.
    AY562945 mRNA. Translation: AAS72373.1.
    AK314857 mRNA. Translation: BAG37373.1.
    Z86090 Genomic DNA. Translation: CAI17933.1.
    CH471095 Genomic DNA. Translation: EAW60388.1.
    BC001736 mRNA. Translation: AAH01736.1.
    BC021146 mRNA. Translation: AAH21146.1.
    U71092 Genomic DNA. Translation: AAC14587.1. Sequence problems.
    CCDSiCCDS14004.1.
    PIRiJC7080.
    RefSeqiNP_005288.3. NM_005297.3.
    UniGeneiHs.248122.

    Genome annotation databases

    EnsembliENST00000249016; ENSP00000249016; ENSG00000128285.
    GeneIDi2847.
    KEGGihsa:2847.
    UCSCiuc003ayz.3. human.

    Polymorphism databases

    DMDMi33860175.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB063174 mRNA. Translation: BAB60890.1 .
    AF490537 mRNA. Translation: AAO14670.1 .
    CR456497 mRNA. Translation: CAG30383.1 .
    BT006725 mRNA. Translation: AAP35371.1 .
    AY562945 mRNA. Translation: AAS72373.1 .
    AK314857 mRNA. Translation: BAG37373.1 .
    Z86090 Genomic DNA. Translation: CAI17933.1 .
    CH471095 Genomic DNA. Translation: EAW60388.1 .
    BC001736 mRNA. Translation: AAH01736.1 .
    BC021146 mRNA. Translation: AAH21146.1 .
    U71092 Genomic DNA. Translation: AAC14587.1 . Sequence problems.
    CCDSi CCDS14004.1.
    PIRi JC7080.
    RefSeqi NP_005288.3. NM_005297.3.
    UniGenei Hs.248122.

    3D structure databases

    ProteinModelPortali Q99705.
    SMRi Q99705. Positions 97-389.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000249016.

    Chemistry

    BindingDBi Q99705.
    ChEMBLi CHEMBL2111437.
    GuidetoPHARMACOLOGYi 280.

    Protein family/group databases

    TCDBi 9.A.14.13.6. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q99705.

    Polymorphism databases

    DMDMi 33860175.

    Proteomic databases

    PaxDbi Q99705.
    PRIDEi Q99705.

    Protocols and materials databases

    DNASUi 2847.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249016 ; ENSP00000249016 ; ENSG00000128285 .
    GeneIDi 2847.
    KEGGi hsa:2847.
    UCSCi uc003ayz.3. human.

    Organism-specific databases

    CTDi 2847.
    GeneCardsi GC22P041074.
    HGNCi HGNC:4479. MCHR1.
    HPAi HPA004149.
    MIMi 601751. gene.
    neXtProti NX_Q99705.
    PharmGKBi PA28867.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282817.
    HOGENOMi HOG000000704.
    HOVERGENi HBG105726.
    InParanoidi Q99705.
    KOi K04320.
    OMAi ITPVWLY.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi Q99705.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Melanin-concentrating_hormone_receptor_1.
    GenomeRNAii 2847.
    NextBioi 11231.
    PROi Q99705.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99705.
    Bgeei Q99705.
    CleanExi HS_MCHR1.
    Genevestigatori Q99705.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004047. MCH1_rcpt.
    IPR008361. MCH_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01507. MCH1RECEPTOR.
    PR01783. MCHRECEPTOR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor."
      Shimomura Y., Mori M., Sugo T., Ishibashi Y., Abe M., Kurokawa T., Onda H., Nishimura O., Sumino Y., Fujino M.
      Biochem. Biophys. Res. Commun. 261:622-626(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-25; VAL-28; ASP-32; HIS-210; MET-305; GLN-317; SER-377 AND MET-411, CHARACTERIZATION OF VARIANT ASP-32.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
      Tissue: Brain.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
      Tissue: Brain.
    7. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-32.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
      Tissue: Brain.
    10. "Characterization of a human gene related to genes encoding somatostatin receptors."
      Kolakowski L.F. Jr., Jung B.P., Nguyen T., Johnson M.P., Lynch K.R., Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.
      FEBS Lett. 398:253-258(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-422.
    11. Cited for: FUNCTION.
    12. "Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization."
      Francke F., Ward R.J., Jenkins L., Kellett E., Richter D., Milligan G., Baechner D.
      J. Biol. Chem. 281:32496-32507(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NCDN.
    13. "Melanin-concentrating hormone receptor mutations and human obesity: functional analysis."
      Gibson W.T., Pissios P., Trombly D.J., Luan J., Keogh J., Wareham N.J., Maratos-Flier E., O'Rahilly S., Farooqi I.S.
      Obes. Res. 12:743-749(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HIS-250 AND GLN-317, CHARACTERIZATION OF VARIANT GLN-317.
    14. "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2."
      Hawes B.E., Green B., O'Neill K., Fried S., Arreaza M.G., Qiu P., Simon J.S.
      Obes. Res. 12:1327-1334(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ARG-34, CHARACTERIZATION OF VARIANT ARG-34.

    Entry informationi

    Entry nameiMCHR1_HUMAN
    AccessioniPrimary (citable) accession number: Q99705
    Secondary accession number(s): B2RBX6
    , Q5R3J1, Q96S47, Q9BV08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 15, 2003
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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