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Q99705

- MCHR1_HUMAN

UniProt

Q99705 - MCHR1_HUMAN

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Protein

Melanin-concentrating hormone receptor 1

Gene

MCHR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. hormone binding Source: Ensembl
  3. melanin-concentrating hormone receptor activity Source: Ensembl
  4. neuropeptide receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
  2. feeding behavior Source: ProtInc
  3. generation of precursor metabolites and energy Source: ProtInc
  4. G-protein coupled receptor signaling pathway Source: ProtInc
  5. positive regulation of calcium ion transport Source: Ensembl
  6. positive regulation of cytosolic calcium ion concentration Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Protein family/group databases

TCDBi9.A.14.13.6. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
SLC-1
Somatostatin receptor-like protein
Gene namesi
Name:MCHR1
Synonyms:GPR24, SLC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:4479. MCHR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 113113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13623Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini137 – 14812CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei149 – 17123Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini172 – 18514ExtracellularSequence AnalysisAdd
BLAST
Transmembranei186 – 20823Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini209 – 22719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei228 – 25023Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini251 – 27828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei279 – 30123Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini302 – 32120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei322 – 34423Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini345 – 35814ExtracellularSequence AnalysisAdd
BLAST
Transmembranei359 – 38123Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini382 – 42241CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. nonmotile primary cilium Source: BHF-UCL
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Melanin-concentrating hormone receptor 1PRO_0000069734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99705.
PRIDEiQ99705.

PTM databases

PhosphoSiteiQ99705.

Expressioni

Tissue specificityi

Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

Gene expression databases

BgeeiQ99705.
CleanExiHS_MCHR1.
ExpressionAtlasiQ99705. baseline and differential.
GenevestigatoriQ99705.

Organism-specific databases

HPAiHPA004149.

Interactioni

Subunit structurei

Interacts with NCDN.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000249016.

Structurei

3D structure databases

ProteinModelPortaliQ99705.
SMRiQ99705. Positions 97-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG282817.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ99705.
KOiK04320.
OMAiITPVWLY.
OrthoDBiEOG7BKCVQ.
PhylomeDBiQ99705.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99705-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP
60 70 80 90 100
AWVEGSSARL WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP
110 120 130 140 150
RTGSISYINI IMPSVFGTIC LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF
160 170 180 190 200
IINLSVVDLL FLLGMPFMIH QLMGNGVWHF GETMCTLITA MDANSQFTST
210 220 230 240 250
YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS FISITPVWLY
260 270 280 290 300
ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI
310 320 330 340 350
LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS
360 370 380 390 400
ISRPTLTFVY LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ
410 420
GQLRAVSNAQ TADEERTESK GT
Length:422
Mass (Da):45,963
Last modified:August 15, 2003 - v2
Checksum:i3986919A18183818
GO

Sequence cautioni

The sequence AAC14587.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251T → M.1 Publication
Corresponds to variant rs117372135 [ dbSNP | Ensembl ].
VAR_026652
Natural varianti28 – 281D → V.1 Publication
Corresponds to variant rs112405400 [ dbSNP | Ensembl ].
VAR_026653
Natural varianti32 – 321N → D No significant functional differences. 7 Publications
Corresponds to variant rs133072 [ dbSNP | Ensembl ].
VAR_016221
Natural varianti34 – 341G → R No changes in receptor binding or functional signaling. 1 Publication
VAR_026654
Natural varianti103 – 1031G → R.
Corresponds to variant rs11914085 [ dbSNP | Ensembl ].
VAR_049417
Natural varianti210 – 2101R → H.1 Publication
VAR_026655
Natural varianti250 – 2501Y → H.1 Publication
VAR_026656
Natural varianti305 – 3051T → M.1 Publication
VAR_026657
Natural varianti317 – 3171R → Q.2 Publications
Corresponds to variant rs45439291 [ dbSNP | Ensembl ].
VAR_026658
Natural varianti377 – 3771P → S.1 Publication
VAR_026659
Natural varianti411 – 4111T → M.1 Publication
Corresponds to variant rs149604804 [ dbSNP | Ensembl ].
VAR_026660

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063174 mRNA. Translation: BAB60890.1.
AF490537 mRNA. Translation: AAO14670.1.
CR456497 mRNA. Translation: CAG30383.1.
BT006725 mRNA. Translation: AAP35371.1.
AY562945 mRNA. Translation: AAS72373.1.
AK314857 mRNA. Translation: BAG37373.1.
Z86090 Genomic DNA. Translation: CAI17933.1.
CH471095 Genomic DNA. Translation: EAW60388.1.
BC001736 mRNA. Translation: AAH01736.1.
BC021146 mRNA. Translation: AAH21146.1.
U71092 Genomic DNA. Translation: AAC14587.1. Sequence problems.
CCDSiCCDS14004.1.
PIRiJC7080.
RefSeqiNP_005288.3. NM_005297.3.
UniGeneiHs.248122.

Genome annotation databases

EnsembliENST00000249016; ENSP00000249016; ENSG00000128285.
GeneIDi2847.
KEGGihsa:2847.
UCSCiuc003ayz.3. human.

Polymorphism databases

DMDMi33860175.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063174 mRNA. Translation: BAB60890.1 .
AF490537 mRNA. Translation: AAO14670.1 .
CR456497 mRNA. Translation: CAG30383.1 .
BT006725 mRNA. Translation: AAP35371.1 .
AY562945 mRNA. Translation: AAS72373.1 .
AK314857 mRNA. Translation: BAG37373.1 .
Z86090 Genomic DNA. Translation: CAI17933.1 .
CH471095 Genomic DNA. Translation: EAW60388.1 .
BC001736 mRNA. Translation: AAH01736.1 .
BC021146 mRNA. Translation: AAH21146.1 .
U71092 Genomic DNA. Translation: AAC14587.1 . Sequence problems.
CCDSi CCDS14004.1.
PIRi JC7080.
RefSeqi NP_005288.3. NM_005297.3.
UniGenei Hs.248122.

3D structure databases

ProteinModelPortali Q99705.
SMRi Q99705. Positions 97-389.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000249016.

Chemistry

BindingDBi Q99705.
ChEMBLi CHEMBL2111437.
GuidetoPHARMACOLOGYi 280.

Protein family/group databases

TCDBi 9.A.14.13.6. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei Q99705.

Polymorphism databases

DMDMi 33860175.

Proteomic databases

PaxDbi Q99705.
PRIDEi Q99705.

Protocols and materials databases

DNASUi 2847.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249016 ; ENSP00000249016 ; ENSG00000128285 .
GeneIDi 2847.
KEGGi hsa:2847.
UCSCi uc003ayz.3. human.

Organism-specific databases

CTDi 2847.
GeneCardsi GC22P041074.
HGNCi HGNC:4479. MCHR1.
HPAi HPA004149.
MIMi 601751. gene.
neXtProti NX_Q99705.
PharmGKBi PA28867.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282817.
GeneTreei ENSGT00760000118797.
HOGENOMi HOG000000704.
HOVERGENi HBG105726.
InParanoidi Q99705.
KOi K04320.
OMAi ITPVWLY.
OrthoDBi EOG7BKCVQ.
PhylomeDBi Q99705.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Melanin-concentrating_hormone_receptor_1.
GenomeRNAii 2847.
NextBioi 11231.
PROi Q99705.
SOURCEi Search...

Gene expression databases

Bgeei Q99705.
CleanExi HS_MCHR1.
ExpressionAtlasi Q99705. baseline and differential.
Genevestigatori Q99705.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor."
    Shimomura Y., Mori M., Sugo T., Ishibashi Y., Abe M., Kurokawa T., Onda H., Nishimura O., Sumino Y., Fujino M.
    Biochem. Biophys. Res. Commun. 261:622-626(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-25; VAL-28; ASP-32; HIS-210; MET-305; GLN-317; SER-377 AND MET-411, CHARACTERIZATION OF VARIANT ASP-32.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
    Tissue: Brain.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
    Tissue: Brain.
  7. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-32.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
    Tissue: Brain.
  10. "Characterization of a human gene related to genes encoding somatostatin receptors."
    Kolakowski L.F. Jr., Jung B.P., Nguyen T., Johnson M.P., Lynch K.R., Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.
    FEBS Lett. 398:253-258(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-422.
  11. Cited for: FUNCTION.
  12. "Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization."
    Francke F., Ward R.J., Jenkins L., Kellett E., Richter D., Milligan G., Baechner D.
    J. Biol. Chem. 281:32496-32507(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCDN.
  13. "Melanin-concentrating hormone receptor mutations and human obesity: functional analysis."
    Gibson W.T., Pissios P., Trombly D.J., Luan J., Keogh J., Wareham N.J., Maratos-Flier E., O'Rahilly S., Farooqi I.S.
    Obes. Res. 12:743-749(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HIS-250 AND GLN-317, CHARACTERIZATION OF VARIANT GLN-317.
  14. "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2."
    Hawes B.E., Green B., O'Neill K., Fried S., Arreaza M.G., Qiu P., Simon J.S.
    Obes. Res. 12:1327-1334(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARG-34, CHARACTERIZATION OF VARIANT ARG-34.

Entry informationi

Entry nameiMCHR1_HUMAN
AccessioniPrimary (citable) accession number: Q99705
Secondary accession number(s): B2RBX6
, Q5R3J1, Q96S47, Q9BV08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3