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Protein

Melanin-concentrating hormone receptor 1

Gene

MCHR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • melanin-concentrating hormone receptor activity Source: GO_Central
  • neuropeptide receptor activity Source: ProtInc

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
  • cell surface receptor signaling pathway Source: GO_Central
  • feeding behavior Source: ProtInc
  • generation of precursor metabolites and energy Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-5620922. BBSome-mediated cargo-targeting to cilium.
SIGNORiQ99705.

Protein family/group databases

TCDBi9.A.14.13.6. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
SLC-1
Somatostatin receptor-like protein
Gene namesi
Name:MCHR1
Synonyms:GPR24, SLC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:4479. MCHR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 113113ExtracellularSequence analysisAdd
BLAST
Transmembranei114 – 13623Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini137 – 14812CytoplasmicSequence analysisAdd
BLAST
Transmembranei149 – 17123Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini172 – 18514ExtracellularSequence analysisAdd
BLAST
Transmembranei186 – 20823Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini209 – 22719CytoplasmicSequence analysisAdd
BLAST
Transmembranei228 – 25023Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini251 – 27828ExtracellularSequence analysisAdd
BLAST
Transmembranei279 – 30123Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini302 – 32120CytoplasmicSequence analysisAdd
BLAST
Transmembranei322 – 34423Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini345 – 35814ExtracellularSequence analysisAdd
BLAST
Transmembranei359 – 38123Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini382 – 42241CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • nonmotile primary cilium Source: BHF-UCL
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28867.

Chemistry

ChEMBLiCHEMBL2111437.
GuidetoPHARMACOLOGYi280.

Polymorphism and mutation databases

BioMutaiMCHR1.
DMDMi33860175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Melanin-concentrating hormone receptor 1PRO_0000069734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99705.
PRIDEiQ99705.

PTM databases

iPTMnetiQ99705.
PhosphoSiteiQ99705.

Expressioni

Tissue specificityi

Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

Gene expression databases

BgeeiENSG00000128285.
CleanExiHS_MCHR1.
ExpressionAtlasiQ99705. baseline and differential.
GenevisibleiQ99705. HS.

Interactioni

Subunit structurei

Interacts with NCDN.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000249016.

Chemistry

BindingDBiQ99705.

Structurei

3D structure databases

ProteinModelPortaliQ99705.
SMRiQ99705. Positions 97-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ99705.
KOiK04320.
OMAiITPVWLY.
OrthoDBiEOG091G0HEN.
PhylomeDBiQ99705.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP
60 70 80 90 100
AWVEGSSARL WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP
110 120 130 140 150
RTGSISYINI IMPSVFGTIC LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF
160 170 180 190 200
IINLSVVDLL FLLGMPFMIH QLMGNGVWHF GETMCTLITA MDANSQFTST
210 220 230 240 250
YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS FISITPVWLY
260 270 280 290 300
ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI
310 320 330 340 350
LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS
360 370 380 390 400
ISRPTLTFVY LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ
410 420
GQLRAVSNAQ TADEERTESK GT
Length:422
Mass (Da):45,963
Last modified:August 15, 2003 - v2
Checksum:i3986919A18183818
GO

Sequence cautioni

The sequence AAC14587 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251T → M.1 Publication
Corresponds to variant rs117372135 [ dbSNP | Ensembl ].
VAR_026652
Natural varianti28 – 281D → V.1 Publication
Corresponds to variant rs112405400 [ dbSNP | Ensembl ].
VAR_026653
Natural varianti32 – 321N → D No significant functional differences. 7 Publications
Corresponds to variant rs133072 [ dbSNP | Ensembl ].
VAR_016221
Natural varianti34 – 341G → R No changes in receptor binding or functional signaling. 1 Publication
VAR_026654
Natural varianti103 – 1031G → R.
Corresponds to variant rs11914085 [ dbSNP | Ensembl ].
VAR_049417
Natural varianti210 – 2101R → H.1 Publication
Corresponds to variant rs750210146 [ dbSNP | Ensembl ].
VAR_026655
Natural varianti250 – 2501Y → H.1 Publication
VAR_026656
Natural varianti305 – 3051T → M.1 Publication
Corresponds to variant rs550313335 [ dbSNP | Ensembl ].
VAR_026657
Natural varianti317 – 3171R → Q.2 Publications
Corresponds to variant rs45439291 [ dbSNP | Ensembl ].
VAR_026658
Natural varianti377 – 3771P → S.1 Publication
Corresponds to variant rs539260735 [ dbSNP | Ensembl ].
VAR_026659
Natural varianti411 – 4111T → M.1 Publication
Corresponds to variant rs149604804 [ dbSNP | Ensembl ].
VAR_026660

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063174 mRNA. Translation: BAB60890.1.
AF490537 mRNA. Translation: AAO14670.1.
CR456497 mRNA. Translation: CAG30383.1.
BT006725 mRNA. Translation: AAP35371.1.
AY562945 mRNA. Translation: AAS72373.1.
AK314857 mRNA. Translation: BAG37373.1.
Z86090 Genomic DNA. Translation: CAI17933.1.
CH471095 Genomic DNA. Translation: EAW60388.1.
BC001736 mRNA. Translation: AAH01736.1.
BC021146 mRNA. Translation: AAH21146.1.
U71092 Genomic DNA. Translation: AAC14587.1. Sequence problems.
CCDSiCCDS14004.1.
PIRiJC7080.
RefSeqiNP_005288.3. NM_005297.3.
UniGeneiHs.248122.

Genome annotation databases

EnsembliENST00000249016; ENSP00000249016; ENSG00000128285.
GeneIDi2847.
KEGGihsa:2847.
UCSCiuc003ayz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063174 mRNA. Translation: BAB60890.1.
AF490537 mRNA. Translation: AAO14670.1.
CR456497 mRNA. Translation: CAG30383.1.
BT006725 mRNA. Translation: AAP35371.1.
AY562945 mRNA. Translation: AAS72373.1.
AK314857 mRNA. Translation: BAG37373.1.
Z86090 Genomic DNA. Translation: CAI17933.1.
CH471095 Genomic DNA. Translation: EAW60388.1.
BC001736 mRNA. Translation: AAH01736.1.
BC021146 mRNA. Translation: AAH21146.1.
U71092 Genomic DNA. Translation: AAC14587.1. Sequence problems.
CCDSiCCDS14004.1.
PIRiJC7080.
RefSeqiNP_005288.3. NM_005297.3.
UniGeneiHs.248122.

3D structure databases

ProteinModelPortaliQ99705.
SMRiQ99705. Positions 97-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000249016.

Chemistry

BindingDBiQ99705.
ChEMBLiCHEMBL2111437.
GuidetoPHARMACOLOGYi280.

Protein family/group databases

TCDBi9.A.14.13.6. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ99705.
PhosphoSiteiQ99705.

Polymorphism and mutation databases

BioMutaiMCHR1.
DMDMi33860175.

Proteomic databases

PaxDbiQ99705.
PRIDEiQ99705.

Protocols and materials databases

DNASUi2847.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249016; ENSP00000249016; ENSG00000128285.
GeneIDi2847.
KEGGihsa:2847.
UCSCiuc003ayz.4. human.

Organism-specific databases

CTDi2847.
GeneCardsiMCHR1.
HGNCiHGNC:4479. MCHR1.
MIMi601751. gene.
neXtProtiNX_Q99705.
PharmGKBiPA28867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ99705.
KOiK04320.
OMAiITPVWLY.
OrthoDBiEOG091G0HEN.
PhylomeDBiQ99705.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-5620922. BBSome-mediated cargo-targeting to cilium.
SIGNORiQ99705.

Miscellaneous databases

GeneWikiiMelanin-concentrating_hormone_receptor_1.
GenomeRNAii2847.
PROiQ99705.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128285.
CleanExiHS_MCHR1.
ExpressionAtlasiQ99705. baseline and differential.
GenevisibleiQ99705. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCHR1_HUMAN
AccessioniPrimary (citable) accession number: Q99705
Secondary accession number(s): B2RBX6
, Q5R3J1, Q96S47, Q9BV08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: September 7, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.