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Protein

Fasciculation and elongation protein zeta-1

Gene

FEZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.2 Publications

GO - Biological processi

  • axon guidance Source: ProtInc
  • cell adhesion Source: ProtInc
  • cellular response to growth factor stimulus Source: Ensembl
  • establishment of mitochondrion localization Source: Ensembl
  • negative regulation of autophagosome assembly Source: GO_Central
  • nervous system development Source: ProtInc
  • positive regulation of neuron projection development Source: Ensembl
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149557-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciculation and elongation protein zeta-1
Alternative name(s):
Zygin I
Zygin-1
Gene namesi
Name:FEZ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3659. FEZ1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi248E → A: No effect on SCOC--binding. 1 Publication1
Mutagenesisi254L → P: Loss of SCOC-binding. No effect on ULK1-binding. 1 Publication1
Mutagenesisi260L → P: Loss of SCOC-binding. No effect on ULK1-binding. 1 Publication1
Mutagenesisi264K → A: No effect on SCOC-binding. 1 Publication1

Organism-specific databases

DisGeNETi9638.
MalaCardsiFEZ1.
OpenTargetsiENSG00000149557.
PharmGKBiPA28100.

Polymorphism and mutation databases

BioMutaiFEZ1.
DMDMi13431526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895251 – 392Fasciculation and elongation protein zeta-1Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineBy similarity1
Disulfide bondi133Interchain1 Publication
Modified residuei298PhosphoserineBy similarity1
Modified residuei316PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.1 Publication
Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99689.
MaxQBiQ99689.
PaxDbiQ99689.
PeptideAtlasiQ99689.
PRIDEiQ99689.

PTM databases

iPTMnetiQ99689.
PhosphoSitePlusiQ99689.

Expressioni

Tissue specificityi

Mainly expressed in brain.

Gene expression databases

BgeeiENSG00000149557.
CleanExiHS_FEZ1.
ExpressionAtlasiQ99689. baseline and differential.
GenevisibleiQ99689. HS.

Organism-specific databases

HPAiHPA038490.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. May form heterodimers with FEZ2. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon (By similarity). Interacts with UBE4B. Interacts with SAP30L. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1. Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP126Q9P2H02EBI-396435,EBI-473176
HTTP428585EBI-396435,EBI-466029
NEK1Q96PY62EBI-396435,EBI-373615
TXNDC9O145302EBI-396435,EBI-707554

Protein-protein interaction databases

BioGridi114997. 77 interactors.
DIPiDIP-32494N.
IntActiQ99689. 38 interactors.
MINTiMINT-1403506.
STRINGi9606.ENSP00000278919.

Structurei

3D structure databases

ProteinModelPortaliQ99689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili230 – 298Sequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi95 – 98Poly-Glu4
Compositional biasi140 – 145Poly-Glu6
Compositional biasi182 – 186Poly-Glu5

Sequence similaritiesi

Belongs to the zygin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3919. Eukaryota.
ENOG410Z11E. LUCA.
GeneTreeiENSGT00390000017627.
HOGENOMiHOG000019494.
HOVERGENiHBG005657.
InParanoidiQ99689.
OMAiWRDPNME.
OrthoDBiEOG091G0AC6.
PhylomeDBiQ99689.
TreeFamiTF313128.

Family and domain databases

InterProiIPR011680. FEZ.
IPR015642. FEZ_1.
[Graphical view]
PANTHERiPTHR12394. PTHR12394. 1 hit.
PTHR12394:SF4. PTHR12394:SF4. 1 hit.
PfamiPF07763. FEZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q99689-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAPLVSLDE EFEDLRPSCS EDPEEKPQCF YGSSPHHLED PSLSELENFS
60 70 80 90 100
SEIISFKSME DLVNEFDEKL NVCFRNYNAK TENLAPVKNQ LQIQEEEETL
110 120 130 140 150
QDEEVWDALT DNYIPSLSED WRDPNIEALN GNCSDTEIHE KEEEEFNEKS
160 170 180 190 200
ENDSGINEEP LLTADQVIEE IEEMMQNSPD PEEEEEVLEE EDGGETSSQA
210 220 230 240 250
DSVLLQEMQA LTQTFNNNWS YEGLRHMSGS ELTELLDQVE GAIRDFSEEL
260 270 280 290 300
VQQLARRDEL EFEKEVKNSF ITVLIEVQNK QKEQRELMKK RRKEKGLSLQ
310 320 330 340 350
SSRIEKGNQM PLKRFSMEGI SNILQSGIRQ TFGSSGTDKQ YLNTVIPYEK
360 370 380 390
KASPPSVEDL QMLTNILFAM KEDNEKVPTL LTDYILKVLC PT
Length:392
Mass (Da):45,119
Last modified:May 1, 1997 - v1
Checksum:i4226ED5EA17706F2
GO
Isoform Short (identifier: Q99689-2) [UniParc]FASTAAdd to basket
Also known as: FEZ1-T

The sequence of this isoform differs from the canonical sequence as follows:
     105-392: Missing.

Show »
Length:104
Mass (Da):12,074
Checksum:iA614EFAFF872EAF8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020461123D → E.Corresponds to variant rs597570dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006951105 – 392Missing in isoform Short. 1 PublicationAdd BLAST288

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60060 mRNA. Translation: AAC51282.1.
U60062 mRNA. Translation: AAC51284.1.
U69139 mRNA. Translation: AAB40660.1.
CR456817 mRNA. Translation: CAG33098.1.
CR541954 mRNA. Translation: CAG46752.1.
BC009545 mRNA. Translation: AAH09545.1.
CCDSiCCDS31716.1. [Q99689-1]
CCDS44758.1. [Q99689-2]
RefSeqiNP_005094.1. NM_005103.4. [Q99689-1]
NP_072043.1. NM_022549.3. [Q99689-2]
XP_005271791.1. XM_005271734.2. [Q99689-1]
XP_005271792.1. XM_005271735.2. [Q99689-1]
UniGeneiHs.224008.
Hs.732083.

Genome annotation databases

EnsembliENST00000278919; ENSP00000278919; ENSG00000149557. [Q99689-1]
ENST00000366139; ENSP00000393425; ENSG00000149557. [Q99689-2]
ENST00000524435; ENSP00000431521; ENSG00000149557. [Q99689-2]
GeneIDi9638.
KEGGihsa:9638.
UCSCiuc001qbx.4. human. [Q99689-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60060 mRNA. Translation: AAC51282.1.
U60062 mRNA. Translation: AAC51284.1.
U69139 mRNA. Translation: AAB40660.1.
CR456817 mRNA. Translation: CAG33098.1.
CR541954 mRNA. Translation: CAG46752.1.
BC009545 mRNA. Translation: AAH09545.1.
CCDSiCCDS31716.1. [Q99689-1]
CCDS44758.1. [Q99689-2]
RefSeqiNP_005094.1. NM_005103.4. [Q99689-1]
NP_072043.1. NM_022549.3. [Q99689-2]
XP_005271791.1. XM_005271734.2. [Q99689-1]
XP_005271792.1. XM_005271735.2. [Q99689-1]
UniGeneiHs.224008.
Hs.732083.

3D structure databases

ProteinModelPortaliQ99689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114997. 77 interactors.
DIPiDIP-32494N.
IntActiQ99689. 38 interactors.
MINTiMINT-1403506.
STRINGi9606.ENSP00000278919.

PTM databases

iPTMnetiQ99689.
PhosphoSitePlusiQ99689.

Polymorphism and mutation databases

BioMutaiFEZ1.
DMDMi13431526.

Proteomic databases

EPDiQ99689.
MaxQBiQ99689.
PaxDbiQ99689.
PeptideAtlasiQ99689.
PRIDEiQ99689.

Protocols and materials databases

DNASUi9638.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278919; ENSP00000278919; ENSG00000149557. [Q99689-1]
ENST00000366139; ENSP00000393425; ENSG00000149557. [Q99689-2]
ENST00000524435; ENSP00000431521; ENSG00000149557. [Q99689-2]
GeneIDi9638.
KEGGihsa:9638.
UCSCiuc001qbx.4. human. [Q99689-1]

Organism-specific databases

CTDi9638.
DisGeNETi9638.
GeneCardsiFEZ1.
HGNCiHGNC:3659. FEZ1.
HPAiHPA038490.
MalaCardsiFEZ1.
MIMi604825. gene.
neXtProtiNX_Q99689.
OpenTargetsiENSG00000149557.
PharmGKBiPA28100.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3919. Eukaryota.
ENOG410Z11E. LUCA.
GeneTreeiENSGT00390000017627.
HOGENOMiHOG000019494.
HOVERGENiHBG005657.
InParanoidiQ99689.
OMAiWRDPNME.
OrthoDBiEOG091G0AC6.
PhylomeDBiQ99689.
TreeFamiTF313128.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149557-MONOMER.

Miscellaneous databases

ChiTaRSiFEZ1. human.
GeneWikiiFEZ1.
GenomeRNAii9638.
PROiQ99689.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149557.
CleanExiHS_FEZ1.
ExpressionAtlasiQ99689. baseline and differential.
GenevisibleiQ99689. HS.

Family and domain databases

InterProiIPR011680. FEZ.
IPR015642. FEZ_1.
[Graphical view]
PANTHERiPTHR12394. PTHR12394. 1 hit.
PTHR12394:SF4. PTHR12394:SF4. 1 hit.
PfamiPF07763. FEZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEZ1_HUMAN
AccessioniPrimary (citable) accession number: Q99689
Secondary accession number(s): O00679, O00728, Q6IBI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.