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Protein

Homeobox protein Meis3

Gene

MEIS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi262 – 324Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Meis3
Alternative name(s):
Meis1-related protein 2
Gene namesi
Name:MEIS3
Synonyms:MRG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105419.17
HGNCiHGNC:29537 MEIS3
neXtProtiNX_Q99687

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105419
PharmGKBiPA30742

Polymorphism and mutation databases

BioMutaiMEIS3
DMDMi59803105

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491101 – 375Homeobox protein Meis3Add BLAST375

Proteomic databases

MaxQBiQ99687
PeptideAtlasiQ99687
PRIDEiQ99687

PTM databases

iPTMnetiQ99687
PhosphoSitePlusiQ99687

Expressioni

Gene expression databases

BgeeiENSG00000105419
CleanExiHS_MEIS3
ExpressionAtlasiQ99687 baseline and differential
GenevisibleiQ99687 HS

Organism-specific databases

HPAiHPA046699

Interactioni

Protein-protein interaction databases

BioGridi121245, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ99687
SMRiQ99687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi210 – 249Ser/Thr-richAdd BLAST40
Compositional biasi252 – 259Asp/Glu-rich (acidic)8

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00550000074260
HOGENOMiHOG000253923
HOVERGENiHBG055193
InParanoidiQ99687
KOiK16671
OMAiPGSMGMS
PhylomeDBiQ99687
TreeFamiTF318093

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99687-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRYDELPH YPGIVDGPAA LASFPETVPA VPGPYGPHRP PQPLPPGLDS
60 70 80 90 100
DGLKREKDEI YGHPLFPLLA LVFEKCELAT CSPRDGAGAG LGTPPGGDVC
110 120 130 140 150
SSDSFNEDIA AFAKQVRSER PLFSSNPELD NLMIQAIQVL RFHLLELEKV
160 170 180 190 200
HDLCDNFCHR YITCLKGKMP IDLVIEDRDG GCREDFEDYP ASCPSLPDQN
210 220 230 240 250
NMWIRDHEDS GSVHLGTPGP SSGGLASQSG DNSSDQGDGL DTSVASPSSG
260 270 280 290 300
GEDEDLDQER RRNKKRGIFP KVATNIMRAW LFQHLSHPYP SEEQKKQLAQ
310 320 330 340 350
DTGLTILQVN NWFINARRRI VQPMIDQSNR TGQGAAFSPE GQPIGGYTET
360 370
QPHVAVRPPG SVGMSLNLEG EWHYL
Length:375
Mass (Da):41,115
Last modified:February 15, 2005 - v3
Checksum:i7C29818279800786
GO
Isoform 2 (identifier: Q99687-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-286: S → SRRSEAPVLPDVCLGLGSPSPGPRWARPWGSDCGRPGRQSDSCWWLQ

Show »
Length:421
Mass (Da):46,175
Checksum:i3622AAB62D32561F
GO
Isoform 3 (identifier: Q99687-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-166: Missing.

Show »
Length:358
Mass (Da):39,052
Checksum:i7B9569CB90C91C8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 4MARR → LASQ in CAB95771 (PubMed:17974005).Curated4
Sequence conflicti1 – 4MARR → LASQ in CAH18472 (PubMed:17974005).Curated4
Sequence conflicti168 – 169KM → RP (PubMed:9049632).Curated2
Sequence conflicti202M → I (PubMed:9049632).Curated1
Sequence conflicti238D → V (PubMed:9049632).Curated1
Sequence conflicti260R → P (PubMed:9049632).Curated1
Sequence conflicti351Q → E (PubMed:9049632).Curated1
Sequence conflicti356 – 360VRPPG → FRAPA (PubMed:9049632).Curated5
Sequence conflicti364 – 370MSLNLEG → DEFGTRKE (PubMed:9049632).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012892150 – 166Missing in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_012893286S → SRRSEAPVLPDVCLGLGSPS PGPRWARPWGSDCGRPGRQS DSCWWLQ in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289950 mRNA Translation: BAF82639.1
AL359938 mRNA Translation: CAB95771.1
CR749687 mRNA Translation: CAH18472.1
CH471126 Genomic DNA Translation: EAW57482.1
BC025404 mRNA Translation: AAH25404.1
BC069251 mRNA Translation: AAH69251.1
U68385 mRNA Translation: AAB19195.1
CCDSiCCDS33064.1 [Q99687-2]
CCDS46132.1 [Q99687-3]
CCDS74406.1 [Q99687-1]
RefSeqiNP_001009813.1, NM_001009813.2 [Q99687-3]
NP_001287988.1, NM_001301059.1 [Q99687-1]
NP_064545.1, NM_020160.2 [Q99687-2]
UniGeneiHs.356135
Hs.380923

Genome annotation databases

EnsembliENST00000441740; ENSP00000388667; ENSG00000105419 [Q99687-3]
ENST00000558555; ENSP00000454073; ENSG00000105419 [Q99687-1]
ENST00000559524; ENSP00000452854; ENSG00000105419 [Q99687-2]
ENST00000561293; ENSP00000453307; ENSG00000105419 [Q99687-2]
GeneIDi56917
KEGGihsa:56917
UCSCiuc002pgs.5 human [Q99687-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMEIS3_HUMAN
AccessioniPrimary (citable) accession number: Q99687
Secondary accession number(s): A8K1N5
, Q6NT73, Q8TC66, Q9NPW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health