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Protein

Homeobox protein Meis3

Gene

MEIS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi262 – 32463Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Meis3
Alternative name(s):
Meis1-related protein 2
Gene namesi
Name:MEIS3
Synonyms:MRG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29537. MEIS3.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30742.

Polymorphism and mutation databases

BioMutaiMEIS3.
DMDMi59803105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Homeobox protein Meis3PRO_0000049110Add
BLAST

Proteomic databases

MaxQBiQ99687.
PeptideAtlasiQ99687.
PRIDEiQ99687.

PTM databases

iPTMnetiQ99687.
PhosphoSiteiQ99687.

Expressioni

Gene expression databases

BgeeiENSG00000105419.
CleanExiHS_MEIS3.
ExpressionAtlasiQ99687. baseline and differential.
GenevisibleiQ99687. HS.

Organism-specific databases

HPAiHPA046699.

Interactioni

Protein-protein interaction databases

BioGridi121245. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99687.
SMRiQ99687. Positions 269-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi210 – 24940Ser/Thr-richAdd
BLAST
Compositional biasi252 – 2598Asp/Glu-rich (acidic)

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00550000074260.
HOGENOMiHOG000253923.
HOVERGENiHBG055193.
InParanoidiQ99687.
KOiK16671.
OMAiPDSLKHH.
PhylomeDBiQ99687.
TreeFamiTF318093.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR032453. PKNOX/Meis_N.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF16493. Meis_PKNOX_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99687-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRYDELPH YPGIVDGPAA LASFPETVPA VPGPYGPHRP PQPLPPGLDS
60 70 80 90 100
DGLKREKDEI YGHPLFPLLA LVFEKCELAT CSPRDGAGAG LGTPPGGDVC
110 120 130 140 150
SSDSFNEDIA AFAKQVRSER PLFSSNPELD NLMIQAIQVL RFHLLELEKV
160 170 180 190 200
HDLCDNFCHR YITCLKGKMP IDLVIEDRDG GCREDFEDYP ASCPSLPDQN
210 220 230 240 250
NMWIRDHEDS GSVHLGTPGP SSGGLASQSG DNSSDQGDGL DTSVASPSSG
260 270 280 290 300
GEDEDLDQER RRNKKRGIFP KVATNIMRAW LFQHLSHPYP SEEQKKQLAQ
310 320 330 340 350
DTGLTILQVN NWFINARRRI VQPMIDQSNR TGQGAAFSPE GQPIGGYTET
360 370
QPHVAVRPPG SVGMSLNLEG EWHYL
Length:375
Mass (Da):41,115
Last modified:February 15, 2005 - v3
Checksum:i7C29818279800786
GO
Isoform 2 (identifier: Q99687-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-286: S → SRRSEAPVLPDVCLGLGSPSPGPRWARPWGSDCGRPGRQSDSCWWLQ

Show »
Length:421
Mass (Da):46,175
Checksum:i3622AAB62D32561F
GO
Isoform 3 (identifier: Q99687-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-166: Missing.

Show »
Length:358
Mass (Da):39,052
Checksum:i7B9569CB90C91C8A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 44MARR → LASQ in CAB95771 (PubMed:17974005).Curated
Sequence conflicti1 – 44MARR → LASQ in CAH18472 (PubMed:17974005).Curated
Sequence conflicti168 – 1692KM → RP (PubMed:9049632).Curated
Sequence conflicti202 – 2021M → I (PubMed:9049632).Curated
Sequence conflicti238 – 2381D → V (PubMed:9049632).Curated
Sequence conflicti260 – 2601R → P (PubMed:9049632).Curated
Sequence conflicti351 – 3511Q → E (PubMed:9049632).Curated
Sequence conflicti356 – 3605VRPPG → FRAPA (PubMed:9049632).Curated
Sequence conflicti364 – 3707MSLNLEG → DEFGTRKE (PubMed:9049632).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei150 – 16617Missing in isoform 3. 1 PublicationVSP_012892Add
BLAST
Alternative sequencei286 – 2861S → SRRSEAPVLPDVCLGLGSPS PGPRWARPWGSDCGRPGRQS DSCWWLQ in isoform 2. 2 PublicationsVSP_012893

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289950 mRNA. Translation: BAF82639.1.
AL359938 mRNA. Translation: CAB95771.1.
CR749687 mRNA. Translation: CAH18472.1.
CH471126 Genomic DNA. Translation: EAW57482.1.
BC025404 mRNA. Translation: AAH25404.1.
BC069251 mRNA. Translation: AAH69251.1.
U68385 mRNA. Translation: AAB19195.1.
CCDSiCCDS33064.1. [Q99687-2]
CCDS46132.1. [Q99687-3]
CCDS74406.1. [Q99687-1]
RefSeqiNP_001009813.1. NM_001009813.2. [Q99687-3]
NP_001287988.1. NM_001301059.1. [Q99687-1]
NP_064545.1. NM_020160.2. [Q99687-2]
UniGeneiHs.356135.
Hs.380923.

Genome annotation databases

EnsembliENST00000441740; ENSP00000388667; ENSG00000105419. [Q99687-3]
ENST00000558555; ENSP00000454073; ENSG00000105419. [Q99687-1]
ENST00000559524; ENSP00000452854; ENSG00000105419. [Q99687-2]
ENST00000561293; ENSP00000453307; ENSG00000105419. [Q99687-2]
GeneIDi56917.
KEGGihsa:56917.
UCSCiuc002pgs.5. human. [Q99687-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289950 mRNA. Translation: BAF82639.1.
AL359938 mRNA. Translation: CAB95771.1.
CR749687 mRNA. Translation: CAH18472.1.
CH471126 Genomic DNA. Translation: EAW57482.1.
BC025404 mRNA. Translation: AAH25404.1.
BC069251 mRNA. Translation: AAH69251.1.
U68385 mRNA. Translation: AAB19195.1.
CCDSiCCDS33064.1. [Q99687-2]
CCDS46132.1. [Q99687-3]
CCDS74406.1. [Q99687-1]
RefSeqiNP_001009813.1. NM_001009813.2. [Q99687-3]
NP_001287988.1. NM_001301059.1. [Q99687-1]
NP_064545.1. NM_020160.2. [Q99687-2]
UniGeneiHs.356135.
Hs.380923.

3D structure databases

ProteinModelPortaliQ99687.
SMRiQ99687. Positions 269-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121245. 1 interaction.

PTM databases

iPTMnetiQ99687.
PhosphoSiteiQ99687.

Polymorphism and mutation databases

BioMutaiMEIS3.
DMDMi59803105.

Proteomic databases

MaxQBiQ99687.
PeptideAtlasiQ99687.
PRIDEiQ99687.

Protocols and materials databases

DNASUi56917.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000441740; ENSP00000388667; ENSG00000105419. [Q99687-3]
ENST00000558555; ENSP00000454073; ENSG00000105419. [Q99687-1]
ENST00000559524; ENSP00000452854; ENSG00000105419. [Q99687-2]
ENST00000561293; ENSP00000453307; ENSG00000105419. [Q99687-2]
GeneIDi56917.
KEGGihsa:56917.
UCSCiuc002pgs.5. human. [Q99687-1]

Organism-specific databases

CTDi56917.
GeneCardsiMEIS3.
HGNCiHGNC:29537. MEIS3.
HPAiHPA046699.
neXtProtiNX_Q99687.
PharmGKBiPA30742.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074260.
HOGENOMiHOG000253923.
HOVERGENiHBG055193.
InParanoidiQ99687.
KOiK16671.
OMAiPDSLKHH.
PhylomeDBiQ99687.
TreeFamiTF318093.

Miscellaneous databases

ChiTaRSiMEIS3. human.
GenomeRNAii56917.
PROiQ99687.

Gene expression databases

BgeeiENSG00000105419.
CleanExiHS_MEIS3.
ExpressionAtlasiQ99687. baseline and differential.
GenevisibleiQ99687. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR032453. PKNOX/Meis_N.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF16493. Meis_PKNOX_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEIS3_HUMAN
AccessioniPrimary (citable) accession number: Q99687
Secondary accession number(s): A8K1N5
, Q6NT73, Q8TC66, Q9NPW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.