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Q99684

- GFI1_HUMAN

UniProt

Q99684 - GFI1_HUMAN

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Protein

Zinc finger protein Gfi-1

Gene

GFI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.11 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri255 – 27824C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41924C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProt
  2. transcription regulatory region DNA binding Source: BHF-UCL
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. auditory receptor cell differentiation Source: Ensembl
  2. cell fate commitment Source: Ensembl
  3. cellular response to lipopolysaccharide Source: UniProtKB
  4. inner ear morphogenesis Source: Ensembl
  5. mechanosensory behavior Source: Ensembl
  6. negative regulation of calcidiol 1-monooxygenase activity Source: BHF-UCL
  7. negative regulation of cell fate specification Source: Ensembl
  8. negative regulation of neuron projection development Source: UniProtKB
  9. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  10. negative regulation of transcription, DNA-templated Source: UniProtKB
  11. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  12. negative regulation of vitamin D biosynthetic process Source: BHF-UCL
  13. positive regulation of cell fate specification Source: Ensembl
  14. positive regulation of interleukin-6-mediated signaling pathway Source: UniProtKB
  15. regulation of toll-like receptor signaling pathway Source: UniProtKB
  16. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: ProtInc
  17. viral process Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ99684.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Gfi-1
Alternative name(s):
Growth factor independent protein 1
Zinc finger protein 163
Gene namesi
Name:GFI1
Synonyms:ZNF163
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:4237. GFI1.

Subcellular locationi

Nucleus 5 Publications
Note: Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.

GO - Cellular componenti

  1. nuclear body Source: UniProtKB
  2. nuclear matrix Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Neutropenia, severe congenital 2, autosomal dominant (SCN2) [MIM:613107]: A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti382 – 3821N → S in SCN2; zero neutrophil count. marked monocytosis and reduced T- and B-lymphocyte number leading to recurrent infectious complications. Abolishes recognition of DNA binding site of zinc finger. Diminished repression activity and elevated ELA2 expression. No effect on repression of CDKN1A/p21 transcription. 1 Publication
Corresponds to variant rs28936381 [ dbSNP | Ensembl ].
VAR_016212
Dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) [MIM:607847]: Relatively mild form of neutropenia diagnosed in adults, but predisposing to leukemia in a subset of patients.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti403 – 4031K → R in NI-CINA; Neutropenic and elevated monocytosis but no history of infectious complications. No effect on DNA binding but diminished GFI1 repression activity. 1 Publication
Corresponds to variant rs28936382 [ dbSNP | Ensembl ].
VAR_016213

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21P → A: Abrogates transcriptional repression. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi607847. phenotype.
613107. phenotype.
Orphaneti486. Autosomal dominant severe congenital neutropenia.
PharmGKBiPA24344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Zinc finger protein Gfi-1PRO_0000047193Add
BLAST

Post-translational modificationi

Ubiquitinated. Ubiquitination and degradation by the proteasome is inhibited by the ubiquitin ligase, ARIH2.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ99684.
PRIDEiQ99684.

PTM databases

PhosphoSiteiQ99684.

Expressioni

Inductioni

Down-regulated by TGFB1.2 Publications

Gene expression databases

BgeeiQ99684.
CleanExiHS_GFI1.
ExpressionAtlasiQ99684. baseline and differential.
GenevestigatoriQ99684.

Organism-specific databases

HPAiCAB011197.

Interactioni

Subunit structurei

Interacts with U2AF1L4. Component of RCOR-GFI-KDM1A-HDAC complexes. Interacts directly with RCOR1, KDM1A and HDAC2 (By similarity). Also interacts with HDAC1. Interacts (via the zinc-finger domain) with ARIH2; the interaction prevents GFI1 ubiquitination and proteasomal degradation. Interacts with PIAS3; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity. Forms a complex with EHMT2 and HDAC1 to promote 'Lys-9' dimethylation of H3 (H3K9Me2) and repress expression of target genes. Interacts directly with EHMT2. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly with AJUBA (via ITS LIM domains); the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes and, occurs independently of the SNAG domain. Interacts with SPI1; the interaction inhibits SPI1 transcriptional activity and represses SPI1-regulated macrophage-specific genes required for proper granulocyte development. Interacts with RUNX1T1; the interaction represses HDAC-mediated transcriptional activity. Interacts with RELA; the interaction occurs on liposaccharide (LPS) stimulation and controls RELA DNA binding activity and regulates endotoxin-mediated TOLL-like receptor inflammatory response. Interacts (via the C-terminal zinc fingers) with ZBTB17; the interaction results in the recruitment of GFI1 to the CDKN1A/p21 and CDKN1B promoters and repression of transcription.By similarity9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AjubaQ91XC04EBI-949368,EBI-1565930From a different organism.
CHAF1AQ131114EBI-949368,EBI-1020839
EHMT2Q96KQ72EBI-949368,EBI-744366
HDAC1Q135474EBI-949368,EBI-301834
PRDM5Q9NQX12EBI-949368,EBI-4292031
RELAQ042062EBI-949368,EBI-73886
Spi1P174332EBI-949368,EBI-607588From a different organism.

Protein-protein interaction databases

BioGridi108940. 15 interactions.
DIPiDIP-38452N.
IntActiQ99684. 15 interactions.
MINTiMINT-149356.
STRINGi9606.ENSP00000294702.

Structurei

3D structure databases

ProteinModelPortaliQ99684.
SMRiQ99684. Positions 235-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020SNAG domainBy similarityAdd
BLAST
Regioni140 – 257118Required for interaction with RELAAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 20952Ala/Gly-richAdd
BLAST

Domaini

Zinc fingers 3, 4 and 5 are required for DNA-binding and for interaction with SPI1.1 Publication
The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors.By similarity

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri255 – 27824C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41924C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00740000115096.
HOVERGENiHBG006967.
InParanoidiQ99684.
KOiK09223.
OMAiPFPLPFK.
OrthoDBiEOG72RN05.
PhylomeDBiQ99684.
TreeFamiTF350784.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99684-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE NVPAPSRADS TSNAGGAKAE
60 70 80 90 100
PRDRLSPESQ LTEAPDRASA SPDSCEGSVC ERSSEFEDFW RPPSPSASPA
110 120 130 140 150
SEKSMCPSLD EAQPFPLPFK PYSWSGLAGS DLRHLVQSYR PCGALERGAG
160 170 180 190 200
LGLFCEPAPE PGHPAALYGP KRAAGGAGAG APGSCSAGAG ATAGPGLGLY
210 220 230 240 250
GDFGSAAAGL YERPTAAAGL LYPERGHGLH ADKGAGVKVE SELLCTRLLL
260 270 280 290 300
GGGSYKCIKC SKVFSTPHGL EVHVRRSHSG TRPFACEMCG KTFGHAVSLE
310 320 330 340 350
QHKAVHSQER SFDCKICGKS FKRSSTLSTH LLIHSDTRPY PCQYCGKRFH
360 370 380 390 400
QKSDMKKHTF IHTGEKPHKC QVCGKAFSQS SNLITHSRKH TGFKPFGCDL
410 420
CGKGFQRKVD LRRHRETQHG LK
Length:422
Mass (Da):45,297
Last modified:August 15, 2003 - v2
Checksum:i740A466F72C5FC72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 775DSCEG → RQLRS in AAB37272. (PubMed:9051000)Curated
Sequence conflicti184 – 1863SCS → NCI in AAB37272. (PubMed:9051000)Curated
Sequence conflicti213 – 2131R → K in AAB37272. (PubMed:9051000)Curated
Sequence conflicti228 – 2281G → R in AAB37272. (PubMed:9051000)Curated
Sequence conflicti232 – 2321D → N in AAB37272. (PubMed:9051000)Curated
Sequence conflicti367 – 3671P → L in AAB37272. (PubMed:9051000)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361S → N.
Corresponds to variant rs34631763 [ dbSNP | Ensembl ].
VAR_052722
Natural varianti382 – 3821N → S in SCN2; zero neutrophil count. marked monocytosis and reduced T- and B-lymphocyte number leading to recurrent infectious complications. Abolishes recognition of DNA binding site of zinc finger. Diminished repression activity and elevated ELA2 expression. No effect on repression of CDKN1A/p21 transcription. 1 Publication
Corresponds to variant rs28936381 [ dbSNP | Ensembl ].
VAR_016212
Natural varianti403 – 4031K → R in NI-CINA; Neutropenic and elevated monocytosis but no history of infectious complications. No effect on DNA binding but diminished GFI1 repression activity. 1 Publication
Corresponds to variant rs28936382 [ dbSNP | Ensembl ].
VAR_016213

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67369 mRNA. Translation: AAB37272.1.
BC032751 mRNA. Translation: AAH32751.1.
BC074866 mRNA. Translation: AAH74866.1.
BC074867 mRNA. Translation: AAH74867.1.
CCDSiCCDS30773.1.
RefSeqiNP_001120687.1. NM_001127215.1.
NP_001120688.1. NM_001127216.1.
NP_005254.2. NM_005263.3.
XP_005270806.1. XM_005270749.2.
UniGeneiHs.73172.

Genome annotation databases

EnsembliENST00000294702; ENSP00000294702; ENSG00000162676.
ENST00000370332; ENSP00000359357; ENSG00000162676.
ENST00000427103; ENSP00000399719; ENSG00000162676.
GeneIDi2672.
KEGGihsa:2672.
UCSCiuc001dou.4. human.

Polymorphism databases

DMDMi33860154.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

GFI1base

GFI1 mutation db

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67369 mRNA. Translation: AAB37272.1 .
BC032751 mRNA. Translation: AAH32751.1 .
BC074866 mRNA. Translation: AAH74866.1 .
BC074867 mRNA. Translation: AAH74867.1 .
CCDSi CCDS30773.1.
RefSeqi NP_001120687.1. NM_001127215.1.
NP_001120688.1. NM_001127216.1.
NP_005254.2. NM_005263.3.
XP_005270806.1. XM_005270749.2.
UniGenei Hs.73172.

3D structure databases

ProteinModelPortali Q99684.
SMRi Q99684. Positions 235-422.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108940. 15 interactions.
DIPi DIP-38452N.
IntActi Q99684. 15 interactions.
MINTi MINT-149356.
STRINGi 9606.ENSP00000294702.

PTM databases

PhosphoSitei Q99684.

Polymorphism databases

DMDMi 33860154.

Proteomic databases

PaxDbi Q99684.
PRIDEi Q99684.

Protocols and materials databases

DNASUi 2672.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294702 ; ENSP00000294702 ; ENSG00000162676 .
ENST00000370332 ; ENSP00000359357 ; ENSG00000162676 .
ENST00000427103 ; ENSP00000399719 ; ENSG00000162676 .
GeneIDi 2672.
KEGGi hsa:2672.
UCSCi uc001dou.4. human.

Organism-specific databases

CTDi 2672.
GeneCardsi GC01M092940.
HGNCi HGNC:4237. GFI1.
HPAi CAB011197.
MIMi 600871. gene.
607847. phenotype.
613107. phenotype.
neXtProti NX_Q99684.
Orphaneti 486. Autosomal dominant severe congenital neutropenia.
PharmGKBi PA24344.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00740000115096.
HOVERGENi HBG006967.
InParanoidi Q99684.
KOi K09223.
OMAi PFPLPFK.
OrthoDBi EOG72RN05.
PhylomeDBi Q99684.
TreeFami TF350784.

Enzyme and pathway databases

SignaLinki Q99684.

Miscellaneous databases

GeneWikii GFI1.
GenomeRNAii 2672.
NextBioi 10546.
PROi Q99684.
SOURCEi Search...

Gene expression databases

Bgeei Q99684.
CleanExi HS_GFI1.
ExpressionAtlasi Q99684. baseline and differential.
Genevestigatori Q99684.

Family and domain databases

Gene3Di 3.30.160.60. 6 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22."
    Roberts T., Cowell J.K.
    Oncogene 14:1003-1005(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Testis.
  3. "Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor."
    Zweidler-Mckay P.A., Grimes H.L., Flubacher M.M., Tsichlis P.N.
    Mol. Cell. Biol. 16:4024-4034(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING, SUBCELLULAR LOCATION, FUNCTION.
  4. "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3."
    Roedel B., Tavassoli K., Karsunky H., Schmidt T., Bachmann M., Schaper F., Heinrich P., Shuai K., Elsaesser H.-P., Moeroey T.
    EMBO J. 19:5845-5855(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIAS3, SUBCELLULAR LOCATION, FUNCTION.
  5. "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism."
    McGhee L., Bryan J., Elliott L., Grimes H.L., Kazanjian A., Davis J.N., Meyers S.
    J. Cell. Biochem. 89:1005-1018(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH RUNX1T1; HDAC1; HDAC2 AND HDAC3, INTERACTION WITH RUNX1T1, SUBCELLULAR LOCATION.
  6. "Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1."
    Duan Z., Zarebski A., Montoya-Durango D., Grimes H.L., Horwitz M.
    Mol. Cell. Biol. 25:10338-10351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH EHMT2 AND HDAC1, INTERACTION WITH EHMT2 AND HDAC1, FUNCTION.
  7. "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1."
    Marteijn J.A., van der Meer L.T., van Emst L., van Reijmersdal S., Wissink W., de Witte T., Jansen J.H., Van der Reijden B.A.
    Blood 110:3128-3135(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ARIH2, UBIQUITINATION.
  8. "The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction."
    Dahl R., Iyer S.R., Owens K.S., Cuylear D.D., Simon M.C.
    J. Biol. Chem. 282:6473-6483(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SPI1, DOMAIN ZINC-FINGER, FUNCTION, MUTAGENESIS OF PRO-2.
  9. "Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor."
    Montoya-Durango D.E., Velu C.S., Kazanjian A., Rojas M.E., Jay C.M., Longmore G.D., Grimes H.L.
    J. Biol. Chem. 283:32056-32065(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AJUBA IN THE GFI1-AJUBA-HDAC COMPLEX, SUBCELLULAR LOCATION, FUNCTION.
  10. "Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth."
    Ossovskaya V.S., Dolganov G., Basbaum A.I.
    J. Neurosci. Methods 177:322-333(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1."
    Basu S., Liu Q., Qiu Y., Dong F.
    Proc. Natl. Acad. Sci. U.S.A. 106:1433-1438(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ZBTB17.
  12. "Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65."
    Sharif-Askari E., Vassen L., Kosan C., Khandanpour C., Gaudreau M.C., Heyd F., Okayama T., Jin J., Rojas M.E., Grimes H.L., Zeng H., Moroy T.
    Mol. Cell. Biol. 30:3929-3942(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RELA, SUBCELLULAR LOCATION, INDUCTION, FUNCTION.
  13. "A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A."
    Liu Q., Basu S., Qiu Y., Tang F., Dong F.
    Oncogene 29:2843-2852(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZBTB17, FUNCTION, INDUCTION, CHARACTERIZATION OF VARIANT SER-382.
  14. Cited for: VARIANT NI-CINA ARG-403, VARIANT SCN2 SER-382, CHARACTERIZATION OF VARIANTS NI-CINA ARG-403 AND SCN2 SER-382, FUNCTION.

Entry informationi

Entry nameiGFI1_HUMAN
AccessioniPrimary (citable) accession number: Q99684
Secondary accession number(s): Q8N564
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 15, 2003
Last modified: October 29, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3