Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q99684

- GFI1_HUMAN

UniProt

Q99684 - GFI1_HUMAN

Protein

Zinc finger protein Gfi-1

Gene

GFI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (15 Aug 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.11 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri255 – 27824C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41924C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProt
    3. transcription regulatory region DNA binding Source: BHF-UCL
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. auditory receptor cell differentiation Source: Ensembl
    2. cell fate commitment Source: Ensembl
    3. cellular response to lipopolysaccharide Source: UniProtKB
    4. inner ear morphogenesis Source: Ensembl
    5. mechanosensory behavior Source: Ensembl
    6. negative regulation of calcidiol 1-monooxygenase activity Source: BHF-UCL
    7. negative regulation of cell fate specification Source: Ensembl
    8. negative regulation of neuron projection development Source: UniProtKB
    9. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
    10. negative regulation of transcription, DNA-templated Source: UniProtKB
    11. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    12. negative regulation of vitamin D biosynthetic process Source: BHF-UCL
    13. positive regulation of cell fate specification Source: Ensembl
    14. positive regulation of interleukin-6-mediated signaling pathway Source: UniProtKB
    15. regulation of toll-like receptor signaling pathway Source: UniProtKB
    16. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: ProtInc
    17. viral process Source: ProtInc

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ99684.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein Gfi-1
    Alternative name(s):
    Growth factor independent protein 1
    Zinc finger protein 163
    Gene namesi
    Name:GFI1
    Synonyms:ZNF163
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4237. GFI1.

    Subcellular locationi

    Nucleus 5 Publications
    Note: Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.

    GO - Cellular componenti

    1. nuclear body Source: UniProtKB
    2. nuclear matrix Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. transcriptional repressor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Neutropenia, severe congenital 2, autosomal dominant (SCN2) [MIM:613107]: A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti382 – 3821N → S in SCN2; zero neutrophil count. marked monocytosis and reduced T- and B-lymphocyte number leading to recurrent infectious complications. Abolishes recognition of DNA binding site of zinc finger. Diminished repression activity and elevated ELA2 expression. No effect on repression of CDKN1A/p21 transcription. 1 Publication
    Corresponds to variant rs28936381 [ dbSNP | Ensembl ].
    VAR_016212
    Dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) [MIM:607847]: Relatively mild form of neutropenia diagnosed in adults, but predisposing to leukemia in a subset of patients.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti403 – 4031K → R in NI-CINA; Neutropenic and elevated monocytosis but no history of infectious complications. No effect on DNA binding but diminished GFI1 repression activity. 1 Publication
    Corresponds to variant rs28936382 [ dbSNP | Ensembl ].
    VAR_016213

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi2 – 21P → A: Abrogates transcriptional repression. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi607847. phenotype.
    613107. phenotype.
    Orphaneti486. Autosomal dominant severe congenital neutropenia.
    PharmGKBiPA24344.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Zinc finger protein Gfi-1PRO_0000047193Add
    BLAST

    Post-translational modificationi

    Ubiquitinated. Ubiquitination and degradation by the proteasome is inhibited by the ubiquitin ligase, ARIH2.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ99684.
    PRIDEiQ99684.

    PTM databases

    PhosphoSiteiQ99684.

    Expressioni

    Inductioni

    Down-regulated by TGFB1.2 Publications

    Gene expression databases

    ArrayExpressiQ99684.
    BgeeiQ99684.
    CleanExiHS_GFI1.
    GenevestigatoriQ99684.

    Organism-specific databases

    HPAiCAB011197.

    Interactioni

    Subunit structurei

    Interacts with U2AF1L4. Component of RCOR-GFI-KDM1A-HDAC complexes. Interacts directly with RCOR1, KDM1A and HDAC2 By similarity. Also interacts with HDAC1. Interacts (via the zinc-finger domain) with ARIH2; the interaction prevents GFI1 ubiquitination and proteasomal degradation. Interacts with PIAS3; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity. Forms a complex with EHMT2 and HDAC1 to promote 'Lys-9' dimethylation of H3 (H3K9Me2) and repress expression of target genes. Interacts directly with EHMT2. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly with AJUBA (via ITS LIM domains); the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes and, occurs independently of the SNAG domain. Interacts with SPI1; the interaction inhibits SPI1 transcriptional activity and represses SPI1-regulated macrophage-specific genes required for proper granulocyte development. Interacts with RUNX1T1; the interaction represses HDAC-mediated transcriptional activity. Interacts with RELA; the interaction occurs on liposaccharide (LPS) stimulation and controls RELA DNA binding activity and regulates endotoxin-mediated TOLL-like receptor inflammatory response. Interacts (via the C-terminal zinc fingers) with ZBTB17; the interaction results in the recruitment of GFI1 to the CDKN1A/p21 and CDKN1B promoters and repression of transcription.By similarity9 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AjubaQ91XC04EBI-949368,EBI-1565930From a different organism.
    CHAF1AQ131114EBI-949368,EBI-1020839
    EHMT2Q96KQ72EBI-949368,EBI-744366
    HDAC1Q135474EBI-949368,EBI-301834
    PRDM5Q9NQX12EBI-949368,EBI-4292031
    RELAQ042062EBI-949368,EBI-73886
    Spi1P174332EBI-949368,EBI-607588From a different organism.

    Protein-protein interaction databases

    BioGridi108940. 15 interactions.
    DIPiDIP-38452N.
    IntActiQ99684. 15 interactions.
    MINTiMINT-149356.
    STRINGi9606.ENSP00000294702.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99684.
    SMRiQ99684. Positions 255-422.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2020SNAG domainBy similarityAdd
    BLAST
    Regioni140 – 257118Required for interaction with RELAAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi158 – 20952Ala/Gly-richAdd
    BLAST

    Domaini

    Zinc fingers 3, 4 and 5 are required for DNA-binding and for interaction with SPI1.1 Publication
    The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors.By similarity

    Sequence similaritiesi

    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri255 – 27824C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41924C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG006967.
    InParanoidiQ99684.
    KOiK09223.
    OMAiPFPLPFK.
    OrthoDBiEOG72RN05.
    PhylomeDBiQ99684.
    TreeFamiTF350784.

    Family and domain databases

    Gene3Di3.30.160.60. 6 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 6 hits.
    SM00343. ZnF_C2HC. 1 hit.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99684-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE NVPAPSRADS TSNAGGAKAE    50
    PRDRLSPESQ LTEAPDRASA SPDSCEGSVC ERSSEFEDFW RPPSPSASPA 100
    SEKSMCPSLD EAQPFPLPFK PYSWSGLAGS DLRHLVQSYR PCGALERGAG 150
    LGLFCEPAPE PGHPAALYGP KRAAGGAGAG APGSCSAGAG ATAGPGLGLY 200
    GDFGSAAAGL YERPTAAAGL LYPERGHGLH ADKGAGVKVE SELLCTRLLL 250
    GGGSYKCIKC SKVFSTPHGL EVHVRRSHSG TRPFACEMCG KTFGHAVSLE 300
    QHKAVHSQER SFDCKICGKS FKRSSTLSTH LLIHSDTRPY PCQYCGKRFH 350
    QKSDMKKHTF IHTGEKPHKC QVCGKAFSQS SNLITHSRKH TGFKPFGCDL 400
    CGKGFQRKVD LRRHRETQHG LK 422
    Length:422
    Mass (Da):45,297
    Last modified:August 15, 2003 - v2
    Checksum:i740A466F72C5FC72
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 775DSCEG → RQLRS in AAB37272. (PubMed:9051000)Curated
    Sequence conflicti184 – 1863SCS → NCI in AAB37272. (PubMed:9051000)Curated
    Sequence conflicti213 – 2131R → K in AAB37272. (PubMed:9051000)Curated
    Sequence conflicti228 – 2281G → R in AAB37272. (PubMed:9051000)Curated
    Sequence conflicti232 – 2321D → N in AAB37272. (PubMed:9051000)Curated
    Sequence conflicti367 – 3671P → L in AAB37272. (PubMed:9051000)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361S → N.
    Corresponds to variant rs34631763 [ dbSNP | Ensembl ].
    VAR_052722
    Natural varianti382 – 3821N → S in SCN2; zero neutrophil count. marked monocytosis and reduced T- and B-lymphocyte number leading to recurrent infectious complications. Abolishes recognition of DNA binding site of zinc finger. Diminished repression activity and elevated ELA2 expression. No effect on repression of CDKN1A/p21 transcription. 1 Publication
    Corresponds to variant rs28936381 [ dbSNP | Ensembl ].
    VAR_016212
    Natural varianti403 – 4031K → R in NI-CINA; Neutropenic and elevated monocytosis but no history of infectious complications. No effect on DNA binding but diminished GFI1 repression activity. 1 Publication
    Corresponds to variant rs28936382 [ dbSNP | Ensembl ].
    VAR_016213

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67369 mRNA. Translation: AAB37272.1.
    BC032751 mRNA. Translation: AAH32751.1.
    BC074866 mRNA. Translation: AAH74866.1.
    BC074867 mRNA. Translation: AAH74867.1.
    CCDSiCCDS30773.1.
    RefSeqiNP_001120687.1. NM_001127215.1.
    NP_001120688.1. NM_001127216.1.
    NP_005254.2. NM_005263.3.
    XP_005270806.1. XM_005270749.2.
    UniGeneiHs.73172.

    Genome annotation databases

    EnsembliENST00000294702; ENSP00000294702; ENSG00000162676.
    ENST00000370332; ENSP00000359357; ENSG00000162676.
    ENST00000427103; ENSP00000399719; ENSG00000162676.
    GeneIDi2672.
    KEGGihsa:2672.
    UCSCiuc001dou.4. human.

    Polymorphism databases

    DMDMi33860154.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GFI1base

    GFI1 mutation db

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67369 mRNA. Translation: AAB37272.1 .
    BC032751 mRNA. Translation: AAH32751.1 .
    BC074866 mRNA. Translation: AAH74866.1 .
    BC074867 mRNA. Translation: AAH74867.1 .
    CCDSi CCDS30773.1.
    RefSeqi NP_001120687.1. NM_001127215.1.
    NP_001120688.1. NM_001127216.1.
    NP_005254.2. NM_005263.3.
    XP_005270806.1. XM_005270749.2.
    UniGenei Hs.73172.

    3D structure databases

    ProteinModelPortali Q99684.
    SMRi Q99684. Positions 255-422.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108940. 15 interactions.
    DIPi DIP-38452N.
    IntActi Q99684. 15 interactions.
    MINTi MINT-149356.
    STRINGi 9606.ENSP00000294702.

    PTM databases

    PhosphoSitei Q99684.

    Polymorphism databases

    DMDMi 33860154.

    Proteomic databases

    PaxDbi Q99684.
    PRIDEi Q99684.

    Protocols and materials databases

    DNASUi 2672.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294702 ; ENSP00000294702 ; ENSG00000162676 .
    ENST00000370332 ; ENSP00000359357 ; ENSG00000162676 .
    ENST00000427103 ; ENSP00000399719 ; ENSG00000162676 .
    GeneIDi 2672.
    KEGGi hsa:2672.
    UCSCi uc001dou.4. human.

    Organism-specific databases

    CTDi 2672.
    GeneCardsi GC01M092940.
    HGNCi HGNC:4237. GFI1.
    HPAi CAB011197.
    MIMi 600871. gene.
    607847. phenotype.
    613107. phenotype.
    neXtProti NX_Q99684.
    Orphaneti 486. Autosomal dominant severe congenital neutropenia.
    PharmGKBi PA24344.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG006967.
    InParanoidi Q99684.
    KOi K09223.
    OMAi PFPLPFK.
    OrthoDBi EOG72RN05.
    PhylomeDBi Q99684.
    TreeFami TF350784.

    Enzyme and pathway databases

    SignaLinki Q99684.

    Miscellaneous databases

    GeneWikii GFI1.
    GenomeRNAii 2672.
    NextBioi 10546.
    PROi Q99684.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99684.
    Bgeei Q99684.
    CleanExi HS_GFI1.
    Genevestigatori Q99684.

    Family and domain databases

    Gene3Di 3.30.160.60. 6 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 6 hits.
    SM00343. ZnF_C2HC. 1 hit.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22."
      Roberts T., Cowell J.K.
      Oncogene 14:1003-1005(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone marrow.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Testis.
    3. "Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor."
      Zweidler-Mckay P.A., Grimes H.L., Flubacher M.M., Tsichlis P.N.
      Mol. Cell. Biol. 16:4024-4034(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING, SUBCELLULAR LOCATION, FUNCTION.
    4. "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3."
      Roedel B., Tavassoli K., Karsunky H., Schmidt T., Bachmann M., Schaper F., Heinrich P., Shuai K., Elsaesser H.-P., Moeroey T.
      EMBO J. 19:5845-5855(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PIAS3, SUBCELLULAR LOCATION, FUNCTION.
    5. "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism."
      McGhee L., Bryan J., Elliott L., Grimes H.L., Kazanjian A., Davis J.N., Meyers S.
      J. Cell. Biochem. 89:1005-1018(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH RUNX1T1; HDAC1; HDAC2 AND HDAC3, INTERACTION WITH RUNX1T1, SUBCELLULAR LOCATION.
    6. "Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1."
      Duan Z., Zarebski A., Montoya-Durango D., Grimes H.L., Horwitz M.
      Mol. Cell. Biol. 25:10338-10351(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH EHMT2 AND HDAC1, INTERACTION WITH EHMT2 AND HDAC1, FUNCTION.
    7. "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1."
      Marteijn J.A., van der Meer L.T., van Emst L., van Reijmersdal S., Wissink W., de Witte T., Jansen J.H., Van der Reijden B.A.
      Blood 110:3128-3135(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ARIH2, UBIQUITINATION.
    8. "The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction."
      Dahl R., Iyer S.R., Owens K.S., Cuylear D.D., Simon M.C.
      J. Biol. Chem. 282:6473-6483(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SPI1, DOMAIN ZINC-FINGER, FUNCTION, MUTAGENESIS OF PRO-2.
    9. "Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor."
      Montoya-Durango D.E., Velu C.S., Kazanjian A., Rojas M.E., Jay C.M., Longmore G.D., Grimes H.L.
      J. Biol. Chem. 283:32056-32065(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AJUBA IN THE GFI1-AJUBA-HDAC COMPLEX, SUBCELLULAR LOCATION, FUNCTION.
    10. "Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth."
      Ossovskaya V.S., Dolganov G., Basbaum A.I.
      J. Neurosci. Methods 177:322-333(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1."
      Basu S., Liu Q., Qiu Y., Dong F.
      Proc. Natl. Acad. Sci. U.S.A. 106:1433-1438(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ZBTB17.
    12. "Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65."
      Sharif-Askari E., Vassen L., Kosan C., Khandanpour C., Gaudreau M.C., Heyd F., Okayama T., Jin J., Rojas M.E., Grimes H.L., Zeng H., Moroy T.
      Mol. Cell. Biol. 30:3929-3942(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RELA, SUBCELLULAR LOCATION, INDUCTION, FUNCTION.
    13. "A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A."
      Liu Q., Basu S., Qiu Y., Tang F., Dong F.
      Oncogene 29:2843-2852(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZBTB17, FUNCTION, INDUCTION, CHARACTERIZATION OF VARIANT SER-382.
    14. Cited for: VARIANT NI-CINA ARG-403, VARIANT SCN2 SER-382, CHARACTERIZATION OF VARIANTS NI-CINA ARG-403 AND SCN2 SER-382, FUNCTION.

    Entry informationi

    Entry nameiGFI1_HUMAN
    AccessioniPrimary (citable) accession number: Q99684
    Secondary accession number(s): Q8N564
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 15, 2003
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3