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Protein

Probable G-protein coupled receptor 22

Gene

GPR22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • peptide binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 22
Gene namesi
Name:GPR22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:4477. GPR22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini67 – 8519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei86 – 10621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini107 – 1159ExtracellularSequence Analysis
Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 20831ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini230 – 31586CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei316 – 33621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini337 – 34913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei350 – 37021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini371 – 43363CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28865.

Polymorphism and mutation databases

BioMutaiGPR22.
DMDMi116242502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Probable G-protein coupled receptor 22PRO_0000069543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ99680.
PaxDbiQ99680.
PRIDEiQ99680.

PTM databases

PhosphoSiteiQ99680.

Expressioni

Tissue specificityi

In the brain regions frontal cortex, caudate, putamen and thalamus; not in pons, hypothalamus and hippocampus.

Gene expression databases

BgeeiQ99680.
CleanExiHS_GPR22.
ExpressionAtlasiQ99680. baseline and differential.
GenevisibleiQ99680. HS.

Organism-specific databases

HPAiHPA012043.

Interactioni

Protein-protein interaction databases

BioGridi109104. 3 interactions.
IntActiQ99680. 3 interactions.
STRINGi9606.ENSP00000302676.

Structurei

3D structure databases

ProteinModelPortaliQ99680.
SMRiQ99680. Positions 60-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG286382.
GeneTreeiENSGT00730000111017.
HOVERGENiHBG051802.
InParanoidiQ99680.
KOiK04319.
OMAiRAVMLMT.
OrthoDBiEOG7JMGDG.
PhylomeDBiQ99680.
TreeFamiTF318505.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML
60 70 80 90 100
EIVLGLGSNL TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI
110 120 130 140 150
VILLLSLESN TALICCFHEA CVSFASVSTA INVFAITLDR YDISVKPANR
160 170 180 190 200
ILTMGRAVML MISIWIFSFF SFLIPFIEVN FFSLQSGNTW ENKTLLCVST
210 220 230 240 250
NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI RIGTRFSTGQ
260 270 280 290 300
KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR
310 320 330 340 350
HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL
360 370 380 390 400
CFLVMAYGTT IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV
410 420 430
IHNSWIDPKR NKKITFEDSE IREKCLVPQV VTD
Length:433
Mass (Da):49,265
Last modified:October 17, 2006 - v2
Checksum:i2D4DC8AC567C4DC1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti425 – 4251C → R in AAC51304 (PubMed:9073069).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66581 Genomic DNA. Translation: AAC51304.1.
AC002381 Genomic DNA. Translation: AAB63815.1.
CCDSiCCDS5744.1.
RefSeqiNP_005286.2. NM_005295.2.
UniGeneiHs.657277.

Genome annotation databases

EnsembliENST00000304402; ENSP00000302676; ENSG00000172209.
GeneIDi2845.
KEGGihsa:2845.
UCSCiuc003vef.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66581 Genomic DNA. Translation: AAC51304.1.
AC002381 Genomic DNA. Translation: AAB63815.1.
CCDSiCCDS5744.1.
RefSeqiNP_005286.2. NM_005295.2.
UniGeneiHs.657277.

3D structure databases

ProteinModelPortaliQ99680.
SMRiQ99680. Positions 60-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109104. 3 interactions.
IntActiQ99680. 3 interactions.
STRINGi9606.ENSP00000302676.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ99680.

Polymorphism and mutation databases

BioMutaiGPR22.
DMDMi116242502.

Proteomic databases

MaxQBiQ99680.
PaxDbiQ99680.
PRIDEiQ99680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304402; ENSP00000302676; ENSG00000172209.
GeneIDi2845.
KEGGihsa:2845.
UCSCiuc003vef.3. human.

Organism-specific databases

CTDi2845.
GeneCardsiGC07P107110.
HGNCiHGNC:4477. GPR22.
HPAiHPA012043.
MIMi601910. gene.
neXtProtiNX_Q99680.
PharmGKBiPA28865.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG286382.
GeneTreeiENSGT00730000111017.
HOVERGENiHBG051802.
InParanoidiQ99680.
KOiK04319.
OMAiRAVMLMT.
OrthoDBiEOG7JMGDG.
PhylomeDBiQ99680.
TreeFamiTF318505.

Miscellaneous databases

GeneWikiiGPR22.
GenomeRNAii2845.
NextBioi11223.
PROiQ99680.
SOURCEiSearch...

Gene expression databases

BgeeiQ99680.
CleanExiHS_GPR22.
ExpressionAtlasiQ99680. baseline and differential.
GenevisibleiQ99680. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes."
    O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q., Kolakowski L.F. Jr., Lynch K.R., George S.R.
    Gene 187:75-81(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGPR22_HUMAN
AccessioniPrimary (citable) accession number: Q99680
Secondary accession number(s): O14554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: June 24, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.