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Q99680 (GPR22_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 22
Gene names
Name:GPR22
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

In the brain regions frontal cortex, caudate, putamen and thalamus; not in pons, hypothalamus and hippocampus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Probable G-protein coupled receptor 22
PRO_0000069543

Regions

Topological domain1 – 4545Extracellular Potential
Transmembrane46 – 6621Helical; Name=1; Potential
Topological domain67 – 8519Cytoplasmic Potential
Transmembrane86 – 10621Helical; Name=2; Potential
Topological domain107 – 1159Extracellular Potential
Transmembrane116 – 13621Helical; Name=3; Potential
Topological domain137 – 15620Cytoplasmic Potential
Transmembrane157 – 17721Helical; Name=4; Potential
Topological domain178 – 20831Extracellular Potential
Transmembrane209 – 22921Helical; Name=5; Potential
Topological domain230 – 31586Cytoplasmic Potential
Transmembrane316 – 33621Helical; Name=6; Potential
Topological domain337 – 34913Extracellular Potential
Transmembrane350 – 37021Helical; Name=7; Potential
Topological domain371 – 43363Cytoplasmic Potential

Amino acid modifications

Glycosylation161N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict4251C → R in AAC51304. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q99680 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 2D4DC8AC567C4DC1

FASTA43349,265
        10         20         30         40         50         60 
MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL 

        70         80         90        100        110        120 
TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA 

       130        140        150        160        170        180 
CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN 

       190        200        210        220        230        240 
FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI 

       250        260        270        280        290        300 
RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR 

       310        320        330        340        350        360 
HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT 

       370        380        390        400        410        420 
IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE 

       430 
IREKCLVPQV VTD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes."
O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q., Kolakowski L.F. Jr., Lynch K.R., George S.R.
Gene 187:75-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66581 Genomic DNA. Translation: AAC51304.1.
AC002381 Genomic DNA. Translation: AAB63815.1.
CCDSCCDS5744.1.
RefSeqNP_005286.2. NM_005295.2.
UniGeneHs.657277.

3D structure databases

ProteinModelPortalQ99680.
SMRQ99680. Positions 60-238.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109104. 3 interactions.
IntActQ99680. 3 interactions.
STRING9606.ENSP00000302676.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ99680.

Polymorphism databases

DMDM116242502.

Proteomic databases

PaxDbQ99680.
PRIDEQ99680.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304402; ENSP00000302676; ENSG00000172209.
GeneID2845.
KEGGhsa:2845.
UCSCuc003vef.3. human.

Organism-specific databases

CTD2845.
GeneCardsGC07P107110.
HGNCHGNC:4477. GPR22.
HPAHPA012043.
MIM601910. gene.
neXtProtNX_Q99680.
PharmGKBPA28865.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG286382.
HOVERGENHBG051802.
InParanoidQ99680.
KOK04319.
OMARAVMLMT.
OrthoDBEOG7JMGDG.
PhylomeDBQ99680.
TreeFamTF318505.

Gene expression databases

ArrayExpressQ99680.
BgeeQ99680.
CleanExHS_GPR22.
GenevestigatorQ99680.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR22.
GenomeRNAi2845.
NextBio11223.
PROQ99680.
SOURCESearch...

Entry information

Entry nameGPR22_HUMAN
AccessionPrimary (citable) accession number: Q99680
Secondary accession number(s): O14554
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries