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Q99680

- GPR22_HUMAN

UniProt

Q99680 - GPR22_HUMAN

Protein

Probable G-protein coupled receptor 22

Gene

GPR22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 22
    Gene namesi
    Name:GPR22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:4477. GPR22.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28865.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Probable G-protein coupled receptor 22PRO_0000069543Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ99680.
    PRIDEiQ99680.

    PTM databases

    PhosphoSiteiQ99680.

    Expressioni

    Tissue specificityi

    In the brain regions frontal cortex, caudate, putamen and thalamus; not in pons, hypothalamus and hippocampus.

    Gene expression databases

    ArrayExpressiQ99680.
    BgeeiQ99680.
    CleanExiHS_GPR22.
    GenevestigatoriQ99680.

    Organism-specific databases

    HPAiHPA012043.

    Interactioni

    Protein-protein interaction databases

    BioGridi109104. 3 interactions.
    IntActiQ99680. 3 interactions.
    STRINGi9606.ENSP00000302676.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99680.
    SMRiQ99680. Positions 60-238.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 8519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 1159ExtracellularSequence Analysis
    Topological domaini137 – 15620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini230 – 31586CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini337 – 34913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini371 – 43363CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG286382.
    HOVERGENiHBG051802.
    InParanoidiQ99680.
    KOiK04319.
    OMAiRAVMLMT.
    OrthoDBiEOG7JMGDG.
    PhylomeDBiQ99680.
    TreeFamiTF318505.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99680-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML    50
    EIVLGLGSNL TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI 100
    VILLLSLESN TALICCFHEA CVSFASVSTA INVFAITLDR YDISVKPANR 150
    ILTMGRAVML MISIWIFSFF SFLIPFIEVN FFSLQSGNTW ENKTLLCVST 200
    NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI RIGTRFSTGQ 250
    KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR 300
    HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL 350
    CFLVMAYGTT IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV 400
    IHNSWIDPKR NKKITFEDSE IREKCLVPQV VTD 433
    Length:433
    Mass (Da):49,265
    Last modified:October 17, 2006 - v2
    Checksum:i2D4DC8AC567C4DC1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti425 – 4251C → R in AAC51304. (PubMed:9073069)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66581 Genomic DNA. Translation: AAC51304.1.
    AC002381 Genomic DNA. Translation: AAB63815.1.
    CCDSiCCDS5744.1.
    RefSeqiNP_005286.2. NM_005295.2.
    UniGeneiHs.657277.

    Genome annotation databases

    EnsembliENST00000304402; ENSP00000302676; ENSG00000172209.
    GeneIDi2845.
    KEGGihsa:2845.
    UCSCiuc003vef.3. human.

    Polymorphism databases

    DMDMi116242502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66581 Genomic DNA. Translation: AAC51304.1 .
    AC002381 Genomic DNA. Translation: AAB63815.1 .
    CCDSi CCDS5744.1.
    RefSeqi NP_005286.2. NM_005295.2.
    UniGenei Hs.657277.

    3D structure databases

    ProteinModelPortali Q99680.
    SMRi Q99680. Positions 60-238.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109104. 3 interactions.
    IntActi Q99680. 3 interactions.
    STRINGi 9606.ENSP00000302676.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q99680.

    Polymorphism databases

    DMDMi 116242502.

    Proteomic databases

    PaxDbi Q99680.
    PRIDEi Q99680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304402 ; ENSP00000302676 ; ENSG00000172209 .
    GeneIDi 2845.
    KEGGi hsa:2845.
    UCSCi uc003vef.3. human.

    Organism-specific databases

    CTDi 2845.
    GeneCardsi GC07P107110.
    HGNCi HGNC:4477. GPR22.
    HPAi HPA012043.
    MIMi 601910. gene.
    neXtProti NX_Q99680.
    PharmGKBi PA28865.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286382.
    HOVERGENi HBG051802.
    InParanoidi Q99680.
    KOi K04319.
    OMAi RAVMLMT.
    OrthoDBi EOG7JMGDG.
    PhylomeDBi Q99680.
    TreeFami TF318505.

    Miscellaneous databases

    GeneWikii GPR22.
    GenomeRNAii 2845.
    NextBioi 11223.
    PROi Q99680.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99680.
    Bgeei Q99680.
    CleanExi HS_GPR22.
    Genevestigatori Q99680.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes."
      O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q., Kolakowski L.F. Jr., Lynch K.R., George S.R.
      Gene 187:75-81(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGPR22_HUMAN
    AccessioniPrimary (citable) accession number: Q99680
    Secondary accession number(s): O14554
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3