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Q99680

- GPR22_HUMAN

UniProt

Q99680 - GPR22_HUMAN

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Protein

Probable G-protein coupled receptor 22

Gene

GPR22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 22
Gene namesi
Name:GPR22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:4477. GPR22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini67 – 8519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei86 – 10621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini107 – 1159ExtracellularSequence Analysis
Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 20831ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini230 – 31586CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei316 – 33621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini337 – 34913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei350 – 37021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini371 – 43363CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Probable G-protein coupled receptor 22PRO_0000069543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ99680.
PaxDbiQ99680.
PRIDEiQ99680.

PTM databases

PhosphoSiteiQ99680.

Expressioni

Tissue specificityi

In the brain regions frontal cortex, caudate, putamen and thalamus; not in pons, hypothalamus and hippocampus.

Gene expression databases

BgeeiQ99680.
CleanExiHS_GPR22.
ExpressionAtlasiQ99680. baseline.
GenevestigatoriQ99680.

Organism-specific databases

HPAiHPA012043.

Interactioni

Protein-protein interaction databases

BioGridi109104. 3 interactions.
IntActiQ99680. 3 interactions.
STRINGi9606.ENSP00000302676.

Structurei

3D structure databases

ProteinModelPortaliQ99680.
SMRiQ99680. Positions 60-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG286382.
GeneTreeiENSGT00730000111017.
HOVERGENiHBG051802.
InParanoidiQ99680.
KOiK04319.
OMAiRAVMLMT.
OrthoDBiEOG7JMGDG.
PhylomeDBiQ99680.
TreeFamiTF318505.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99680-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML
60 70 80 90 100
EIVLGLGSNL TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI
110 120 130 140 150
VILLLSLESN TALICCFHEA CVSFASVSTA INVFAITLDR YDISVKPANR
160 170 180 190 200
ILTMGRAVML MISIWIFSFF SFLIPFIEVN FFSLQSGNTW ENKTLLCVST
210 220 230 240 250
NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI RIGTRFSTGQ
260 270 280 290 300
KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR
310 320 330 340 350
HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL
360 370 380 390 400
CFLVMAYGTT IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV
410 420 430
IHNSWIDPKR NKKITFEDSE IREKCLVPQV VTD
Length:433
Mass (Da):49,265
Last modified:October 17, 2006 - v2
Checksum:i2D4DC8AC567C4DC1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti425 – 4251C → R in AAC51304. (PubMed:9073069)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66581 Genomic DNA. Translation: AAC51304.1.
AC002381 Genomic DNA. Translation: AAB63815.1.
CCDSiCCDS5744.1.
RefSeqiNP_005286.2. NM_005295.2.
UniGeneiHs.657277.

Genome annotation databases

EnsembliENST00000304402; ENSP00000302676; ENSG00000172209.
GeneIDi2845.
KEGGihsa:2845.
UCSCiuc003vef.3. human.

Polymorphism databases

DMDMi116242502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66581 Genomic DNA. Translation: AAC51304.1 .
AC002381 Genomic DNA. Translation: AAB63815.1 .
CCDSi CCDS5744.1.
RefSeqi NP_005286.2. NM_005295.2.
UniGenei Hs.657277.

3D structure databases

ProteinModelPortali Q99680.
SMRi Q99680. Positions 60-238.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109104. 3 interactions.
IntActi Q99680. 3 interactions.
STRINGi 9606.ENSP00000302676.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q99680.

Polymorphism databases

DMDMi 116242502.

Proteomic databases

MaxQBi Q99680.
PaxDbi Q99680.
PRIDEi Q99680.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304402 ; ENSP00000302676 ; ENSG00000172209 .
GeneIDi 2845.
KEGGi hsa:2845.
UCSCi uc003vef.3. human.

Organism-specific databases

CTDi 2845.
GeneCardsi GC07P107110.
HGNCi HGNC:4477. GPR22.
HPAi HPA012043.
MIMi 601910. gene.
neXtProti NX_Q99680.
PharmGKBi PA28865.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG286382.
GeneTreei ENSGT00730000111017.
HOVERGENi HBG051802.
InParanoidi Q99680.
KOi K04319.
OMAi RAVMLMT.
OrthoDBi EOG7JMGDG.
PhylomeDBi Q99680.
TreeFami TF318505.

Miscellaneous databases

GeneWikii GPR22.
GenomeRNAii 2845.
NextBioi 11223.
PROi Q99680.
SOURCEi Search...

Gene expression databases

Bgeei Q99680.
CleanExi HS_GPR22.
ExpressionAtlasi Q99680. baseline.
Genevestigatori Q99680.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes."
    O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q., Kolakowski L.F. Jr., Lynch K.R., George S.R.
    Gene 187:75-81(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGPR22_HUMAN
AccessioniPrimary (citable) accession number: Q99680
Secondary accession number(s): O14554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3