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Protein

Probable G-protein coupled receptor 21

Gene

GPR21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-31352-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 21
Gene namesi
Name:GPR21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:4476. GPR21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini54 – 75CytoplasmicSequence analysisAdd BLAST22
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 104ExtracellularSequence analysis8
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 147CytoplasmicSequence analysisAdd BLAST22
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 191ExtracellularSequence analysisAdd BLAST23
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 252CytoplasmicSequence analysisAdd BLAST40
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 283ExtracellularSequence analysis10
Transmembranei284 – 304Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini305 – 349CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000011454.
ENSG00000188394.
PharmGKBiPA28864.

Polymorphism and mutation databases

DMDMi2495040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695421 – 349Probable G-protein coupled receptor 21Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99679.
PRIDEiQ99679.

PTM databases

iPTMnetiQ99679.
PhosphoSitePlusiQ99679.

Expressioni

Tissue specificityi

Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus, hippocampus.

Gene expression databases

BgeeiENSG00000188394.
GenevisibleiQ99679. HS.

Organism-specific databases

HPAiHPA041651.

Interactioni

Protein-protein interaction databases

BioGridi109103. 73 interactors.
IntActiQ99679. 1 interactor.
STRINGi9606.ENSP00000362746.

Structurei

3D structure databases

ProteinModelPortaliQ99679.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00750000117238.
ENSGT00790000123085.
HOGENOMiHOG000261615.
HOVERGENiHBG051801.
InParanoidiQ99679.
KOiK04318.
OMAiTGHSNRF.
OrthoDBiEOG091G092Z.
PhylomeDBiQ99679.
TreeFamiTF332372.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99679-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTLDGNQS SHPFCLLAFG YLETVNFCLL EVLIIVFLTV LIISGNIIVI
60 70 80 90 100
FVFHCAPLLN HHTTSYFIQT MAYADLFVGV SCVVPSLSLL HHPLPVEESL
110 120 130 140 150
TCQIFGFVVS VLKSVSMASL ACISIDRYIA ITKPLTYNTL VTPWRLRLCI
160 170 180 190 200
FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW CAESWHTDSY FTLFIVMMLY
210 220 230 240 250
APAALIVCFT YFNIFRICQQ HTKDISERQA RFSSQSGETG EVQACPDKRY
260 270 280 290 300
AMVLFRITSV FYILWLPYII YFLLESSTGH SNRFASFLTT WLAISNSFCN
310 320 330 340
CVIYSLSNSV FQRGLKRLSG AMCTSCASQT TANDPYTVRS KGPLNGCHI
Length:349
Mass (Da):39,515
Last modified:May 1, 1997 - v1
Checksum:i5369DFC216E9EEC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66580 Genomic DNA. Translation: AAC51303.1.
AK313539 mRNA. Translation: BAG36316.1.
CH471090 Genomic DNA. Translation: EAW87559.1.
BC066885 mRNA. Translation: AAH66885.2.
BC066886 mRNA. Translation: AAH66886.2.
BC067532 mRNA. Translation: AAH67532.2.
BC067533 mRNA. Translation: AAH67533.2.
CCDSiCCDS6849.1.
RefSeqiNP_005285.1. NM_005294.2.
XP_005251990.1. XM_005251933.3.
UniGeneiHs.722039.

Genome annotation databases

EnsembliENST00000373642; ENSP00000362746; ENSG00000188394.
GeneIDi2844.
KEGGihsa:2844.
UCSCiuc011lzk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66580 Genomic DNA. Translation: AAC51303.1.
AK313539 mRNA. Translation: BAG36316.1.
CH471090 Genomic DNA. Translation: EAW87559.1.
BC066885 mRNA. Translation: AAH66885.2.
BC066886 mRNA. Translation: AAH66886.2.
BC067532 mRNA. Translation: AAH67532.2.
BC067533 mRNA. Translation: AAH67533.2.
CCDSiCCDS6849.1.
RefSeqiNP_005285.1. NM_005294.2.
XP_005251990.1. XM_005251933.3.
UniGeneiHs.722039.

3D structure databases

ProteinModelPortaliQ99679.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109103. 73 interactors.
IntActiQ99679. 1 interactor.
STRINGi9606.ENSP00000362746.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ99679.
PhosphoSitePlusiQ99679.

Polymorphism and mutation databases

DMDMi2495040.

Proteomic databases

PaxDbiQ99679.
PRIDEiQ99679.

Protocols and materials databases

DNASUi2844.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373642; ENSP00000362746; ENSG00000188394.
GeneIDi2844.
KEGGihsa:2844.
UCSCiuc011lzk.3. human.

Organism-specific databases

CTDi2844.
GeneCardsiGPR21.
HGNCiHGNC:4476. GPR21.
HPAiHPA041651.
MIMi601909. gene.
neXtProtiNX_Q99679.
OpenTargetsiENSG00000011454.
ENSG00000188394.
PharmGKBiPA28864.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00750000117238.
ENSGT00790000123085.
HOGENOMiHOG000261615.
HOVERGENiHBG051801.
InParanoidiQ99679.
KOiK04318.
OMAiTGHSNRF.
OrthoDBiEOG091G092Z.
PhylomeDBiQ99679.
TreeFamiTF332372.

Enzyme and pathway databases

BioCyciZFISH:G66-31352-MONOMER.

Miscellaneous databases

GeneWikiiGPR21.
GenomeRNAii2844.
PROiQ99679.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188394.
GenevisibleiQ99679. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR21_HUMAN
AccessioniPrimary (citable) accession number: Q99679
Secondary accession number(s): B2R8W9, Q6NXU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.