Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q99679 (GPR21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 21
Gene names
Name:GPR21
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus, hippocampus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Probable G-protein coupled receptor 21
PRO_0000069542

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 5321Helical; Name=1; Potential
Topological domain54 – 7522Cytoplasmic Potential
Transmembrane76 – 9621Helical; Name=2; Potential
Topological domain97 – 1048Extracellular Potential
Transmembrane105 – 12521Helical; Name=3; Potential
Topological domain126 – 14722Cytoplasmic Potential
Transmembrane148 – 16821Helical; Name=4; Potential
Topological domain169 – 19123Extracellular Potential
Transmembrane192 – 21221Helical; Name=5; Potential
Topological domain213 – 25240Cytoplasmic Potential
Transmembrane253 – 27321Helical; Name=6; Potential
Topological domain274 – 28310Extracellular Potential
Transmembrane284 – 30421Helical; Name=7; Potential
Topological domain305 – 34945Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation81N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q99679 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 5369DFC216E9EEC4

FASTA34939,515
        10         20         30         40         50         60 
MNSTLDGNQS SHPFCLLAFG YLETVNFCLL EVLIIVFLTV LIISGNIIVI FVFHCAPLLN 

        70         80         90        100        110        120 
HHTTSYFIQT MAYADLFVGV SCVVPSLSLL HHPLPVEESL TCQIFGFVVS VLKSVSMASL 

       130        140        150        160        170        180 
ACISIDRYIA ITKPLTYNTL VTPWRLRLCI FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW 

       190        200        210        220        230        240 
CAESWHTDSY FTLFIVMMLY APAALIVCFT YFNIFRICQQ HTKDISERQA RFSSQSGETG 

       250        260        270        280        290        300 
EVQACPDKRY AMVLFRITSV FYILWLPYII YFLLESSTGH SNRFASFLTT WLAISNSFCN 

       310        320        330        340 
CVIYSLSNSV FQRGLKRLSG AMCTSCASQT TANDPYTVRS KGPLNGCHI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes."
O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q., Kolakowski L.F. Jr., Lynch K.R., George S.R.
Gene 187:75-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66580 Genomic DNA. Translation: AAC51303.1.
AK313539 mRNA. Translation: BAG36316.1.
CH471090 Genomic DNA. Translation: EAW87559.1.
BC066885 mRNA. Translation: AAH66885.2.
BC066886 mRNA. Translation: AAH66886.2.
BC067532 mRNA. Translation: AAH67532.2.
BC067533 mRNA. Translation: AAH67533.2.
CCDSCCDS6849.1.
RefSeqNP_005285.1. NM_005294.2.
XP_005251990.1. XM_005251933.1.
UniGeneHs.722039.

3D structure databases

ProteinModelPortalQ99679.
SMRQ99679. Positions 33-318.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109103. 1 interaction.
IntActQ99679. 1 interaction.
STRING9606.ENSP00000362746.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ99679.

Polymorphism databases

DMDM2495040.

Proteomic databases

PaxDbQ99679.
PRIDEQ99679.

Protocols and materials databases

DNASU2844.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373642; ENSP00000362746; ENSG00000188394.
GeneID2844.
KEGGhsa:2844.
UCSCuc011lzk.3. human.

Organism-specific databases

CTD2844.
GeneCardsGC09P125795.
HGNCHGNC:4476. GPR21.
HPAHPA041651.
MIM601909. gene.
neXtProtNX_Q99679.
PharmGKBPA28864.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG254574.
HOGENOMHOG000261615.
HOVERGENHBG051801.
InParanoidQ99679.
KOK04318.
OMATGHSNRF.
OrthoDBEOG7B05D5.
PhylomeDBQ99679.
TreeFamTF332372.

Gene expression databases

BgeeQ99679.
GenevestigatorQ99679.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR21.
GenomeRNAi2844.
NextBio11219.
PROQ99679.
SOURCESearch...

Entry information

Entry nameGPR21_HUMAN
AccessionPrimary (citable) accession number: Q99679
Secondary accession number(s): B2R8W9, Q6NXU2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries