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Q99679

- GPR21_HUMAN

UniProt

Q99679 - GPR21_HUMAN

Protein

Probable G-protein coupled receptor 21

Gene

GPR21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. glucose homeostasis Source: Ensembl
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. negative regulation of insulin receptor signaling pathway Source: Ensembl
    4. positive regulation of multicellular organism growth Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 21
    Gene namesi
    Name:GPR21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:4476. GPR21.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28864.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Probable G-protein coupled receptor 21PRO_0000069542Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ99679.
    PRIDEiQ99679.

    PTM databases

    PhosphoSiteiQ99679.

    Expressioni

    Tissue specificityi

    Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus, hippocampus.

    Gene expression databases

    BgeeiQ99679.
    GenevestigatoriQ99679.

    Organism-specific databases

    HPAiHPA041651.

    Interactioni

    Protein-protein interaction databases

    BioGridi109103. 1 interaction.
    IntActiQ99679. 1 interaction.
    STRINGi9606.ENSP00000362746.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99679.
    SMRiQ99679. Positions 33-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini54 – 7522CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 1048ExtracellularSequence Analysis
    Topological domaini126 – 14722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 19123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 25240CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28310ExtracellularSequence Analysis
    Topological domaini305 – 34945CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG254574.
    HOGENOMiHOG000261615.
    HOVERGENiHBG051801.
    InParanoidiQ99679.
    KOiK04318.
    OMAiTGHSNRF.
    OrthoDBiEOG7B05D5.
    PhylomeDBiQ99679.
    TreeFamiTF332372.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99679-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSTLDGNQS SHPFCLLAFG YLETVNFCLL EVLIIVFLTV LIISGNIIVI    50
    FVFHCAPLLN HHTTSYFIQT MAYADLFVGV SCVVPSLSLL HHPLPVEESL 100
    TCQIFGFVVS VLKSVSMASL ACISIDRYIA ITKPLTYNTL VTPWRLRLCI 150
    FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW CAESWHTDSY FTLFIVMMLY 200
    APAALIVCFT YFNIFRICQQ HTKDISERQA RFSSQSGETG EVQACPDKRY 250
    AMVLFRITSV FYILWLPYII YFLLESSTGH SNRFASFLTT WLAISNSFCN 300
    CVIYSLSNSV FQRGLKRLSG AMCTSCASQT TANDPYTVRS KGPLNGCHI 349
    Length:349
    Mass (Da):39,515
    Last modified:May 1, 1997 - v1
    Checksum:i5369DFC216E9EEC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66580 Genomic DNA. Translation: AAC51303.1.
    AK313539 mRNA. Translation: BAG36316.1.
    CH471090 Genomic DNA. Translation: EAW87559.1.
    BC066885 mRNA. Translation: AAH66885.2.
    BC066886 mRNA. Translation: AAH66886.2.
    BC067532 mRNA. Translation: AAH67532.2.
    BC067533 mRNA. Translation: AAH67533.2.
    CCDSiCCDS6849.1.
    RefSeqiNP_005285.1. NM_005294.2.
    XP_005251990.1. XM_005251933.1.
    UniGeneiHs.722039.

    Genome annotation databases

    EnsembliENST00000373642; ENSP00000362746; ENSG00000188394.
    GeneIDi2844.
    KEGGihsa:2844.
    UCSCiuc011lzk.3. human.

    Polymorphism databases

    DMDMi2495040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66580 Genomic DNA. Translation: AAC51303.1 .
    AK313539 mRNA. Translation: BAG36316.1 .
    CH471090 Genomic DNA. Translation: EAW87559.1 .
    BC066885 mRNA. Translation: AAH66885.2 .
    BC066886 mRNA. Translation: AAH66886.2 .
    BC067532 mRNA. Translation: AAH67532.2 .
    BC067533 mRNA. Translation: AAH67533.2 .
    CCDSi CCDS6849.1.
    RefSeqi NP_005285.1. NM_005294.2.
    XP_005251990.1. XM_005251933.1.
    UniGenei Hs.722039.

    3D structure databases

    ProteinModelPortali Q99679.
    SMRi Q99679. Positions 33-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109103. 1 interaction.
    IntActi Q99679. 1 interaction.
    STRINGi 9606.ENSP00000362746.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q99679.

    Polymorphism databases

    DMDMi 2495040.

    Proteomic databases

    PaxDbi Q99679.
    PRIDEi Q99679.

    Protocols and materials databases

    DNASUi 2844.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373642 ; ENSP00000362746 ; ENSG00000188394 .
    GeneIDi 2844.
    KEGGi hsa:2844.
    UCSCi uc011lzk.3. human.

    Organism-specific databases

    CTDi 2844.
    GeneCardsi GC09P125795.
    HGNCi HGNC:4476. GPR21.
    HPAi HPA041651.
    MIMi 601909. gene.
    neXtProti NX_Q99679.
    PharmGKBi PA28864.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254574.
    HOGENOMi HOG000261615.
    HOVERGENi HBG051801.
    InParanoidi Q99679.
    KOi K04318.
    OMAi TGHSNRF.
    OrthoDBi EOG7B05D5.
    PhylomeDBi Q99679.
    TreeFami TF332372.

    Miscellaneous databases

    GeneWikii GPR21.
    GenomeRNAii 2844.
    NextBioi 11219.
    PROi Q99679.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99679.
    Genevestigatori Q99679.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes."
      O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q., Kolakowski L.F. Jr., Lynch K.R., George S.R.
      Gene 187:75-81(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiGPR21_HUMAN
    AccessioniPrimary (citable) accession number: Q99679
    Secondary accession number(s): B2R8W9, Q6NXU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3