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Protein

Probable G-protein coupled receptor 21

Gene

GPR21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. glucose homeostasis Source: Ensembl
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. negative regulation of insulin receptor signaling pathway Source: Ensembl
  4. positive regulation of multicellular organism growth Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 21
Gene namesi
Name:GPR21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:4476. GPR21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 5321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini54 – 7522CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini97 – 1048ExtracellularSequence Analysis
Transmembranei105 – 12521Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini126 – 14722CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini169 – 19123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini213 – 25240CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini274 – 28310ExtracellularSequence Analysis
Transmembranei284 – 30421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini305 – 34945CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Probable G-protein coupled receptor 21PRO_0000069542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99679.
PRIDEiQ99679.

PTM databases

PhosphoSiteiQ99679.

Expressioni

Tissue specificityi

Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus, hippocampus.

Gene expression databases

BgeeiQ99679.
ExpressionAtlasiQ99679. baseline.
GenevestigatoriQ99679.

Organism-specific databases

HPAiHPA041651.

Interactioni

Protein-protein interaction databases

BioGridi109103. 1 interaction.
IntActiQ99679. 1 interaction.
STRINGi9606.ENSP00000362746.

Structurei

3D structure databases

ProteinModelPortaliQ99679.
SMRiQ99679. Positions 33-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254574.
GeneTreeiENSGT00750000117238.
ENSGT00780000121940.
HOGENOMiHOG000261615.
HOVERGENiHBG051801.
InParanoidiQ99679.
KOiK04318.
OMAiTGHSNRF.
OrthoDBiEOG7B05D5.
PhylomeDBiQ99679.
TreeFamiTF332372.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99679-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSTLDGNQS SHPFCLLAFG YLETVNFCLL EVLIIVFLTV LIISGNIIVI
60 70 80 90 100
FVFHCAPLLN HHTTSYFIQT MAYADLFVGV SCVVPSLSLL HHPLPVEESL
110 120 130 140 150
TCQIFGFVVS VLKSVSMASL ACISIDRYIA ITKPLTYNTL VTPWRLRLCI
160 170 180 190 200
FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW CAESWHTDSY FTLFIVMMLY
210 220 230 240 250
APAALIVCFT YFNIFRICQQ HTKDISERQA RFSSQSGETG EVQACPDKRY
260 270 280 290 300
AMVLFRITSV FYILWLPYII YFLLESSTGH SNRFASFLTT WLAISNSFCN
310 320 330 340
CVIYSLSNSV FQRGLKRLSG AMCTSCASQT TANDPYTVRS KGPLNGCHI
Length:349
Mass (Da):39,515
Last modified:May 1, 1997 - v1
Checksum:i5369DFC216E9EEC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66580 Genomic DNA. Translation: AAC51303.1.
AK313539 mRNA. Translation: BAG36316.1.
CH471090 Genomic DNA. Translation: EAW87559.1.
BC066885 mRNA. Translation: AAH66885.2.
BC066886 mRNA. Translation: AAH66886.2.
BC067532 mRNA. Translation: AAH67532.2.
BC067533 mRNA. Translation: AAH67533.2.
CCDSiCCDS6849.1.
RefSeqiNP_005285.1. NM_005294.2.
XP_005251990.1. XM_005251933.1.
UniGeneiHs.722039.

Genome annotation databases

EnsembliENST00000373642; ENSP00000362746; ENSG00000188394.
GeneIDi2844.
KEGGihsa:2844.
UCSCiuc011lzk.3. human.

Polymorphism databases

DMDMi2495040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66580 Genomic DNA. Translation: AAC51303.1.
AK313539 mRNA. Translation: BAG36316.1.
CH471090 Genomic DNA. Translation: EAW87559.1.
BC066885 mRNA. Translation: AAH66885.2.
BC066886 mRNA. Translation: AAH66886.2.
BC067532 mRNA. Translation: AAH67532.2.
BC067533 mRNA. Translation: AAH67533.2.
CCDSiCCDS6849.1.
RefSeqiNP_005285.1. NM_005294.2.
XP_005251990.1. XM_005251933.1.
UniGeneiHs.722039.

3D structure databases

ProteinModelPortaliQ99679.
SMRiQ99679. Positions 33-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109103. 1 interaction.
IntActiQ99679. 1 interaction.
STRINGi9606.ENSP00000362746.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ99679.

Polymorphism databases

DMDMi2495040.

Proteomic databases

PaxDbiQ99679.
PRIDEiQ99679.

Protocols and materials databases

DNASUi2844.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373642; ENSP00000362746; ENSG00000188394.
GeneIDi2844.
KEGGihsa:2844.
UCSCiuc011lzk.3. human.

Organism-specific databases

CTDi2844.
GeneCardsiGC09P125795.
HGNCiHGNC:4476. GPR21.
HPAiHPA041651.
MIMi601909. gene.
neXtProtiNX_Q99679.
PharmGKBiPA28864.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG254574.
GeneTreeiENSGT00750000117238.
ENSGT00780000121940.
HOGENOMiHOG000261615.
HOVERGENiHBG051801.
InParanoidiQ99679.
KOiK04318.
OMAiTGHSNRF.
OrthoDBiEOG7B05D5.
PhylomeDBiQ99679.
TreeFamiTF332372.

Miscellaneous databases

GeneWikiiGPR21.
GenomeRNAii2844.
NextBioi11219.
PROiQ99679.
SOURCEiSearch...

Gene expression databases

BgeeiQ99679.
ExpressionAtlasiQ99679. baseline.
GenevestigatoriQ99679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes."
    O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q., Kolakowski L.F. Jr., Lynch K.R., George S.R.
    Gene 187:75-81(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPR21_HUMAN
AccessioniPrimary (citable) accession number: Q99679
Secondary accession number(s): B2R8W9, Q6NXU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: February 4, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.