Q99679 (GPR21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 21

Gene names

Name:

GPR21

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus, hippocampus.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Probable G-protein coupled receptor 21		PRO_0000069542
Regions
	Topological domain	1 – 32	32	Extracellular Potential
	Transmembrane	33 – 53	21	Helical; Name=1; Potential
	Topological domain	54 – 75	22	Cytoplasmic Potential
	Transmembrane	76 – 96	21	Helical; Name=2; Potential
	Topological domain	97 – 104	8	Extracellular Potential
	Transmembrane	105 – 125	21	Helical; Name=3; Potential
	Topological domain	126 – 147	22	Cytoplasmic Potential
	Transmembrane	148 – 168	21	Helical; Name=4; Potential
	Topological domain	169 – 191	23	Extracellular Potential
	Transmembrane	192 – 212	21	Helical; Name=5; Potential
	Topological domain	213 – 252	40	Cytoplasmic Potential
	Transmembrane	253 – 273	21	Helical; Name=6; Potential
	Topological domain	274 – 283	10	Extracellular Potential
	Transmembrane	284 – 304	21	Helical; Name=7; Potential
	Topological domain	305 – 349	45	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	2	1	N-linked (GlcNAc...) Potential
	Glycosylation	8	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q99679 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 5369DFC216E9EEC4	FASTA	349	39,515
	10 20 30 40 50 60 MNSTLDGNQS SHPFCLLAFG YLETVNFCLL EVLIIVFLTV LIISGNIIVI FVFHCAPLLN 70 80 90 100 110 120 HHTTSYFIQT MAYADLFVGV SCVVPSLSLL HHPLPVEESL TCQIFGFVVS VLKSVSMASL 130 140 150 160 170 180 ACISIDRYIA ITKPLTYNTL VTPWRLRLCI FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW 190 200 210 220 230 240 CAESWHTDSY FTLFIVMMLY APAALIVCFT YFNIFRICQQ HTKDISERQA RFSSQSGETG 250 260 270 280 290 300 EVQACPDKRY AMVLFRITSV FYILWLPYII YFLLESSTGH SNRFASFLTT WLAISNSFCN 310 320 330 340 CVIYSLSNSV FQRGLKRLSG AMCTSCASQT TANDPYTVRS KGPLNGCHI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes." O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q., Kolakowski L.F. Jr., Lynch K.R., George S.R. Gene 187:75-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U66580 Genomic DNA. Translation: AAC51303.1. AK313539 mRNA. Translation: BAG36316.1. CH471090 Genomic DNA. Translation: EAW87559.1. BC066885 mRNA. Translation: AAH66885.2. BC066886 mRNA. Translation: AAH66886.2. BC067532 mRNA. Translation: AAH67532.2. BC067533 mRNA. Translation: AAH67533.2.
IPI	IPI00017043.
RefSeq	NP_005285.1. NM_005294.2.
UniGene	Hs.731933. Hs.740981.
3D structure databases
ProteinModelPortal	Q99679.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99679. 1 interaction.
STRING	9606.ENSP00000362746.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q99679.
Polymorphism databases
DMDM	2495040.
Proteomic databases
PaxDb	Q99679.
PRIDE	Q99679.
Protocols and materials databases
DNASU	2844.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373642; ENSP00000362746; ENSG00000188394.
GeneID	2844.
KEGG	hsa:2844.
UCSC	uc011lzk.2. human.
Organism-specific databases
CTD	2844.
GeneCards	GC09P125795.
HGNC	HGNC:4476. GPR21.
HPA	HPA041651.
MIM	601909. gene.
neXtProt	NX_Q99679.
PharmGKB	PA28864.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254574.
HOGENOM	HOG000261615.
HOVERGEN	HBG051801.
InParanoid	Q99679.
KO	K04318.
OMA	TGHSNRF.
OrthoDB	EOG4NGGMW.
PhylomeDB	Q99679.
Gene expression databases
ArrayExpress	Q99679.
Bgee	Q99679.
Genevestigator	Q99679.
GermOnline	ENSG00000188394. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2844.
NextBio	11219.
SOURCE	Search...

Entry information

Entry name

GPR21_HUMAN

Accession

Primary (citable) accession number: Q99679
Secondary accession number(s): B2R8W9, Q6NXU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.