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Protein

G-protein coupled receptor 20

Gene

GPR20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-32213-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 20
Gene namesi
Name:GPR20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:4475. GPR20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 69Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini70 – 86CytoplasmicSequence analysisAdd BLAST17
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 125ExtracellularSequence analysisAdd BLAST18
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini147 – 168CytoplasmicSequence analysisAdd BLAST22
Transmembranei169 – 189Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini190 – 196ExtracellularSequence analysis7
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 238CytoplasmicSequence analysisAdd BLAST21
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 275ExtracellularSequence analysisAdd BLAST16
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 358CytoplasmicSequence analysisAdd BLAST62

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi148R → A: Abolishes G(i) activation. 1 Publication1

Organism-specific databases

DisGeNETi2843.
OpenTargetsiENSG00000204882.
ENSG00000275181.
PharmGKBiPA28863.

Polymorphism and mutation databases

BioMutaiGPR20.
DMDMi281185467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695411 – 358G-protein coupled receptor 20Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99678.
PRIDEiQ99678.

PTM databases

iPTMnetiQ99678.
PhosphoSitePlusiQ99678.

Expressioni

Tissue specificityi

Ubiquitous with highest levels in intestinal tissues. In the brain detected in thalamus, putamen, and caudate, but not in frontal cortex, pons and hypothalamus.1 Publication

Gene expression databases

BgeeiENSG00000204882.
CleanExiHS_GPR20.
GenevisibleiQ99678. HS.

Interactioni

Protein-protein interaction databases

BioGridi109102. 3 interactors.
IntActiQ99678. 3 interactors.
STRINGi9606.ENSP00000366970.

Structurei

3D structure databases

ProteinModelPortaliQ99678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II20. Eukaryota.
ENOG410ZKM2. LUCA.
GeneTreeiENSGT00860000133901.
HOGENOMiHOG000112787.
HOVERGENiHBG051800.
InParanoidiQ99678.
KOiK04317.
OMAiCLRCAFP.
OrthoDBiEOG091G09CE.
PhylomeDBiQ99678.
TreeFamiTF330828.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVSPAGPS AGAVPNATAV TTVRTNASGL EVPLFHLFAR LDEELHGTFP
60 70 80 90 100
GLWLALMAVH GAIFLAGLVL NGLALYVFCC RTRAKTPSVI YTINLVVTDL
110 120 130 140 150
LVGLSLPTRF AVYYGARGCL RCAFPHVLGY FLNMHCSILF LTCICVDRYL
160 170 180 190 200
AIVRPEGSRR CRQPACARAV CAFVWLAAGA VTLSVLGVTG SRPCCRVFAL
210 220 230 240 250
TVLEFLLPLL VISVFTGRIM CALSRPGLLH QGRQRRVRAM QLLLTVLIIF
260 270 280 290 300
LVCFTPFHAR QVAVALWPDM PHHTSLVVYH VAVTLSSLNS CMDPIVYCFV
310 320 330 340 350
TSGFQATVRG LFGQHGEREP SSGDVVSMHR SSKGSGRHHI LSAGPHALTQ

ALANGPEA
Length:358
Mass (Da):38,650
Last modified:December 15, 2009 - v2
Checksum:i5A34126C51BA732C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53 – 54WL → CV in AAC51302 (PubMed:9073069).Curated2
Sequence conflicti157 – 160GSRR → APAA in AAC51302 (PubMed:9073069).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055917230H → R.2 PublicationsCorresponds to variant rs10875472dbSNPEnsembl.1
Natural variantiVAR_055918260R → C.Corresponds to variant rs36092215dbSNPEnsembl.1
Natural variantiVAR_055919313G → S.Corresponds to variant rs34591516dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66579 Genomic DNA. Translation: AAC51302.1.
CH471060 Genomic DNA. Translation: EAW92227.1.
BC117409 mRNA. Translation: AAI17410.1.
CCDSiCCDS34949.1.
RefSeqiNP_005284.2. NM_005293.2.
UniGeneiHs.152432.
Hs.188859.

Genome annotation databases

EnsembliENST00000377741; ENSP00000366970; ENSG00000204882.
ENST00000613887; ENSP00000479665; ENSG00000275181.
GeneIDi2843.
KEGGihsa:2843.
UCSCiuc003ywf.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66579 Genomic DNA. Translation: AAC51302.1.
CH471060 Genomic DNA. Translation: EAW92227.1.
BC117409 mRNA. Translation: AAI17410.1.
CCDSiCCDS34949.1.
RefSeqiNP_005284.2. NM_005293.2.
UniGeneiHs.152432.
Hs.188859.

3D structure databases

ProteinModelPortaliQ99678.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109102. 3 interactors.
IntActiQ99678. 3 interactors.
STRINGi9606.ENSP00000366970.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ99678.
PhosphoSitePlusiQ99678.

Polymorphism and mutation databases

BioMutaiGPR20.
DMDMi281185467.

Proteomic databases

PaxDbiQ99678.
PRIDEiQ99678.

Protocols and materials databases

DNASUi2843.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377741; ENSP00000366970; ENSG00000204882.
ENST00000613887; ENSP00000479665; ENSG00000275181.
GeneIDi2843.
KEGGihsa:2843.
UCSCiuc003ywf.5. human.

Organism-specific databases

CTDi2843.
DisGeNETi2843.
GeneCardsiGPR20.
H-InvDBHIX0034725.
HGNCiHGNC:4475. GPR20.
MIMi601908. gene.
neXtProtiNX_Q99678.
OpenTargetsiENSG00000204882.
ENSG00000275181.
PharmGKBiPA28863.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II20. Eukaryota.
ENOG410ZKM2. LUCA.
GeneTreeiENSGT00860000133901.
HOGENOMiHOG000112787.
HOVERGENiHBG051800.
InParanoidiQ99678.
KOiK04317.
OMAiCLRCAFP.
OrthoDBiEOG091G09CE.
PhylomeDBiQ99678.
TreeFamiTF330828.

Enzyme and pathway databases

BioCyciZFISH:G66-32213-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiGPR20.
GenomeRNAii2843.
PROiQ99678.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204882.
CleanExiHS_GPR20.
GenevisibleiQ99678. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR20_HUMAN
AccessioniPrimary (citable) accession number: Q99678
Secondary accession number(s): Q17R96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 2009
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.