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Protein

Lysophosphatidic acid receptor 4

Gene

LPAR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.

Protein family/group databases

TCDBi9.A.14.13.9. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 4
Short name:
LPA receptor 4
Short name:
LPA-4
Alternative name(s):
G-protein coupled receptor 23
P2Y purinoceptor 9
Short name:
P2Y9
P2Y5-like receptor
Purinergic receptor 9
Gene namesi
Name:LPAR4
Synonyms:GPR23, LPA4, P2RY9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4478. LPAR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini65 – 739CytoplasmicSequence Analysis
Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini95 – 11218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15522CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini177 – 20327ExtracellularSequence AnalysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 25430CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei255 – 27521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini276 – 29419ExtracellularSequence AnalysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini316 – 37055CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394222.

Polymorphism and mutation databases

BioMutaiLPAR4.
DMDMi2495042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Lysophosphatidic acid receptor 4PRO_0000070033Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 188PROSITE-ProRule annotation
Glycosylationi183 – 1831N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99677.
PRIDEiQ99677.

Expressioni

Tissue specificityi

High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.1 Publication

Gene expression databases

BgeeiQ99677.
CleanExiHS_LPAR4.
ExpressionAtlasiQ99677. baseline and differential.
GenevisibleiQ99677. HS.

Organism-specific databases

HPAiHPA054951.
HPA055571.

Interactioni

Protein-protein interaction databases

BioGridi109105. 38 interactions.
IntActiQ99677. 1 interaction.
STRINGi9606.ENSP00000362398.

Structurei

3D structure databases

ProteinModelPortaliQ99677.
SMRiQ99677. Positions 44-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147814.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101917.
InParanoidiQ99677.
KOiK04275.
OMAiNCSLERF.
OrthoDBiEOG7K3TM5.
PhylomeDBiQ99677.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRRFIDFQ FQDSNSSLRP RLGNATANNT CIVDDSFKYN LNGAVYSVVF
60 70 80 90 100
ILGLITNSVS LFVFCFRMKM RSETAIFITN LAVSDLLFVC TLPFKIFYNF
110 120 130 140 150
NRHWPFGDTL CKISGTAFLT NIYGSMLFLT CISVDRFLAI VYPFRSRTIR
160 170 180 190 200
TRRNSAIVCA GVWILVLSGG ISASLFSTTN VNNATTTCFE GFSKRVWKTY
210 220 230 240 250
LSKITIFIEV VGFIIPLILN VSCSSVVLRT LRKPATLSQI GTNKKKVLKM
260 270 280 290 300
ITVHMAVFVV CFVPYNSVLF LYALVRSQAI TNCFLERFAK IMYPITLCLA
310 320 330 340 350
TLNCCFDPFI YYFTLESFQK SFYINAHIRM ESLFKTETPL TTKPSLPAIQ
360 370
EEVSDQTTNN GGELMLESTF
Length:370
Mass (Da):41,895
Last modified:May 1, 1997 - v1
Checksum:i20857F52A3929E48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491V → A in AAH69996 (PubMed:15489334).Curated
Sequence conflicti192 – 1921F → L in AAB66322 (PubMed:9223435).Curated
Sequence conflicti240 – 2401I → V in AAH95538 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66578 Genomic DNA. Translation: AAC51301.1.
U90323 Genomic DNA. Translation: AAB62087.1.
U90322 mRNA. Translation: AAB62088.1.
AF005419 Genomic DNA. Translation: AAB66322.1.
AY301274 Genomic DNA. Translation: AAP58404.1.
AK314134 mRNA. Translation: BAG36824.1.
AL590083 Genomic DNA. Translation: CAD18851.1.
CH471104 Genomic DNA. Translation: EAW98596.1.
BC069996 mRNA. Translation: AAH69996.1.
BC074722 mRNA. Translation: AAH74722.1.
BC095538 mRNA. Translation: AAH95538.1.
CCDSiCCDS14441.1.
PIRiJC5549.
RefSeqiNP_001264929.1. NM_001278000.1.
NP_005287.1. NM_005296.2.
XP_005262183.1. XM_005262126.2.
XP_006724702.1. XM_006724639.2.
XP_011529223.1. XM_011530921.1.
UniGeneiHs.522701.

Genome annotation databases

EnsembliENST00000435339; ENSP00000408205; ENSG00000147145.
ENST00000614823; ENSP00000478261; ENSG00000147145.
GeneIDi2846.
KEGGihsa:2846.
UCSCiuc010nme.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66578 Genomic DNA. Translation: AAC51301.1.
U90323 Genomic DNA. Translation: AAB62087.1.
U90322 mRNA. Translation: AAB62088.1.
AF005419 Genomic DNA. Translation: AAB66322.1.
AY301274 Genomic DNA. Translation: AAP58404.1.
AK314134 mRNA. Translation: BAG36824.1.
AL590083 Genomic DNA. Translation: CAD18851.1.
CH471104 Genomic DNA. Translation: EAW98596.1.
BC069996 mRNA. Translation: AAH69996.1.
BC074722 mRNA. Translation: AAH74722.1.
BC095538 mRNA. Translation: AAH95538.1.
CCDSiCCDS14441.1.
PIRiJC5549.
RefSeqiNP_001264929.1. NM_001278000.1.
NP_005287.1. NM_005296.2.
XP_005262183.1. XM_005262126.2.
XP_006724702.1. XM_006724639.2.
XP_011529223.1. XM_011530921.1.
UniGeneiHs.522701.

3D structure databases

ProteinModelPortaliQ99677.
SMRiQ99677. Positions 44-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109105. 38 interactions.
IntActiQ99677. 1 interaction.
STRINGi9606.ENSP00000362398.

Chemistry

BindingDBiQ99677.
ChEMBLiCHEMBL5968.
GuidetoPHARMACOLOGYi94.

Protein family/group databases

TCDBi9.A.14.13.9. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiLPAR4.
DMDMi2495042.

Proteomic databases

PaxDbiQ99677.
PRIDEiQ99677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435339; ENSP00000408205; ENSG00000147145.
ENST00000614823; ENSP00000478261; ENSG00000147145.
GeneIDi2846.
KEGGihsa:2846.
UCSCiuc010nme.3. human.

Organism-specific databases

CTDi2846.
GeneCardsiGC0XP078004.
HGNCiHGNC:4478. LPAR4.
HPAiHPA054951.
HPA055571.
MIMi300086. gene.
neXtProtiNX_Q99677.
PharmGKBiPA162394222.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147814.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101917.
InParanoidiQ99677.
KOiK04275.
OMAiNCSLERF.
OrthoDBiEOG7K3TM5.
PhylomeDBiQ99677.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.

Miscellaneous databases

GeneWikiiLPAR4.
GenomeRNAii2846.
NextBioi11227.
PROiQ99677.
SOURCEiSearch...

Gene expression databases

BgeeiQ99677.
CleanExiHS_LPAR4.
ExpressionAtlasiQ99677. baseline and differential.
GenevisibleiQ99677. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes."
    O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q., Kolakowski L.F. Jr., Lynch K.R., George S.R.
    Gene 187:75-81(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning, characterization and chromosomal localization of a novel human purinergic receptor (P2Y9)."
    Bohm S.K., Khitin L.M., Payan D.P., Bunnett N.W.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor."
    Janssens R., Boeynaems J.-M., Godart M., Communi D.
    Biochem. Biophys. Res. Commun. 236:106-112(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  6. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  9. "Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family."
    Noguchi K., Ishii S., Shimizu T.
    J. Biol. Chem. 278:25600-25606(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-183.
    Tissue: Plasma.

Entry informationi

Entry nameiLPAR4_HUMAN
AccessioniPrimary (citable) accession number: Q99677
Secondary accession number(s): B2RAC7
, O15132, Q502U9, Q6NSP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: July 22, 2015
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.