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Q99676 (ZN184_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 184
Gene names
Name:ZNF184
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length751 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Tissue specificity

Predominant expression in testis.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 19 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Non-traceable author statement Ref.4. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 751751Zinc finger protein 184
PRO_0000047443

Regions

Domain28 – 9972KRAB
Zinc finger222 – 24423C2H2-type 1
Zinc finger250 – 27223C2H2-type 2
Zinc finger278 – 30023C2H2-type 3
Zinc finger306 – 32823C2H2-type 4
Zinc finger334 – 35623C2H2-type 5
Zinc finger362 – 38423C2H2-type 6
Zinc finger390 – 41223C2H2-type 7
Zinc finger418 – 44023C2H2-type 8
Zinc finger446 – 46823C2H2-type 9
Zinc finger474 – 49623C2H2-type 10
Zinc finger502 – 52423C2H2-type 11
Zinc finger530 – 55223C2H2-type 12
Zinc finger558 – 58023C2H2-type 13
Zinc finger586 – 60823C2H2-type 14
Zinc finger614 – 63623C2H2-type 15
Zinc finger642 – 66423C2H2-type 16
Zinc finger670 – 69223C2H2-type 17
Zinc finger698 – 72023C2H2-type 18
Zinc finger726 – 74823C2H2-type 19

Amino acid modifications

Modified residue1171Phosphoserine Ref.5
Modified residue1221Phosphoserine Ref.5

Natural variations

Natural variant271A → S. Ref.1 Ref.3 Ref.4
Corresponds to variant rs1883216 [ dbSNP | Ensembl ].
VAR_045989

Experimental info

Sequence conflict2861G → C in BAG35662. Ref.1
Sequence conflict2951Q → R in AAC51180. Ref.4
Sequence conflict3591E → G in AAC51180. Ref.4
Sequence conflict379 – 3813QHQ → PHP in AAC51180. Ref.4
Sequence conflict4981R → G in AAC51180. Ref.4
Sequence conflict5261Q → G in AAC51180. Ref.4
Sequence conflict5331K → E in AAC51180. Ref.4
Sequence conflict547 – 5493KHE → QHQ in AAC51180. Ref.4
Sequence conflict7461R → K in AAC51180. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q99676 [UniParc].

Last modified November 30, 2010. Version 4.
Checksum: 249DFB302C6BC97D

FASTA75186,174
        10         20         30         40         50         60 
MEDLSSPDST LLQGGHNLLS SASFQEAVTF KDVIVDFTQE EWKQLDPGQR DLFRDVTLEN 

        70         80         90        100        110        120 
YTHLVSIGLQ VSKPDVISQL EQGTEPWIME PSIPVGTCAD WETRLENSVS APEPDISEEE 

       130        140        150        160        170        180 
LSPEVIVEKH KRDDSWSSNL LESWEYEGSL ERQQANQQTL PKEIKVTEKT IPSWEKGPVN 

       190        200        210        220        230        240 
NEFGKSVNVS SNLVTQEPSP EETSTKRSIK QNSNPVKKEK SCKCNECGKA FSYCSALIRH 

       250        260        270        280        290        300 
QRTHTGEKPY KCNECEKAFS RSENLINHQR IHTGDKPYKC DQCGKGFIEG PSLTQHQRIH 

       310        320        330        340        350        360 
TGEKPYKCDE CGKAFSQRTH LVQHQRIHTG EKPYTCNECG KAFSQRGHFM EHQKIHTGEK 

       370        380        390        400        410        420 
PFKCDECDKT FTRSTHLTQH QKIHTGEKTY KCNECGKAFN GPSTFIRHHM IHTGEKPYEC 

       430        440        450        460        470        480 
NECGKAFSQH SNLTQHQKTH TGEKPYDCAE CGKSFSYWSS LAQHLKIHTG EKPYKCNECG 

       490        500        510        520        530        540 
KAFSYCSSLT QHRRIHTREK PFECSECGKA FSYLSNLNQH QKTHTQEKAY ECKECGKAFI 

       550        560        570        580        590        600 
RSSSLAKHER IHTGEKPYQC HECGKTFSYG SSLIQHRKIH TGERPYKCNE CGRAFNQNIH 

       610        620        630        640        650        660 
LTQHKRIHTG AKPYECAECG KAFRHCSSLA QHQKTHTEEK PYQCNKCEKT FSQSSHLTQH 

       670        680        690        700        710        720 
QRIHTGEKPY KCNECDKAFS RSTHLTEHQN THTGEKPYNC NECRKTFSQS TYLIQHQRIH 

       730        740        750 
SGEKPFGCND CGKSFRYRSA LNKHQRLHPG I 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-27.
Tissue: Testis.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-27.
Tissue: Placenta.
[4]"Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3."
Goldwurm S., Menzies M.L., Banyer J.L., Powell B.L.W., Jazwinska E.C.
Genomics 40:486-489(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-751, VARIANT SER-27.
Tissue: Placenta.
[5]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK312804 mRNA. Translation: BAG35662.1.
AL021918 Genomic DNA. Translation: CAA17278.1.
BC022992 mRNA. Translation: AAH22992.1.
U66561 mRNA. Translation: AAC51180.1.
RefSeqNP_009080.2. NM_007149.2.
XP_005249436.1. XM_005249379.1.
XP_005249437.1. XM_005249380.1.
UniGeneHs.158174.

3D structure databases

ProteinModelPortalQ99676.
SMRQ99676. Positions 22-76, 219-750.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113524. 5 interactions.
IntActQ99676. 3 interactions.
STRING9606.ENSP00000211936.

PTM databases

PhosphoSiteQ99676.

Polymorphism databases

DMDM313104299.

Proteomic databases

PaxDbQ99676.
PRIDEQ99676.

Protocols and materials databases

DNASU7738.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000211936; ENSP00000211936; ENSG00000096654.
ENST00000377419; ENSP00000366636; ENSG00000096654.
GeneID7738.
KEGGhsa:7738.
UCSCuc003nji.3. human.

Organism-specific databases

CTD7738.
GeneCardsGC06M027436.
HGNCHGNC:12975. ZNF184.
HPAHPA003226.
MIM602277. gene.
neXtProtNX_Q99676.
PharmGKBPA37557.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ99676.
KOK09228.
OMATEPWIME.
OrthoDBEOG7KSX7Q.
PhylomeDBQ99676.
TreeFamTF350822.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeQ99676.
CleanExHS_ZNF184.
GenevestigatorQ99676.

Family and domain databases

Gene3D3.30.160.60. 19 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF184.
GenomeRNAi7738.
NextBio29952.
PROQ99676.
SOURCESearch...

Entry information

Entry nameZN184_HUMAN
AccessionPrimary (citable) accession number: Q99676
Secondary accession number(s): B2R715, O60792, Q8TBA9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM