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Q99676

- ZN184_HUMAN

UniProt

Q99676 - ZN184_HUMAN

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Protein

Zinc finger protein 184

Gene
ZNF184
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24423C2H2-type 1Add
BLAST
Zinc fingeri250 – 27223C2H2-type 2Add
BLAST
Zinc fingeri278 – 30023C2H2-type 3Add
BLAST
Zinc fingeri306 – 32823C2H2-type 4Add
BLAST
Zinc fingeri334 – 35623C2H2-type 5Add
BLAST
Zinc fingeri362 – 38423C2H2-type 6Add
BLAST
Zinc fingeri390 – 41223C2H2-type 7Add
BLAST
Zinc fingeri418 – 44023C2H2-type 8Add
BLAST
Zinc fingeri446 – 46823C2H2-type 9Add
BLAST
Zinc fingeri474 – 49623C2H2-type 10Add
BLAST
Zinc fingeri502 – 52423C2H2-type 11Add
BLAST
Zinc fingeri530 – 55223C2H2-type 12Add
BLAST
Zinc fingeri558 – 58023C2H2-type 13Add
BLAST
Zinc fingeri586 – 60823C2H2-type 14Add
BLAST
Zinc fingeri614 – 63623C2H2-type 15Add
BLAST
Zinc fingeri642 – 66423C2H2-type 16Add
BLAST
Zinc fingeri670 – 69223C2H2-type 17Add
BLAST
Zinc fingeri698 – 72023C2H2-type 18Add
BLAST
Zinc fingeri726 – 74823C2H2-type 19Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 184
Gene namesi
Name:ZNF184
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:12975. ZNF184.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 751751Zinc finger protein 184PRO_0000047443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171Phosphoserine1 Publication
Modified residuei122 – 1221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99676.
PaxDbiQ99676.
PRIDEiQ99676.

PTM databases

PhosphoSiteiQ99676.

Expressioni

Tissue specificityi

Predominant expression in testis.

Gene expression databases

BgeeiQ99676.
CleanExiHS_ZNF184.
GenevestigatoriQ99676.

Organism-specific databases

HPAiHPA003226.

Interactioni

Protein-protein interaction databases

BioGridi113524. 5 interactions.
IntActiQ99676. 3 interactions.
STRINGi9606.ENSP00000211936.

Structurei

3D structure databases

ProteinModelPortaliQ99676.
SMRiQ99676. Positions 219-750.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 9972KRABAdd
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24423C2H2-type 1Add
BLAST
Zinc fingeri250 – 27223C2H2-type 2Add
BLAST
Zinc fingeri278 – 30023C2H2-type 3Add
BLAST
Zinc fingeri306 – 32823C2H2-type 4Add
BLAST
Zinc fingeri334 – 35623C2H2-type 5Add
BLAST
Zinc fingeri362 – 38423C2H2-type 6Add
BLAST
Zinc fingeri390 – 41223C2H2-type 7Add
BLAST
Zinc fingeri418 – 44023C2H2-type 8Add
BLAST
Zinc fingeri446 – 46823C2H2-type 9Add
BLAST
Zinc fingeri474 – 49623C2H2-type 10Add
BLAST
Zinc fingeri502 – 52423C2H2-type 11Add
BLAST
Zinc fingeri530 – 55223C2H2-type 12Add
BLAST
Zinc fingeri558 – 58023C2H2-type 13Add
BLAST
Zinc fingeri586 – 60823C2H2-type 14Add
BLAST
Zinc fingeri614 – 63623C2H2-type 15Add
BLAST
Zinc fingeri642 – 66423C2H2-type 16Add
BLAST
Zinc fingeri670 – 69223C2H2-type 17Add
BLAST
Zinc fingeri698 – 72023C2H2-type 18Add
BLAST
Zinc fingeri726 – 74823C2H2-type 19Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ99676.
KOiK09228.
OMAiTEPWIME.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ99676.
TreeFamiTF350822.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99676-1 [UniParc]FASTAAdd to Basket

« Hide

MEDLSSPDST LLQGGHNLLS SASFQEAVTF KDVIVDFTQE EWKQLDPGQR    50
DLFRDVTLEN YTHLVSIGLQ VSKPDVISQL EQGTEPWIME PSIPVGTCAD 100
WETRLENSVS APEPDISEEE LSPEVIVEKH KRDDSWSSNL LESWEYEGSL 150
ERQQANQQTL PKEIKVTEKT IPSWEKGPVN NEFGKSVNVS SNLVTQEPSP 200
EETSTKRSIK QNSNPVKKEK SCKCNECGKA FSYCSALIRH QRTHTGEKPY 250
KCNECEKAFS RSENLINHQR IHTGDKPYKC DQCGKGFIEG PSLTQHQRIH 300
TGEKPYKCDE CGKAFSQRTH LVQHQRIHTG EKPYTCNECG KAFSQRGHFM 350
EHQKIHTGEK PFKCDECDKT FTRSTHLTQH QKIHTGEKTY KCNECGKAFN 400
GPSTFIRHHM IHTGEKPYEC NECGKAFSQH SNLTQHQKTH TGEKPYDCAE 450
CGKSFSYWSS LAQHLKIHTG EKPYKCNECG KAFSYCSSLT QHRRIHTREK 500
PFECSECGKA FSYLSNLNQH QKTHTQEKAY ECKECGKAFI RSSSLAKHER 550
IHTGEKPYQC HECGKTFSYG SSLIQHRKIH TGERPYKCNE CGRAFNQNIH 600
LTQHKRIHTG AKPYECAECG KAFRHCSSLA QHQKTHTEEK PYQCNKCEKT 650
FSQSSHLTQH QRIHTGEKPY KCNECDKAFS RSTHLTEHQN THTGEKPYNC 700
NECRKTFSQS TYLIQHQRIH SGEKPFGCND CGKSFRYRSA LNKHQRLHPG 750
I 751
Length:751
Mass (Da):86,174
Last modified:November 30, 2010 - v4
Checksum:i249DFB302C6BC97D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271A → S.3 Publications
Corresponds to variant rs1883216 [ dbSNP | Ensembl ].
VAR_045989

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti286 – 2861G → C in BAG35662. 1 Publication
Sequence conflicti295 – 2951Q → R in AAC51180. 1 Publication
Sequence conflicti359 – 3591E → G in AAC51180. 1 Publication
Sequence conflicti379 – 3813QHQ → PHP in AAC51180. 1 Publication
Sequence conflicti498 – 4981R → G in AAC51180. 1 Publication
Sequence conflicti526 – 5261Q → G in AAC51180. 1 Publication
Sequence conflicti533 – 5331K → E in AAC51180. 1 Publication
Sequence conflicti547 – 5493KHE → QHQ in AAC51180. 1 Publication
Sequence conflicti746 – 7461R → K in AAC51180. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312804 mRNA. Translation: BAG35662.1.
AL021918 Genomic DNA. Translation: CAA17278.1.
BC022992 mRNA. Translation: AAH22992.1.
U66561 mRNA. Translation: AAC51180.1.
CCDSiCCDS4624.1.
RefSeqiNP_009080.2. NM_007149.2.
XP_005249436.1. XM_005249379.1.
XP_005249437.1. XM_005249380.1.
UniGeneiHs.158174.

Genome annotation databases

EnsembliENST00000211936; ENSP00000211936; ENSG00000096654.
ENST00000377419; ENSP00000366636; ENSG00000096654.
GeneIDi7738.
KEGGihsa:7738.
UCSCiuc003nji.3. human.

Polymorphism databases

DMDMi313104299.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312804 mRNA. Translation: BAG35662.1 .
AL021918 Genomic DNA. Translation: CAA17278.1 .
BC022992 mRNA. Translation: AAH22992.1 .
U66561 mRNA. Translation: AAC51180.1 .
CCDSi CCDS4624.1.
RefSeqi NP_009080.2. NM_007149.2.
XP_005249436.1. XM_005249379.1.
XP_005249437.1. XM_005249380.1.
UniGenei Hs.158174.

3D structure databases

ProteinModelPortali Q99676.
SMRi Q99676. Positions 219-750.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113524. 5 interactions.
IntActi Q99676. 3 interactions.
STRINGi 9606.ENSP00000211936.

PTM databases

PhosphoSitei Q99676.

Polymorphism databases

DMDMi 313104299.

Proteomic databases

MaxQBi Q99676.
PaxDbi Q99676.
PRIDEi Q99676.

Protocols and materials databases

DNASUi 7738.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000211936 ; ENSP00000211936 ; ENSG00000096654 .
ENST00000377419 ; ENSP00000366636 ; ENSG00000096654 .
GeneIDi 7738.
KEGGi hsa:7738.
UCSCi uc003nji.3. human.

Organism-specific databases

CTDi 7738.
GeneCardsi GC06M027436.
HGNCi HGNC:12975. ZNF184.
HPAi HPA003226.
MIMi 602277. gene.
neXtProti NX_Q99676.
PharmGKBi PA37557.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q99676.
KOi K09228.
OMAi TEPWIME.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q99676.
TreeFami TF350822.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF184.
GenomeRNAii 7738.
NextBioi 29952.
PROi Q99676.
SOURCEi Search...

Gene expression databases

Bgeei Q99676.
CleanExi HS_ZNF184.
Genevestigatori Q99676.

Family and domain databases

Gene3Di 3.30.160.60. 19 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-27.
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-27.
    Tissue: Placenta.
  4. "Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3."
    Goldwurm S., Menzies M.L., Banyer J.L., Powell B.L.W., Jazwinska E.C.
    Genomics 40:486-489(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-751, VARIANT SER-27.
    Tissue: Placenta.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiZN184_HUMAN
AccessioniPrimary (citable) accession number: Q99676
Secondary accession number(s): B2R715, O60792, Q8TBA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 131 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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