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Protein

Zinc finger protein 184

Gene

ZNF184

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 664C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri670 – 692C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri698 – 720C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri726 – 748C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000096654-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 184
Gene namesi
Name:ZNF184
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12975. ZNF184.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7738.
OpenTargetsiENSG00000096654.
PharmGKBiPA37557.

Polymorphism and mutation databases

BioMutaiZNF184.
DMDMi313104299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474431 – 751Zinc finger protein 184Add BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99676.
MaxQBiQ99676.
PaxDbiQ99676.
PeptideAtlasiQ99676.
PRIDEiQ99676.

PTM databases

iPTMnetiQ99676.
PhosphoSitePlusiQ99676.

Expressioni

Tissue specificityi

Predominant expression in testis.

Gene expression databases

BgeeiENSG00000096654.
CleanExiHS_ZNF184.
ExpressionAtlasiQ99676. baseline and differential.
GenevisibleiQ99676. HS.

Organism-specific databases

HPAiHPA003226.

Interactioni

Protein-protein interaction databases

BioGridi113524. 16 interactors.
IntActiQ99676. 3 interactors.
STRINGi9606.ENSP00000211936.

Structurei

3D structure databases

ProteinModelPortaliQ99676.
SMRiQ99676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 99KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 664C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri670 – 692C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri698 – 720C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri726 – 748C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ99676.
KOiK09228.
OMAiNSNPVKK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ99676.
TreeFamiTF350822.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 10 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDLSSPDST LLQGGHNLLS SASFQEAVTF KDVIVDFTQE EWKQLDPGQR
60 70 80 90 100
DLFRDVTLEN YTHLVSIGLQ VSKPDVISQL EQGTEPWIME PSIPVGTCAD
110 120 130 140 150
WETRLENSVS APEPDISEEE LSPEVIVEKH KRDDSWSSNL LESWEYEGSL
160 170 180 190 200
ERQQANQQTL PKEIKVTEKT IPSWEKGPVN NEFGKSVNVS SNLVTQEPSP
210 220 230 240 250
EETSTKRSIK QNSNPVKKEK SCKCNECGKA FSYCSALIRH QRTHTGEKPY
260 270 280 290 300
KCNECEKAFS RSENLINHQR IHTGDKPYKC DQCGKGFIEG PSLTQHQRIH
310 320 330 340 350
TGEKPYKCDE CGKAFSQRTH LVQHQRIHTG EKPYTCNECG KAFSQRGHFM
360 370 380 390 400
EHQKIHTGEK PFKCDECDKT FTRSTHLTQH QKIHTGEKTY KCNECGKAFN
410 420 430 440 450
GPSTFIRHHM IHTGEKPYEC NECGKAFSQH SNLTQHQKTH TGEKPYDCAE
460 470 480 490 500
CGKSFSYWSS LAQHLKIHTG EKPYKCNECG KAFSYCSSLT QHRRIHTREK
510 520 530 540 550
PFECSECGKA FSYLSNLNQH QKTHTQEKAY ECKECGKAFI RSSSLAKHER
560 570 580 590 600
IHTGEKPYQC HECGKTFSYG SSLIQHRKIH TGERPYKCNE CGRAFNQNIH
610 620 630 640 650
LTQHKRIHTG AKPYECAECG KAFRHCSSLA QHQKTHTEEK PYQCNKCEKT
660 670 680 690 700
FSQSSHLTQH QRIHTGEKPY KCNECDKAFS RSTHLTEHQN THTGEKPYNC
710 720 730 740 750
NECRKTFSQS TYLIQHQRIH SGEKPFGCND CGKSFRYRSA LNKHQRLHPG

I
Length:751
Mass (Da):86,174
Last modified:November 30, 2010 - v4
Checksum:i249DFB302C6BC97D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286G → C in BAG35662 (PubMed:14702039).Curated1
Sequence conflicti295Q → R in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti359E → G in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti379 – 381QHQ → PHP in AAC51180 (PubMed:9073517).Curated3
Sequence conflicti498R → G in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti526Q → G in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti533K → E in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti547 – 549KHE → QHQ in AAC51180 (PubMed:9073517).Curated3
Sequence conflicti746R → K in AAC51180 (PubMed:9073517).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04598927A → S.3 PublicationsCorresponds to variant rs1883216dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312804 mRNA. Translation: BAG35662.1.
AL021918 Genomic DNA. Translation: CAA17278.1.
BC022992 mRNA. Translation: AAH22992.1.
U66561 mRNA. Translation: AAC51180.1.
CCDSiCCDS4624.1.
RefSeqiNP_001305820.1. NM_001318891.1.
NP_001305821.1. NM_001318892.1.
NP_001305822.1. NM_001318893.1.
NP_009080.2. NM_007149.2.
UniGeneiHs.158174.

Genome annotation databases

EnsembliENST00000211936; ENSP00000211936; ENSG00000096654.
ENST00000377419; ENSP00000366636; ENSG00000096654.
GeneIDi7738.
KEGGihsa:7738.
UCSCiuc003nji.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312804 mRNA. Translation: BAG35662.1.
AL021918 Genomic DNA. Translation: CAA17278.1.
BC022992 mRNA. Translation: AAH22992.1.
U66561 mRNA. Translation: AAC51180.1.
CCDSiCCDS4624.1.
RefSeqiNP_001305820.1. NM_001318891.1.
NP_001305821.1. NM_001318892.1.
NP_001305822.1. NM_001318893.1.
NP_009080.2. NM_007149.2.
UniGeneiHs.158174.

3D structure databases

ProteinModelPortaliQ99676.
SMRiQ99676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113524. 16 interactors.
IntActiQ99676. 3 interactors.
STRINGi9606.ENSP00000211936.

PTM databases

iPTMnetiQ99676.
PhosphoSitePlusiQ99676.

Polymorphism and mutation databases

BioMutaiZNF184.
DMDMi313104299.

Proteomic databases

EPDiQ99676.
MaxQBiQ99676.
PaxDbiQ99676.
PeptideAtlasiQ99676.
PRIDEiQ99676.

Protocols and materials databases

DNASUi7738.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000211936; ENSP00000211936; ENSG00000096654.
ENST00000377419; ENSP00000366636; ENSG00000096654.
GeneIDi7738.
KEGGihsa:7738.
UCSCiuc003nji.4. human.

Organism-specific databases

CTDi7738.
DisGeNETi7738.
GeneCardsiZNF184.
HGNCiHGNC:12975. ZNF184.
HPAiHPA003226.
MIMi602277. gene.
neXtProtiNX_Q99676.
OpenTargetsiENSG00000096654.
PharmGKBiPA37557.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ99676.
KOiK09228.
OMAiNSNPVKK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ99676.
TreeFamiTF350822.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000096654-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF184.
GenomeRNAii7738.
PROiQ99676.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000096654.
CleanExiHS_ZNF184.
ExpressionAtlasiQ99676. baseline and differential.
GenevisibleiQ99676. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 10 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN184_HUMAN
AccessioniPrimary (citable) accession number: Q99676
Secondary accession number(s): B2R715, O60792, Q8TBA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 154 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.