Q99676 (ZN184_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 184

Gene names

Name:

ZNF184

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	751 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Tissue specificity	Predominant expression in testis.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 19 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Non-traceable author statement. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Non-traceable author statement. Source: UniProtKB zinc ion binding Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 751	751	Zinc finger protein 184		PRO_0000047443
Regions
	Domain	28 – 99	72	KRAB
	Zinc finger	222 – 244	23	C2H2-type 1
	Zinc finger	250 – 272	23	C2H2-type 2
	Zinc finger	278 – 300	23	C2H2-type 3
	Zinc finger	306 – 328	23	C2H2-type 4
	Zinc finger	334 – 356	23	C2H2-type 5
	Zinc finger	362 – 384	23	C2H2-type 6
	Zinc finger	390 – 412	23	C2H2-type 7
	Zinc finger	418 – 440	23	C2H2-type 8
	Zinc finger	446 – 468	23	C2H2-type 9
	Zinc finger	474 – 496	23	C2H2-type 10
	Zinc finger	502 – 524	23	C2H2-type 11
	Zinc finger	530 – 552	23	C2H2-type 12
	Zinc finger	558 – 580	23	C2H2-type 13
	Zinc finger	586 – 608	23	C2H2-type 14
	Zinc finger	614 – 636	23	C2H2-type 15
	Zinc finger	642 – 664	23	C2H2-type 16
	Zinc finger	670 – 692	23	C2H2-type 17
	Zinc finger	698 – 720	23	C2H2-type 18
	Zinc finger	726 – 748	23	C2H2-type 19
Amino acid modifications
	Modified residue	117	1	Phosphoserine Ref.5
	Modified residue	122	1	Phosphoserine Ref.5
Natural variations
	Natural variant	27	1	A → S. Ref.1 Ref.3 Ref.4 Corresponds to variant rs1883216 [ dbSNP | Ensembl ].		VAR_045989
Experimental info
	Sequence conflict	286	1	G → C in BAG35662. Ref.1
	Sequence conflict	295	1	Q → R in AAC51180. Ref.4
	Sequence conflict	359	1	E → G in AAC51180. Ref.4
	Sequence conflict	379 – 381	3	QHQ → PHP in AAC51180. Ref.4
	Sequence conflict	498	1	R → G in AAC51180. Ref.4
	Sequence conflict	526	1	Q → G in AAC51180. Ref.4
	Sequence conflict	533	1	K → E in AAC51180. Ref.4
	Sequence conflict	547 – 549	3	KHE → QHQ in AAC51180. Ref.4
	Sequence conflict	746	1	R → K in AAC51180. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q99676 [UniParc]. Last modified November 30, 2010. Version 4. Checksum: 249DFB302C6BC97D	FASTA	751	86,174
	10 20 30 40 50 60 MEDLSSPDST LLQGGHNLLS SASFQEAVTF KDVIVDFTQE EWKQLDPGQR DLFRDVTLEN 70 80 90 100 110 120 YTHLVSIGLQ VSKPDVISQL EQGTEPWIME PSIPVGTCAD WETRLENSVS APEPDISEEE 130 140 150 160 170 180 LSPEVIVEKH KRDDSWSSNL LESWEYEGSL ERQQANQQTL PKEIKVTEKT IPSWEKGPVN 190 200 210 220 230 240 NEFGKSVNVS SNLVTQEPSP EETSTKRSIK QNSNPVKKEK SCKCNECGKA FSYCSALIRH 250 260 270 280 290 300 QRTHTGEKPY KCNECEKAFS RSENLINHQR IHTGDKPYKC DQCGKGFIEG PSLTQHQRIH 310 320 330 340 350 360 TGEKPYKCDE CGKAFSQRTH LVQHQRIHTG EKPYTCNECG KAFSQRGHFM EHQKIHTGEK 370 380 390 400 410 420 PFKCDECDKT FTRSTHLTQH QKIHTGEKTY KCNECGKAFN GPSTFIRHHM IHTGEKPYEC 430 440 450 460 470 480 NECGKAFSQH SNLTQHQKTH TGEKPYDCAE CGKSFSYWSS LAQHLKIHTG EKPYKCNECG 490 500 510 520 530 540 KAFSYCSSLT QHRRIHTREK PFECSECGKA FSYLSNLNQH QKTHTQEKAY ECKECGKAFI 550 560 570 580 590 600 RSSSLAKHER IHTGEKPYQC HECGKTFSYG SSLIQHRKIH TGERPYKCNE CGRAFNQNIH 610 620 630 640 650 660 LTQHKRIHTG AKPYECAECG KAFRHCSSLA QHQKTHTEEK PYQCNKCEKT FSQSSHLTQH 670 680 690 700 710 720 QRIHTGEKPY KCNECDKAFS RSTHLTEHQN THTGEKPYNC NECRKTFSQS TYLIQHQRIH 730 740 750 SGEKPFGCND CGKSFRYRSA LNKHQRLHPG I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-27. Tissue: Testis.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-27. Tissue: Placenta.
[4]	"Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3." Goldwurm S., Menzies M.L., Banyer J.L., Powell B.L.W., Jazwinska E.C. Genomics 40:486-489(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-751, VARIANT SER-27. Tissue: Placenta.
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-122, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK312804 mRNA. Translation: BAG35662.1. AL021918 Genomic DNA. Translation: CAA17278.1. BC022992 mRNA. Translation: AAH22992.1. U66561 mRNA. Translation: AAC51180.1.
IPI	IPI00293575.
RefSeq	NP_009080.2. NM_007149.2.
UniGene	Hs.158174.
3D structure databases
ProteinModelPortal	Q99676.
SMR	Q99676. Positions 22-76, 219-750.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99676. 3 interactions.
STRING	9606.ENSP00000211936.
PTM databases
PhosphoSite	Q99676.
Polymorphism databases
DMDM	205371856.
Proteomic databases
PaxDb	Q99676.
PRIDE	Q99676.
Protocols and materials databases
DNASU	7738.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000211936; ENSP00000211936; ENSG00000096654. ENST00000377419; ENSP00000366636; ENSG00000096654.
GeneID	7738.
KEGG	hsa:7738.
UCSC	uc003nji.3. human.
Organism-specific databases
CTD	7738.
GeneCards	GC06M027436.
HGNC	HGNC:12975. ZNF184.
HPA	HPA003226.
MIM	602277. gene.
neXtProt	NX_Q99676.
PharmGKB	PA37557.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q99676.
KO	K09228.
OMA	TEPWIME.
OrthoDB	EOG48KR9M.
PhylomeDB	Q99676.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q99676.
CleanEx	HS_ZNF184.
Genevestigator	Q99676.
GermOnline	ENSG00000096654. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 19 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 19 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 19 hits. PS50157. ZINC_FINGER_C2H2_2. 19 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7738.
NextBio	29952.
SOURCE	Search...

Entry information

Entry name

ZN184_HUMAN

Accession

Primary (citable) accession number: Q99676
Secondary accession number(s): B2R715, O60792, Q8TBA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 119 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.