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Protein

Cell growth regulator with RING finger domain protein 1

Gene

CGRRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Able to inhibit growth in several cell lines.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri274 – 309RING-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

GO - Biological processi

  • cell cycle arrest Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: ProtInc

Keywordsi

Biological processCell cycle, Growth arrest
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cell growth regulator with RING finger domain protein 1
Alternative name(s):
Cell growth regulatory gene 19 protein
RING finger protein 197
Gene namesi
Name:CGRRF1
Synonyms:CGR19, RNF197
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100532.11
HGNCiHGNC:15528 CGRRF1
MIMi606138 gene
neXtProtiNX_Q99675

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10668
OpenTargetsiENSG00000100532
PharmGKBiPA134985671

Polymorphism and mutation databases

BioMutaiCGRRF1
DMDMi44887778

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558691 – 332Cell growth regulator with RING finger domain protein 1Add BLAST332

Proteomic databases

MaxQBiQ99675
PaxDbiQ99675
PeptideAtlasiQ99675
PRIDEiQ99675

PTM databases

iPTMnetiQ99675
PhosphoSitePlusiQ99675

Expressioni

Tissue specificityi

Ubiquitously expressed with high expression in testis and the cerebellum.1 Publication

Inductioni

Up-regulated by endoplasmic reticulum (ER) stress triggered by thapsigargin or tunicamycin.1 Publication

Gene expression databases

BgeeiENSG00000100532
CleanExiHS_CGRRF1
ExpressionAtlasiQ99675 baseline and differential
GenevisibleiQ99675 HS

Organism-specific databases

HPAiHPA002930

Interactioni

Protein-protein interaction databases

BioGridi11591042 interactors.
IntActiQ99675 10 interactors.
MINTiQ99675
STRINGi9606.ENSP00000216420

Structurei

Secondary structure

1332
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi275 – 280Combined sources6
Turni287 – 290Combined sources4
Helixi298 – 301Combined sources4
Turni306 – 308Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EA5NMR-A264-318[»]
ProteinModelPortaliQ99675
SMRiQ99675
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99675

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri274 – 309RING-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITZ9 Eukaryota
ENOG4111F4I LUCA
GeneTreeiENSGT00390000004542
HOGENOMiHOG000111607
HOVERGENiHBG050932
InParanoidiQ99675
OMAiFYCFRIS
OrthoDBiEOG091G0G0X
PhylomeDBiQ99675
TreeFamiTF328102

Family and domain databases

Gene3Di3.30.40.101 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVFLVTLY EYSPLFYIAV VFTCFIVTTG LVLGWFGWDV PVILRNSEET
60 70 80 90 100
QFSTRVFKKQ MRQVKNPFGL EITNPSSASI TTGITLTTDC LEDSLLTCYW
110 120 130 140 150
GCSVQKLYEA LQKHVYCFRI STPQALEDAL YSEYLYQEQY FIKKDSKEEI
160 170 180 190 200
YCQLPRDTKI EDFGTVPRSR YPLVALLTLA DEDDREIYDI ISMVSVIHIP
210 220 230 240 250
DRTYKLSCRI LYQYLLLAQG QFHDLKQLFM SANNNFTPSN NSSSEEKNTD
260 270 280 290 300
RSLLEKVGLS ESEVEPSEEN SKDCVVCQNG TVNWVLLPCR HTCLCDGCVK
310 320 330
YFQQCPMCRQ FVQESFALCS QKEQDKDKPK TL
Length:332
Mass (Da):38,242
Last modified:May 1, 1997 - v1
Checksum:i2F1FC0D12B710C80
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103S → N in AAH15063 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052081117C → Y. Corresponds to variant dbSNP:rs11555279Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66469 mRNA Translation: AAC50897.1
BC015063 mRNA Translation: AAH15063.1
CCDSiCCDS9719.1
RefSeqiNP_006559.1, NM_006568.2
UniGeneiHs.59106

Genome annotation databases

EnsembliENST00000216420; ENSP00000216420; ENSG00000100532
GeneIDi10668
KEGGihsa:10668
UCSCiuc001xay.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCGRF1_HUMAN
AccessioniPrimary (citable) accession number: Q99675
Secondary accession number(s): Q96BX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome