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Protein

Cell growth regulator with RING finger domain protein 1

Gene

CGRRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Able to inhibit growth in several cell lines.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 30936RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell cycle arrest Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: ProtInc
  • response to stress Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cell growth regulator with RING finger domain protein 1
Alternative name(s):
Cell growth regulatory gene 19 protein
RING finger protein 197
Gene namesi
Name:CGRRF1
Synonyms:CGR19, RNF197
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15528. CGRRF1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985671.

Polymorphism and mutation databases

BioMutaiCGRRF1.
DMDMi44887778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Cell growth regulator with RING finger domain protein 1PRO_0000055869Add
BLAST

Proteomic databases

EPDiQ99675.
MaxQBiQ99675.
PaxDbiQ99675.
PeptideAtlasiQ99675.
PRIDEiQ99675.

PTM databases

iPTMnetiQ99675.
PhosphoSiteiQ99675.

Expressioni

Gene expression databases

BgeeiENSG00000100532.
CleanExiHS_CGRRF1.
ExpressionAtlasiQ99675. baseline and differential.
GenevisibleiQ99675. HS.

Organism-specific databases

HPAiHPA002930.

Interactioni

Protein-protein interaction databases

BioGridi115910. 36 interactions.
IntActiQ99675. 7 interactions.
STRINGi9606.ENSP00000216420.

Structurei

Secondary structure

1
332
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi275 – 2806Combined sources
Turni287 – 2904Combined sources
Helixi298 – 3014Combined sources
Turni306 – 3083Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EA5NMR-A264-318[»]
ProteinModelPortaliQ99675.
SMRiQ99675. Positions 226-318.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99675.

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 30936RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITZ9. Eukaryota.
ENOG4111F4I. LUCA.
GeneTreeiENSGT00390000004542.
HOGENOMiHOG000111607.
HOVERGENiHBG050932.
InParanoidiQ99675.
OMAiVIHIPDK.
OrthoDBiEOG091G0G0X.
PhylomeDBiQ99675.
TreeFamiTF328102.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVFLVTLY EYSPLFYIAV VFTCFIVTTG LVLGWFGWDV PVILRNSEET
60 70 80 90 100
QFSTRVFKKQ MRQVKNPFGL EITNPSSASI TTGITLTTDC LEDSLLTCYW
110 120 130 140 150
GCSVQKLYEA LQKHVYCFRI STPQALEDAL YSEYLYQEQY FIKKDSKEEI
160 170 180 190 200
YCQLPRDTKI EDFGTVPRSR YPLVALLTLA DEDDREIYDI ISMVSVIHIP
210 220 230 240 250
DRTYKLSCRI LYQYLLLAQG QFHDLKQLFM SANNNFTPSN NSSSEEKNTD
260 270 280 290 300
RSLLEKVGLS ESEVEPSEEN SKDCVVCQNG TVNWVLLPCR HTCLCDGCVK
310 320 330
YFQQCPMCRQ FVQESFALCS QKEQDKDKPK TL
Length:332
Mass (Da):38,242
Last modified:May 1, 1997 - v1
Checksum:i2F1FC0D12B710C80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031S → N in AAH15063 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171C → Y.
Corresponds to variant rs11555279 [ dbSNP | Ensembl ].
VAR_052081

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66469 mRNA. Translation: AAC50897.1.
BC015063 mRNA. Translation: AAH15063.1.
CCDSiCCDS9719.1.
RefSeqiNP_006559.1. NM_006568.2.
UniGeneiHs.59106.

Genome annotation databases

EnsembliENST00000216420; ENSP00000216420; ENSG00000100532.
GeneIDi10668.
KEGGihsa:10668.
UCSCiuc001xay.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66469 mRNA. Translation: AAC50897.1.
BC015063 mRNA. Translation: AAH15063.1.
CCDSiCCDS9719.1.
RefSeqiNP_006559.1. NM_006568.2.
UniGeneiHs.59106.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EA5NMR-A264-318[»]
ProteinModelPortaliQ99675.
SMRiQ99675. Positions 226-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115910. 36 interactions.
IntActiQ99675. 7 interactions.
STRINGi9606.ENSP00000216420.

PTM databases

iPTMnetiQ99675.
PhosphoSiteiQ99675.

Polymorphism and mutation databases

BioMutaiCGRRF1.
DMDMi44887778.

Proteomic databases

EPDiQ99675.
MaxQBiQ99675.
PaxDbiQ99675.
PeptideAtlasiQ99675.
PRIDEiQ99675.

Protocols and materials databases

DNASUi10668.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216420; ENSP00000216420; ENSG00000100532.
GeneIDi10668.
KEGGihsa:10668.
UCSCiuc001xay.4. human.

Organism-specific databases

CTDi10668.
GeneCardsiCGRRF1.
HGNCiHGNC:15528. CGRRF1.
HPAiHPA002930.
MIMi606138. gene.
neXtProtiNX_Q99675.
PharmGKBiPA134985671.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITZ9. Eukaryota.
ENOG4111F4I. LUCA.
GeneTreeiENSGT00390000004542.
HOGENOMiHOG000111607.
HOVERGENiHBG050932.
InParanoidiQ99675.
OMAiVIHIPDK.
OrthoDBiEOG091G0G0X.
PhylomeDBiQ99675.
TreeFamiTF328102.

Miscellaneous databases

EvolutionaryTraceiQ99675.
GenomeRNAii10668.
PROiQ99675.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100532.
CleanExiHS_CGRRF1.
ExpressionAtlasiQ99675. baseline and differential.
GenevisibleiQ99675. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCGRF1_HUMAN
AccessioniPrimary (citable) accession number: Q99675
Secondary accession number(s): Q96BX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.