Q99666 (RGPD5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RANBP2-like and GRIP domain-containing protein 5/6

Alternative name(s):
Ran-binding protein 2-like 1/2
Short name=RanBP2-like 1/2
Short name=RanBP2L1
Short name=RanBP2L2
Sperm membrane protein BS-63

Gene names

Name:	RGPD5
Synonyms:	RANBP2L1, RGP5, RGP7, RGPD7
AND
Name:	RGPD6
Synonyms:	RANBP2L2, RGP6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1765 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm Ref.5.
Tissue specificity	Expressed in testis. Ref.1
Miscellaneous	One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.
Sequence similarities	Contains 1 GRIP domain. Contains 2 RanBD1 domains. Contains 3 TPR repeats.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat TPR repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein targeting to Golgi Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q99666-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99666-2)

The sequence of this isoform differs from the canonical sequence as follows:
     868-904: VATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNT → EAAHRHFTIEKHGDSKWIIYRFTKQLCGTERARAKIS
     905-1765: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1765	1765	RANBP2-like and GRIP domain-containing protein 5/6		PRO_0000204915
Regions
	Repeat	26 – 59	34	TPR 1
	Repeat	60 – 93	34	TPR 2
	Repeat	648 – 681	34	TPR 3
	Domain	1036 – 1172	137	RanBD1 1
	Domain	1333 – 1469	137	RanBD1 2
	Domain	1702 – 1752	51	GRIP
	Compositional bias	1261 – 1266	6	Poly-Ser
Amino acid modifications
	Modified residue	19	1	Phosphothreonine Ref.8
	Modified residue	21	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	868 – 904	37	VATTG…GSSNT → EAAHRHFTIEKHGDSKWIIY RFTKQLCGTERARAKIS in isoform 2.		VSP_038968
	Alternative sequence	905 – 1765	861	Missing in isoform 2.		VSP_038969
Experimental info
	Sequence conflict	174	1	L → V in AAB41848. Ref.1
	Sequence conflict	204	1	N → H in AAB41848. Ref.1
	Sequence conflict	214	1	Y → H in AAB41848. Ref.1
	Sequence conflict	229	1	Q → R in AAB41848. Ref.1
	Sequence conflict	257	1	E → G in AAB41848. Ref.1
	Sequence conflict	270	1	K → E in AAB41848. Ref.1
	Sequence conflict	451	1	L → S in AAB41848. Ref.1
	Sequence conflict	736	1	P → S in AAB41848. Ref.1
	Sequence conflict	784	1	K → R in AAB41848. Ref.1
	Sequence conflict	893	1	A → G in AAB41848. Ref.1
	Sequence conflict	905	1	E → D in AAB41848. Ref.1
	Sequence conflict	946	1	F → L in AAB41848. Ref.1
	Sequence conflict	1074	1	R → S in AAB41848. Ref.1
	Sequence conflict	1135	1	D → H in AAB41848. Ref.1
	Sequence conflict	1612	1	S → P in AAB41848. Ref.1
	Sequence conflict	1682	1	L → P in AAB41848. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: DC699DC82C67749D	FASTA	1,765	198,924
	10 20 30 40 50 60 MRRSKADVER YVASVLGLTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC TYINVQERDP 70 80 90 100 110 120 KAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWVER 130 140 150 160 170 180 AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL FDLIQSELYV RPDDVHVNIR LVELYRSTKR 190 200 210 220 230 240 LKDAVAHCHE AERNIALRSS LEWNSCVVQT LKEYLESLQC LESDKSDWQA TNTDLLLAYA 250 260 270 280 290 300 NLMLLTLSTR DVQENRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMYAGSLLLK 310 320 330 340 350 360 MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLREGKAG QNLLEMMACD RLSQSGHMLL 370 380 390 400 410 420 SLSRGKQDFL KEVVETFANK IGQSALYDAL FSSQSPKDTS FLGSDDIGKI DVQEPELEDL 430 440 450 460 470 480 ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA LPGIRKWLKQ LFHRLPHETS RLETNAPESI 490 500 510 520 530 540 CILDLEVFLL GVVYTSHLQL KEKCNSHHSS YQPLCLPFPV CKQLCTERQK SWWDAVCTLI 550 560 570 580 590 600 HRKAVPGNLA KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KYLQKTGSGL NSFYGQLEYI 610 620 630 640 650 660 GRSVHYWKKV LPLLKIIKKN SIPEPIDPLF KHFHSVDIQA SEIVEYEEDA HITFAMLDAV 670 680 690 700 710 720 NGNIEDAVTA FESIKSVVSY WNLALIFHRK AEDIENDALS PEEQEECRNY LTKTRDYLIK 730 740 750 760 770 780 IIDDGDSNLS VVKKLPVPLE SVKQMLNSVM QELEDYSEGG PLYKNGSLRN ADSEIKHSTP 790 800 810 820 830 840 SPTKYSLSPS KSYKYSPETP PRWTEDRNSL LNMICQQVEA IKKEMQELKL NSSKSASRHR 850 860 870 880 890 900 WPTENYGPDS VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLLR PAANVTPTKG 910 920 930 940 950 960 SSNTEFKSTK EGFSIPVSAD GFKFGISEPG NQEKKREKPL ENDTGFQAQD ISGRKKGRGV 970 980 990 1000 1010 1020 IFGQTSSTFT FADVAKSTSG EGFQFGKKDL NFKGFSGAGE KLFSSRYGKM ANKANTSGDF 1030 1040 1050 1060 1070 1080 EKDDDAYKTE DSDDIHFEPV VQMPEKVELV TGEEGEKVLY SQGVKLFRFD AEVRQWKERG 1090 1100 1110 1120 1130 1140 LGNLKILKNE VNGKLRMLMR REQVLKVCAN HWITTTMNLK PLSGSDRAWM WSASDFSDGD 1150 1160 1170 1180 1190 1200 AKLERLAAKF KTPELAEEFK QKFEECQRLL LDIPLQTPHK LVDTGRAAKL IQRAEEMKSG 1210 1220 1230 1240 1250 1260 LKDFKTFLTN DQTKVTEEEN KGSGTGAAGA SDTTIKPNAE NTGPTLEWDN YDLREDALDD 1270 1280 1290 1300 1310 1320 SVSSSSVHAS PLASSPVRKN LFRFDESTTG SNFSFKSALS LSKSPAKLNQ SGTSVGTDEE 1330 1340 1350 1360 1370 1380 SVVTQEEERD GQYFEPVVPL PDLVEVSSGE ENEQVVFSHR AEIYRYDKDV GQWKERGIGD 1390 1400 1410 1420 1430 1440 IKILQNYDNK QVRIVMRRDQ VLKLCANHRI TPDMSLQNMK GTERVWVWTA CDFADGERKV 1450 1460 1470 1480 1490 1500 EHLAVRFKLQ DVADSFKKIF DEAKTAQEKD SLITPHVSRS STPRESPCGK IAVAILEETT 1510 1520 1530 1540 1550 1560 RERTDVIQGD DVADAASEVE VSSTSETTTK AVVSPPKFVF VSESVKRIFS SEKSKPFVFG 1570 1580 1590 1600 1610 1620 NSSATGSLFG FSFNAPLKSN NSETSSVAQS GSESKVEPKK CELSKNSDIE QSSDSKVKNL 1630 1640 1650 1660 1670 1680 SASFPTEESS INYTFKTPEK EPPLWHAEFT KEELVQKLRS TTKSADHLNG LLREIEATNA 1690 1700 1710 1720 1730 1740 VLMEQIKLLK SEIRRLERNQ EREKSAANLE YLKNVLLQFI FLKPGSERER LLPVINTMLQ 1750 1760 LSPEEKGKLA AVAQDEEENA SRSSG
	Isoform 2 [UniParc]. Checksum: 32030C739F6E72EE	FASTA	904	103,334
	10 20 30 40 50 60 MRRSKADVER YVASVLGLTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC TYINVQERDP 70 80 90 100 110 120 KAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWVER 130 140 150 160 170 180 AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL FDLIQSELYV RPDDVHVNIR LVELYRSTKR 190 200 210 220 230 240 LKDAVAHCHE AERNIALRSS LEWNSCVVQT LKEYLESLQC LESDKSDWQA TNTDLLLAYA 250 260 270 280 290 300 NLMLLTLSTR DVQENRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMYAGSLLLK 310 320 330 340 350 360 MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLREGKAG QNLLEMMACD RLSQSGHMLL 370 380 390 400 410 420 SLSRGKQDFL KEVVETFANK IGQSALYDAL FSSQSPKDTS FLGSDDIGKI DVQEPELEDL 430 440 450 460 470 480 ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA LPGIRKWLKQ LFHRLPHETS RLETNAPESI 490 500 510 520 530 540 CILDLEVFLL GVVYTSHLQL KEKCNSHHSS YQPLCLPFPV CKQLCTERQK SWWDAVCTLI 550 560 570 580 590 600 HRKAVPGNLA KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KYLQKTGSGL NSFYGQLEYI 610 620 630 640 650 660 GRSVHYWKKV LPLLKIIKKN SIPEPIDPLF KHFHSVDIQA SEIVEYEEDA HITFAMLDAV 670 680 690 700 710 720 NGNIEDAVTA FESIKSVVSY WNLALIFHRK AEDIENDALS PEEQEECRNY LTKTRDYLIK 730 740 750 760 770 780 IIDDGDSNLS VVKKLPVPLE SVKQMLNSVM QELEDYSEGG PLYKNGSLRN ADSEIKHSTP 790 800 810 820 830 840 SPTKYSLSPS KSYKYSPETP PRWTEDRNSL LNMICQQVEA IKKEMQELKL NSSKSASRHR 850 860 870 880 890 900 WPTENYGPDS VPDGYQGSQT FHGAPLTEAA HRHFTIEKHG DSKWIIYRFT KQLCGTERAR AKIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene." Wang L.F., Zhu H.D., Miao S.Y., Cao D.F., Wu Y.W., Zong S.D., Koide S.S. Arch. Androl. 42:71-84(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Testis.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1009-1765 (ISOFORM 1). Tissue: Brain.
[5]	"Complex genomic rearrangements lead to novel primate gene function." Ciccarelli F.D., von Mering C., Suyama M., Harrington E.D., Izaurralde E., Bork P. Genome Res. 15:343-351(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[6]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19 AND SER-21, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U64675 mRNA. Translation: AAB41848.2. AL136868 mRNA. Translation: CAB66802.1. AC013271 Genomic DNA. Translation: AAY14902.1. AC123886 Genomic DNA. Translation: AAY14839.1. AC108938 Genomic DNA. Translation: AAY24132.1. AC109815 Genomic DNA. No translation available. AB209082 mRNA. Translation: BAD92319.1.
IPI	IPI00100787. IPI00293568.
RefSeq	NP_001032955.1. NM_001037866.1. NP_001116835.1. NM_001123363.3. NP_005045.2. NM_005054.2. NP_115636.1. NM_032260.2.
UniGene	Hs.469630. Hs.645445.
3D structure databases
ProteinModelPortal	Q99666.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99666. 5 interactions.
STRING	9606.ENSP00000016946.
PTM databases
PhosphoSite	Q99666.
Proteomic databases
PaxDb	Q99666.
PRIDE	Q99666.
Protocols and materials databases
DNASU	729540. 84220.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000016946; ENSP00000016946; ENSG00000015568. ENST00000272454; ENSP00000272454; ENSG00000015568. ENST00000329516; ENSP00000330842; ENSG00000183054. ENST00000330331; ENSP00000330023; ENSG00000183054. ENST00000393283; ENSP00000376962; ENSG00000015568.
GeneID	729540. 84220.
KEGG	hsa:729540. hsa:84220.
UCSC	uc002tfc.3. human. uc002tfe.1. human.
Organism-specific databases
CTD	729540. 84220.
GeneCards	GC02M111271. GC02P110550.
HGNC	HGNC:32418. RGPD5. HGNC:32419. RGPD6.
MIM	612708. gene. 612709. gene. 612710. gene.
neXtProt	NX_Q99666.
PharmGKB	PA142671074.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5171.
HOGENOM	HOG000089994.
HOVERGEN	HBG108404.
InParanoid	Q53T03.
OrthoDB	EOG4J3WG2.
PhylomeDB	Q99666.
Gene expression databases
ArrayExpress	Q99666.
Bgee	Q99666.
CleanEx	HS_RGPD5. HS_RGPD8.
Genevestigator	Q99666.
GermOnline	ENSG00000015568. Homo sapiens. ENSG00000183054. Homo sapiens.
Family and domain databases
Gene3D	1.10.220.60. 1 hit. 1.25.40.10. 2 hits. 2.30.29.30. 2 hits.
InterPro	IPR000237. GRIP. IPR011993. PH_like_dom. IPR000156. Ran_bind_dom. IPR001440. TPR-1. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Pfam	PF01465. GRIP. 1 hit. PF00638. Ran_BP1. 2 hits. PF00515. TPR_1. 1 hit. [Graphical view]
SMART	SM00755. Grip. 1 hit. SM00160. RanBD. 2 hits. [Graphical view]
PROSITE	PS50913. GRIP. 1 hit. PS50196. RANBD1. 2 hits. PS50005. TPR. 1 hit. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RGPD5. human.
NextBio	130592.
SOURCE	Search...

Entry information

Entry name

RGPD5_HUMAN

Accession

Primary (citable) accession number: Q99666
Secondary accession number(s): Q53QN2 , Q53T03, Q59GM7, Q9H0B2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 98 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.