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Q99665

- I12R2_HUMAN

UniProt

Q99665 - I12R2_HUMAN

Protein

Interleukin-12 receptor subunit beta-2

Gene

IL12RB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

    GO - Molecular functioni

    1. cytokine receptor activity Source: UniProtKB

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. cytokine-mediated signaling pathway Source: GOC
    3. interferon-gamma production Source: Ensembl
    4. peptidyl-tyrosine phosphorylation Source: Ensembl
    5. positive regulation of cell proliferation Source: ProtInc
    6. positive regulation of interferon-gamma production Source: BHF-UCL
    7. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-12 receptor subunit beta-2
    Short name:
    IL-12 receptor subunit beta-2
    Short name:
    IL-12R subunit beta-2
    Short name:
    IL-12R-beta-2
    Short name:
    IL-12RB2
    Gene namesi
    Name:IL12RB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:5972. IL12RB2.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi678 – 6781Y → F: No loss of STAT4 activation. No loss of SOCS3 binding. 3 Publications
    Mutagenesisi767 – 7671Y → F: No loss of STAT4 activation. No loss of SOCS3 binding. 3 Publications
    Mutagenesisi800 – 8001Y → F: Loss of STAT4 activation. Abolishes SOCS3 binding. 3 Publications
    Mutagenesisi801 – 8011L → A: Abolishes in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication
    Mutagenesisi802 – 8021P → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication
    Mutagenesisi803 – 8031S → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication
    Mutagenesisi804 – 8041N → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication

    Organism-specific databases

    Orphaneti117. Behcet disease.
    PharmGKBiPA29787.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 862839Interleukin-12 receptor subunit beta-2PRO_0000010920Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
    Modified residuei800 – 8001Phosphotyrosine2 Publications

    Post-translational modificationi

    On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ99665.
    PRIDEiQ99665.

    PTM databases

    PhosphoSiteiQ99665.

    Expressioni

    Tissue specificityi

    Isoform 2 is expressed at similar levels in both naive and activated T-cells.1 Publication

    Developmental stagei

    Maximum levels in Th1 cells between day 3 and day 8 of activation.

    Inductioni

    In vitro, up-regulated by IFN-alpha.1 Publication

    Gene expression databases

    BgeeiQ99665.
    CleanExiHS_IL12RB2.
    GenevestigatoriQ99665.

    Organism-specific databases

    HPAiHPA024168.

    Interactioni

    Subunit structurei

    Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain. Interaction, in vitro and in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation. Binds STAT4 through a membrane-distal C-terminal region.

    Protein-protein interaction databases

    BioGridi109809. 4 interactions.
    DIPiDIP-6011N.
    IntActiQ99665. 2 interactions.
    MINTiMINT-6780861.
    STRINGi9606.ENSP00000262345.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99665.
    SMRiQ99665. Positions 60-605.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 622599ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini644 – 862219CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei623 – 64321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini126 – 22196Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini226 – 31994Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini320 – 419100Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini423 – 52098Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini521 – 620100Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni796 – 8016Required for STAT4 binding

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi305 – 3095WSXWS motif
    Motifi662 – 6709Box 1 motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi208 – 2114Poly-Ser
    Compositional biasi750 – 7534Poly-Pro

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG122790.
    HOGENOMiHOG000049086.
    HOVERGENiHBG052059.
    InParanoidiQ99665.
    KOiK05064.
    OMAiTWAKKYP.
    OrthoDBiEOG7FXZXN.
    PhylomeDBiQ99665.
    TreeFamiTF338122.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR003529. Hematopoietin_rcpt_Gp130_CS.
    IPR013783. Ig-like_fold.
    IPR010457. IgC2-like_lig-bd.
    IPR015321. IL-6_rcpt_alpha-bd.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF09240. IL6Ra-bind. 1 hit.
    PF06328. Lep_receptor_Ig. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 4 hits.
    PROSITEiPS50853. FN3. 5 hits.
    PS01353. HEMATOPO_REC_L_F2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99665-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT    50
    CSLKPRQGCF HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV 100
    CKLACINSDE IQICGAEIFV GVAPEQPQNL SCIQKGEQGT VACTWERGRD 150
    THLYTEYTLQ LSGPKNLTWQ KQCKDIYCDY LDFGINLTPE SPESNFTAKV 200
    TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS RCTLYWRDEG 250
    LVLLNRLRYR PSNSRLWNMV NVTKAKGRHD LLDLKPFTEY EFQISSKLHL 300
    YKGSWSDWSE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFWKNLSV 350
    SEARGKILHY QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA 400
    NSKGSSLPTR INIMNLCEAG LLAPRQVSAN SEGMDNILVT WQPPRKDPSA 450
    VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN VSALISENIK SYICYEIRVY 500
    ALSGDQGGCS SILGNSKHKA PLSGPHINAI TEEKGSILIS WNSIPVQEQM 550
    GCLLHYRIYW KERDSNSQPQ LCEIPYRVSQ NSHPINSLQP RVTYVLWMTA 600
    LTAAGESSHG NEREFCLQGK ANWMAFVAPS ICIAIIMVGI FSTHYFQQKV 650
    FVLLAALRPQ WCSREIPDPA NSTCAKKYPI AEEKTQLPLD RLLIDWPTPE 700
    DPEPLVISEV LHQVTPVFRH PPCSNWPQRE KGIQGHQASE KDMMHSASSP 750
    PPPRALQAES RQLVDLYKVL ESRGSDPKPE NPACPWTVLP AGDLPTHDGY 800
    LPSNIDDLPS HEAPLADSLE ELEPQHISLS VFPSSSLHPL TFSCGDKLTL 850
    DQLKMRCDSL ML 862
    Length:862
    Mass (Da):97,135
    Last modified:May 1, 1997 - v1
    Checksum:i67C0E0D946B8DD58
    GO
    Isoform 2 (identifier: Q99665-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         650-659: VFVLLAALRP → RRHSCPWTGS
         660-862: Missing.

    Show »
    Length:659
    Mass (Da):74,607
    Checksum:i66A09C2666CCC64E
    GO
    Isoform 3 (identifier: Q99665-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         487-572: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:776
    Mass (Da):87,484
    Checksum:i85F77F1E5D18E2C1
    GO

    Polymorphismi

    Heterozygotic variants Gly-313 and Arg-720 are associated with atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131M → V.1 Publication
    Corresponds to variant rs17129772 [ dbSNP | Ensembl ].
    VAR_021278
    Natural varianti149 – 1491R → Q.1 Publication
    Corresponds to variant rs17129792 [ dbSNP | Ensembl ].
    VAR_021279
    Natural varianti185 – 1851I → V.
    Corresponds to variant rs2307146 [ dbSNP | Ensembl ].
    VAR_014805
    Natural varianti201 – 2011T → I.
    Corresponds to variant rs7526769 [ dbSNP | Ensembl ].
    VAR_019525
    Natural varianti313 – 3131R → G.1 Publication
    VAR_019526
    Natural varianti420 – 4201G → R.
    Corresponds to variant rs2307148 [ dbSNP | Ensembl ].
    VAR_014806
    Natural varianti420 – 4201G → S.
    Corresponds to variant rs2307148 [ dbSNP | Ensembl ].
    VAR_049169
    Natural varianti426 – 4261Q → H.2 Publications
    Corresponds to variant rs2307145 [ dbSNP | Ensembl ].
    VAR_014807
    Natural varianti465 – 4651G → D.1 Publication
    Corresponds to variant rs2307153 [ dbSNP | Ensembl ].
    VAR_014808
    Natural varianti625 – 6251A → V.
    Corresponds to variant rs2307154 [ dbSNP | Ensembl ].
    VAR_016097
    Natural varianti720 – 7201H → R.1 Publication
    VAR_019527
    Natural varianti808 – 8081L → R.1 Publication
    Corresponds to variant rs17838066 [ dbSNP | Ensembl ].
    VAR_021280

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei487 – 57286Missing in isoform 3. 1 PublicationVSP_044784Add
    BLAST
    Alternative sequencei650 – 65910VFVLLAALRP → RRHSCPWTGS in isoform 2. 1 PublicationVSP_011112
    Alternative sequencei660 – 862203Missing in isoform 2. 1 PublicationVSP_011113Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64198 mRNA. Translation: AAB36675.1.
    AY640177 Genomic DNA. Translation: AAT45456.1.
    CH471059 Genomic DNA. Translation: EAX06499.1.
    AL358512, AL389925 Genomic DNA. Translation: CAH69960.1.
    AL389925, AL358512 Genomic DNA. Translation: CAH70407.1.
    BC104772 mRNA. Translation: AAI04773.1.
    BC104774 mRNA. Translation: AAI04775.1.
    BC143249 mRNA. Translation: AAI43250.1.
    CCDSiCCDS58006.1. [Q99665-2]
    CCDS58007.1. [Q99665-3]
    CCDS638.1. [Q99665-1]
    RefSeqiNP_001245143.1. NM_001258214.1. [Q99665-2]
    NP_001245144.1. NM_001258215.1. [Q99665-3]
    NP_001245145.1. NM_001258216.1.
    NP_001550.1. NM_001559.2. [Q99665-1]
    XP_005270882.1. XM_005270825.1. [Q99665-1]
    XP_005270884.1. XM_005270827.1. [Q99665-1]
    XP_005270885.1. XM_005270828.1. [Q99665-1]
    XP_006710680.1. XM_006710617.1. [Q99665-3]
    UniGeneiHs.479347.

    Genome annotation databases

    EnsembliENST00000262345; ENSP00000262345; ENSG00000081985. [Q99665-1]
    ENST00000371000; ENSP00000360039; ENSG00000081985. [Q99665-2]
    ENST00000541374; ENSP00000445276; ENSG00000081985. [Q99665-2]
    ENST00000544434; ENSP00000442443; ENSG00000081985. [Q99665-3]
    GeneIDi3595.
    KEGGihsa:3595.
    UCSCiuc001ddu.3. human. [Q99665-1]
    uc010oqi.2. human. [Q99665-2]

    Polymorphism databases

    DMDMi12229836.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64198 mRNA. Translation: AAB36675.1 .
    AY640177 Genomic DNA. Translation: AAT45456.1 .
    CH471059 Genomic DNA. Translation: EAX06499.1 .
    AL358512 , AL389925 Genomic DNA. Translation: CAH69960.1 .
    AL389925 , AL358512 Genomic DNA. Translation: CAH70407.1 .
    BC104772 mRNA. Translation: AAI04773.1 .
    BC104774 mRNA. Translation: AAI04775.1 .
    BC143249 mRNA. Translation: AAI43250.1 .
    CCDSi CCDS58006.1. [Q99665-2 ]
    CCDS58007.1. [Q99665-3 ]
    CCDS638.1. [Q99665-1 ]
    RefSeqi NP_001245143.1. NM_001258214.1. [Q99665-2 ]
    NP_001245144.1. NM_001258215.1. [Q99665-3 ]
    NP_001245145.1. NM_001258216.1.
    NP_001550.1. NM_001559.2. [Q99665-1 ]
    XP_005270882.1. XM_005270825.1. [Q99665-1 ]
    XP_005270884.1. XM_005270827.1. [Q99665-1 ]
    XP_005270885.1. XM_005270828.1. [Q99665-1 ]
    XP_006710680.1. XM_006710617.1. [Q99665-3 ]
    UniGenei Hs.479347.

    3D structure databases

    ProteinModelPortali Q99665.
    SMRi Q99665. Positions 60-605.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109809. 4 interactions.
    DIPi DIP-6011N.
    IntActi Q99665. 2 interactions.
    MINTi MINT-6780861.
    STRINGi 9606.ENSP00000262345.

    PTM databases

    PhosphoSitei Q99665.

    Polymorphism databases

    DMDMi 12229836.

    Proteomic databases

    PaxDbi Q99665.
    PRIDEi Q99665.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262345 ; ENSP00000262345 ; ENSG00000081985 . [Q99665-1 ]
    ENST00000371000 ; ENSP00000360039 ; ENSG00000081985 . [Q99665-2 ]
    ENST00000541374 ; ENSP00000445276 ; ENSG00000081985 . [Q99665-2 ]
    ENST00000544434 ; ENSP00000442443 ; ENSG00000081985 . [Q99665-3 ]
    GeneIDi 3595.
    KEGGi hsa:3595.
    UCSCi uc001ddu.3. human. [Q99665-1 ]
    uc010oqi.2. human. [Q99665-2 ]

    Organism-specific databases

    CTDi 3595.
    GeneCardsi GC01P067773.
    HGNCi HGNC:5972. IL12RB2.
    HPAi HPA024168.
    MIMi 601642. gene.
    neXtProti NX_Q99665.
    Orphaneti 117. Behcet disease.
    PharmGKBi PA29787.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG122790.
    HOGENOMi HOG000049086.
    HOVERGENi HBG052059.
    InParanoidi Q99665.
    KOi K05064.
    OMAi TWAKKYP.
    OrthoDBi EOG7FXZXN.
    PhylomeDBi Q99665.
    TreeFami TF338122.

    Miscellaneous databases

    ChiTaRSi IL12RB2. human.
    GeneWikii Interleukin_12_receptor,_beta_2_subunit.
    GenomeRNAii 3595.
    NextBioi 14049.
    PROi Q99665.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99665.
    CleanExi HS_IL12RB2.
    Genevestigatori Q99665.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR003529. Hematopoietin_rcpt_Gp130_CS.
    IPR013783. Ig-like_fold.
    IPR010457. IgC2-like_lig-bd.
    IPR015321. IL-6_rcpt_alpha-bd.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF09240. IL6Ra-bind. 1 hit.
    PF06328. Lep_receptor_Ig. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 4 hits.
    PROSITEi PS50853. FN3. 5 hits.
    PS01353. HEMATOPO_REC_L_F2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits."
      Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.-Y., Gately M.K., Gubler U.
      Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Genomic organization of the human interleukin-12 receptor beta2-chain gene."
      van Rietschoten J.G.I., Smits H.H., Westland R., Verweij C.L., den Hartog M.T., Wierenga E.A.
      Immunogenetics 51:30-36(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: T-cell.
    3. SeattleSNPs variation discovery resource
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-13; GLN-149; HIS-426; ASP-465 AND ARG-808.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT HIS-426.
      Tissue: Brain.
    7. "Direct interaction of STAT4 with the IL-12 receptor."
      Yao B.B., Niu P., Surowy C.S., Faltynek C.R.
      Arch. Biochem. Biophys. 368:147-155(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STAT4, PHOSPHORYLATION AT TYR-800, MUTAGENESIS OF LEU-801; PRO-802; SER-803 AND ASN-804.
    8. "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus."
      Yamamoto K., Shibata F., Miura O., Kamiyama R., Hirosawa S., Miyasaka N.
      Biochem. Biophys. Res. Commun. 257:400-404(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH JAK2, MUTAGENESIS OF TYR-678; TYR-767 AND TYR-800.
    9. "Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling."
      Naeger L.K., McKinney J., Salvekar A., Hoey T.
      J. Biol. Chem. 274:1875-1878(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STAT4, MUTAGENESIS OF TYR-678; TYR-767 AND TYR-800.
    10. "Selective expression of an interleukin-12 receptor component by human T helper 1 cells."
      Rogge L., Barberis-Maino L., Biffi M., Passini N., Presky D.H., Gubler U., Sinigaglia F.
      J. Exp. Med. 185:825-831(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    11. "SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit."
      Yamamoto K., Yamaguchi M., Miyasaka N., Miura O.
      Biochem. Biophys. Res. Commun. 310:1188-1193(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, INTERACTION WITH SOCS3, MUTAGENESIS OF TYR-678; TYR-767 AND TYR-800.
    12. Cited for: VARIANTS GLY-313 AND ARG-720.

    Entry informationi

    Entry nameiI12R2_HUMAN
    AccessioniPrimary (citable) accession number: Q99665
    Secondary accession number(s): B1AN98
    , B7ZKL9, F5H7L6, Q2M3V3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3