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Q99665

- I12R2_HUMAN

UniProt

Q99665 - I12R2_HUMAN

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Protein

Interleukin-12 receptor subunit beta-2

Gene

IL12RB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

GO - Molecular functioni

  1. cytokine receptor activity Source: UniProtKB

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. cytokine-mediated signaling pathway Source: GOC
  3. interferon-gamma production Source: Ensembl
  4. peptidyl-tyrosine phosphorylation Source: Ensembl
  5. positive regulation of cell proliferation Source: ProtInc
  6. positive regulation of interferon-gamma production Source: BHF-UCL
  7. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 receptor subunit beta-2
Short name:
IL-12 receptor subunit beta-2
Short name:
IL-12R subunit beta-2
Short name:
IL-12R-beta-2
Short name:
IL-12RB2
Gene namesi
Name:IL12RB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:5972. IL12RB2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 622599ExtracellularSequence AnalysisAdd
BLAST
Transmembranei623 – 64321HelicalSequence AnalysisAdd
BLAST
Topological domaini644 – 862219CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi678 – 6781Y → F: No loss of STAT4 activation. No loss of SOCS3 binding. 3 Publications
Mutagenesisi767 – 7671Y → F: No loss of STAT4 activation. No loss of SOCS3 binding. 3 Publications
Mutagenesisi800 – 8001Y → F: Loss of STAT4 activation. Abolishes SOCS3 binding. 3 Publications
Mutagenesisi801 – 8011L → A: Abolishes in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication
Mutagenesisi802 – 8021P → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication
Mutagenesisi803 – 8031S → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication
Mutagenesisi804 – 8041N → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication

Organism-specific databases

Orphaneti117. Behcet disease.
PharmGKBiPA29787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 862839Interleukin-12 receptor subunit beta-2PRO_0000010920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
Modified residuei800 – 8001Phosphotyrosine1 Publication

Post-translational modificationi

On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ99665.
PRIDEiQ99665.

PTM databases

PhosphoSiteiQ99665.

Expressioni

Tissue specificityi

Isoform 2 is expressed at similar levels in both naive and activated T-cells.1 Publication

Developmental stagei

Maximum levels in Th1 cells between day 3 and day 8 of activation.

Inductioni

In vitro, up-regulated by IFN-alpha.1 Publication

Gene expression databases

BgeeiQ99665.
CleanExiHS_IL12RB2.
GenevestigatoriQ99665.

Organism-specific databases

HPAiHPA024168.

Interactioni

Subunit structurei

Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain. Interaction, in vitro and in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation. Binds STAT4 through a membrane-distal C-terminal region.

Protein-protein interaction databases

BioGridi109809. 4 interactions.
DIPiDIP-6011N.
IntActiQ99665. 2 interactions.
MINTiMINT-6780861.
STRINGi9606.ENSP00000262345.

Structurei

3D structure databases

ProteinModelPortaliQ99665.
SMRiQ99665. Positions 60-605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 22196Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini226 – 31994Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini320 – 419100Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini423 – 52098Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini521 – 620100Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni796 – 8016Required for STAT4 binding

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi305 – 3095WSXWS motif
Motifi662 – 6709Box 1 motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi208 – 2114Poly-Ser
Compositional biasi750 – 7534Poly-Pro

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG122790.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000049086.
HOVERGENiHBG052059.
InParanoidiQ99665.
KOiK05064.
OMAiTWAKKYP.
OrthoDBiEOG7FXZXN.
PhylomeDBiQ99665.
TreeFamiTF338122.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015321. IL-6_rcpt_alpha-bd.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF09240. IL6Ra-bind. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99665-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT
60 70 80 90 100
CSLKPRQGCF HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV
110 120 130 140 150
CKLACINSDE IQICGAEIFV GVAPEQPQNL SCIQKGEQGT VACTWERGRD
160 170 180 190 200
THLYTEYTLQ LSGPKNLTWQ KQCKDIYCDY LDFGINLTPE SPESNFTAKV
210 220 230 240 250
TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS RCTLYWRDEG
260 270 280 290 300
LVLLNRLRYR PSNSRLWNMV NVTKAKGRHD LLDLKPFTEY EFQISSKLHL
310 320 330 340 350
YKGSWSDWSE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFWKNLSV
360 370 380 390 400
SEARGKILHY QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA
410 420 430 440 450
NSKGSSLPTR INIMNLCEAG LLAPRQVSAN SEGMDNILVT WQPPRKDPSA
460 470 480 490 500
VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN VSALISENIK SYICYEIRVY
510 520 530 540 550
ALSGDQGGCS SILGNSKHKA PLSGPHINAI TEEKGSILIS WNSIPVQEQM
560 570 580 590 600
GCLLHYRIYW KERDSNSQPQ LCEIPYRVSQ NSHPINSLQP RVTYVLWMTA
610 620 630 640 650
LTAAGESSHG NEREFCLQGK ANWMAFVAPS ICIAIIMVGI FSTHYFQQKV
660 670 680 690 700
FVLLAALRPQ WCSREIPDPA NSTCAKKYPI AEEKTQLPLD RLLIDWPTPE
710 720 730 740 750
DPEPLVISEV LHQVTPVFRH PPCSNWPQRE KGIQGHQASE KDMMHSASSP
760 770 780 790 800
PPPRALQAES RQLVDLYKVL ESRGSDPKPE NPACPWTVLP AGDLPTHDGY
810 820 830 840 850
LPSNIDDLPS HEAPLADSLE ELEPQHISLS VFPSSSLHPL TFSCGDKLTL
860
DQLKMRCDSL ML
Length:862
Mass (Da):97,135
Last modified:May 1, 1997 - v1
Checksum:i67C0E0D946B8DD58
GO
Isoform 2 (identifier: Q99665-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     650-659: VFVLLAALRP → RRHSCPWTGS
     660-862: Missing.

Show »
Length:659
Mass (Da):74,607
Checksum:i66A09C2666CCC64E
GO
Isoform 3 (identifier: Q99665-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     487-572: Missing.

Note: No experimental confirmation available.

Show »
Length:776
Mass (Da):87,484
Checksum:i85F77F1E5D18E2C1
GO

Polymorphismi

Heterozygotic variants Gly-313 and Arg-720 are associated with atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131M → V.1 Publication
Corresponds to variant rs17129772 [ dbSNP | Ensembl ].
VAR_021278
Natural varianti149 – 1491R → Q.1 Publication
Corresponds to variant rs17129792 [ dbSNP | Ensembl ].
VAR_021279
Natural varianti185 – 1851I → V.
Corresponds to variant rs2307146 [ dbSNP | Ensembl ].
VAR_014805
Natural varianti201 – 2011T → I.
Corresponds to variant rs7526769 [ dbSNP | Ensembl ].
VAR_019525
Natural varianti313 – 3131R → G.1 Publication
VAR_019526
Natural varianti420 – 4201G → R.
Corresponds to variant rs2307148 [ dbSNP | Ensembl ].
VAR_014806
Natural varianti420 – 4201G → S.
Corresponds to variant rs2307148 [ dbSNP | Ensembl ].
VAR_049169
Natural varianti426 – 4261Q → H.2 Publications
Corresponds to variant rs2307145 [ dbSNP | Ensembl ].
VAR_014807
Natural varianti465 – 4651G → D.1 Publication
Corresponds to variant rs2307153 [ dbSNP | Ensembl ].
VAR_014808
Natural varianti625 – 6251A → V.
Corresponds to variant rs2307154 [ dbSNP | Ensembl ].
VAR_016097
Natural varianti720 – 7201H → R.1 Publication
VAR_019527
Natural varianti808 – 8081L → R.1 Publication
Corresponds to variant rs17838066 [ dbSNP | Ensembl ].
VAR_021280

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei487 – 57286Missing in isoform 3. 1 PublicationVSP_044784Add
BLAST
Alternative sequencei650 – 65910VFVLLAALRP → RRHSCPWTGS in isoform 2. 1 PublicationVSP_011112
Alternative sequencei660 – 862203Missing in isoform 2. 1 PublicationVSP_011113Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64198 mRNA. Translation: AAB36675.1.
AY640177 Genomic DNA. Translation: AAT45456.1.
CH471059 Genomic DNA. Translation: EAX06499.1.
AL358512, AL389925 Genomic DNA. Translation: CAH69960.1.
AL389925, AL358512 Genomic DNA. Translation: CAH70407.1.
BC104772 mRNA. Translation: AAI04773.1.
BC104774 mRNA. Translation: AAI04775.1.
BC143249 mRNA. Translation: AAI43250.1.
CCDSiCCDS58006.1. [Q99665-2]
CCDS58007.1. [Q99665-3]
CCDS638.1. [Q99665-1]
RefSeqiNP_001245143.1. NM_001258214.1. [Q99665-2]
NP_001245144.1. NM_001258215.1. [Q99665-3]
NP_001245145.1. NM_001258216.1.
NP_001550.1. NM_001559.2. [Q99665-1]
XP_005270882.1. XM_005270825.1. [Q99665-1]
XP_005270884.1. XM_005270827.1. [Q99665-1]
XP_005270885.1. XM_005270828.1. [Q99665-1]
XP_006710680.1. XM_006710617.1. [Q99665-3]
UniGeneiHs.479347.

Genome annotation databases

EnsembliENST00000262345; ENSP00000262345; ENSG00000081985. [Q99665-1]
ENST00000371000; ENSP00000360039; ENSG00000081985. [Q99665-2]
ENST00000544434; ENSP00000442443; ENSG00000081985. [Q99665-3]
GeneIDi3595.
KEGGihsa:3595.
UCSCiuc001ddu.3. human. [Q99665-1]
uc010oqi.2. human. [Q99665-2]

Polymorphism databases

DMDMi12229836.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64198 mRNA. Translation: AAB36675.1 .
AY640177 Genomic DNA. Translation: AAT45456.1 .
CH471059 Genomic DNA. Translation: EAX06499.1 .
AL358512 , AL389925 Genomic DNA. Translation: CAH69960.1 .
AL389925 , AL358512 Genomic DNA. Translation: CAH70407.1 .
BC104772 mRNA. Translation: AAI04773.1 .
BC104774 mRNA. Translation: AAI04775.1 .
BC143249 mRNA. Translation: AAI43250.1 .
CCDSi CCDS58006.1. [Q99665-2 ]
CCDS58007.1. [Q99665-3 ]
CCDS638.1. [Q99665-1 ]
RefSeqi NP_001245143.1. NM_001258214.1. [Q99665-2 ]
NP_001245144.1. NM_001258215.1. [Q99665-3 ]
NP_001245145.1. NM_001258216.1.
NP_001550.1. NM_001559.2. [Q99665-1 ]
XP_005270882.1. XM_005270825.1. [Q99665-1 ]
XP_005270884.1. XM_005270827.1. [Q99665-1 ]
XP_005270885.1. XM_005270828.1. [Q99665-1 ]
XP_006710680.1. XM_006710617.1. [Q99665-3 ]
UniGenei Hs.479347.

3D structure databases

ProteinModelPortali Q99665.
SMRi Q99665. Positions 60-605.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109809. 4 interactions.
DIPi DIP-6011N.
IntActi Q99665. 2 interactions.
MINTi MINT-6780861.
STRINGi 9606.ENSP00000262345.

PTM databases

PhosphoSitei Q99665.

Polymorphism databases

DMDMi 12229836.

Proteomic databases

PaxDbi Q99665.
PRIDEi Q99665.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262345 ; ENSP00000262345 ; ENSG00000081985 . [Q99665-1 ]
ENST00000371000 ; ENSP00000360039 ; ENSG00000081985 . [Q99665-2 ]
ENST00000544434 ; ENSP00000442443 ; ENSG00000081985 . [Q99665-3 ]
GeneIDi 3595.
KEGGi hsa:3595.
UCSCi uc001ddu.3. human. [Q99665-1 ]
uc010oqi.2. human. [Q99665-2 ]

Organism-specific databases

CTDi 3595.
GeneCardsi GC01P067773.
HGNCi HGNC:5972. IL12RB2.
HPAi HPA024168.
MIMi 601642. gene.
neXtProti NX_Q99665.
Orphaneti 117. Behcet disease.
PharmGKBi PA29787.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG122790.
GeneTreei ENSGT00550000074436.
HOGENOMi HOG000049086.
HOVERGENi HBG052059.
InParanoidi Q99665.
KOi K05064.
OMAi TWAKKYP.
OrthoDBi EOG7FXZXN.
PhylomeDBi Q99665.
TreeFami TF338122.

Miscellaneous databases

ChiTaRSi IL12RB2. human.
GeneWikii Interleukin_12_receptor,_beta_2_subunit.
GenomeRNAii 3595.
NextBioi 14049.
PROi Q99665.
SOURCEi Search...

Gene expression databases

Bgeei Q99665.
CleanExi HS_IL12RB2.
Genevestigatori Q99665.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015321. IL-6_rcpt_alpha-bd.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF09240. IL6Ra-bind. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 4 hits.
PROSITEi PS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits."
    Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.-Y., Gately M.K., Gubler U.
    Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Genomic organization of the human interleukin-12 receptor beta2-chain gene."
    van Rietschoten J.G.I., Smits H.H., Westland R., Verweij C.L., den Hartog M.T., Wierenga E.A.
    Immunogenetics 51:30-36(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: T-cell.
  3. SeattleSNPs variation discovery resource
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-13; GLN-149; HIS-426; ASP-465 AND ARG-808.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT HIS-426.
    Tissue: Brain.
  7. "Direct interaction of STAT4 with the IL-12 receptor."
    Yao B.B., Niu P., Surowy C.S., Faltynek C.R.
    Arch. Biochem. Biophys. 368:147-155(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STAT4, PHOSPHORYLATION AT TYR-800, MUTAGENESIS OF LEU-801; PRO-802; SER-803 AND ASN-804.
  8. "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus."
    Yamamoto K., Shibata F., Miura O., Kamiyama R., Hirosawa S., Miyasaka N.
    Biochem. Biophys. Res. Commun. 257:400-404(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH JAK2, MUTAGENESIS OF TYR-678; TYR-767 AND TYR-800.
  9. "Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling."
    Naeger L.K., McKinney J., Salvekar A., Hoey T.
    J. Biol. Chem. 274:1875-1878(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STAT4, MUTAGENESIS OF TYR-678; TYR-767 AND TYR-800.
  10. "Selective expression of an interleukin-12 receptor component by human T helper 1 cells."
    Rogge L., Barberis-Maino L., Biffi M., Passini N., Presky D.H., Gubler U., Sinigaglia F.
    J. Exp. Med. 185:825-831(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  11. "SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit."
    Yamamoto K., Yamaguchi M., Miyasaka N., Miura O.
    Biochem. Biophys. Res. Commun. 310:1188-1193(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, INTERACTION WITH SOCS3, MUTAGENESIS OF TYR-678; TYR-767 AND TYR-800.
  12. Cited for: VARIANTS GLY-313 AND ARG-720.

Entry informationi

Entry nameiI12R2_HUMAN
AccessioniPrimary (citable) accession number: Q99665
Secondary accession number(s): B1AN98
, B7ZKL9, F5H7L6, Q2M3V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3