Q99665 (I12R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-12 receptor subunit beta-2
Short name=IL-12 receptor subunit beta-2
Short name=IL-12R subunit beta-2
Short name=IL-12R-beta-2
Short name=IL-12RB2

Gene names

Name:

IL12RB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	862 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Subunit structure	Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain. Interaction, in vitro and in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation. Binds STAT4 through a membrane-distal C-terminal region.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Isoform 2 is expressed at similar levels in both naive and activated T-cells. Ref.10
Developmental stage	Maximum levels in Th1 cells between day 3 and day 8 of activation.
Induction	In vitro, up-regulated by IFN-alpha. Ref.10
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Post-translational modification	On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. Ref.11
Polymorphism	Heterozygotic variants Gly-313 and Arg-720 are associated with atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	interferon-gamma production Inferred from electronic annotation. Source: Compara peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Traceable author statement Ref.1. Source: ProtInc positive regulation of interferon-gamma production Inferred from direct assay PubMed 11114383. Source: BHF-UCL response to lipopolysaccharide Inferred from electronic annotation. Source: Compara
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	cytokine receptor activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q99665-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99665-2)

The sequence of this isoform differs from the canonical sequence as follows:
     650-659: VFVLLAALRP → RRHSCPWTGS
     660-862: Missing.

Isoform 3 (identifier: Q99665-3)

The sequence of this isoform differs from the canonical sequence as follows:
     487-572: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 862	839	Interleukin-12 receptor subunit beta-2		PRO_0000010920
Regions
	Topological domain	24 – 622	599	Extracellular Potential
	Transmembrane	623 – 643	21	Helical; Potential
	Topological domain	644 – 862	219	Cytoplasmic Potential
	Domain	124 – 218	95	Fibronectin type-III 1
	Domain	224 – 316	93	Fibronectin type-III 2
	Domain	317 – 415	99	Fibronectin type-III 3
	Domain	420 – 517	98	Fibronectin type-III 4
	Domain	521 – 617	97	Fibronectin type-III 5
	Region	796 – 801	6	Required for STAT4 binding
	Motif	305 – 309	5	WSXWS motif
	Motif	662 – 670	9	Box 1 motif
	Compositional bias	208 – 211	4	Poly-Ser
	Compositional bias	750 – 753	4	Poly-Pro
Amino acid modifications
	Modified residue	800	1	Phosphotyrosine
	Glycosylation	48	1	N-linked (GlcNAc...) Potential
	Glycosylation	129	1	N-linked (GlcNAc...) Potential
	Glycosylation	166	1	N-linked (GlcNAc...) Potential
	Glycosylation	195	1	N-linked (GlcNAc...) Potential
	Glycosylation	271	1	N-linked (GlcNAc...) Potential
	Glycosylation	347	1	N-linked (GlcNAc...) Potential
	Glycosylation	376	1	N-linked (GlcNAc...) Potential
	Glycosylation	480	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	487 – 572	86	Missing in isoform 3.		VSP_044784
	Alternative sequence	650 – 659	10	VFVLLAALRP → RRHSCPWTGS in isoform 2.		VSP_011112
	Alternative sequence	660 – 862	203	Missing in isoform 2.		VSP_011113
	Natural variant	13	1	M → V. Ref.3 Corresponds to variant rs17129772 [ dbSNP | Ensembl ].		VAR_021278
	Natural variant	149	1	R → Q. Ref.3 Corresponds to variant rs17129792 [ dbSNP | Ensembl ].		VAR_021279
	Natural variant	185	1	I → V. Corresponds to variant rs2307146 [ dbSNP | Ensembl ].		VAR_014805
	Natural variant	201	1	T → I. Corresponds to variant rs7526769 [ dbSNP | Ensembl ].		VAR_019525
	Natural variant	313	1	R → G. Ref.12		VAR_019526
	Natural variant	420	1	G → R. Corresponds to variant rs2307148 [ dbSNP | Ensembl ].		VAR_014806
	Natural variant	420	1	G → S. Corresponds to variant rs2307148 [ dbSNP | Ensembl ].		VAR_049169
	Natural variant	426	1	Q → H. Ref.3 Ref.6 Corresponds to variant rs2307145 [ dbSNP | Ensembl ].		VAR_014807
	Natural variant	465	1	G → D. Ref.3 Corresponds to variant rs2307153 [ dbSNP | Ensembl ].		VAR_014808
	Natural variant	625	1	A → V. Corresponds to variant rs2307154 [ dbSNP | Ensembl ].		VAR_016097
	Natural variant	720	1	H → R. Ref.12		VAR_019527
	Natural variant	808	1	L → R. Ref.3 Corresponds to variant rs17838066 [ dbSNP | Ensembl ].		VAR_021280
Experimental info
	Mutagenesis	678	1	Y → F: No loss of STAT4 activation. No loss of SOCS3 binding. Ref.8 Ref.9 Ref.11
	Mutagenesis	767	1	Y → F: No loss of STAT4 activation. No loss of SOCS3 binding. Ref.8 Ref.9 Ref.11
	Mutagenesis	800	1	Y → F: Loss of STAT4 activation. Abolishes SOCS3 binding. Ref.8 Ref.9 Ref.11
	Mutagenesis	801	1	L → A: Abolishes in vitro STAT4 binding to a phosphorylated Y-800 peptide. Ref.7
	Mutagenesis	802	1	P → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. Ref.7
	Mutagenesis	803	1	S → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. Ref.7
	Mutagenesis	804	1	N → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 67C0E0D946B8DD58	FASTA	862	97,135
	10 20 30 40 50 60 MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT CSLKPRQGCF 70 80 90 100 110 120 HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV CKLACINSDE IQICGAEIFV 130 140 150 160 170 180 GVAPEQPQNL SCIQKGEQGT VACTWERGRD THLYTEYTLQ LSGPKNLTWQ KQCKDIYCDY 190 200 210 220 230 240 LDFGINLTPE SPESNFTAKV TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS 250 260 270 280 290 300 RCTLYWRDEG LVLLNRLRYR PSNSRLWNMV NVTKAKGRHD LLDLKPFTEY EFQISSKLHL 310 320 330 340 350 360 YKGSWSDWSE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFWKNLSV SEARGKILHY 370 380 390 400 410 420 QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA NSKGSSLPTR INIMNLCEAG 430 440 450 460 470 480 LLAPRQVSAN SEGMDNILVT WQPPRKDPSA VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN 490 500 510 520 530 540 VSALISENIK SYICYEIRVY ALSGDQGGCS SILGNSKHKA PLSGPHINAI TEEKGSILIS 550 560 570 580 590 600 WNSIPVQEQM GCLLHYRIYW KERDSNSQPQ LCEIPYRVSQ NSHPINSLQP RVTYVLWMTA 610 620 630 640 650 660 LTAAGESSHG NEREFCLQGK ANWMAFVAPS ICIAIIMVGI FSTHYFQQKV FVLLAALRPQ 670 680 690 700 710 720 WCSREIPDPA NSTCAKKYPI AEEKTQLPLD RLLIDWPTPE DPEPLVISEV LHQVTPVFRH 730 740 750 760 770 780 PPCSNWPQRE KGIQGHQASE KDMMHSASSP PPPRALQAES RQLVDLYKVL ESRGSDPKPE 790 800 810 820 830 840 NPACPWTVLP AGDLPTHDGY LPSNIDDLPS HEAPLADSLE ELEPQHISLS VFPSSSLHPL 850 860 TFSCGDKLTL DQLKMRCDSL ML
	Isoform 2 [UniParc]. Checksum: 66A09C2666CCC64E	FASTA	659	74,607
	10 20 30 40 50 60 MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT CSLKPRQGCF 70 80 90 100 110 120 HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV CKLACINSDE IQICGAEIFV 130 140 150 160 170 180 GVAPEQPQNL SCIQKGEQGT VACTWERGRD THLYTEYTLQ LSGPKNLTWQ KQCKDIYCDY 190 200 210 220 230 240 LDFGINLTPE SPESNFTAKV TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS 250 260 270 280 290 300 RCTLYWRDEG LVLLNRLRYR PSNSRLWNMV NVTKAKGRHD LLDLKPFTEY EFQISSKLHL 310 320 330 340 350 360 YKGSWSDWSE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFWKNLSV SEARGKILHY 370 380 390 400 410 420 QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA NSKGSSLPTR INIMNLCEAG 430 440 450 460 470 480 LLAPRQVSAN SEGMDNILVT WQPPRKDPSA VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN 490 500 510 520 530 540 VSALISENIK SYICYEIRVY ALSGDQGGCS SILGNSKHKA PLSGPHINAI TEEKGSILIS 550 560 570 580 590 600 WNSIPVQEQM GCLLHYRIYW KERDSNSQPQ LCEIPYRVSQ NSHPINSLQP RVTYVLWMTA 610 620 630 640 650 LTAAGESSHG NEREFCLQGK ANWMAFVAPS ICIAIIMVGI FSTHYFQQKR RHSCPWTGS
	Isoform 3 [UniParc]. Checksum: 85F77F1E5D18E2C1	FASTA	776	87,484
	10 20 30 40 50 60 MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT CSLKPRQGCF 70 80 90 100 110 120 HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV CKLACINSDE IQICGAEIFV 130 140 150 160 170 180 GVAPEQPQNL SCIQKGEQGT VACTWERGRD THLYTEYTLQ LSGPKNLTWQ KQCKDIYCDY 190 200 210 220 230 240 LDFGINLTPE SPESNFTAKV TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS 250 260 270 280 290 300 RCTLYWRDEG LVLLNRLRYR PSNSRLWNMV NVTKAKGRHD LLDLKPFTEY EFQISSKLHL 310 320 330 340 350 360 YKGSWSDWSE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFWKNLSV SEARGKILHY 370 380 390 400 410 420 QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA NSKGSSLPTR INIMNLCEAG 430 440 450 460 470 480 LLAPRQVSAN SEGMDNILVT WQPPRKDPSA VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN 490 500 510 520 530 540 VSALISEIPY RVSQNSHPIN SLQPRVTYVL WMTALTAAGE SSHGNEREFC LQGKANWMAF 550 560 570 580 590 600 VAPSICIAII MVGIFSTHYF QQKVFVLLAA LRPQWCSREI PDPANSTCAK KYPIAEEKTQ 610 620 630 640 650 660 LPLDRLLIDW PTPEDPEPLV ISEVLHQVTP VFRHPPCSNW PQREKGIQGH QASEKDMMHS 670 680 690 700 710 720 ASSPPPPRAL QAESRQLVDL YKVLESRGSD PKPENPACPW TVLPAGDLPT HDGYLPSNID 730 740 750 760 770 DLPSHEAPLA DSLEELEPQH ISLSVFPSSS LHPLTFSCGD KLTLDQLKMR CDSLML

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits." Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.-Y., Gately M.K., Gubler U. Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Genomic organization of the human interleukin-12 receptor beta2-chain gene." van Rietschoten J.G.I., Smits H.H., Westland R., Verweij C.L., den Hartog M.T., Wierenga E.A. Immunogenetics 51:30-36(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: T-cell.
[3]	SeattleSNPs variation discovery resource Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-13; GLN-149; HIS-426; ASP-465 AND ARG-808.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT HIS-426. Tissue: Brain.
[7]	"Direct interaction of STAT4 with the IL-12 receptor." Yao B.B., Niu P., Surowy C.S., Faltynek C.R. Arch. Biochem. Biophys. 368:147-155(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH STAT4, MUTAGENESIS OF LEU-801; PRO-802; SER-803 AND ASN-804.
[8]	"Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus." Yamamoto K., Shibata F., Miura O., Kamiyama R., Hirosawa S., Miyasaka N. Biochem. Biophys. Res. Commun. 257:400-404(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH JAK2, MUTAGENESIS OF TYR-678; TYR-767 AND TYR-800.
[9]	"Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling." Naeger L.K., McKinney J., Salvekar A., Hoey T. J. Biol. Chem. 274:1875-1878(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH STAT4, MUTAGENESIS OF TYR-678; TYR-767 AND TYR-800.
[10]	"Selective expression of an interleukin-12 receptor component by human T helper 1 cells." Rogge L., Barberis-Maino L., Biffi M., Passini N., Presky D.H., Gubler U., Sinigaglia F. J. Exp. Med. 185:825-831(1997) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INDUCTION.
[11]	"SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit." Yamamoto K., Yamaguchi M., Miyasaka N., Miura O. Biochem. Biophys. Res. Commun. 310:1188-1193(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION, INTERACTION WITH SOCS3, MUTAGENESIS OF TYR-678; TYR-767 AND TYR-800.
[12]	"Mutations of the IL-12 receptor beta2 chain gene in atopic subjects." Matsui E., Kaneko H., Fukao T., Teramoto T., Inoue R., Watanabe M., Kasahara K., Kondo N. Biochem. Biophys. Res. Commun. 266:551-555(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS GLY-313 AND ARG-720.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	U64198 mRNA. Translation: AAB36675.1. AY640177 Genomic DNA. Translation: AAT45456.1. CH471059 Genomic DNA. Translation: EAX06499.1. AL358512, AL389925 Genomic DNA. Translation: CAH69960.1. AL389925, AL358512 Genomic DNA. Translation: CAH70407.1. BC104772 mRNA. Translation: AAI04773.1. BC104774 mRNA. Translation: AAI04775.1. BC143249 mRNA. Translation: AAI43250.1.
IPI	IPI00438855. IPI00438856. IPI01011400.
RefSeq	NP_001245143.1. NM_001258214.1. NP_001245144.1. NM_001258215.1. NP_001245145.1. NM_001258216.1. NP_001550.1. NM_001559.2.
UniGene	Hs.479347.
3D structure databases
ProteinModelPortal	Q99665.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6011N.
STRING	9606.ENSP00000262345.
PTM databases
PhosphoSite	Q99665.
Polymorphism databases
DMDM	12229836.
Proteomic databases
PaxDb	Q99665.
PRIDE	Q99665.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262345; ENSP00000262345; ENSG00000081985. ENST00000371000; ENSP00000360039; ENSG00000081985. ENST00000541374; ENSP00000445276; ENSG00000081985. ENST00000544434; ENSP00000442443; ENSG00000081985.
GeneID	3595.
KEGG	hsa:3595.
UCSC	uc001ddu.3. human. uc010oqi.2. human.
Organism-specific databases
CTD	3595.
GeneCards	GC01P067773.
HGNC	HGNC:5972. IL12RB2.
HPA	HPA024168.
MIM	601642. gene.
neXtProt	NX_Q99665.
Orphanet	117. Behcet disease.
PharmGKB	PA29787.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG122790.
HOGENOM	HOG000049086.
HOVERGEN	HBG052059.
InParanoid	Q99665.
KO	K05064.
OMA	TWAKKYP.
OrthoDB	EOG4BRWKF.
PhylomeDB	Q99665.
Enzyme and pathway databases
Pathway_Interaction_DB	il12_2pathway. IL12-mediated signaling events. il27pathway. IL27-mediated signaling events.
Gene expression databases
ArrayExpress	Q99665.
Bgee	Q99665.
CleanEx	HS_IL12RB2.
Genevestigator	Q99665.
GermOnline	ENSG00000081985. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR003961. Fibronectin_type3. IPR003529. Hematopoietin_rcpt_Gp130_CS. IPR013783. Ig-like_fold. IPR010457. IgC2-like_lig-bd. IPR015321. IL6_recept-bd. [Graphical view]
Pfam	PF00041. fn3. 2 hits. PF09240. IL6Ra-bind. 1 hit. PF06328. Lep_receptor_Ig. 1 hit. [Graphical view]
SMART	SM00060. FN3. 4 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 5 hits.
PROSITE	PS50853. FN3. 5 hits. PS01353. HEMATOPO_REC_L_F2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IL12RB2. human.
GenomeRNAi	3595.
NextBio	14049.
SOURCE	Search...

Entry information

Entry name

I12R2_HUMAN

Accession

Primary (citable) accession number: Q99665
Secondary accession number(s): B1AN98 , B7ZKL9, F5H7L6, Q2M3V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 128 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.