Unreviewed, UniProtKB/TrEMBL Q99662 (Q99662_HUMAN)

Names and origin

Protein names

Recommended name:
    Tyrosine-protein kinase receptor RuleBase RU000311V2
    EC=2.7.10.1

Gene names

Name:

KIT EMBL AAC50969.1

Organism

Homo sapiens (Human) EMBL AAC50969.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	972 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. RuleBase RU000311V2
Subcellular location	Membrane; Single-pass type I membrane protein By similarity. RuleBase RU000311V2
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU000307V5 Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. RuleBase RU000311V2

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain RuleBase RU003326V0 Transmembrane RuleBase RU000311V2
Ligand	ATP-binding RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Receptor RuleBase RU000311V2 Transferase Tyrosine-protein kinase RuleBase RU000307V5
PTM	Phosphoprotein RuleBase RU003595V0
Gene Ontology (GO)
Biological process	cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara epithelial cell proliferation Inferred from electronic annotation. Source: Compara myeloid leukocyte differentiation Inferred from electronic annotation. Source: Compara peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara protein kinase cascade Inferred from electronic annotation. Source: Compara regulation of pigmentation during development Inferred from electronic annotation. Source: Compara response to radiation Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: Compara transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	external side of plasma membrane Inferred from electronic annotation. Source: Compara
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: Compara stem cell factor receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q99662-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: D59DEFE9AF761FDA	FASTA	972	109,451
	10 20 30 40 50 60 MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PGEPSPPSIH PGKSDLIVRV GDEIRLLCTD 70 80 90 100 110 120 PGFVKWTFEI LDETNENKQN EWITEKAEAT NTGKYTCTNK HGLSNSIYVF VRDPAKLFLV 130 140 150 160 170 180 DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG CQGKPLPKDL RFIPDPKAGI MIKSVKRAYH 190 200 210 220 230 240 RLCLHCSVDQ EGKSVLSEKF ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS 250 260 270 280 290 300 SVYSTWKREN SQTKLQEKYN SWHHGDFNYE RQATLTISSA RVNDSGVFMC YANNTFGSAN 310 320 330 340 350 360 VTTTLEVVDK GFINIFPMIN TTVFVNDGEN VDLIVEYEAF PKPEHQQWIY MNRTFTDKWE 370 380 390 400 410 420 DYPKSENESN IRYVSELHLT RLKGTEGGTY TFLVSNSDVN AAIAFNVYVN TKPEILTYDR 430 440 450 460 470 480 LVNGMLQCVA AGFPEPTIDW YFCPGTEQRC SASVLPVDVQ TLNSSGPPFG KLVVQSSIDS 490 500 510 520 530 540 SAFKHNGTVE CKAYNDVGKT SAYFNFAFKE QIHPHTLFTP LLIGFVIVAG MMCIIVMILT 550 560 570 580 590 600 YKYLQKPMYE VQWKVVEEIN GNNYVYIDPT QLPYDHKWEF PRNRLSFGKT LGAGAFGKVV 610 620 630 640 650 660 EATAYGLIKS DAAMTVAVKM LKPSAHLTER EALMSELKVL SYLGNHMNIV NLLGACTIGG 670 680 690 700 710 720 PTLVITEYCC YGDLLNFLRR KRDSFICSKQ EDHAEAALYK NLLHSKESSC SDSTNEYMDM 730 740 750 760 770 780 KPGVSYVVPT KADKRRSVRI GSYIERDVTP AIMEDDELAL DLEDLLSFSY QVAKGMAFLA 790 800 810 820 830 840 SKNCIHRDLA ARNILLTHGR ITKICDFGLA RDIKNDSNYV VKGNARLPVK WMAPESIFNC 850 860 870 880 890 900 VYTFESDVWS YGIFLWELFS LGSSPYPGMP VDSKFYKMIK EGFRMLSPEH APAEMYDIMK 910 920 930 940 950 960 TCWDADPLKR PTFKQIVQLI EKQISESTNH IYSNLANCSP NRQKPVVDHS VRINSVGSTA 970 SSSQPLLVHD DV

References

[1]	"Genomic organization of the human c-kit gene: evolution of the receptor tyrosine kinase subclass III." Andre C., Martin E., Cornu F., Hu W.X., Wang X.P., Galibert F. Oncogene 7:685-691(1992) [PubMed: 1373482] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes." Andre C., Hampe A., Lachaume P., Martin E., Wang X.P., Manus V., Hu W.X., Galibert F. Genomics 39:216-226(1997) [PubMed: 9027509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Trachea EMBL BAG64945.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U63834 Genomic DNA. Translation: AAC50969.1. AK304031 mRNA. Translation: BAG64945.1.
IPI	IPI00848233.
RefSeq	NP_001087241.1.
UniGene	Hs.479754
3D structure databases
HSSP	HSSP built from PDB template 1RJB based on UniProtKB P36888.
SMR	Q99662. Positions 36-307, 543-689, 755-929.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000157404. Homo sapiens. [Contig view]
GeneID	3815.
Organism-specific databases
HGNC	HGNC:6342. KIT.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q99662.
Gene expression databases
ArrayExpress	Q99662.
Bgee	Q99662.
Family and domain databases
InterPro	IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR001824. Recept_tyr_kinase-III_CS. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. IPR016243. TyrPK_CSF1-R. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF00047. ig. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PIRSF	PIRSF000615. TyrPK_CSF1-R. 1 hit.
ProDom	PD000001. Prot_kinase. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00240. RECEPTOR_TYR_KIN_III. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	14995.

Entry information

Entry name

Q99662_HUMAN

Accession

Primary (citable) accession number: Q99662

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	May 1, 1997
Last modified:	May 5, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)