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Q99650

- OSMR_HUMAN

UniProt

Q99650 - OSMR_HUMAN

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Protein

Oncostatin-M-specific receptor subunit beta

Gene

OSMR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.2 Publications

GO - Molecular functioni

  1. growth factor binding Source: BHF-UCL
  2. oncostatin-M receptor activity Source: ProtInc

GO - Biological processi

  1. cell proliferation Source: ProtInc
  2. cell surface receptor signaling pathway Source: ProtInc
  3. oncostatin-M-mediated signaling pathway Source: GOC
  4. positive regulation of acute inflammatory response Source: BHF-UCL
  5. positive regulation of cell proliferation Source: BHF-UCL
  6. response to cytokine Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiQ99650.

Names & Taxonomyi

Protein namesi
Recommended name:
Oncostatin-M-specific receptor subunit beta
Alternative name(s):
Interleukin-31 receptor subunit beta
Short name:
IL-31 receptor subunit beta
Short name:
IL-31R subunit beta
Short name:
IL-31R-beta
Short name:
IL-31RB
Gene namesi
Name:OSMR
Synonyms:OSMRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8507. OSMR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 740713ExtracellularSequence AnalysisAdd
BLAST
Transmembranei741 – 76121HelicalSequence AnalysisAdd
BLAST
Topological domaini762 – 979218CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. oncostatin-M receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Amyloidosis, primary localized cutaneous, 1 (PLCA1) [MIM:105250]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti618 – 6181G → A in PLCA1. 1 Publication
VAR_043513
Natural varianti647 – 6471D → V in PLCA1. 1 Publication
VAR_065810
Natural varianti691 – 6911I → T in PLCA1. 1 Publication
VAR_043514
Natural varianti694 – 6941P → L in PLCA1. 1 Publication
VAR_065811
Natural varianti697 – 6971K → T in PLCA1. 1 Publication
VAR_065812

Keywords - Diseasei

Amyloidosis, Disease mutation

Organism-specific databases

MIMi105250. phenotype.
Orphaneti353220. Familial primary localized cutaneous amyloidosis.
PharmGKBiPA32837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 979952Oncostatin-M-specific receptor subunit betaPRO_0000259759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi245 ↔ 255By similarity
Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence Analysis
Modified residuei826 – 8261Phosphoserine1 Publication
Modified residuei889 – 8891Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99650.
PaxDbiQ99650.
PRIDEiQ99650.

PTM databases

PhosphoSiteiQ99650.

Expressioni

Tissue specificityi

Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.1 Publication

Inductioni

Activated by oncostatin-M. Up-regulated by IFNG/IFN-gamma and bacterial lipopolysaccharides (LPS).2 Publications

Gene expression databases

BgeeiQ99650.
CleanExiHS_OSMR.
ExpressionAtlasiQ99650. baseline and differential.
GenevestigatoriQ99650.

Organism-specific databases

HPAiHPA017278.

Interactioni

Subunit structurei

Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.1 Publication

Protein-protein interaction databases

BioGridi114617. 5 interactions.
IntActiQ99650. 3 interactions.
MINTiMINT-4537651.
STRINGi9606.ENSP00000274276.

Structurei

3D structure databases

ProteinModelPortaliQ99650.
SMRiQ99650. Positions 30-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini335 – 42894Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini433 – 52896Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini529 – 62395Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini625 – 736112Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi415 – 4195WSXWS motif
Motifi770 – 7789Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity
The box 1 motif is required for JAK interaction and/or activation.By similarity

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43445.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000115294.
HOVERGENiHBG082088.
InParanoidiQ99650.
KOiK05057.
OMAiQSYTLFE.
OrthoDBiEOG7V49XP.
PhylomeDBiQ99650.
TreeFamiTF338122.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99650-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALFAVFQTT FFLTLLSLRT YQSEVLAERL PLTPVSLKVS TNSTRQSLHL
60 70 80 90 100
QWTVHNLPYH QELKMVFQIQ ISRIETSNVI WVGNYSTTVK WNQVLHWSWE
110 120 130 140 150
SELPLECATH FVRIKSLVDD AKFPEPNFWS NWSSWEEVSV QDSTGQDILF
160 170 180 190 200
VFPKDKLVEE GTNVTICYVS RNIQNNVSCY LEGKQIHGEQ LDPHVTAFNL
210 220 230 240 250
NSVPFIRNKG TNIYCEASQG NVSEGMKGIV LFVSKVLEEP KDFSCETEDF
260 270 280 290 300
KTLHCTWDPG TDTALGWSKQ PSQSYTLFES FSGEKKLCTH KNWCNWQITQ
310 320 330 340 350
DSQETYNFTL IAENYLRKRS VNILFNLTHR VYLMNPFSVN FENVNATNAI
360 370 380 390 400
MTWKVHSIRN NFTYLCQIEL HGEGKMMQYN VSIKVNGEYF LSELEPATEY
410 420 430 440 450
MARVRCADAS HFWKWSEWSG QNFTTLEAAP SEAPDVWRIV SLEPGNHTVT
460 470 480 490 500
LFWKPLSKLH ANGKILFYNV VVENLDKPSS SELHSIPAPA NSTKLILDRC
510 520 530 540 550
SYQICVIANN SVGASPASVI VISADPENKE VEEERIAGTE GGFSLSWKPQ
560 570 580 590 600
PGDVIGYVVD WCDHTQDVLG DFQWKNVGPN TTSTVISTDA FRPGVRYDFR
610 620 630 640 650
IYGLSTKRIA CLLEKKTGYS QELAPSDNPH VLVDTLTSHS FTLSWKDYST
660 670 680 690 700
ESQPGFIQGY HVYLKSKARQ CHPRFEKAVL SDGSECCKYK IDNPEEKALI
710 720 730 740 750
VDNLKPESFY EFFITPFTSA GEGPSATFTK VTTPDEHSSM LIHILLPMVF
760 770 780 790 800
CVLLIMVMCY LKSQWIKETC YPDIPDPYKS SILSLIKFKE NPHLIIMNVS
810 820 830 840 850
DCIPDAIEVV SKPEGTKIQF LGTRKSLTET ELTKPNYLYL LPTEKNHSGP
860 870 880 890 900
GPCICFENLT YNQAASDSGS CGHVPVSPKA PSMLGLMTSP ENVLKALEKN
910 920 930 940 950
YMNSLGEIPA GETSLNYVSQ LASPMFGDKD SLPTNPVEAP HCSEYKMQMA
960 970
VSLRLALPPP TENSSLSSIT LLDPGEHYC
Length:979
Mass (Da):110,509
Last modified:May 1, 1997 - v1
Checksum:i179852CA3D90D9EF
GO
Isoform 2 (identifier: Q99650-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-342: VYLMNPFSVNFE → GETRVVTAHRGH
     343-979: Missing.

Show »
Length:342
Mass (Da):39,504
Checksum:i85C6A38D7B8CC73C
GO

Sequence cautioni

The sequence AAH63468.1 differs from that shown. Reason: Frameshift at positions 232 and 288. Curated
The sequence AAH63468.1 differs from that shown. Reason: Erroneous termination at position 216. Translated as Glu.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871H → Q.
Corresponds to variant rs34675408 [ dbSNP | Ensembl ].
VAR_043512
Natural varianti210 – 2101G → W.1 Publication
Corresponds to variant rs17855841 [ dbSNP | Ensembl ].
VAR_028972
Natural varianti527 – 5271E → K.
Corresponds to variant rs10941412 [ dbSNP | Ensembl ].
VAR_028973
Natural varianti553 – 5531D → N.
Corresponds to variant rs2278329 [ dbSNP | Ensembl ].
VAR_028974
Natural varianti618 – 6181G → A in PLCA1. 1 Publication
VAR_043513
Natural varianti647 – 6471D → V in PLCA1. 1 Publication
VAR_065810
Natural varianti691 – 6911I → T in PLCA1. 1 Publication
VAR_043514
Natural varianti694 – 6941P → L in PLCA1. 1 Publication
VAR_065811
Natural varianti697 – 6971K → T in PLCA1. 1 Publication
VAR_065812
Natural varianti936 – 9361P → S.
Corresponds to variant rs3749737 [ dbSNP | Ensembl ].
VAR_028975
Natural varianti959 – 9591P → R.
Corresponds to variant rs34080825 [ dbSNP | Ensembl ].
VAR_043515

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei331 – 34212VYLMN…SVNFE → GETRVVTAHRGH in isoform 2. 1 PublicationVSP_021527Add
BLAST
Alternative sequencei343 – 979637Missing in isoform 2. 1 PublicationVSP_021528Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60805 mRNA. Translation: AAC50946.1.
BC010943 mRNA. Translation: AAH10943.1.
BC063468 mRNA. Translation: AAH63468.1. Sequence problems.
BC125209 mRNA. Translation: AAI25210.1.
BC125210 mRNA. Translation: AAI25211.1.
CCDSiCCDS3928.1. [Q99650-1]
CCDS54847.1. [Q99650-2]
RefSeqiNP_001161827.1. NM_001168355.1. [Q99650-2]
NP_003990.1. NM_003999.2. [Q99650-1]
UniGeneiHs.120658.
Hs.658389.

Genome annotation databases

EnsembliENST00000274276; ENSP00000274276; ENSG00000145623. [Q99650-1]
ENST00000502536; ENSP00000422023; ENSG00000145623. [Q99650-2]
GeneIDi9180.
KEGGihsa:9180.
UCSCiuc003jlm.2. human. [Q99650-2]
uc003jln.2. human. [Q99650-1]

Polymorphism databases

DMDMi74724833.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60805 mRNA. Translation: AAC50946.1 .
BC010943 mRNA. Translation: AAH10943.1 .
BC063468 mRNA. Translation: AAH63468.1 . Sequence problems.
BC125209 mRNA. Translation: AAI25210.1 .
BC125210 mRNA. Translation: AAI25211.1 .
CCDSi CCDS3928.1. [Q99650-1 ]
CCDS54847.1. [Q99650-2 ]
RefSeqi NP_001161827.1. NM_001168355.1. [Q99650-2 ]
NP_003990.1. NM_003999.2. [Q99650-1 ]
UniGenei Hs.120658.
Hs.658389.

3D structure databases

ProteinModelPortali Q99650.
SMRi Q99650. Positions 30-421.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114617. 5 interactions.
IntActi Q99650. 3 interactions.
MINTi MINT-4537651.
STRINGi 9606.ENSP00000274276.

PTM databases

PhosphoSitei Q99650.

Polymorphism databases

DMDMi 74724833.

Proteomic databases

MaxQBi Q99650.
PaxDbi Q99650.
PRIDEi Q99650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274276 ; ENSP00000274276 ; ENSG00000145623 . [Q99650-1 ]
ENST00000502536 ; ENSP00000422023 ; ENSG00000145623 . [Q99650-2 ]
GeneIDi 9180.
KEGGi hsa:9180.
UCSCi uc003jlm.2. human. [Q99650-2 ]
uc003jln.2. human. [Q99650-1 ]

Organism-specific databases

CTDi 9180.
GeneCardsi GC05P038845.
HGNCi HGNC:8507. OSMR.
HPAi HPA017278.
MIMi 105250. phenotype.
601743. gene.
neXtProti NX_Q99650.
Orphaneti 353220. Familial primary localized cutaneous amyloidosis.
PharmGKBi PA32837.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43445.
GeneTreei ENSGT00550000074436.
HOGENOMi HOG000115294.
HOVERGENi HBG082088.
InParanoidi Q99650.
KOi K05057.
OMAi QSYTLFE.
OrthoDBi EOG7V49XP.
PhylomeDBi Q99650.
TreeFami TF338122.

Enzyme and pathway databases

SignaLinki Q99650.

Miscellaneous databases

ChiTaRSi OSMR. human.
GeneWikii Oncostatin_M_receptor.
GenomeRNAii 9180.
NextBioi 34417.
PROi Q99650.
SOURCEi Search...

Gene expression databases

Bgeei Q99650.
CleanExi HS_OSMR.
ExpressionAtlasi Q99650. baseline and differential.
Genevestigatori Q99650.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
PROSITEi PS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
    Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.
    J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, INDUCTION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT TRP-210.
    Tissue: Colon and Placenta.
  3. Cited for: FUNCTION, OLIGOMERIZATION, INDUCTION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826 AND SER-889, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: VARIANTS PLCA1 ALA-618 AND THR-691.
  7. Cited for: VARIANTS PLCA1 VAL-647; LEU-694 AND THR-697.

Entry informationi

Entry nameiOSMR_HUMAN
AccessioniPrimary (citable) accession number: Q99650
Secondary accession number(s): Q6P4E8, Q96QJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3