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Q99650

- OSMR_HUMAN

UniProt

Q99650 - OSMR_HUMAN

Protein

Oncostatin-M-specific receptor subunit beta

Gene

OSMR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.2 Publications

    GO - Molecular functioni

    1. growth factor binding Source: BHF-UCL
    2. oncostatin-M receptor activity Source: ProtInc

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. cell surface receptor signaling pathway Source: ProtInc
    3. oncostatin-M-mediated signaling pathway Source: GOC
    4. positive regulation of acute inflammatory response Source: BHF-UCL
    5. positive regulation of cell proliferation Source: BHF-UCL
    6. response to cytokine Source: BHF-UCL

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiQ99650.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oncostatin-M-specific receptor subunit beta
    Alternative name(s):
    Interleukin-31 receptor subunit beta
    Short name:
    IL-31 receptor subunit beta
    Short name:
    IL-31R subunit beta
    Short name:
    IL-31R-beta
    Short name:
    IL-31RB
    Gene namesi
    Name:OSMR
    Synonyms:OSMRB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8507. OSMR.

    Subcellular locationi

    GO - Cellular componenti

    1. oncostatin-M receptor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Amyloidosis, primary localized cutaneous, 1 (PLCA1) [MIM:105250]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti618 – 6181G → A in PLCA1. 1 Publication
    VAR_043513
    Natural varianti647 – 6471D → V in PLCA1. 1 Publication
    VAR_065810
    Natural varianti691 – 6911I → T in PLCA1. 1 Publication
    VAR_043514
    Natural varianti694 – 6941P → L in PLCA1. 1 Publication
    VAR_065811
    Natural varianti697 – 6971K → T in PLCA1. 1 Publication
    VAR_065812

    Keywords - Diseasei

    Amyloidosis, Disease mutation

    Organism-specific databases

    MIMi105250. phenotype.
    Orphaneti353220. Familial primary localized cutaneous amyloidosis.
    PharmGKBiPA32837.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 979952Oncostatin-M-specific receptor subunit betaPRO_0000259759Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi245 ↔ 255By similarity
    Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence Analysis
    Modified residuei826 – 8261Phosphoserine1 Publication
    Modified residuei889 – 8891Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ99650.
    PaxDbiQ99650.
    PRIDEiQ99650.

    PTM databases

    PhosphoSiteiQ99650.

    Expressioni

    Tissue specificityi

    Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.1 Publication

    Inductioni

    Activated by oncostatin-M. Up-regulated by IFNG/IFN-gamma and bacterial lipopolysaccharides (LPS).2 Publications

    Gene expression databases

    ArrayExpressiQ99650.
    BgeeiQ99650.
    CleanExiHS_OSMR.
    GenevestigatoriQ99650.

    Organism-specific databases

    HPAiHPA017278.

    Interactioni

    Subunit structurei

    Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.1 Publication

    Protein-protein interaction databases

    BioGridi114617. 5 interactions.
    IntActiQ99650. 3 interactions.
    MINTiMINT-4537651.
    STRINGi9606.ENSP00000274276.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99650.
    SMRiQ99650. Positions 30-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 740713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini762 – 979218CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei741 – 76121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini335 – 42894Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini433 – 52896Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini529 – 62395Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini625 – 736112Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi415 – 4195WSXWS motif
    Motifi770 – 7789Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity
    The box 1 motif is required for JAK interaction and/or activation.By similarity

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43445.
    HOGENOMiHOG000115294.
    HOVERGENiHBG082088.
    InParanoidiQ99650.
    KOiK05057.
    OMAiQSYTLFE.
    OrthoDBiEOG7V49XP.
    PhylomeDBiQ99650.
    TreeFamiTF338122.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR003529. Hematopoietin_rcpt_Gp130_CS.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 3 hits.
    PROSITEiPS50853. FN3. 4 hits.
    PS01353. HEMATOPO_REC_L_F2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99650-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALFAVFQTT FFLTLLSLRT YQSEVLAERL PLTPVSLKVS TNSTRQSLHL    50
    QWTVHNLPYH QELKMVFQIQ ISRIETSNVI WVGNYSTTVK WNQVLHWSWE 100
    SELPLECATH FVRIKSLVDD AKFPEPNFWS NWSSWEEVSV QDSTGQDILF 150
    VFPKDKLVEE GTNVTICYVS RNIQNNVSCY LEGKQIHGEQ LDPHVTAFNL 200
    NSVPFIRNKG TNIYCEASQG NVSEGMKGIV LFVSKVLEEP KDFSCETEDF 250
    KTLHCTWDPG TDTALGWSKQ PSQSYTLFES FSGEKKLCTH KNWCNWQITQ 300
    DSQETYNFTL IAENYLRKRS VNILFNLTHR VYLMNPFSVN FENVNATNAI 350
    MTWKVHSIRN NFTYLCQIEL HGEGKMMQYN VSIKVNGEYF LSELEPATEY 400
    MARVRCADAS HFWKWSEWSG QNFTTLEAAP SEAPDVWRIV SLEPGNHTVT 450
    LFWKPLSKLH ANGKILFYNV VVENLDKPSS SELHSIPAPA NSTKLILDRC 500
    SYQICVIANN SVGASPASVI VISADPENKE VEEERIAGTE GGFSLSWKPQ 550
    PGDVIGYVVD WCDHTQDVLG DFQWKNVGPN TTSTVISTDA FRPGVRYDFR 600
    IYGLSTKRIA CLLEKKTGYS QELAPSDNPH VLVDTLTSHS FTLSWKDYST 650
    ESQPGFIQGY HVYLKSKARQ CHPRFEKAVL SDGSECCKYK IDNPEEKALI 700
    VDNLKPESFY EFFITPFTSA GEGPSATFTK VTTPDEHSSM LIHILLPMVF 750
    CVLLIMVMCY LKSQWIKETC YPDIPDPYKS SILSLIKFKE NPHLIIMNVS 800
    DCIPDAIEVV SKPEGTKIQF LGTRKSLTET ELTKPNYLYL LPTEKNHSGP 850
    GPCICFENLT YNQAASDSGS CGHVPVSPKA PSMLGLMTSP ENVLKALEKN 900
    YMNSLGEIPA GETSLNYVSQ LASPMFGDKD SLPTNPVEAP HCSEYKMQMA 950
    VSLRLALPPP TENSSLSSIT LLDPGEHYC 979
    Length:979
    Mass (Da):110,509
    Last modified:May 1, 1997 - v1
    Checksum:i179852CA3D90D9EF
    GO
    Isoform 2 (identifier: Q99650-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         331-342: VYLMNPFSVNFE → GETRVVTAHRGH
         343-979: Missing.

    Show »
    Length:342
    Mass (Da):39,504
    Checksum:i85C6A38D7B8CC73C
    GO

    Sequence cautioni

    The sequence AAH63468.1 differs from that shown. Reason: Frameshift at positions 232 and 288.
    The sequence AAH63468.1 differs from that shown. Reason: Erroneous termination at position 216. Translated as Glu.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti187 – 1871H → Q.
    Corresponds to variant rs34675408 [ dbSNP | Ensembl ].
    VAR_043512
    Natural varianti210 – 2101G → W.1 Publication
    Corresponds to variant rs17855841 [ dbSNP | Ensembl ].
    VAR_028972
    Natural varianti527 – 5271E → K.
    Corresponds to variant rs10941412 [ dbSNP | Ensembl ].
    VAR_028973
    Natural varianti553 – 5531D → N.
    Corresponds to variant rs2278329 [ dbSNP | Ensembl ].
    VAR_028974
    Natural varianti618 – 6181G → A in PLCA1. 1 Publication
    VAR_043513
    Natural varianti647 – 6471D → V in PLCA1. 1 Publication
    VAR_065810
    Natural varianti691 – 6911I → T in PLCA1. 1 Publication
    VAR_043514
    Natural varianti694 – 6941P → L in PLCA1. 1 Publication
    VAR_065811
    Natural varianti697 – 6971K → T in PLCA1. 1 Publication
    VAR_065812
    Natural varianti936 – 9361P → S.
    Corresponds to variant rs3749737 [ dbSNP | Ensembl ].
    VAR_028975
    Natural varianti959 – 9591P → R.
    Corresponds to variant rs34080825 [ dbSNP | Ensembl ].
    VAR_043515

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei331 – 34212VYLMN…SVNFE → GETRVVTAHRGH in isoform 2. 1 PublicationVSP_021527Add
    BLAST
    Alternative sequencei343 – 979637Missing in isoform 2. 1 PublicationVSP_021528Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60805 mRNA. Translation: AAC50946.1.
    BC010943 mRNA. Translation: AAH10943.1.
    BC063468 mRNA. Translation: AAH63468.1. Sequence problems.
    BC125209 mRNA. Translation: AAI25210.1.
    BC125210 mRNA. Translation: AAI25211.1.
    CCDSiCCDS3928.1. [Q99650-1]
    CCDS54847.1. [Q99650-2]
    RefSeqiNP_001161827.1. NM_001168355.1. [Q99650-2]
    NP_003990.1. NM_003999.2. [Q99650-1]
    UniGeneiHs.120658.
    Hs.658389.

    Genome annotation databases

    EnsembliENST00000274276; ENSP00000274276; ENSG00000145623. [Q99650-1]
    ENST00000502536; ENSP00000422023; ENSG00000145623. [Q99650-2]
    GeneIDi9180.
    KEGGihsa:9180.
    UCSCiuc003jlm.2. human. [Q99650-2]
    uc003jln.2. human. [Q99650-1]

    Polymorphism databases

    DMDMi74724833.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60805 mRNA. Translation: AAC50946.1 .
    BC010943 mRNA. Translation: AAH10943.1 .
    BC063468 mRNA. Translation: AAH63468.1 . Sequence problems.
    BC125209 mRNA. Translation: AAI25210.1 .
    BC125210 mRNA. Translation: AAI25211.1 .
    CCDSi CCDS3928.1. [Q99650-1 ]
    CCDS54847.1. [Q99650-2 ]
    RefSeqi NP_001161827.1. NM_001168355.1. [Q99650-2 ]
    NP_003990.1. NM_003999.2. [Q99650-1 ]
    UniGenei Hs.120658.
    Hs.658389.

    3D structure databases

    ProteinModelPortali Q99650.
    SMRi Q99650. Positions 30-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114617. 5 interactions.
    IntActi Q99650. 3 interactions.
    MINTi MINT-4537651.
    STRINGi 9606.ENSP00000274276.

    PTM databases

    PhosphoSitei Q99650.

    Polymorphism databases

    DMDMi 74724833.

    Proteomic databases

    MaxQBi Q99650.
    PaxDbi Q99650.
    PRIDEi Q99650.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274276 ; ENSP00000274276 ; ENSG00000145623 . [Q99650-1 ]
    ENST00000502536 ; ENSP00000422023 ; ENSG00000145623 . [Q99650-2 ]
    GeneIDi 9180.
    KEGGi hsa:9180.
    UCSCi uc003jlm.2. human. [Q99650-2 ]
    uc003jln.2. human. [Q99650-1 ]

    Organism-specific databases

    CTDi 9180.
    GeneCardsi GC05P038845.
    HGNCi HGNC:8507. OSMR.
    HPAi HPA017278.
    MIMi 105250. phenotype.
    601743. gene.
    neXtProti NX_Q99650.
    Orphaneti 353220. Familial primary localized cutaneous amyloidosis.
    PharmGKBi PA32837.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43445.
    HOGENOMi HOG000115294.
    HOVERGENi HBG082088.
    InParanoidi Q99650.
    KOi K05057.
    OMAi QSYTLFE.
    OrthoDBi EOG7V49XP.
    PhylomeDBi Q99650.
    TreeFami TF338122.

    Enzyme and pathway databases

    SignaLinki Q99650.

    Miscellaneous databases

    ChiTaRSi OSMR. human.
    GeneWikii Oncostatin_M_receptor.
    GenomeRNAii 9180.
    NextBioi 34417.
    PROi Q99650.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99650.
    Bgeei Q99650.
    CleanExi HS_OSMR.
    Genevestigatori Q99650.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR003529. Hematopoietin_rcpt_Gp130_CS.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 3 hits.
    PROSITEi PS50853. FN3. 4 hits.
    PS01353. HEMATOPO_REC_L_F2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
      Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.
      J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, INDUCTION, TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT TRP-210.
      Tissue: Colon and Placenta.
    3. Cited for: FUNCTION, OLIGOMERIZATION, INDUCTION.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826 AND SER-889, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: VARIANTS PLCA1 ALA-618 AND THR-691.
    7. Cited for: VARIANTS PLCA1 VAL-647; LEU-694 AND THR-697.

    Entry informationi

    Entry nameiOSMR_HUMAN
    AccessioniPrimary (citable) accession number: Q99650
    Secondary accession number(s): Q6P4E8, Q96QJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3