Reviewed, UniProtKB/Swiss-Prot Q99650 (OSMR_HUMAN)

Names and origin

Protein names

Recommended name:
    Oncostatin-M specific receptor subunit beta

Gene names

Name:	OSMR
Synonyms:	OSMRB

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	979 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Ref.1 Ref.3
Subunit structure	Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor. Ref.1 Ref.3
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines. Ref.1
Induction	Activated by oncostatin-M. Up-regulated by IFNG and lipopolysaccharide. Ref.1 Ref.3
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding By similarity. The box 1 motif is required for JAK interaction and/or activation By similarity.
Involvement in disease	Defects in OSMR are the cause of amyloidosis type 9 (AMYL9) [MIM:105250]; also known as primary cutaneous amyloidosis (PCA), primary localized cutaneous amyloidosis (PLCA), familial lichen amyloidosis or familial cutaneous lichen amyloidosis. AMYL9 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Ref.6
Sequence similarities	Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Amyloidosis Disease mutation
Domain	Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	cell proliferation Ref.1 Traceable author statement. Source: ProtInc cell surface receptor linked signal transduction Ref.1 Traceable author statement. Source: ProtInc positive regulation of acute inflammatory response Ref.1 Inferred by curator. Source: UniProtKB positive regulation of cell proliferation Ref.1 Inferred from genetic interaction. Source: UniProtKB response to cytokine stimulus Ref.1 Inferred from direct assay. Source: UniProtKB
Cellular component	oncostatin-M receptor complex Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	growth factor binding Ref.1 Inferred from physical interaction. Source: UniProtKB oncostatin-M receptor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q99650-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99650-2)

The sequence of this isoform differs from the canonical sequence as follows:
     331-342: VYLMNPFSVNFE → GETRVVTAHRGH
     343-979: Missing.

Isoform 3 (identifier: Q99650-3)

The sequence of this isoform differs from the canonical sequence as follows:
     216-979: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 979	952	Oncostatin-M specific receptor subunit beta		PRO_0000259759
Regions
	Topological domain	28 – 740	713	Extracellular Potential
	Transmembrane	741 – 761	21	Potential
	Topological domain	762 – 979	218	Cytoplasmic Potential
	Domain	332 – 424	93	Fibronectin type-III 1
	Domain	430 – 524	95	Fibronectin type-III 2
	Domain	526 – 619	94	Fibronectin type-III 3
	Domain	625 – 732	108	Fibronectin type-III 4
	Motif	415 – 419	5	WSXWS motif
	Motif	770 – 778	9	Box 1 motif
Amino acid modifications
	Modified residue	826	1	Phosphoserine Ref.5
	Modified residue	837	1	Phosphotyrosine Ref.4
	Modified residue	889	1	Phosphoserine Ref.5
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
	Glycosylation	326	1	N-linked (GlcNAc...) Potential
	Glycosylation	380	1	N-linked (GlcNAc...) Potential
	Glycosylation	446	1	N-linked (GlcNAc...) Potential
	Glycosylation	580	1	N-linked (GlcNAc...) Potential
	Disulfide bond	245 ↔ 255		By similarity
Natural variations
	Alternative sequence	216 – 979	764	Missing in isoform 3.		VSP_021529
	Alternative sequence	331 – 342	12	VYLMN…SVNFE → GETRVVTAHRGH in isoform 2.		VSP_021527
	Alternative sequence	343 – 979	637	Missing in isoform 2.		VSP_021528
	Natural variant	187	1	H → Q: dbSNP rs34675408.		VAR_043512
	Natural variant	210	1	G → W: dbSNP rs17855841. Ref.2		VAR_028972
	Natural variant	527	1	E → K: dbSNP rs10941412.		VAR_028973
	Natural variant	553	1	D → N: dbSNP rs2278329.		VAR_028974
	Natural variant	618	1	G → A in AMYL9. Ref.6		VAR_043513
	Natural variant	691	1	I → T in AMYL9. Ref.6		VAR_043514
	Natural variant	936	1	P → S: dbSNP rs3749737.		VAR_028975
	Natural variant	959	1	P → R: dbSNP rs34080825.		VAR_043515

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 179852CA3D90D9EF	FASTA	979	110,509
	10 20 30 40 50 60 MALFAVFQTT FFLTLLSLRT YQSEVLAERL PLTPVSLKVS TNSTRQSLHL QWTVHNLPYH 70 80 90 100 110 120 QELKMVFQIQ ISRIETSNVI WVGNYSTTVK WNQVLHWSWE SELPLECATH FVRIKSLVDD 130 140 150 160 170 180 AKFPEPNFWS NWSSWEEVSV QDSTGQDILF VFPKDKLVEE GTNVTICYVS RNIQNNVSCY 190 200 210 220 230 240 LEGKQIHGEQ LDPHVTAFNL NSVPFIRNKG TNIYCEASQG NVSEGMKGIV LFVSKVLEEP 250 260 270 280 290 300 KDFSCETEDF KTLHCTWDPG TDTALGWSKQ PSQSYTLFES FSGEKKLCTH KNWCNWQITQ 310 320 330 340 350 360 DSQETYNFTL IAENYLRKRS VNILFNLTHR VYLMNPFSVN FENVNATNAI MTWKVHSIRN 370 380 390 400 410 420 NFTYLCQIEL HGEGKMMQYN VSIKVNGEYF LSELEPATEY MARVRCADAS HFWKWSEWSG 430 440 450 460 470 480 QNFTTLEAAP SEAPDVWRIV SLEPGNHTVT LFWKPLSKLH ANGKILFYNV VVENLDKPSS 490 500 510 520 530 540 SELHSIPAPA NSTKLILDRC SYQICVIANN SVGASPASVI VISADPENKE VEEERIAGTE 550 560 570 580 590 600 GGFSLSWKPQ PGDVIGYVVD WCDHTQDVLG DFQWKNVGPN TTSTVISTDA FRPGVRYDFR 610 620 630 640 650 660 IYGLSTKRIA CLLEKKTGYS QELAPSDNPH VLVDTLTSHS FTLSWKDYST ESQPGFIQGY 670 680 690 700 710 720 HVYLKSKARQ CHPRFEKAVL SDGSECCKYK IDNPEEKALI VDNLKPESFY EFFITPFTSA 730 740 750 760 770 780 GEGPSATFTK VTTPDEHSSM LIHILLPMVF CVLLIMVMCY LKSQWIKETC YPDIPDPYKS 790 800 810 820 830 840 SILSLIKFKE NPHLIIMNVS DCIPDAIEVV SKPEGTKIQF LGTRKSLTET ELTKPNYLYL 850 860 870 880 890 900 LPTEKNHSGP GPCICFENLT YNQAASDSGS CGHVPVSPKA PSMLGLMTSP ENVLKALEKN 910 920 930 940 950 960 YMNSLGEIPA GETSLNYVSQ LASPMFGDKD SLPTNPVEAP HCSEYKMQMA VSLRLALPPP 970 TENSSLSSIT LLDPGEHYC
	Isoform 2. Checksum: 85C6A38D7B8CC73C	FASTA	342	39,504
	10 20 30 40 50 60 MALFAVFQTT FFLTLLSLRT YQSEVLAERL PLTPVSLKVS TNSTRQSLHL QWTVHNLPYH 70 80 90 100 110 120 QELKMVFQIQ ISRIETSNVI WVGNYSTTVK WNQVLHWSWE SELPLECATH FVRIKSLVDD 130 140 150 160 170 180 AKFPEPNFWS NWSSWEEVSV QDSTGQDILF VFPKDKLVEE GTNVTICYVS RNIQNNVSCY 190 200 210 220 230 240 LEGKQIHGEQ LDPHVTAFNL NSVPFIRNKG TNIYCEASQG NVSEGMKGIV LFVSKVLEEP 250 260 270 280 290 300 KDFSCETEDF KTLHCTWDPG TDTALGWSKQ PSQSYTLFES FSGEKKLCTH KNWCNWQITQ 310 320 330 340 DSQETYNFTL IAENYLRKRS VNILFNLTHR GETRVVTAHR GH
	Isoform 3. Checksum: 3FA9A70B4E84A5FD	FASTA	215	24,929
	10 20 30 40 50 60 MALFAVFQTT FFLTLLSLRT YQSEVLAERL PLTPVSLKVS TNSTRQSLHL QWTVHNLPYH 70 80 90 100 110 120 QELKMVFQIQ ISRIETSNVI WVGNYSTTVK WNQVLHWSWE SELPLECATH FVRIKSLVDD 130 140 150 160 170 180 AKFPEPNFWS NWSSWEEVSV QDSTGQDILF VFPKDKLVEE GTNVTICYVS RNIQNNVSCY 190 200 210 LEGKQIHGEQ LDPHVTAFNL NSVPFIRNKG TNIYC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation." Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D. J. Biol. Chem. 271:32635-32643(1996) [PubMed: 8999038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, INDUCTION, TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT TRP-210. Tissue: Colon and Placenta.
[3]	"Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice." Dillon S.R., Sprecher C., Hammond A., Bilsborough J., Rosenfeld-Franklin M., Presnell S.R., Haugen H.S., Maurer M., Harder B., Johnston J., Bort S., Mudri S., Kuijper J.L., Bukowski T., Shea P., Dong D.L., Dasovich M., Grant F.J. , Lockwood L., Levin S.D., LeCiel C., Waggie K., Day H., Topouzis S., Kramer J., Kuestner R., Chen Z., Foster D., Parrish-Novak J., Gross J.A. Nat. Immunol. 5:752-760(2004) [PubMed: 15184896] [Abstract] Cited for: FUNCTION, OLIGOMERIZATION, INDUCTION.
[4]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-837, MASS SPECTROMETRY.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826 AND SER-889, MASS SPECTROMETRY.
[6]	"Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis." Arita K., South A.P., Hans-Filho G., Sakuma T.H., Lai-Cheong J., Clements S., Odashiro M., Odashiro D.N., Hans-Neto G., Hans N.R., Holder M.V., Bhogal B.S., Hartshorne S.T., Akiyama M., Shimizu H., McGrath J.A. Am. J. Hum. Genet. 82:73-80(2008) [PubMed: 18179886] [Abstract] Cited for: VARIANTS AMYL9 ALA-618 AND THR-691.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U60805 mRNA. Translation: AAC50946.1. BC010943 mRNA. Translation: AAH10943.1. BC063468 mRNA. Translation: AAH63468.1. BC125209 mRNA. Translation: AAI25210.1. BC125210 mRNA. Translation: AAI25211.1.
IPI	IPI00022674. IPI00807654. IPI00807681.
RefSeq	NP_003990.1.
UniGene	Hs.120658
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q99650.
Proteomic databases
PRIDE	Q99650.
Genome annotation databases
Ensembl	ENSG00000145623. Homo sapiens. [Contig view]
GeneID	9180.
KEGG	hsa:9180.
Organism-specific databases
GeneCards	GC05P038881.
HGNC	HGNC:8507. OSMR.
HPA	HPA017278.
MIM	105250. phenotype. 601743. gene.
Orphanet	137807. Cutaneous amyloidosis.
PharmGKB	PA32837.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q99650.
OMA	Q99650. SFTLSWK.
Gene expression databases
ArrayExpress	Q99650.
Bgee	Q99650.
CleanEx	HS_OSMR.
GermOnline	ENSG00000145623. Homo sapiens.
Family and domain databases
InterPro	IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003529. Hematopoietin_rcpt_gp130_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 2 hits.
Pfam	PF00041. fn3. 2 hits. [Graphical view]
SMART	SM00060. FN3. 4 hits. [Graphical view]
PROSITE	PS50853. FN3. 4 hits. PS01353. HEMATOPO_REC_L_F2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	34417.
SOURCE	Search...

Entry information

Entry name

OSMR_HUMAN

Accession

Primary (citable) accession number: Q99650
Secondary accession number(s): Q6P4E8, Q96QJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	May 1, 1997
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)