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Q99645 (EPYC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Epiphycan
Alternative name(s):
Dermatan sulfate proteoglycan 3
Proteoglycan-Lb
Short name=PG-Lb
Small chondroitin/dermatan sulfate proteoglycan
Gene names
Name:EPYC
Synonyms:DSPG3, PGLB, SLRR3B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Cartilage, ligament, and placenta. Ref.1

Post-translational modification

The O-linked polysaccharides on Thr-60 and Ser-96 are probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64 By similarity.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

Contains 6 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityPolymorphism
   DomainLeucine-rich repeat
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
Proteoglycan
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfemale pregnancy

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglycosaminoglycan binding

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 322303Epiphycan
PRO_0000032768

Regions

Domain106 – 14338LRRNT
Repeat144 – 16522LRR 1
Repeat168 – 18922LRR 2
Repeat192 – 21322LRR 3
Repeat238 – 25821LRR 4
Repeat259 – 28022LRR 5
Repeat290 – 31021LRR 6
Compositional bias81 – 877Poly-Glu

Amino acid modifications

Glycosylation601O-linked (GalNAc...) By similarity
Glycosylation641O-linked (Xyl...) (dermatan sulfate) By similarity
Glycosylation961O-linked (GalNAc...) By similarity
Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Disulfide bond118 ↔ 130 By similarity
Disulfide bond279 ↔ 312 By similarity

Natural variations

Natural variant1501S → C.
Corresponds to variant rs17784152 [ dbSNP | Ensembl ].
VAR_031595

Experimental info

Sequence conflict141F → L in AAC50945. Ref.1
Sequence conflict521D → G in AAH30958. Ref.4
Sequence conflict1201L → W in AAC50945. Ref.1
Sequence conflict2131L → S in AAC50945. Ref.1
Sequence conflict2811V → G in AAC50945. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q99645 [UniParc].

Last modified April 3, 2007. Version 3.
Checksum: E11061A38AA7240E

FASTA32236,637
        10         20         30         40         50         60 
MKTLAGLVLG LVIFDAAVTA PTLESINYDS ETYDATLEDL DNLYNYENIP VDKVEIEIAT 

        70         80         90        100        110        120 
VMPSGNRELL TPPPQPEKAQ EEEEEEESTP RLIDGSSPQE PEFTGVLGPH TNEDFPTCLL 

       130        140        150        160        170        180 
CTCISTTVYC DDHELDAIPP LPKNTAYFYS RFNRIKKINK NDFASLSDLK RIDLTSNLIS 

       190        200        210        220        230        240 
EIDEDAFRKL PQLRELVLRD NKIRQLPELP TTLTFIDISN NRLGRKGIKQ EAFKDMYDLH 

       250        260        270        280        290        300 
HLYLTDNNLD HIPLPLPENL RALHLQNNNI LEMHEDTFCN VKNLTYIRKA LEDIRLDGNP 

       310        320 
INLSKTPQAY MCLPRLPVGS LV 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of human DSPG3, a small dermatan sulfate proteoglycan."
Deere M., Johnson H.J., Garza S., Harrison W.R., Yoon S.-J., Elder F.F.B., Kucherlapati R., Hoeoek M., Hecht J.T.
Genomics 38:399-404(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Chondrocyte.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59111 mRNA. Translation: AAC50945.1.
AK290642 mRNA. Translation: BAF83331.1.
CH471054 Genomic DNA. Translation: EAW97444.1.
BC030958 mRNA. Translation: AAH30958.1.
RefSeqNP_004941.2. NM_004950.4.
UniGeneHs.435680.

3D structure databases

ProteinModelPortalQ99645.
SMRQ99645. Positions 121-316.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ99645.

PTM databases

PhosphoSiteQ99645.

Polymorphism databases

DMDM143811386.

Proteomic databases

PaxDbQ99645.
PRIDEQ99645.

Protocols and materials databases

DNASU1833.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261172; ENSP00000261172; ENSG00000083782.
GeneID1833.
KEGGhsa:1833.
UCSCuc001tbk.3. human.

Organism-specific databases

CTD1833.
GeneCardsGC12M091357.
HGNCHGNC:3053. EPYC.
HPAHPA038212.
HPA045455.
MIM601657. gene.
neXtProtNX_Q99645.
PharmGKBPA162385144.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314832.
HOGENOMHOG000273909.
HOVERGENHBG006850.
InParanoidQ99645.
KOK08127.
OMACDDHELD.
OrthoDBEOG757CXS.
PhylomeDBQ99645.
TreeFamTF351924.

Gene expression databases

ArrayExpressQ99645.
BgeeQ99645.
CleanExHS_EPYC.
GenevestigatorQ99645.

Family and domain databases

InterProIPR027217. Epiphycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PANTHERPTHR24371:SF4. PTHR24371:SF4. 1 hit.
PfamPF01462. LRRNT. 1 hit.
[Graphical view]
SMARTSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi1833.
NextBio7487.
PROQ99645.
SOURCESearch...

Entry information

Entry nameEPYC_HUMAN
AccessionPrimary (citable) accession number: Q99645
Secondary accession number(s): A8K3M7, Q8NEJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: April 3, 2007
Last modified: February 19, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM