EPYC

Functionⁱ

May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.

GO - Molecular functionⁱ

glycosaminoglycan binding
Source: ProtInc
Traceable author statementⁱ
- 8975717

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axonogenesis Source: GO_Central
female pregnancy
Source: ProtInc
Traceable author statementⁱ
- 8975717

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Epiphycan Alternative name(s): Dermatan sulfate proteoglycan 3 Proteoglycan-Lb Short name: PG-Lb Small chondroitin/dermatan sulfate proteoglycan
Gene namesⁱ	Name:EPYC Synonyms:DSPG3, PGLB, SLRR3B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000083782.7.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3053. EPYC.
MIMⁱ	601657. gene.
neXtProtⁱ	NX_Q99645.

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1833.
Open Targets More...OpenTargetsⁱ	ENSG00000083782.
PharmGKBⁱ	PA162385144.

Polymorphism and mutation databases

BioMutaⁱ	EPYC.
DMDMⁱ	143811386.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000032768	20 – 322	EpiphycanAdd BLAST		303

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	60	O-linked (GalNAc...) threonineBy similarity	1
Glycosylationⁱ	64	O-linked (Xyl...) (dermatan sulfate) serineBy similarity	1
Glycosylationⁱ	96	O-linked (GalNAc...) serineBy similarity	1
Disulfide bondⁱ	118 ↔ 130	By similarity
Disulfide bondⁱ	279 ↔ 312	By similarity
Glycosylationⁱ	283	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	302	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

The O-linked polysaccharides on Thr-60 and Ser-96 are probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64 (By similarity).By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbⁱ	Q99645.
PeptideAtlas More...PeptideAtlasⁱ	Q99645.
PRIDEⁱ	Q99645.

PTM databases

iPTMnetⁱ	Q99645.
PhosphoSitePlusⁱ	Q99645.

Expressionⁱ

Tissue specificityⁱ

Cartilage, ligament, and placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000083782.
CleanExⁱ	HS_EPYC.
ExpressionAtlasⁱ	Q99645. baseline and differential.
Genevisibleⁱ	Q99645. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038212. HPA045455.

HPAⁱ

HPA038212.
HPA045455.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	108167. 2 interactors.
IntActⁱ	Q99645. 2 interactors.
STRINGⁱ	9606.ENSP00000261172.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99645.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	106 – 143	LRRNTAdd BLAST	38
Repeatⁱ	144 – 165	LRR 1Add BLAST	22
Repeatⁱ	168 – 189	LRR 2Add BLAST	22
Repeatⁱ	192 – 213	LRR 3Add BLAST	22
Repeatⁱ	238 – 258	LRR 4Add BLAST	21
Repeatⁱ	259 – 280	LRR 5Add BLAST	22
Repeatⁱ	290 – 310	LRR 6Add BLAST	21

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	81 – 87	Poly-Glu		7

Sequence similaritiesⁱ

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG0619. Eukaryota. COG4886. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110781.
HOGENOMⁱ	HOG000273909.
HOVERGENⁱ	HBG006850.
InParanoidⁱ	Q99645.
KEGG Orthology (KO) More...KOⁱ	K08127.
OMAⁱ	CDDHELD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C68.
PhylomeDBⁱ	Q99645.
TreeFamⁱ	TF351924.

Family and domain databases

Gene3Dⁱ	3.80.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR027217. Epiphycan. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR032675. LRR_dom_sf. IPR000372. LRRNT.
PANTHERⁱ	PTHR24373:SF123. PTHR24373:SF123. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855. LRR_8. 1 hit.
SMARTⁱ	View protein in SMART SM00369. LRR_TYP. 4 hits. SM00013. LRRNT. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51450. LRR. 4 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q99645-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKTLAGLVLG LVIFDAAVTA PTLESINYDS ETYDATLEDL DNLYNYENIP 
        60         70         80         90        100
VDKVEIEIAT VMPSGNRELL TPPPQPEKAQ EEEEEEESTP RLIDGSSPQE 
       110        120        130        140        150
PEFTGVLGPH TNEDFPTCLL CTCISTTVYC DDHELDAIPP LPKNTAYFYS 
       160        170        180        190        200
RFNRIKKINK NDFASLSDLK RIDLTSNLIS EIDEDAFRKL PQLRELVLRD 
       210        220        230        240        250
NKIRQLPELP TTLTFIDISN NRLGRKGIKQ EAFKDMYDLH HLYLTDNNLD 
       260        270        280        290        300
HIPLPLPENL RALHLQNNNI LEMHEDTFCN VKNLTYIRKA LEDIRLDGNP 
       310        320 
INLSKTPQAY MCLPRLPVGS LV

Length:322

Mass (Da):36,637

Last modified:April 3, 2007 - v3

Checksum:ⁱE11061A38AA7240E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	14	F → L in AAC50945 (PubMed:8975717).Curated	1
Sequence conflictⁱ	52	D → G in AAH30958 (PubMed:15489334).Curated	1
Sequence conflictⁱ	120	L → W in AAC50945 (PubMed:8975717).Curated	1
Sequence conflictⁱ	213	L → S in AAC50945 (PubMed:8975717).Curated	1
Sequence conflictⁱ	281	V → G in AAC50945 (PubMed:8975717).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031595	150	S → C. Corresponds to variant dbSNP:rs17784152Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U59111 mRNA. Translation: AAC50945.1. AK290642 mRNA. Translation: BAF83331.1. CH471054 Genomic DNA. Translation: EAW97444.1. BC030958 mRNA. Translation: AAH30958.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31870.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_004941.2. NM_004950.4.
UniGeneⁱ	Hs.435680.

Genome annotation databases

Ensemblⁱ	ENST00000261172; ENSP00000261172; ENSG00000083782.
GeneIDⁱ	1833.
KEGGⁱ	hsa:1833.
UCSC genome browser More...UCSCⁱ	uc001tbk.3. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q99645	A0A024RBC3 F8VSI4 A0A077GZZ5 UPI0005D03DD8	Homo sapiens (Human)	322	UniRef100_Q99645	Cluster: Epiphycan	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q99645	P79119 UPI000952893B A0A2K5F600 UPI000625E92A UPI0003C90E47 UPI000B7B10C2 H0XUC1 UPI00093E32CB G7N7X9 A0A2K6N2E8 +82	Bos taurus (Bovine) Bos indicus (Zebu) Aotus nancymaae (Ma's night monkey) Tupaia chinensis (Chinese tree shrew) Papio anubis (Olive baboon) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Hipposideros armiger (great roundleaf bat) Macaca mulatta (Rhesus macaque) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) And more	321	UniRef90_P79119	Cluster: Epiphycan	93

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q99645	P79119 UPI000952893B A0A2K5F600 UPI000625E92A UPI0003C90E47 UPI000B7B10C2 H0XUC1 UPI00093E32CB A0A2K5NMY3 A0A2J8XNC8 +82	Bos taurus (Bovine) Bos indicus (Zebu) Aotus nancymaae (Ma's night monkey) Tupaia chinensis (Chinese tree shrew) Papio anubis (Olive baboon) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Hipposideros armiger (great roundleaf bat) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) And more	321	UniRef50_P79119	Cluster: Epiphycan	93

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U59111 mRNA. Translation: AAC50945.1. AK290642 mRNA. Translation: BAF83331.1. CH471054 Genomic DNA. Translation: EAW97444.1. BC030958 mRNA. Translation: AAH30958.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31870.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_004941.2. NM_004950.4.
UniGeneⁱ	Hs.435680.

3D structure databases

ProteinModelPortalⁱ	Q99645.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108167. 2 interactors.
IntActⁱ	Q99645. 2 interactors.
STRINGⁱ	9606.ENSP00000261172.

PTM databases

iPTMnetⁱ	Q99645.
PhosphoSitePlusⁱ	Q99645.

Polymorphism and mutation databases

BioMutaⁱ	EPYC.
DMDMⁱ	143811386.

Proteomic databases

PaxDbⁱ	Q99645.
PeptideAtlas More...PeptideAtlasⁱ	Q99645.
PRIDEⁱ	Q99645.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1833.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000261172; ENSP00000261172; ENSG00000083782.
GeneIDⁱ	1833.
KEGGⁱ	hsa:1833.
UCSC genome browser More...UCSCⁱ	uc001tbk.3. human.

Organism-specific databases

CTDⁱ	1833.
DisGeNET More...DisGeNETⁱ	1833.
EuPathDBⁱ	HostDB:ENSG00000083782.7.
GeneCardsⁱ	EPYC.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3053. EPYC.
Human Protein Atlas More...HPAⁱ	HPA038212. HPA045455.
MIMⁱ	601657. gene.
neXtProtⁱ	NX_Q99645.
Open Targets More...OpenTargetsⁱ	ENSG00000083782.
PharmGKBⁱ	PA162385144.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0619. Eukaryota. COG4886. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110781.
HOGENOMⁱ	HOG000273909.
HOVERGENⁱ	HBG006850.
InParanoidⁱ	Q99645.
KEGG Orthology (KO) More...KOⁱ	K08127.
OMAⁱ	CDDHELD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C68.
PhylomeDBⁱ	Q99645.
TreeFamⁱ	TF351924.

Miscellaneous databases

GenomeRNAiⁱ	1833.
Protein Ontology More...PROⁱ	PR:Q99645.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000083782.
CleanExⁱ	HS_EPYC.
ExpressionAtlasⁱ	Q99645. baseline and differential.
Genevisibleⁱ	Q99645. HS.

Family and domain databases

Gene3Dⁱ	3.80.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR027217. Epiphycan. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR032675. LRR_dom_sf. IPR000372. LRRNT.
PANTHERⁱ	PTHR24373:SF123. PTHR24373:SF123. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855. LRR_8. 1 hit.
SMARTⁱ	View protein in SMART SM00369. LRR_TYP. 4 hits. SM00013. LRRNT. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51450. LRR. 4 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EPYC_HUMAN
Accessionⁱ	Q99645Primary (citable) accession number: Q99645 Secondary accession number(s): A8K3M7, Q8NEJ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
	Last sequence update:	April 3, 2007
	Last modified:	February 28, 2018
	This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99645 (EPYC_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Epiphycan

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ