UniProtKB - Q99645 (EPYC_HUMAN)
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Protein
Epiphycan
Gene
EPYC
Organism
Homo sapiens (Human)
Status
Functioni
May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.
GO - Molecular functioni
- glycosaminoglycan binding Source: ProtInc
GO - Biological processi
- axonogenesis Source: GO_Central
- female pregnancy Source: ProtInc
Names & Taxonomyi
Protein namesi | Recommended name: EpiphycanAlternative name(s): Dermatan sulfate proteoglycan 3 Proteoglycan-Lb Short name: PG-Lb Small chondroitin/dermatan sulfate proteoglycan |
Gene namesi | Name:EPYC Synonyms:DSPG3, PGLB, SLRR3B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000083782.7. |
HGNCi | HGNC:3053. EPYC. |
MIMi | 601657. gene. |
neXtProti | NX_Q99645. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1833. |
OpenTargetsi | ENSG00000083782. |
PharmGKBi | PA162385144. |
Polymorphism and mutation databases
BioMutai | EPYC. |
DMDMi | 143811386. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000032768 | 20 – 322 | EpiphycanAdd BLAST | 303 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 60 | O-linked (GalNAc...) threonineBy similarity | 1 | |
Glycosylationi | 64 | O-linked (Xyl...) (dermatan sulfate) serineBy similarity | 1 | |
Glycosylationi | 96 | O-linked (GalNAc...) serineBy similarity | 1 | |
Disulfide bondi | 118 ↔ 130 | By similarity | ||
Disulfide bondi | 279 ↔ 312 | By similarity | ||
Glycosylationi | 283 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 302 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
The O-linked polysaccharides on Thr-60 and Ser-96 are probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64 (By similarity).By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, ProteoglycanProteomic databases
PaxDbi | Q99645. |
PeptideAtlasi | Q99645. |
PRIDEi | Q99645. |
PTM databases
iPTMneti | Q99645. |
PhosphoSitePlusi | Q99645. |
Expressioni
Tissue specificityi
Cartilage, ligament, and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000083782. |
CleanExi | HS_EPYC. |
ExpressionAtlasi | Q99645. baseline and differential. |
Genevisiblei | Q99645. HS. |
Organism-specific databases
HPAi | HPA038212. HPA045455. |
Interactioni
Protein-protein interaction databases
BioGridi | 108167. 2 interactors. |
IntActi | Q99645. 2 interactors. |
STRINGi | 9606.ENSP00000261172. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 106 – 143 | LRRNTAdd BLAST | 38 | |
Repeati | 144 – 165 | LRR 1Add BLAST | 22 | |
Repeati | 168 – 189 | LRR 2Add BLAST | 22 | |
Repeati | 192 – 213 | LRR 3Add BLAST | 22 | |
Repeati | 238 – 258 | LRR 4Add BLAST | 21 | |
Repeati | 259 – 280 | LRR 5Add BLAST | 22 | |
Repeati | 290 – 310 | LRR 6Add BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 81 – 87 | Poly-Glu | 7 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0619. Eukaryota. COG4886. LUCA. |
GeneTreei | ENSGT00730000110781. |
HOGENOMi | HOG000273909. |
HOVERGENi | HBG006850. |
InParanoidi | Q99645. |
KOi | K08127. |
OMAi | CDDHELD. |
OrthoDBi | EOG091G0C68. |
PhylomeDBi | Q99645. |
TreeFami | TF351924. |
Family and domain databases
Gene3Di | 3.80.10.10. 1 hit. |
InterProi | View protein in InterPro IPR027217. Epiphycan. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR032675. LRR_dom_sf. IPR000372. LRRNT. |
PANTHERi | PTHR24373:SF123. PTHR24373:SF123. 1 hit. |
Pfami | View protein in Pfam PF13855. LRR_8. 1 hit. |
SMARTi | View protein in SMART SM00369. LRR_TYP. 4 hits. SM00013. LRRNT. 1 hit. |
PROSITEi | View protein in PROSITE PS51450. LRR. 4 hits. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q99645-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTLAGLVLG LVIFDAAVTA PTLESINYDS ETYDATLEDL DNLYNYENIP
60 70 80 90 100
VDKVEIEIAT VMPSGNRELL TPPPQPEKAQ EEEEEEESTP RLIDGSSPQE
110 120 130 140 150
PEFTGVLGPH TNEDFPTCLL CTCISTTVYC DDHELDAIPP LPKNTAYFYS
160 170 180 190 200
RFNRIKKINK NDFASLSDLK RIDLTSNLIS EIDEDAFRKL PQLRELVLRD
210 220 230 240 250
NKIRQLPELP TTLTFIDISN NRLGRKGIKQ EAFKDMYDLH HLYLTDNNLD
260 270 280 290 300
HIPLPLPENL RALHLQNNNI LEMHEDTFCN VKNLTYIRKA LEDIRLDGNP
310 320
INLSKTPQAY MCLPRLPVGS LV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | F → L in AAC50945 (PubMed:8975717).Curated | 1 | |
Sequence conflicti | 52 | D → G in AAH30958 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 120 | L → W in AAC50945 (PubMed:8975717).Curated | 1 | |
Sequence conflicti | 213 | L → S in AAC50945 (PubMed:8975717).Curated | 1 | |
Sequence conflicti | 281 | V → G in AAC50945 (PubMed:8975717).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031595 | 150 | S → C. Corresponds to variant dbSNP:rs17784152Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59111 mRNA. Translation: AAC50945.1. AK290642 mRNA. Translation: BAF83331.1. CH471054 Genomic DNA. Translation: EAW97444.1. BC030958 mRNA. Translation: AAH30958.1. |
CCDSi | CCDS31870.1. |
RefSeqi | NP_004941.2. NM_004950.4. |
UniGenei | Hs.435680. |
Genome annotation databases
Ensembli | ENST00000261172; ENSP00000261172; ENSG00000083782. |
GeneIDi | 1833. |
KEGGi | hsa:1833. |
UCSCi | uc001tbk.3. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | EPYC_HUMAN | |
Accessioni | Q99645Primary (citable) accession number: Q99645 Secondary accession number(s): A8K3M7, Q8NEJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | April 3, 2007 | |
Last modified: | February 28, 2018 | |
This is version 158 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |