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Protein

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Gene

PKMYT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Negatively regulated by hyperphosphorylation during mitosis. The hyperphosphorylated form does not associate with CCNB1-CDC2 complexes. The PLK1 protein kinase may be required for mitotic phosphorylation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139ATPPROSITE-ProRule annotation1
Active sitei233Proton acceptorPROSITE-ProRule annotation1
Metal bindingi238Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi251Magnesium; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi116 – 124ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: Reactome
  • G2/M transition of mitotic cell cycle Source: Reactome
  • mitotic nuclear division Source: ProtInc
  • negative regulation of phosphatase activity Source: UniProtKB
  • regulation of cell cycle Source: Reactome
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
  • regulation of mitotic nuclear division Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS05114-MONOMER.
ReactomeiR-HSA-156711. Polo-like kinase mediated events.
R-HSA-69273. Cyclin A/B1 associated events during G2/M transition.
R-HSA-69478. G2/M DNA replication checkpoint.
SignaLinkiQ99640.
SIGNORiQ99640.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC:2.7.11.1)
Alternative name(s):
Myt1 kinase
Gene namesi
Name:PKMYT1
Synonyms:MYT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29650. PKMYT1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • endoplasmic reticulum Source: ProtInc
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: ProtInc
  • Golgi membrane Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi238N → A: Loss of kinase activity. 1 Publication1
Mutagenesisi251D → A: Loss of kinase activity. 1 Publication1
Mutagenesisi486 – 488RNL → AAA: Loss of CDC2-CCNB1 interaction. 1 Publication3

Organism-specific databases

DisGeNETi9088.
OpenTargetsiENSG00000127564.
PharmGKBiPA385.

Chemistry databases

ChEMBLiCHEMBL3984.
GuidetoPHARMACOLOGYi2167.

Polymorphism and mutation databases

BioMutaiPKMYT1.
DMDMi55976573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000865731 – 499Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseAdd BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei17PhosphothreonineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei426Phosphoserine; by PLK11 Publication1
Modified residuei469PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei482PhosphoserineCombined sources1
Modified residuei495Phosphothreonine; by PLK1Combined sources1 Publication1

Post-translational modificationi

Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99640.
MaxQBiQ99640.
PaxDbiQ99640.
PeptideAtlasiQ99640.
PRIDEiQ99640.

PTM databases

iPTMnetiQ99640.
PhosphoSitePlusiQ99640.

Expressioni

Gene expression databases

BgeeiENSG00000127564.
CleanExiHS_MYT1.
HS_PKMYT1.
ExpressionAtlasiQ99640. baseline and differential.
GenevisibleiQ99640. HS.

Organism-specific databases

HPAiCAB046000.
HPA068860.

Interactioni

Subunit structurei

Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNB1P146355EBI-495308,EBI-495332
CDK1P064934EBI-495308,EBI-444308

Protein-protein interaction databases

BioGridi114544. 19 interactors.
IntActiQ99640. 11 interactors.
MINTiMINT-3059438.
STRINGi9606.ENSP00000262300.

Chemistry databases

BindingDBiQ99640.

Structurei

Secondary structure

1499
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi101 – 103Combined sources3
Helixi105 – 109Combined sources5
Beta strandi110 – 119Combined sources10
Beta strandi122 – 129Combined sources8
Turni130 – 132Combined sources3
Beta strandi135 – 144Combined sources10
Helixi148 – 164Combined sources17
Beta strandi173 – 179Combined sources7
Beta strandi182 – 188Combined sources7
Helixi194 – 201Combined sources8
Helixi207 – 226Combined sources20
Helixi236 – 238Combined sources3
Beta strandi239 – 241Combined sources3
Helixi243 – 245Combined sources3
Beta strandi247 – 249Combined sources3
Helixi271 – 273Combined sources3
Helixi276 – 280Combined sources5
Helixi286 – 301Combined sources16
Helixi309 – 315Combined sources7
Turni316 – 318Combined sources3
Helixi322 – 325Combined sources4
Helixi330 – 339Combined sources10
Turni344 – 346Combined sources3
Helixi350 – 354Combined sources5
Helixi357 – 359Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P1AX-ray1.70A75-362[»]
ProteinModelPortaliQ99640.
SMRiQ99640.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99640.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 359Protein kinasePROSITE-ProRule annotationAdd BLAST250

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni398 – 499Interaction with PIN1Add BLAST102
Regioni437 – 499Interaction with CDC2-CCNB1Add BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi382 – 398Membrane-association motifAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 72Pro-richAdd BLAST68

Domaini

The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0601. Eukaryota.
ENOG410XS1M. LUCA.
GeneTreeiENSGT00530000063230.
HOGENOMiHOG000293277.
HOVERGENiHBG053623.
InParanoidiQ99640.
KOiK06633.
PhylomeDBiQ99640.
TreeFamiTF101087.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR016235. Tyr/Thr_kinase_Cdc2_inhib.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000567. TYPK_Myt1. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99640-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLERPPALAM PMPTEGTPPP LSGTPIPVPA YFRHAEPGFS LKRPRGLSRS
60 70 80 90 100
LPPPPPAKGS IPISRLFPPR TPGWHQLQPR RVSFRGEASE TLQSPGYDPS
110 120 130 140 150
RPESFFQQSF QRLSRLGHGS YGEVFKVRSK EDGRLYAVKR SMSPFRGPKD
160 170 180 190 200
RARKLAEVGS HEKVGQHPCC VRLEQAWEEG GILYLQTELC GPSLQQHCEA
210 220 230 240 250
WGASLPEAQV WGYLRDTLLA LAHLHSQGLV HLDVKPANIF LGPRGRCKLG
260 270 280 290 300
DFGLLVELGT AGAGEVQEGD PRYMAPELLQ GSYGTAADVF SLGLTILEVA
310 320 330 340 350
CNMELPHGGE GWQQLRQGYL PPEFTAGLSS ELRSVLVMML EPDPKLRATA
360 370 380 390 400
EALLALPVLR QPRAWGVLWC MAAEALSRGW ALWQALLALL CWLWHGLAHP
410 420 430 440 450
ASWLQPLGPP ATPPGSPPCS LLLDSSLSSN WDDDSLGPSL SPEAVLARTV
460 470 480 490
GSTSTPRSRC TPRDALDLSD INSEPPRGSF PSFEPRNLLS LFEDTLDPT
Length:499
Mass (Da):54,521
Last modified:May 1, 1997 - v1
Checksum:i4DF28A5965265567
GO
Isoform 2 (identifier: Q99640-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-499: SLSPEAVLAR...SLFEDTLDPT → GHPPCLACPP...AGAHPGMPWT

Note: No experimental confirmation available.
Show »
Length:480
Mass (Da):52,146
Checksum:iE3A040B3858812A6
GO
Isoform 3 (identifier: Q99640-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):53,542
Checksum:i0D60B306B464E780
GO
Isoform 4 (identifier: Q99640-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-73: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):47,284
Checksum:iCD5FC8DADE1E8E7E
GO

Sequence cautioni

The sequence CAD28540 differs from that shown. Chimeric cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131E → A in BAG53500 (Ref. 4) Curated1
Sequence conflicti415G → D in AAB71843 (PubMed:9268380).Curated1
Sequence conflicti427L → F in AAB71843 (PubMed:9268380).Curated1
Sequence conflicti491L → M in AAB71843 (PubMed:9268380).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041034103E → Q.1 PublicationCorresponds to variant rs55834293dbSNPEnsembl.1
Natural variantiVAR_019928140R → C.2 PublicationsCorresponds to variant rs4149796dbSNPEnsembl.1
Natural variantiVAR_041035246R → H.1 PublicationCorresponds to variant rs35192104dbSNPEnsembl.1
Natural variantiVAR_041036351E → K.1 PublicationCorresponds to variant rs56382954dbSNPEnsembl.1
Natural variantiVAR_019929417P → R.1 PublicationCorresponds to variant rs4149800dbSNPEnsembl.1
Natural variantiVAR_019930445V → A.1 PublicationCorresponds to variant rs10546dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0468461 – 9Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_0468475 – 73Missing in isoform 4. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_045699439 – 499SLSPE…TLDPT → GHPPCLACPPAGLHSPLRLS WPGLWGAPPPPGAGAHPGMP WT in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014118 mRNA. Translation: AAB71843.1.
U56816 mRNA. Translation: AAC50949.1.
AK097642 mRNA. Translation: BAG53500.1.
AK098452 mRNA. No translation available.
AK301926 mRNA. Translation: BAG63346.1.
AF549406 Genomic DNA. Translation: AAN40703.1.
AC004233 Genomic DNA. Translation: AAC04478.1.
AC004235 Genomic DNA. Translation: AAC04477.1.
CH471112 Genomic DNA. Translation: EAW85439.1.
CH471112 Genomic DNA. Translation: EAW85440.1.
AL713779 mRNA. Translation: CAD28540.1. Sequence problems.
CCDSiCCDS10486.1. [Q99640-1]
CCDS45391.1. [Q99640-2]
CCDS58414.1. [Q99640-3]
CCDS58415.1. [Q99640-4]
RefSeqiNP_001245379.1. NM_001258450.1. [Q99640-4]
NP_001245380.1. NM_001258451.1. [Q99640-3]
NP_004194.3. NM_004203.4. [Q99640-1]
NP_872629.1. NM_182687.2. [Q99640-2]
XP_011521036.1. XM_011522734.2. [Q99640-1]
XP_011521037.1. XM_011522735.2. [Q99640-3]
XP_011521038.1. XM_011522736.2. [Q99640-3]
UniGeneiHs.732385.

Genome annotation databases

EnsembliENST00000262300; ENSP00000262300; ENSG00000127564. [Q99640-1]
ENST00000440027; ENSP00000397739; ENSG00000127564. [Q99640-2]
ENST00000573944; ENSP00000459123; ENSG00000127564. [Q99640-3]
ENST00000574385; ENSP00000458943; ENSG00000127564. [Q99640-3]
ENST00000574730; ENSP00000460868; ENSG00000127564. [Q99640-4]
GeneIDi9088.
KEGGihsa:9088.
UCSCiuc002csm.4. human. [Q99640-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014118 mRNA. Translation: AAB71843.1.
U56816 mRNA. Translation: AAC50949.1.
AK097642 mRNA. Translation: BAG53500.1.
AK098452 mRNA. No translation available.
AK301926 mRNA. Translation: BAG63346.1.
AF549406 Genomic DNA. Translation: AAN40703.1.
AC004233 Genomic DNA. Translation: AAC04478.1.
AC004235 Genomic DNA. Translation: AAC04477.1.
CH471112 Genomic DNA. Translation: EAW85439.1.
CH471112 Genomic DNA. Translation: EAW85440.1.
AL713779 mRNA. Translation: CAD28540.1. Sequence problems.
CCDSiCCDS10486.1. [Q99640-1]
CCDS45391.1. [Q99640-2]
CCDS58414.1. [Q99640-3]
CCDS58415.1. [Q99640-4]
RefSeqiNP_001245379.1. NM_001258450.1. [Q99640-4]
NP_001245380.1. NM_001258451.1. [Q99640-3]
NP_004194.3. NM_004203.4. [Q99640-1]
NP_872629.1. NM_182687.2. [Q99640-2]
XP_011521036.1. XM_011522734.2. [Q99640-1]
XP_011521037.1. XM_011522735.2. [Q99640-3]
XP_011521038.1. XM_011522736.2. [Q99640-3]
UniGeneiHs.732385.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P1AX-ray1.70A75-362[»]
ProteinModelPortaliQ99640.
SMRiQ99640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114544. 19 interactors.
IntActiQ99640. 11 interactors.
MINTiMINT-3059438.
STRINGi9606.ENSP00000262300.

Chemistry databases

BindingDBiQ99640.
ChEMBLiCHEMBL3984.
GuidetoPHARMACOLOGYi2167.

PTM databases

iPTMnetiQ99640.
PhosphoSitePlusiQ99640.

Polymorphism and mutation databases

BioMutaiPKMYT1.
DMDMi55976573.

Proteomic databases

EPDiQ99640.
MaxQBiQ99640.
PaxDbiQ99640.
PeptideAtlasiQ99640.
PRIDEiQ99640.

Protocols and materials databases

DNASUi9088.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262300; ENSP00000262300; ENSG00000127564. [Q99640-1]
ENST00000440027; ENSP00000397739; ENSG00000127564. [Q99640-2]
ENST00000573944; ENSP00000459123; ENSG00000127564. [Q99640-3]
ENST00000574385; ENSP00000458943; ENSG00000127564. [Q99640-3]
ENST00000574730; ENSP00000460868; ENSG00000127564. [Q99640-4]
GeneIDi9088.
KEGGihsa:9088.
UCSCiuc002csm.4. human. [Q99640-1]

Organism-specific databases

CTDi9088.
DisGeNETi9088.
GeneCardsiPKMYT1.
HGNCiHGNC:29650. PKMYT1.
HPAiCAB046000.
HPA068860.
MIMi602474. gene.
neXtProtiNX_Q99640.
OpenTargetsiENSG00000127564.
PharmGKBiPA385.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0601. Eukaryota.
ENOG410XS1M. LUCA.
GeneTreeiENSGT00530000063230.
HOGENOMiHOG000293277.
HOVERGENiHBG053623.
InParanoidiQ99640.
KOiK06633.
PhylomeDBiQ99640.
TreeFamiTF101087.

Enzyme and pathway databases

BioCyciZFISH:HS05114-MONOMER.
ReactomeiR-HSA-156711. Polo-like kinase mediated events.
R-HSA-69273. Cyclin A/B1 associated events during G2/M transition.
R-HSA-69478. G2/M DNA replication checkpoint.
SignaLinkiQ99640.
SIGNORiQ99640.

Miscellaneous databases

ChiTaRSiPKMYT1. human.
EvolutionaryTraceiQ99640.
GeneWikiiPKMYT1.
GenomeRNAii9088.
PROiQ99640.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127564.
CleanExiHS_MYT1.
HS_PKMYT1.
ExpressionAtlasiQ99640. baseline and differential.
GenevisibleiQ99640. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR016235. Tyr/Thr_kinase_Cdc2_inhib.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000567. TYPK_Myt1. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMYT1_HUMAN
AccessioniPrimary (citable) accession number: Q99640
Secondary accession number(s): B3KUN8
, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.