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Q99626

- CDX2_HUMAN

UniProt

Q99626 - CDX2_HUMAN

Protein

Homeobox protein CDX-2

Gene

CDX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi186 – 24560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. double-stranded DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc
    3. transcription corepressor activity Source: Ensembl
    4. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. blood vessel development Source: Ensembl
    3. endosome to lysosome transport Source: Ensembl
    4. establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
    5. labyrinthine layer development Source: Ensembl
    6. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    7. organ morphogenesis Source: ProtInc
    8. positive regulation of cell differentiation Source: Ensembl
    9. positive regulation of cell proliferation Source: Ensembl
    10. positive regulation of transcription, DNA-templated Source: Ensembl
    11. somatic stem cell maintenance Source: Ensembl
    12. transcription from RNA polymerase II promoter Source: ProtInc
    13. trophectodermal cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein CDX-2
    Alternative name(s):
    CDX-3
    Caudal-type homeobox protein 2
    Gene namesi
    Name:CDX2
    Synonyms:CDX3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:1806. CDX2.

    Subcellular locationi

    GO - Cellular componenti

    1. condensed nuclear chromosome Source: Ensembl
    2. nucleus Source: HPA
    3. transcriptional repressor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26352.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Homeobox protein CDX-2PRO_0000048849Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei60 – 601PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation of Ser-60 mediates the transactivation capacity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ99626.
    PaxDbiQ99626.
    PRIDEiQ99626.

    PTM databases

    PhosphoSiteiQ99626.

    Expressioni

    Gene expression databases

    BgeeiQ99626.
    CleanExiHS_CDX2.
    GenevestigatoriQ99626.

    Organism-specific databases

    HPAiCAB002221.
    HPA045669.
    HPA049580.

    Interactioni

    Protein-protein interaction databases

    BioGridi107475. 9 interactions.
    STRINGi9606.ENSP00000370408.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99626.
    SMRiQ99626. Positions 191-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi46 – 538Poly-Ala
    Compositional biasi85 – 928Poly-Ala
    Compositional biasi250 – 2567Poly-Gln
    Compositional biasi257 – 27014Poly-ProAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Caudal homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG304047.
    HOGENOMiHOG000115975.
    HOVERGENiHBG005302.
    InParanoidiQ99626.
    KOiK09312.
    OMAiGPSWPSP.
    OrthoDBiEOG71P2BK.
    PhylomeDBiQ99626.
    TreeFamiTF351605.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR006820. Caudal_activation_dom.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF04731. Caudal_act. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99626-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA    50
    AAANLDSAQS PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS 100
    PAAAMGYSSP ADYHPHHHPH HHPHHPAAAP SCASGLLQTL NPGPPGPAAT 150
    AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ VKTRTKDKYR VVYTDHQRLE 200
    LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK ERKINKKKLQ 250
    QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVPGSVPGVL 300
    GPTGGVLNPT VTQ 313
    Length:313
    Mass (Da):33,520
    Last modified:November 2, 2010 - v3
    Checksum:iB5724F1F7CA569AF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 532AA → Q in AAB40603. (PubMed:9036867)Curated
    Sequence conflicti89 – 891Missing in AAB40603. (PubMed:9036867)Curated
    Sequence conflicti95 – 951G → A in AAB40603. (PubMed:9036867)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti293 – 2931P → S.5 Publications
    Corresponds to variant rs1805107 [ dbSNP | Ensembl ].
    VAR_014530

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13709 mRNA. Translation: CAA74038.1.
    U51096 mRNA. Translation: AAB40603.1.
    AJ278431, AJ278432, AJ278434 Genomic DNA. Translation: CAB94779.1.
    AF007886, AF007884, AF007885 Genomic DNA. Translation: AAD05200.1.
    AL591024 Genomic DNA. Translation: CAH70633.1.
    BC014461 mRNA. Translation: AAH14461.1.
    CCDSiCCDS9328.1.
    PIRiPN0625.
    RefSeqiNP_001256.3. NM_001265.4.
    UniGeneiHs.174249.
    Hs.740844.

    Genome annotation databases

    EnsembliENST00000381020; ENSP00000370408; ENSG00000165556.
    GeneIDi1045.
    KEGGihsa:1045.
    UCSCiuc001urv.4. human.

    Polymorphism databases

    DMDMi311033469.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13709 mRNA. Translation: CAA74038.1 .
    U51096 mRNA. Translation: AAB40603.1 .
    AJ278431 , AJ278432 , AJ278434 Genomic DNA. Translation: CAB94779.1 .
    AF007886 , AF007884 , AF007885 Genomic DNA. Translation: AAD05200.1 .
    AL591024 Genomic DNA. Translation: CAH70633.1 .
    BC014461 mRNA. Translation: AAH14461.1 .
    CCDSi CCDS9328.1.
    PIRi PN0625.
    RefSeqi NP_001256.3. NM_001265.4.
    UniGenei Hs.174249.
    Hs.740844.

    3D structure databases

    ProteinModelPortali Q99626.
    SMRi Q99626. Positions 191-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107475. 9 interactions.
    STRINGi 9606.ENSP00000370408.

    PTM databases

    PhosphoSitei Q99626.

    Polymorphism databases

    DMDMi 311033469.

    Proteomic databases

    MaxQBi Q99626.
    PaxDbi Q99626.
    PRIDEi Q99626.

    Protocols and materials databases

    DNASUi 1045.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381020 ; ENSP00000370408 ; ENSG00000165556 .
    GeneIDi 1045.
    KEGGi hsa:1045.
    UCSCi uc001urv.4. human.

    Organism-specific databases

    CTDi 1045.
    GeneCardsi GC13M028536.
    HGNCi HGNC:1806. CDX2.
    HPAi CAB002221.
    HPA045669.
    HPA049580.
    MIMi 600297. gene.
    neXtProti NX_Q99626.
    PharmGKBi PA26352.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304047.
    HOGENOMi HOG000115975.
    HOVERGENi HBG005302.
    InParanoidi Q99626.
    KOi K09312.
    OMAi GPSWPSP.
    OrthoDBi EOG71P2BK.
    PhylomeDBi Q99626.
    TreeFami TF351605.

    Enzyme and pathway databases

    Reactomei REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

    Miscellaneous databases

    GeneWikii CDX2.
    GenomeRNAii 1045.
    NextBioi 4381.
    PROi Q99626.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99626.
    CleanExi HS_CDX2.
    Genevestigatori Q99626.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR006820. Caudal_activation_dom.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF04731. Caudal_act. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosome assignment of the human CDX2 gene."
      Drummond F.J., Putt W., Fox M., Edwards Y.H.
      Ann. Hum. Genet. 61:393-400(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-293.
    2. "Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis."
      Mallo G.V., Rechreche H., Frigerio J.-M., Rocha D., Zweibaum A., Lacasa M., Jordan B.R., Dusetti N.J., Dagorn J.-C., Iovanna J.L.
      Int. J. Cancer 74:35-44(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-293.
      Tissue: Colon carcinoma.
    3. "The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis."
      Sivagnanasundaram S., Islam I., Talbot I., Drummond F., Walters J.R., Edwards Y.H.
      Br. J. Cancer 84:218-225(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-293.
    4. "Isolation, characterization, and linkage mapping of the human caudal-type homeobox gene, CDX2/3."
      Tanizawa Y., Ueda K., Inoue H., Ayame H., Aoki M., Kuwano A., German M.S., Liu L., Donis-Keller H., Permutt M.A., Oka Y.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-293.
    5. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-293.
      Tissue: Colon.
    7. "Identification of homeobox genes expressed in human T-lymphocytes."
      Inamori K., Takeshita K., Chiba S., Yazaki Y., Hirai H.
      Biochem. Biophys. Res. Commun. 196:203-208(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-232.
      Tissue: T-cell.

    Entry informationi

    Entry nameiCDX2_HUMAN
    AccessioniPrimary (citable) accession number: Q99626
    Secondary accession number(s): O00503
    , Q5VTU7, Q969L8, Q9UD92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3