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Q99626 (CDX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein CDX-2
Alternative name(s):
CDX-3
Caudal-type homeobox protein 2
Gene names
Name:CDX2
Synonyms:CDX3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Subcellular location

Nucleus.

Post-translational modification

Phosphorylation of Ser-60 mediates the transactivation capacity By similarity.

Sequence similarities

Belongs to the Caudal homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from electronic annotation. Source: Ensembl

blood vessel development

Inferred from electronic annotation. Source: Ensembl

endosome to lysosome transport

Inferred from electronic annotation. Source: Ensembl

establishment or maintenance of epithelial cell apical/basal polarity

Inferred from electronic annotation. Source: Ensembl

labyrinthine layer development

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15677472. Source: NTNU_SB

organ morphogenesis

Traceable author statement PubMed 9052785. Source: ProtInc

positive regulation of cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

trophectodermal cell differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcondensed nuclear chromosome

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay. Source: HPA

transcriptional repressor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functiondouble-stranded DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: ProtInc

transcription corepressor activity

Inferred from electronic annotation. Source: Ensembl

transcription regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Homeobox protein CDX-2
PRO_0000048849

Regions

DNA binding186 – 24560Homeobox
Compositional bias46 – 538Poly-Ala
Compositional bias85 – 928Poly-Ala
Compositional bias250 – 2567Poly-Gln
Compositional bias257 – 27014Poly-Pro

Amino acid modifications

Modified residue601Phosphoserine By similarity

Natural variations

Natural variant2931P → S. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6
Corresponds to variant rs1805107 [ dbSNP | Ensembl ].
VAR_014530

Experimental info

Sequence conflict52 – 532AA → Q in AAB40603. Ref.2
Sequence conflict891Missing in AAB40603. Ref.2
Sequence conflict951G → A in AAB40603. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q99626 [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: B5724F1F7CA569AF

FASTA31333,520
        10         20         30         40         50         60 
MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA AAANLDSAQS 

        70         80         90        100        110        120 
PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS PAAAMGYSSP ADYHPHHHPH 

       130        140        150        160        170        180 
HHPHHPAAAP SCASGLLQTL NPGPPGPAAT AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ 

       190        200        210        220        230        240 
VKTRTKDKYR VVYTDHQRLE LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK 

       250        260        270        280        290        300 
ERKINKKKLQ QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVPGSVPGVL 

       310 
GPTGGVLNPT VTQ 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and chromosome assignment of the human CDX2 gene."
Drummond F.J., Putt W., Fox M., Edwards Y.H.
Ann. Hum. Genet. 61:393-400(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-293.
[2]"Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis."
Mallo G.V., Rechreche H., Frigerio J.-M., Rocha D., Zweibaum A., Lacasa M., Jordan B.R., Dusetti N.J., Dagorn J.-C., Iovanna J.L.
Int. J. Cancer 74:35-44(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-293.
Tissue: Colon carcinoma.
[3]"The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis."
Sivagnanasundaram S., Islam I., Talbot I., Drummond F., Walters J.R., Edwards Y.H.
Br. J. Cancer 84:218-225(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-293.
[4]"Isolation, characterization, and linkage mapping of the human caudal-type homeobox gene, CDX2/3."
Tanizawa Y., Ueda K., Inoue H., Ayame H., Aoki M., Kuwano A., German M.S., Liu L., Donis-Keller H., Permutt M.A., Oka Y.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-293.
[5]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-293.
Tissue: Colon.
[7]"Identification of homeobox genes expressed in human T-lymphocytes."
Inamori K., Takeshita K., Chiba S., Yazaki Y., Hirai H.
Biochem. Biophys. Res. Commun. 196:203-208(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-232.
Tissue: T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y13709 mRNA. Translation: CAA74038.1.
U51096 mRNA. Translation: AAB40603.1.
AJ278431, AJ278432, AJ278434 Genomic DNA. Translation: CAB94779.1.
AF007886, AF007884, AF007885 Genomic DNA. Translation: AAD05200.1.
AL591024 Genomic DNA. Translation: CAH70633.1.
BC014461 mRNA. Translation: AAH14461.1.
PIRPN0625.
RefSeqNP_001256.3. NM_001265.4.
UniGeneHs.174249.
Hs.740844.

3D structure databases

ProteinModelPortalQ99626.
SMRQ99626. Positions 191-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107475. 9 interactions.
STRING9606.ENSP00000370408.

PTM databases

PhosphoSiteQ99626.

Polymorphism databases

DMDM311033469.

Proteomic databases

PaxDbQ99626.
PRIDEQ99626.

Protocols and materials databases

DNASU1045.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381020; ENSP00000370408; ENSG00000165556.
GeneID1045.
KEGGhsa:1045.
UCSCuc001urv.4. human.

Organism-specific databases

CTD1045.
GeneCardsGC13M028536.
HGNCHGNC:1806. CDX2.
HPACAB002221.
HPA045669.
HPA049580.
MIM600297. gene.
neXtProtNX_Q99626.
PharmGKBPA26352.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304047.
HOGENOMHOG000115975.
HOVERGENHBG005302.
InParanoidQ99626.
KOK09312.
OMAGPSWPSP.
OrthoDBEOG71P2BK.
PhylomeDBQ99626.
TreeFamTF351605.

Gene expression databases

BgeeQ99626.
CleanExHS_CDX2.
GenevestigatorQ99626.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCDX2.
GenomeRNAi1045.
NextBio4381.
PROQ99626.
SOURCESearch...

Entry information

Entry nameCDX2_HUMAN
AccessionPrimary (citable) accession number: Q99626
Secondary accession number(s): O00503 expand/collapse secondary AC list , Q5VTU7, Q969L8, Q9UD92
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2010
Last modified: April 16, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM