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Q99626

- CDX2_HUMAN

UniProt

Q99626 - CDX2_HUMAN

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Protein
Homeobox protein CDX-2
Gene
CDX2, CDX3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi186 – 24560Homeobox
Add
BLAST

GO - Molecular functioni

  1. double-stranded DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc
  3. transcription corepressor activity Source: Ensembl
  4. transcription regulatory region sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. blood vessel development Source: Ensembl
  3. endosome to lysosome transport Source: Ensembl
  4. establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
  5. labyrinthine layer development Source: Ensembl
  6. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  7. organ morphogenesis Source: ProtInc
  8. positive regulation of cell differentiation Source: Ensembl
  9. positive regulation of cell proliferation Source: Ensembl
  10. positive regulation of transcription, DNA-templated Source: Ensembl
  11. somatic stem cell maintenance Source: Ensembl
  12. transcription from RNA polymerase II promoter Source: ProtInc
  13. trophectodermal cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-2
Alternative name(s):
CDX-3
Caudal-type homeobox protein 2
Gene namesi
Name:CDX2
Synonyms:CDX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:1806. CDX2.

Subcellular locationi

GO - Cellular componenti

  1. condensed nuclear chromosome Source: Ensembl
  2. nucleus Source: HPA
  3. transcriptional repressor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Homeobox protein CDX-2
PRO_0000048849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601Phosphoserine By similarity

Post-translational modificationi

Phosphorylation of Ser-60 mediates the transactivation capacity By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99626.
PaxDbiQ99626.
PRIDEiQ99626.

PTM databases

PhosphoSiteiQ99626.

Expressioni

Gene expression databases

BgeeiQ99626.
CleanExiHS_CDX2.
GenevestigatoriQ99626.

Organism-specific databases

HPAiCAB002221.
HPA045669.
HPA049580.

Interactioni

Protein-protein interaction databases

BioGridi107475. 9 interactions.
STRINGi9606.ENSP00000370408.

Structurei

3D structure databases

ProteinModelPortaliQ99626.
SMRiQ99626. Positions 191-248.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 538Poly-Ala
Compositional biasi85 – 928Poly-Ala
Compositional biasi250 – 2567Poly-Gln
Compositional biasi257 – 27014Poly-Pro
Add
BLAST

Sequence similaritiesi

Belongs to the Caudal homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG304047.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiQ99626.
KOiK09312.
OMAiGPSWPSP.
OrthoDBiEOG71P2BK.
PhylomeDBiQ99626.
TreeFamiTF351605.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99626-1 [UniParc]FASTAAdd to Basket

« Hide

MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA    50
AAANLDSAQS PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS 100
PAAAMGYSSP ADYHPHHHPH HHPHHPAAAP SCASGLLQTL NPGPPGPAAT 150
AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ VKTRTKDKYR VVYTDHQRLE 200
LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK ERKINKKKLQ 250
QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVPGSVPGVL 300
GPTGGVLNPT VTQ 313
Length:313
Mass (Da):33,520
Last modified:November 2, 2010 - v3
Checksum:iB5724F1F7CA569AF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931P → S.5 Publications
Corresponds to variant rs1805107 [ dbSNP | Ensembl ].
VAR_014530

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 532AA → Q in AAB40603. 1 Publication
Sequence conflicti89 – 891Missing in AAB40603. 1 Publication
Sequence conflicti95 – 951G → A in AAB40603. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13709 mRNA. Translation: CAA74038.1.
U51096 mRNA. Translation: AAB40603.1.
AJ278431, AJ278432, AJ278434 Genomic DNA. Translation: CAB94779.1.
AF007886, AF007884, AF007885 Genomic DNA. Translation: AAD05200.1.
AL591024 Genomic DNA. Translation: CAH70633.1.
BC014461 mRNA. Translation: AAH14461.1.
CCDSiCCDS9328.1.
PIRiPN0625.
RefSeqiNP_001256.3. NM_001265.4.
UniGeneiHs.174249.
Hs.740844.

Genome annotation databases

EnsembliENST00000381020; ENSP00000370408; ENSG00000165556.
GeneIDi1045.
KEGGihsa:1045.
UCSCiuc001urv.4. human.

Polymorphism databases

DMDMi311033469.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13709 mRNA. Translation: CAA74038.1 .
U51096 mRNA. Translation: AAB40603.1 .
AJ278431 , AJ278432 , AJ278434 Genomic DNA. Translation: CAB94779.1 .
AF007886 , AF007884 , AF007885 Genomic DNA. Translation: AAD05200.1 .
AL591024 Genomic DNA. Translation: CAH70633.1 .
BC014461 mRNA. Translation: AAH14461.1 .
CCDSi CCDS9328.1.
PIRi PN0625.
RefSeqi NP_001256.3. NM_001265.4.
UniGenei Hs.174249.
Hs.740844.

3D structure databases

ProteinModelPortali Q99626.
SMRi Q99626. Positions 191-248.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107475. 9 interactions.
STRINGi 9606.ENSP00000370408.

PTM databases

PhosphoSitei Q99626.

Polymorphism databases

DMDMi 311033469.

Proteomic databases

MaxQBi Q99626.
PaxDbi Q99626.
PRIDEi Q99626.

Protocols and materials databases

DNASUi 1045.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381020 ; ENSP00000370408 ; ENSG00000165556 .
GeneIDi 1045.
KEGGi hsa:1045.
UCSCi uc001urv.4. human.

Organism-specific databases

CTDi 1045.
GeneCardsi GC13M028536.
HGNCi HGNC:1806. CDX2.
HPAi CAB002221.
HPA045669.
HPA049580.
MIMi 600297. gene.
neXtProti NX_Q99626.
PharmGKBi PA26352.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304047.
HOGENOMi HOG000115975.
HOVERGENi HBG005302.
InParanoidi Q99626.
KOi K09312.
OMAi GPSWPSP.
OrthoDBi EOG71P2BK.
PhylomeDBi Q99626.
TreeFami TF351605.

Enzyme and pathway databases

Reactomei REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Miscellaneous databases

GeneWikii CDX2.
GenomeRNAii 1045.
NextBioi 4381.
PROi Q99626.
SOURCEi Search...

Gene expression databases

Bgeei Q99626.
CleanExi HS_CDX2.
Genevestigatori Q99626.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosome assignment of the human CDX2 gene."
    Drummond F.J., Putt W., Fox M., Edwards Y.H.
    Ann. Hum. Genet. 61:393-400(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-293.
  2. "Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis."
    Mallo G.V., Rechreche H., Frigerio J.-M., Rocha D., Zweibaum A., Lacasa M., Jordan B.R., Dusetti N.J., Dagorn J.-C., Iovanna J.L.
    Int. J. Cancer 74:35-44(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-293.
    Tissue: Colon carcinoma.
  3. "The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis."
    Sivagnanasundaram S., Islam I., Talbot I., Drummond F., Walters J.R., Edwards Y.H.
    Br. J. Cancer 84:218-225(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-293.
  4. "Isolation, characterization, and linkage mapping of the human caudal-type homeobox gene, CDX2/3."
    Tanizawa Y., Ueda K., Inoue H., Ayame H., Aoki M., Kuwano A., German M.S., Liu L., Donis-Keller H., Permutt M.A., Oka Y.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-293.
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-293.
    Tissue: Colon.
  7. "Identification of homeobox genes expressed in human T-lymphocytes."
    Inamori K., Takeshita K., Chiba S., Yazaki Y., Hirai H.
    Biochem. Biophys. Res. Commun. 196:203-208(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-232.
    Tissue: T-cell.

Entry informationi

Entry nameiCDX2_HUMAN
AccessioniPrimary (citable) accession number: Q99626
Secondary accession number(s): O00503
, Q5VTU7, Q969L8, Q9UD92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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