Reviewed, UniProtKB/Swiss-Prot Q99626 (CDX2_HUMAN)

Names and origin

Protein names

Recommended name:
    Homeobox protein CDX-2
Alternative name(s):
    Caudal-type homeobox protein 2
    CDX-3

Gene names

Name:	CDX2
Synonyms:	CDX3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
Subcellular location	Nucleus.
Post-translational modification	Phosphorylation of Ser-60 mediates the transactivation capacity By similarity.
Sequence similarities	Belongs to the Caudal homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator Developmental protein
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	transcription from RNA polymerase II promoter Ref.2 Traceable author statement. Source: ProtInc
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Homeobox protein CDX-2		PRO_0000048849
Regions
	DNA binding	186 – 245	60	Homeobox
	Compositional bias	46 – 53	8	Poly-Ala
	Compositional bias	85 – 92	8	Poly-Ala
	Compositional bias	250 – 256	7	Poly-Gln
	Compositional bias	257 – 270	14	Poly-Pro
Amino acid modifications
	Modified residue	60	1	Phosphoserine By similarity
Natural variations
	Natural variant	293	1	S → P: dbSNP rs1805107. Ref.5		VAR_014530
Experimental info
	Sequence conflict	52 – 53	2	AA → Q in AAB40603. Ref.1
	Sequence conflict	89	1	Missing in AAB40603. Ref.1
	Sequence conflict	95	1	G → A in AAB40603. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q99626-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: B5724F1F7EC8F9AF	FASTA	313	33,510
	10 20 30 40 50 60 MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA AAANLDSAQS 70 80 90 100 110 120 PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS PAAAMGYSSP ADYHPHHHPH 130 140 150 160 170 180 HHPHHPAAAP SCASGLLQTL NPGPPGPAAT AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ 190 200 210 220 230 240 VKTRTKDKYR VVYTDHQRLE LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK 250 260 270 280 290 300 ERKINKKKLQ QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVSGSVPGVL 310 GPTGGVLNPT VTQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis." Mallo G.V., Rechreche H., Frigerio J.-M., Rocha D., Zweibaum A., Lacasa M., Jordan B.R., Dusetti N.J., Dagorn J.-C., Iovanna J.L. Int. J. Cancer 74:35-44(1997) [PubMed: 9036867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon carcinoma.
[2]	"Cloning and chromosome assignment of the human CDX2 gene." Drummond F.J., Putt W., Fox M., Edwards Y.H. Ann. Hum. Genet. 61:393-400(1997) [PubMed: 9459001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Isolation, characterization, and linkage mapping of the human caudal-type homeobox gene, CDX2/3." Tanizawa Y., Ueda K., Inoue H., Ayame H., Aoki M., Kuwano A., German M.S., Liu L., Donis-Keller H., Permutt M.A., Oka Y. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis." Sivagnanasundaram S., Islam I., Talbot I., Drummond F., Walters J.R., Edwards Y.H. Br. J. Cancer 84:218-225(2001) [PubMed: 11161380] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-293.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	U51096 mRNA. Translation: AAB40603.1. Y13709 mRNA. Translation: CAA74038.1. AF007886, AF007884, AF007885 Genomic DNA. Translation: AAD05200.1. AJ278431, AJ278432, AJ278434 Genomic DNA. Translation: CAB94779.1. AL591024 Genomic DNA. Translation: CAH70633.1. BC014461 mRNA. Translation: AAH14461.1.
IPI	IPI00016928.
RefSeq	NP_001256.2.
UniGene	Hs.174249
3D structure databases
HSSP	HSSP built from PDB template 9ANT based on UniProtKB P02833.
ModBase	Search...
PTM databases
PhosphoSite	Q99626.
Proteomic databases
PRIDE	Q99626.
Genome annotation databases
Ensembl	ENSG00000165556. Homo sapiens. [Contig view]
GeneID	1045.
KEGG	hsa:1045.
Organism-specific databases
GeneCards	GC13M027434.
H-InvDB	HIX0011199.
HGNC	HGNC:1806. CDX2.
HPA	CAB002221.
MIM	600297. gene.
PharmGKB	PA26352.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q99626.
HOVERGEN	Q99626.
Gene expression databases
ArrayExpress	Q99626.
Bgee	Q99626.
CleanEx	HS_CDX2.
GermOnline	ENSG00000165556. Homo sapiens.
Family and domain databases
InterPro	IPR006820. Caudal_act. IPR015705. Cdx. IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR000047. HTH_lambrepressr. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PANTHER	PTHR19418:SF175. Cdx. 1 hit.
Pfam	PF04731. Caudal_act. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00031. HTHREPRESSR.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4381.
SOURCE	Search...

Entry information

Entry name

CDX2_HUMAN

Accession

Primary (citable) accession number: Q99626
Secondary accession number(s): O00503, Q5VTU7, Q969L8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2002
Last modified:	June 16, 2009
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)