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Protein

Homeobox protein CDX-2

Gene

CDX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi186 – 245HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
SIGNORiQ99626.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-2
Alternative name(s):
CDX-3
Caudal-type homeobox protein 2
Gene namesi
Name:CDX2
Synonyms:CDX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000165556.9.
HGNCiHGNC:1806. CDX2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1045.
OpenTargetsiENSG00000165556.
PharmGKBiPA26352.

Polymorphism and mutation databases

BioMutaiCdx2.
DMDMi311033469.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488491 – 313Homeobox protein CDX-2Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation of Ser-60 mediates the transactivation capacity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99626.
MaxQBiQ99626.
PaxDbiQ99626.
PeptideAtlasiQ99626.
PRIDEiQ99626.

PTM databases

iPTMnetiQ99626.
PhosphoSitePlusiQ99626.

Expressioni

Gene expression databases

BgeeiENSG00000165556.
CleanExiHS_CDX2.
GenevisibleiQ99626. HS.

Organism-specific databases

HPAiCAB002221.
HPA045669.
HPA049580.

Interactioni

Protein-protein interaction databases

BioGridi107475. 15 interactors.
IntActiQ99626. 3 interactors.
STRINGi9606.ENSP00000370408.

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi195 – 207Combined sources13
Helixi213 – 223Combined sources11
Helixi227 – 254Combined sources28

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LTYX-ray2.66K/M185-255[»]
ProteinModelPortaliQ99626.
SMRiQ99626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 53Poly-Ala8
Compositional biasi85 – 92Poly-Ala8
Compositional biasi250 – 256Poly-Gln7
Compositional biasi257 – 270Poly-ProAdd BLAST14

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0848. Eukaryota.
ENOG4111W2J. LUCA.
GeneTreeiENSGT00530000063388.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiQ99626.
KOiK09312.
OMAiGPSWPSP.
OrthoDBiEOG091G0LXJ.
PhylomeDBiQ99626.
TreeFamiTF351605.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR006820. Caudal_activation_dom.
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA
60 70 80 90 100
AAANLDSAQS PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS
110 120 130 140 150
PAAAMGYSSP ADYHPHHHPH HHPHHPAAAP SCASGLLQTL NPGPPGPAAT
160 170 180 190 200
AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ VKTRTKDKYR VVYTDHQRLE
210 220 230 240 250
LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK ERKINKKKLQ
260 270 280 290 300
QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVPGSVPGVL
310
GPTGGVLNPT VTQ
Length:313
Mass (Da):33,520
Last modified:November 2, 2010 - v3
Checksum:iB5724F1F7CA569AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52 – 53AA → Q in AAB40603 (PubMed:9036867).Curated2
Sequence conflicti89Missing in AAB40603 (PubMed:9036867).Curated1
Sequence conflicti95G → A in AAB40603 (PubMed:9036867).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014530293P → S5 PublicationsCorresponds to variant dbSNP:rs1805107Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13709 mRNA. Translation: CAA74038.1.
U51096 mRNA. Translation: AAB40603.1.
AJ278431, AJ278432, AJ278434 Genomic DNA. Translation: CAB94779.1.
AF007886, AF007884, AF007885 Genomic DNA. Translation: AAD05200.1.
AL591024 Genomic DNA. No translation available.
BC014461 mRNA. Translation: AAH14461.1.
CCDSiCCDS9328.1.
PIRiPN0625.
RefSeqiNP_001256.3. NM_001265.4.
UniGeneiHs.127383.
Hs.174249.
Hs.740844.

Genome annotation databases

EnsembliENST00000381020; ENSP00000370408; ENSG00000165556.
GeneIDi1045.
KEGGihsa:1045.
UCSCiuc001urv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCDX2_HUMAN
AccessioniPrimary (citable) accession number: Q99626
Secondary accession number(s): O00503
, Q5VTU7, Q969L8, Q9UD92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2010
Last modified: November 22, 2017
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families