Q99626 (CDX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein CDX-2

Alternative name(s):
CDX-3
Caudal-type homeobox protein 2

Gene names

Name:	CDX2
Synonyms:	CDX3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
Subcellular location	Nucleus.
Post-translational modification	Phosphorylation of Ser-60 mediates the transactivation capacity By similarity.
Sequence similarities	Belongs to the Caudal homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara blood vessel development Inferred from electronic annotation. Source: Compara endosome to lysosome transport Inferred from electronic annotation. Source: Compara establishment or maintenance of epithelial cell apical/basal polarity Inferred from electronic annotation. Source: Compara labyrinthine layer development Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara organ morphogenesis Traceable author statement PubMed 9052785. Source: ProtInc positive regulation of cell differentiation Inferred from electronic annotation. Source: Compara somatic stem cell maintenance Inferred from electronic annotation. Source: Compara transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc trophectodermal cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	condensed nuclear chromosome Inferred from electronic annotation. Source: Compara transcriptional repressor complex Inferred from electronic annotation. Source: Compara
Molecular_function	sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc transcription corepressor activity Inferred from electronic annotation. Source: Compara transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Homeobox protein CDX-2		PRO_0000048849
Regions
	DNA binding	186 – 245	60	Homeobox
	Compositional bias	46 – 53	8	Poly-Ala
	Compositional bias	85 – 92	8	Poly-Ala
	Compositional bias	250 – 256	7	Poly-Gln
	Compositional bias	257 – 270	14	Poly-Pro
Amino acid modifications
	Modified residue	60	1	Phosphoserine By similarity
Natural variations
	Natural variant	293	1	P → S. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Corresponds to variant rs1805107 [ dbSNP | Ensembl ].		VAR_014530
Experimental info
	Sequence conflict	52 – 53	2	AA → Q in AAB40603. Ref.2
	Sequence conflict	89	1	Missing in AAB40603. Ref.2
	Sequence conflict	95	1	G → A in AAB40603. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q99626 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: B5724F1F7CA569AF	FASTA	313	33,520
	10 20 30 40 50 60 MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA AAANLDSAQS 70 80 90 100 110 120 PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS PAAAMGYSSP ADYHPHHHPH 130 140 150 160 170 180 HHPHHPAAAP SCASGLLQTL NPGPPGPAAT AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ 190 200 210 220 230 240 VKTRTKDKYR VVYTDHQRLE LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK 250 260 270 280 290 300 ERKINKKKLQ QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVPGSVPGVL 310 GPTGGVLNPT VTQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and chromosome assignment of the human CDX2 gene." Drummond F.J., Putt W., Fox M., Edwards Y.H. Ann. Hum. Genet. 61:393-400(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-293.
[2]	"Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis." Mallo G.V., Rechreche H., Frigerio J.-M., Rocha D., Zweibaum A., Lacasa M., Jordan B.R., Dusetti N.J., Dagorn J.-C., Iovanna J.L. Int. J. Cancer 74:35-44(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-293. Tissue: Colon carcinoma.
[3]	"The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis." Sivagnanasundaram S., Islam I., Talbot I., Drummond F., Walters J.R., Edwards Y.H. Br. J. Cancer 84:218-225(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-293.
[4]	"Isolation, characterization, and linkage mapping of the human caudal-type homeobox gene, CDX2/3." Tanizawa Y., Ueda K., Inoue H., Ayame H., Aoki M., Kuwano A., German M.S., Liu L., Donis-Keller H., Permutt M.A., Oka Y. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-293.
[5]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-293. Tissue: Colon.
[7]	"Identification of homeobox genes expressed in human T-lymphocytes." Inamori K., Takeshita K., Chiba S., Yazaki Y., Hirai H. Biochem. Biophys. Res. Commun. 196:203-208(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-232. Tissue: T-cell.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y13709 mRNA. Translation: CAA74038.1. U51096 mRNA. Translation: AAB40603.1. AJ278431, AJ278432, AJ278434 Genomic DNA. Translation: CAB94779.1. AF007886, AF007884, AF007885 Genomic DNA. Translation: AAD05200.1. AL591024 Genomic DNA. Translation: CAH70633.1. BC014461 mRNA. Translation: AAH14461.1.
IPI	IPI00016928.
PIR	PN0625.
RefSeq	NP_001256.3. NM_001265.4.
UniGene	Hs.174249. Hs.740844.
3D structure databases
ProteinModelPortal	Q99626.
SMR	Q99626. Positions 191-248.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000370408.
PTM databases
PhosphoSite	Q99626.
Polymorphism databases
DMDM	311033469.
Proteomic databases
PaxDb	Q99626.
PRIDE	Q99626.
Protocols and materials databases
DNASU	1045.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381020; ENSP00000370408; ENSG00000165556.
GeneID	1045.
KEGG	hsa:1045.
UCSC	uc001urv.3. human.
Organism-specific databases
CTD	1045.
GeneCards	GC13M028536.
HGNC	HGNC:1806. CDX2.
HPA	CAB002221.
MIM	600297. gene.
neXtProt	NX_Q99626.
PharmGKB	PA26352.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG304047.
HOGENOM	HOG000115975.
HOVERGEN	HBG005302.
InParanoid	Q99626.
KO	K09312.
OMA	WMRKPTQ.
OrthoDB	EOG42FSK7.
PhylomeDB	Q99626.
Gene expression databases
Bgee	Q99626.
CleanEx	HS_CDX2.
Genevestigator	Q99626.
GermOnline	ENSG00000165556. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR006820. Caudal_activation_dom. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR000047. HTH_motif. [Graphical view]
Pfam	PF04731. Caudal_act. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1045.
NextBio	4381.
SOURCE	Search...

Entry information

Entry name

CDX2_HUMAN

Accession

Primary (citable) accession number: Q99626
Secondary accession number(s): O00503 , Q5VTU7, Q969L8, Q9UD92

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 2, 2010
Last modified:	April 3, 2013
This is version 122 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.