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Protein

Homeobox protein CDX-2

Gene

CDX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi186 – 24560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-2
Alternative name(s):
CDX-3
Caudal-type homeobox protein 2
Gene namesi
Name:CDX2
Synonyms:CDX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:1806. CDX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26352.

Polymorphism and mutation databases

BioMutaiCdx2.
DMDMi311033469.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Homeobox protein CDX-2PRO_0000048849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation of Ser-60 mediates the transactivation capacity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99626.
PaxDbiQ99626.
PRIDEiQ99626.

PTM databases

PhosphoSiteiQ99626.

Expressioni

Gene expression databases

BgeeiQ99626.
CleanExiHS_CDX2.
GenevisibleiQ99626. HS.

Organism-specific databases

HPAiCAB002221.
HPA045669.
HPA049580.

Interactioni

Protein-protein interaction databases

BioGridi107475. 9 interactions.
STRINGi9606.ENSP00000370408.

Structurei

3D structure databases

ProteinModelPortaliQ99626.
SMRiQ99626. Positions 191-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 538Poly-Ala
Compositional biasi85 – 928Poly-Ala
Compositional biasi250 – 2567Poly-Gln
Compositional biasi257 – 27014Poly-ProAdd
BLAST

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG304047.
GeneTreeiENSGT00530000063388.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiQ99626.
KOiK09312.
OMAiWMRKPTQ.
OrthoDBiEOG71P2BK.
PhylomeDBiQ99626.
TreeFamiTF351605.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA
60 70 80 90 100
AAANLDSAQS PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS
110 120 130 140 150
PAAAMGYSSP ADYHPHHHPH HHPHHPAAAP SCASGLLQTL NPGPPGPAAT
160 170 180 190 200
AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ VKTRTKDKYR VVYTDHQRLE
210 220 230 240 250
LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK ERKINKKKLQ
260 270 280 290 300
QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVPGSVPGVL
310
GPTGGVLNPT VTQ
Length:313
Mass (Da):33,520
Last modified:November 2, 2010 - v3
Checksum:iB5724F1F7CA569AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 532AA → Q in AAB40603 (PubMed:9036867).Curated
Sequence conflicti89 – 891Missing in AAB40603 (PubMed:9036867).Curated
Sequence conflicti95 – 951G → A in AAB40603 (PubMed:9036867).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931P → S.5 Publications
Corresponds to variant rs1805107 [ dbSNP | Ensembl ].
VAR_014530

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13709 mRNA. Translation: CAA74038.1.
U51096 mRNA. Translation: AAB40603.1.
AJ278431, AJ278432, AJ278434 Genomic DNA. Translation: CAB94779.1.
AF007886, AF007884, AF007885 Genomic DNA. Translation: AAD05200.1.
AL591024 Genomic DNA. Translation: CAH70633.1.
BC014461 mRNA. Translation: AAH14461.1.
CCDSiCCDS9328.1.
PIRiPN0625.
RefSeqiNP_001256.3. NM_001265.4.
UniGeneiHs.174249.
Hs.740844.

Genome annotation databases

EnsembliENST00000381020; ENSP00000370408; ENSG00000165556.
GeneIDi1045.
KEGGihsa:1045.
UCSCiuc001urv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13709 mRNA. Translation: CAA74038.1.
U51096 mRNA. Translation: AAB40603.1.
AJ278431, AJ278432, AJ278434 Genomic DNA. Translation: CAB94779.1.
AF007886, AF007884, AF007885 Genomic DNA. Translation: AAD05200.1.
AL591024 Genomic DNA. Translation: CAH70633.1.
BC014461 mRNA. Translation: AAH14461.1.
CCDSiCCDS9328.1.
PIRiPN0625.
RefSeqiNP_001256.3. NM_001265.4.
UniGeneiHs.174249.
Hs.740844.

3D structure databases

ProteinModelPortaliQ99626.
SMRiQ99626. Positions 191-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107475. 9 interactions.
STRINGi9606.ENSP00000370408.

PTM databases

PhosphoSiteiQ99626.

Polymorphism and mutation databases

BioMutaiCdx2.
DMDMi311033469.

Proteomic databases

MaxQBiQ99626.
PaxDbiQ99626.
PRIDEiQ99626.

Protocols and materials databases

DNASUi1045.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381020; ENSP00000370408; ENSG00000165556.
GeneIDi1045.
KEGGihsa:1045.
UCSCiuc001urv.4. human.

Organism-specific databases

CTDi1045.
GeneCardsiGC13M028536.
HGNCiHGNC:1806. CDX2.
HPAiCAB002221.
HPA045669.
HPA049580.
MIMi600297. gene.
neXtProtiNX_Q99626.
PharmGKBiPA26352.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG304047.
GeneTreeiENSGT00530000063388.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiQ99626.
KOiK09312.
OMAiWMRKPTQ.
OrthoDBiEOG71P2BK.
PhylomeDBiQ99626.
TreeFamiTF351605.

Enzyme and pathway databases

ReactomeiREACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Miscellaneous databases

GeneWikiiCDX2.
GenomeRNAii1045.
NextBioi4381.
PROiQ99626.
SOURCEiSearch...

Gene expression databases

BgeeiQ99626.
CleanExiHS_CDX2.
GenevisibleiQ99626. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosome assignment of the human CDX2 gene."
    Drummond F.J., Putt W., Fox M., Edwards Y.H.
    Ann. Hum. Genet. 61:393-400(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-293.
  2. "Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis."
    Mallo G.V., Rechreche H., Frigerio J.-M., Rocha D., Zweibaum A., Lacasa M., Jordan B.R., Dusetti N.J., Dagorn J.-C., Iovanna J.L.
    Int. J. Cancer 74:35-44(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-293.
    Tissue: Colon carcinoma.
  3. "The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis."
    Sivagnanasundaram S., Islam I., Talbot I., Drummond F., Walters J.R., Edwards Y.H.
    Br. J. Cancer 84:218-225(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-293.
  4. "Isolation, characterization, and linkage mapping of the human caudal-type homeobox gene, CDX2/3."
    Tanizawa Y., Ueda K., Inoue H., Ayame H., Aoki M., Kuwano A., German M.S., Liu L., Donis-Keller H., Permutt M.A., Oka Y.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-293.
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-293.
    Tissue: Colon.
  7. "Identification of homeobox genes expressed in human T-lymphocytes."
    Inamori K., Takeshita K., Chiba S., Yazaki Y., Hirai H.
    Biochem. Biophys. Res. Commun. 196:203-208(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-232.
    Tissue: T-cell.

Entry informationi

Entry nameiCDX2_HUMAN
AccessioniPrimary (citable) accession number: Q99626
Secondary accession number(s): O00503
, Q5VTU7, Q969L8, Q9UD92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2010
Last modified: June 24, 2015
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.