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Q99624

- S38A3_HUMAN

UniProt

Q99624 - S38A3_HUMAN

Protein

Sodium-coupled neutral amino acid transporter 3

Gene

SLC38A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.By similarity1 Publication1 Publication

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-KW
    2. L-alanine transmembrane transporter activity Source: UniProtKB
    3. L-asparagine transmembrane transporter activity Source: UniProtKB
    4. L-glutamine transmembrane transporter activity Source: UniProtKB
    5. L-histidine transmembrane transporter activity Source: UniProtKB
    6. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. amino acid transport Source: Reactome
    2. asparagine transport Source: UniProtKB
    3. glutamine transport Source: UniProtKB
    4. histidine transport Source: UniProtKB
    5. ion transport Source: Reactome
    6. L-alanine transport Source: UniProtKB
    7. sodium ion transport Source: UniProtKB-KW
    8. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Amino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.18.6.3. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 3
    Alternative name(s):
    N-system amino acid transporter 1
    Na(+)-coupled neutral amino acid transporter 3
    Solute carrier family 38 member 3
    System N amino acid transporter 1
    Gene namesi
    Name:SLC38A3Imported
    Synonyms:G17, NAT1, SN1, SNAT3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:18044. SLC38A3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: LIFEdb

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38281.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Sodium-coupled neutral amino acid transporter 3PRO_0000093828Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ99624.
    PRIDEiQ99624.

    PTM databases

    PhosphoSiteiQ99624.

    Expressioni

    Gene expression databases

    CleanExiHS_NAT1.
    HS_SLC38A3.
    GenevestigatoriQ99624.

    Interactioni

    Protein-protein interaction databases

    BioGridi116187. 4 interactions.
    IntActiQ99624. 3 interactions.
    MINTiMINT-1384272.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99624.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei408 – 42821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei431 – 45121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei471 – 49121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG059571.
    InParanoidiQ99624.
    KOiK13576.
    PhylomeDBiQ99624.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99624-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAPLQTEMV ELVPNGKHSE GLLPVITPMA GNQRVEDPAR SCMEGKSFLQ    50
    KSPSKEPHFT DFEGKTSFGM SVFNLSNAIM GSGILGLAYA MANTGIILFL 100
    FLLTAVALLS SYSIHLLLKS SGVVGIRAYE QLGYRAFGTP GKLAAALAIT 150
    LQNIGAMSSY LYIIKSELPL VIQTFLNLEE KTSDWYMNGN YLVILVSVTI 200
    ILPLALMRQL GYLGYSSGFS LSCMVFFLIA VIYKKFHVPC PLPPNFNNTT 250
    GNFSHVEIVK EKVQLQVEPE ASAFCTPSYF TLNSQTAYTI PIMAFAFVCH 300
    PEVLPIYTEL KDPSKKKMQH ISNLSIAVMY IMYFLAALFG YLTFYNGVES 350
    ELLHTYSKVD PFDVLILCVR VAVLTAVTLT VPIVLFPVRR AIQQMLFPNQ 400
    EFSWLRHVLI AVGLLTCINL LVIFAPNILG IFGVIGATSA PFLIFIFPAI 450
    FYFRIMPTEK EPARSTPKIL ALCFAMLGFL LMTMSLSFII IDWASGTSRH 500
    GGNH 504
    Length:504
    Mass (Da):55,773
    Last modified:May 1, 1997 - v1
    Checksum:i86E7D205C6001C60
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121L → P in CAG33251. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244548 mRNA. Translation: AAG15313.1.
    U49082 mRNA. Translation: AAB47236.1.
    CR456970 mRNA. Translation: CAG33251.1.
    AK313461 mRNA. Translation: BAG36247.1.
    BX537382 mRNA. Translation: CAD97624.1.
    AC002077 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65050.1.
    BC042875 mRNA. Translation: AAH42875.1.
    RefSeqiNP_006832.1. NM_006841.5.
    XP_006713017.1. XM_006712954.1.
    UniGeneiHs.76460.

    Genome annotation databases

    GeneIDi10991.
    KEGGihsa:10991.
    UCSCiuc003cyn.4. human.

    Polymorphism databases

    DMDMi52783419.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244548 mRNA. Translation: AAG15313.1 .
    U49082 mRNA. Translation: AAB47236.1 .
    CR456970 mRNA. Translation: CAG33251.1 .
    AK313461 mRNA. Translation: BAG36247.1 .
    BX537382 mRNA. Translation: CAD97624.1 .
    AC002077 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65050.1 .
    BC042875 mRNA. Translation: AAH42875.1 .
    RefSeqi NP_006832.1. NM_006841.5.
    XP_006713017.1. XM_006712954.1.
    UniGenei Hs.76460.

    3D structure databases

    ProteinModelPortali Q99624.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116187. 4 interactions.
    IntActi Q99624. 3 interactions.
    MINTi MINT-1384272.

    Chemistry

    DrugBanki DB00174. L-Asparagine.
    DB00130. L-Glutamine.
    DB00117. L-Histidine.
    GuidetoPHARMACOLOGYi 1172.

    Protein family/group databases

    TCDBi 2.A.18.6.3. the amino acid/auxin permease (aaap) family.

    PTM databases

    PhosphoSitei Q99624.

    Polymorphism databases

    DMDMi 52783419.

    Proteomic databases

    MaxQBi Q99624.
    PRIDEi Q99624.

    Protocols and materials databases

    DNASUi 10991.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10991.
    KEGGi hsa:10991.
    UCSCi uc003cyn.4. human.

    Organism-specific databases

    CTDi 10991.
    GeneCardsi GC03P050244.
    HGNCi HGNC:18044. SLC38A3.
    MIMi 604437. gene.
    neXtProti NX_Q99624.
    PharmGKBi PA38281.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG059571.
    InParanoidi Q99624.
    KOi K13576.
    PhylomeDBi Q99624.

    Enzyme and pathway databases

    Reactomei REACT_13796. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    ChiTaRSi SLC38A3. human.
    GeneWikii SLC38A3.
    GenomeRNAii 10991.
    NextBioi 41767.
    PROi Q99624.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_NAT1.
    HS_SLC38A3.
    Genevestigatori Q99624.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter."
      Fei Y.-J., Sugawara M., Nakanishi T., Huang W., Wang H., Prasad P.D., Leibach F.H., Ganapathy V.
      J. Biol. Chem. 275:23707-23717(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: LiverImported.
    2. Latif F., Lerman M., Minna J., Duh F.-M., Koonin E., Bader S.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Corpus callosum.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.
    6. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    9. "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
      The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
      Lerman M.I., Minna J.D.
      Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.

    Entry informationi

    Entry nameiS38A3_HUMAN
    AccessioniPrimary (citable) accession number: Q99624
    Secondary accession number(s): B2R8Q0, Q6IB34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3