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Protein

Sodium-coupled neutral amino acid transporter 3

Gene

SLC38A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.By similarity1 Publication

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: Reactome
  • antiporter activity Source: UniProtKB-KW
  • L-alanine transmembrane transporter activity Source: UniProtKB
  • L-asparagine transmembrane transporter activity Source: UniProtKB
  • L-glutamine transmembrane transporter activity Source: UniProtKB
  • L-histidine transmembrane transporter activity Source: UniProtKB
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145063-MONOMER.
ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.18.6.3. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 3
Alternative name(s):
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
Solute carrier family 38 member 3
System N amino acid transporter 1
Gene namesi
Name:SLC38A3Imported
Synonyms:G17, NAT1, SN1, SNAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18044. SLC38A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10991.
OpenTargetsiENSG00000188338.
PharmGKBiPA38281.

Chemistry databases

DrugBankiDB00174. L-Asparagine.
DB00130. L-Glutamine.
DB00117. L-Histidine.

Polymorphism and mutation databases

BioMutaiSLC38A3.
DMDMi52783419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938281 – 504Sodium-coupled neutral amino acid transporter 3Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Glycosylationi247N-linked (GlcNAc...)Sequence analysis1
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Glycosylationi323N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ99624.
PeptideAtlasiQ99624.
PRIDEiQ99624.

PTM databases

iPTMnetiQ99624.
PhosphoSitePlusiQ99624.

Expressioni

Gene expression databases

CleanExiHS_NAT1.
HS_SLC38A3.
ExpressionAtlasiQ99624. baseline and differential.
GenevisibleiQ99624. HS.

Interactioni

Protein-protein interaction databases

BioGridi116187. 5 interactors.
IntActiQ99624. 3 interactors.
MINTiMINT-1384272.

Structurei

3D structure databases

ProteinModelPortaliQ99624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119147.
HOVERGENiHBG059571.
InParanoidiQ99624.
KOiK13576.
OMAiGHEWEYD.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ99624.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPLQTEMV ELVPNGKHSE GLLPVITPMA GNQRVEDPAR SCMEGKSFLQ
60 70 80 90 100
KSPSKEPHFT DFEGKTSFGM SVFNLSNAIM GSGILGLAYA MANTGIILFL
110 120 130 140 150
FLLTAVALLS SYSIHLLLKS SGVVGIRAYE QLGYRAFGTP GKLAAALAIT
160 170 180 190 200
LQNIGAMSSY LYIIKSELPL VIQTFLNLEE KTSDWYMNGN YLVILVSVTI
210 220 230 240 250
ILPLALMRQL GYLGYSSGFS LSCMVFFLIA VIYKKFHVPC PLPPNFNNTT
260 270 280 290 300
GNFSHVEIVK EKVQLQVEPE ASAFCTPSYF TLNSQTAYTI PIMAFAFVCH
310 320 330 340 350
PEVLPIYTEL KDPSKKKMQH ISNLSIAVMY IMYFLAALFG YLTFYNGVES
360 370 380 390 400
ELLHTYSKVD PFDVLILCVR VAVLTAVTLT VPIVLFPVRR AIQQMLFPNQ
410 420 430 440 450
EFSWLRHVLI AVGLLTCINL LVIFAPNILG IFGVIGATSA PFLIFIFPAI
460 470 480 490 500
FYFRIMPTEK EPARSTPKIL ALCFAMLGFL LMTMSLSFII IDWASGTSRH

GGNH
Length:504
Mass (Da):55,773
Last modified:May 1, 1997 - v1
Checksum:i86E7D205C6001C60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → P in CAG33251 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244548 mRNA. Translation: AAG15313.1.
U49082 mRNA. Translation: AAB47236.1.
CR456970 mRNA. Translation: CAG33251.1.
AK313461 mRNA. Translation: BAG36247.1.
BX537382 mRNA. Translation: CAD97624.1.
AC002077 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65050.1.
BC042875 mRNA. Translation: AAH42875.1.
CCDSiCCDS74940.1.
RefSeqiNP_006832.1. NM_006841.5.
XP_006713017.1. XM_006712954.2.
UniGeneiHs.76460.

Genome annotation databases

EnsembliENST00000614032; ENSP00000481301; ENSG00000188338.
GeneIDi10991.
KEGGihsa:10991.
UCSCiuc032rmu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244548 mRNA. Translation: AAG15313.1.
U49082 mRNA. Translation: AAB47236.1.
CR456970 mRNA. Translation: CAG33251.1.
AK313461 mRNA. Translation: BAG36247.1.
BX537382 mRNA. Translation: CAD97624.1.
AC002077 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65050.1.
BC042875 mRNA. Translation: AAH42875.1.
CCDSiCCDS74940.1.
RefSeqiNP_006832.1. NM_006841.5.
XP_006713017.1. XM_006712954.2.
UniGeneiHs.76460.

3D structure databases

ProteinModelPortaliQ99624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116187. 5 interactors.
IntActiQ99624. 3 interactors.
MINTiMINT-1384272.

Chemistry databases

DrugBankiDB00174. L-Asparagine.
DB00130. L-Glutamine.
DB00117. L-Histidine.

Protein family/group databases

TCDBi2.A.18.6.3. the amino acid/auxin permease (aaap) family.

PTM databases

iPTMnetiQ99624.
PhosphoSitePlusiQ99624.

Polymorphism and mutation databases

BioMutaiSLC38A3.
DMDMi52783419.

Proteomic databases

MaxQBiQ99624.
PeptideAtlasiQ99624.
PRIDEiQ99624.

Protocols and materials databases

DNASUi10991.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614032; ENSP00000481301; ENSG00000188338.
GeneIDi10991.
KEGGihsa:10991.
UCSCiuc032rmu.2. human.

Organism-specific databases

CTDi10991.
DisGeNETi10991.
GeneCardsiSLC38A3.
HGNCiHGNC:18044. SLC38A3.
MIMi604437. gene.
neXtProtiNX_Q99624.
OpenTargetsiENSG00000188338.
PharmGKBiPA38281.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119147.
HOVERGENiHBG059571.
InParanoidiQ99624.
KOiK13576.
OMAiGHEWEYD.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ99624.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145063-MONOMER.
ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSLC38A3. human.
GeneWikiiSLC38A3.
GenomeRNAii10991.
PROiQ99624.
SOURCEiSearch...

Gene expression databases

CleanExiHS_NAT1.
HS_SLC38A3.
ExpressionAtlasiQ99624. baseline and differential.
GenevisibleiQ99624. HS.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS38A3_HUMAN
AccessioniPrimary (citable) accession number: Q99624
Secondary accession number(s): B2R8Q0, Q6IB34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.