Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99624

- S38A3_HUMAN

UniProt

Q99624 - S38A3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sodium-coupled neutral amino acid transporter 3

Gene

SLC38A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.By similarity1 Publication

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-KW
  2. L-alanine transmembrane transporter activity Source: UniProtKB
  3. L-asparagine transmembrane transporter activity Source: UniProtKB
  4. L-glutamine transmembrane transporter activity Source: UniProtKB
  5. L-histidine transmembrane transporter activity Source: UniProtKB
  6. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. asparagine transport Source: UniProtKB
  3. glutamine transport Source: UniProtKB
  4. histidine transport Source: UniProtKB
  5. ion transport Source: Reactome
  6. L-alanine transport Source: UniProtKB
  7. sodium ion transport Source: UniProtKB-KW
  8. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.18.6.3. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 3
Alternative name(s):
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
Solute carrier family 38 member 3
System N amino acid transporter 1
Gene namesi
Name:SLC38A3Imported
Synonyms:G17, NAT1, SN1, SNAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:18044. SLC38A3.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence AnalysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence AnalysisAdd
BLAST
Transmembranei408 – 42821HelicalSequence AnalysisAdd
BLAST
Transmembranei431 – 45121HelicalSequence AnalysisAdd
BLAST
Transmembranei471 – 49121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Sodium-coupled neutral amino acid transporter 3PRO_0000093828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ99624.
PRIDEiQ99624.

PTM databases

PhosphoSiteiQ99624.

Expressioni

Gene expression databases

CleanExiHS_NAT1.
HS_SLC38A3.
GenevestigatoriQ99624.

Interactioni

Protein-protein interaction databases

BioGridi116187. 4 interactions.
IntActiQ99624. 3 interactions.
MINTiMINT-1384272.

Structurei

3D structure databases

ProteinModelPortaliQ99624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119147.
HOVERGENiHBG059571.
InParanoidiQ99624.
KOiK13576.
PhylomeDBiQ99624.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99624-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAPLQTEMV ELVPNGKHSE GLLPVITPMA GNQRVEDPAR SCMEGKSFLQ
60 70 80 90 100
KSPSKEPHFT DFEGKTSFGM SVFNLSNAIM GSGILGLAYA MANTGIILFL
110 120 130 140 150
FLLTAVALLS SYSIHLLLKS SGVVGIRAYE QLGYRAFGTP GKLAAALAIT
160 170 180 190 200
LQNIGAMSSY LYIIKSELPL VIQTFLNLEE KTSDWYMNGN YLVILVSVTI
210 220 230 240 250
ILPLALMRQL GYLGYSSGFS LSCMVFFLIA VIYKKFHVPC PLPPNFNNTT
260 270 280 290 300
GNFSHVEIVK EKVQLQVEPE ASAFCTPSYF TLNSQTAYTI PIMAFAFVCH
310 320 330 340 350
PEVLPIYTEL KDPSKKKMQH ISNLSIAVMY IMYFLAALFG YLTFYNGVES
360 370 380 390 400
ELLHTYSKVD PFDVLILCVR VAVLTAVTLT VPIVLFPVRR AIQQMLFPNQ
410 420 430 440 450
EFSWLRHVLI AVGLLTCINL LVIFAPNILG IFGVIGATSA PFLIFIFPAI
460 470 480 490 500
FYFRIMPTEK EPARSTPKIL ALCFAMLGFL LMTMSLSFII IDWASGTSRH

GGNH
Length:504
Mass (Da):55,773
Last modified:May 1, 1997 - v1
Checksum:i86E7D205C6001C60
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121L → P in CAG33251. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244548 mRNA. Translation: AAG15313.1.
U49082 mRNA. Translation: AAB47236.1.
CR456970 mRNA. Translation: CAG33251.1.
AK313461 mRNA. Translation: BAG36247.1.
BX537382 mRNA. Translation: CAD97624.1.
AC002077 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65050.1.
BC042875 mRNA. Translation: AAH42875.1.
CCDSiCCDS74940.1.
RefSeqiNP_006832.1. NM_006841.5.
XP_006713017.1. XM_006712954.1.
UniGeneiHs.76460.

Genome annotation databases

EnsembliENST00000614032; ENSP00000481301; ENSG00000188338.
GeneIDi10991.
KEGGihsa:10991.
UCSCiuc003cyn.4. human.

Polymorphism databases

DMDMi52783419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244548 mRNA. Translation: AAG15313.1 .
U49082 mRNA. Translation: AAB47236.1 .
CR456970 mRNA. Translation: CAG33251.1 .
AK313461 mRNA. Translation: BAG36247.1 .
BX537382 mRNA. Translation: CAD97624.1 .
AC002077 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65050.1 .
BC042875 mRNA. Translation: AAH42875.1 .
CCDSi CCDS74940.1.
RefSeqi NP_006832.1. NM_006841.5.
XP_006713017.1. XM_006712954.1.
UniGenei Hs.76460.

3D structure databases

ProteinModelPortali Q99624.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116187. 4 interactions.
IntActi Q99624. 3 interactions.
MINTi MINT-1384272.

Chemistry

DrugBanki DB00174. L-Asparagine.
DB00130. L-Glutamine.
DB00117. L-Histidine.
GuidetoPHARMACOLOGYi 1172.

Protein family/group databases

TCDBi 2.A.18.6.3. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSitei Q99624.

Polymorphism databases

DMDMi 52783419.

Proteomic databases

MaxQBi Q99624.
PRIDEi Q99624.

Protocols and materials databases

DNASUi 10991.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000614032 ; ENSP00000481301 ; ENSG00000188338 .
GeneIDi 10991.
KEGGi hsa:10991.
UCSCi uc003cyn.4. human.

Organism-specific databases

CTDi 10991.
GeneCardsi GC03P050244.
HGNCi HGNC:18044. SLC38A3.
MIMi 604437. gene.
neXtProti NX_Q99624.
PharmGKBi PA38281.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119147.
HOVERGENi HBG059571.
InParanoidi Q99624.
KOi K13576.
PhylomeDBi Q99624.

Enzyme and pathway databases

Reactomei REACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSi SLC38A3. human.
GeneWikii SLC38A3.
GenomeRNAii 10991.
NextBioi 41767.
PROi Q99624.
SOURCEi Search...

Gene expression databases

CleanExi HS_NAT1.
HS_SLC38A3.
Genevestigatori Q99624.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter."
    Fei Y.-J., Sugawara M., Nakanishi T., Huang W., Wang H., Prasad P.D., Leibach F.H., Ganapathy V.
    J. Biol. Chem. 275:23707-23717(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: LiverImported.
  2. Latif F., Lerman M., Minna J., Duh F.-M., Koonin E., Bader S.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Corpus callosum.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  6. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  9. "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
    The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
    Lerman M.I., Minna J.D.
    Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiS38A3_HUMAN
AccessioniPrimary (citable) accession number: Q99624
Secondary accession number(s): B2R8Q0, Q6IB34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3