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Protein

Prohibitin-2

Gene

PHB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.1 PublicationBy similarity1 Publication

GO - Molecular functioni

  • amide binding Source: UniProtKB
  • estrogen receptor binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

  • cellular response to calcium ion Source: ARUK-UCL
  • cellular response to hypoxia Source: Ensembl
  • cellular response to retinoic acid Source: Ensembl
  • mammary gland alveolus development Source: Ensembl
  • mammary gland branching involved in thelarche Source: Ensembl
  • mitochondrial calcium ion transmembrane transport Source: Reactome
  • mitochondrion organization Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of DNA binding transcription factor activity Source: UniProtKB
  • negative regulation of intracellular estrogen receptor signaling pathway Source: Ensembl
  • negative regulation of mammary gland epithelial cell proliferation Source: Ensembl
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of cell cycle G1/S phase transition Source: UniProtKB
  • positive regulation of DNA binding transcription factor activity Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of exit from mitosis Source: UniProtKB
  • protein import into nucleus, translocation Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
  • response to wounding Source: Ensembl
  • sister chromatid cohesion Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8949664 Processing of SMDT1
SIGNORiQ99623

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin-2
Alternative name(s):
B-cell receptor-associated protein BAP37
D-prohibitin
Repressor of estrogen receptor activity
Gene namesi
Name:PHB2Imported
Synonyms:BAPImported, REAImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000215021.8
HGNCiHGNC:30306 PHB2
MIMi610704 gene
neXtProtiNX_Q99623

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11331
OpenTargetsiENSG00000215021
PharmGKBiPA142671181

Polymorphism and mutation databases

BioMutaiPHB2
DMDMi74752151

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002138842 – 299Prohibitin-2Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei128PhosphotyrosineCombined sources1
Modified residuei147N6-acetyllysineBy similarity1
Modified residuei151PhosphoserineCombined sources1
Modified residuei200N6-acetyllysineBy similarity1
Modified residuei236N6-acetyllysineBy similarity1
Modified residuei250N6-acetyllysineCombined sources1
Modified residuei262N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99623
MaxQBiQ99623
PaxDbiQ99623
PeptideAtlasiQ99623
PRIDEiQ99623
TopDownProteomicsiQ99623-1 [Q99623-1]
Q99623-2 [Q99623-2]

2D gel databases

OGPiQ99623

PTM databases

CarbonylDBiQ99623
iPTMnetiQ99623
PhosphoSitePlusiQ99623
SwissPalmiQ99623

Expressioni

Developmental stagei

Levels of expression in fibroblasts decrease heterogeneously during cellular aging.1 Publication

Inductioni

Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.1 Publication

Gene expression databases

BgeeiENSG00000215021
CleanExiHS_PHB2
ExpressionAtlasiQ99623 baseline and differential
GenevisibleiQ99623 HS

Organism-specific databases

HPAiCAB014889
CAB026335
HPA039874

Interactioni

Subunit structurei

Interacts with PHB, ESR1, HDAC1 and HDAC5 (By similarity). Interacts with ZNF703 (PubMed:21328542). Interacts with STOML2 (PubMed:21746876). Interacts with ARFGEF3 (PubMed:19496786).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033724EBI-358348,EBI-78473

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116459, 179 interactors
CORUMiQ99623
IntActiQ99623, 75 interactors
MINTiQ99623
STRINGi9606.ENSP00000441875

Structurei

3D structure databases

ProteinModelPortaliQ99623
SMRiQ99623
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 49Necessary for transcriptional repression1 PublicationAdd BLAST31
Regioni150 – 174Necessary for transcriptional repression1 PublicationAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 238Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the prohibitin family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3090 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000075076
HOGENOMiHOG000205692
HOVERGENiHBG004457
InParanoidiQ99623
KOiK17081
OMAiELGTDYD
OrthoDBiEOG091G0IHW
PhylomeDBiQ99623
TreeFamiTF354230

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99623-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQNLKDLAG RLPAGPRGMG TALKLLLGAG AVAYGVRESV FTVEGGHRAI
60 70 80 90 100
FFNRIGGVQQ DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ
110 120 130 140 150
MVNISLRVLS RPNAQELPSM YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA
160 170 180 190 200
SQLITQRAQV SLLIRRELTE RAKDFSLILD DVAITELSFS REYTAAVEAK
210 220 230 240 250
QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE ALSKNPGYIK
260 270 280 290
LRKIRAAQNI SKTIATSQNR IYLTADNLVL NLQDESFTRG SDSLIKGKK
Length:299
Mass (Da):33,296
Last modified:July 1, 1997 - v2
Checksum:iA887CC982BF85C80
GO
Isoform 2 (identifier: Q99623-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-240: Missing.

Show »
Length:261
Mass (Da):29,044
Checksum:iF698CB300517B30A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045311203 – 240Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72511 mRNA Translation: AAC51639.1
AF150962 mRNA Translation: AAD38042.1
AF178980 mRNA Translation: AAF44345.1
AF126021 mRNA Translation: AAF17231.1
AK298217 mRNA Translation: BAG60487.1
U47924 Genomic DNA Translation: AAB51324.1
BC014766 mRNA Translation: AAH14766.1
BC110322 mRNA Translation: AAI10323.1
CCDSiCCDS53741.1 [Q99623-1]
CCDS58207.1 [Q99623-2]
RefSeqiNP_001138303.1, NM_001144831.1 [Q99623-1]
NP_001254629.1, NM_001267700.1 [Q99623-2]
UniGeneiHs.504620

Genome annotation databases

EnsembliENST00000440277; ENSP00000412856; ENSG00000215021 [Q99623-2]
ENST00000535923; ENSP00000441875; ENSG00000215021 [Q99623-1]
GeneIDi11331
KEGGihsa:11331
UCSCiuc058kpb.1 human [Q99623-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPHB2_HUMAN
AccessioniPrimary (citable) accession number: Q99623
Secondary accession number(s): B4DP75
, Q2YDA4, Q7KYU3, Q92978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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