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Protein

C-C motif chemokine 13

Gene

CCL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB
  • receptor binding Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cellular calcium ion homeostasis Source: ProtInc
  • cellular response to interferon-gamma Source: GO_Central
  • cellular response to interleukin-1 Source: GO_Central
  • cellular response to tumor necrosis factor Source: GO_Central
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • cytoskeleton organization Source: UniProtKB
  • eosinophil chemotaxis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • inflammatory response Source: ProtInc
  • lymphocyte chemotaxis Source: GO_Central
  • monocyte chemotaxis Source: GO_Central
  • neutrophil chemotaxis Source: GO_Central
  • positive regulation of ERK1 and ERK2 cascade Source: GO_Central
  • positive regulation of GTPase activity Source: GO_Central
  • positive regulation of inflammatory response Source: GO_Central
  • regulation of cell shape Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181374-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 13
Alternative name(s):
CK-beta-10
Monocyte chemoattractant protein 4
Monocyte chemotactic protein 4
Short name:
MCP-4
NCC-1
Small-inducible cytokine A13
Cleaved into the following 3 chains:
Gene namesi
Name:CCL13
Synonyms:MCP4, NCC1, SCYA13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10611. CCL13.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6357.
OpenTargetsiENSG00000181374.
PharmGKBiPA35544.

Polymorphism and mutation databases

BioMutaiCCL13.
DMDMi3024128.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000000520117 – 98C-C motif chemokine 13, long chainAdd BLAST82
ChainiPRO_000000520222 – 98C-C motif chemokine 13, medium chainAdd BLAST77
ChainiPRO_000000520324 – 98C-C motif chemokine 13, short chainAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid; in short chain1 Publication1
Disulfide bondi34 ↔ 581 Publication
Disulfide bondi35 ↔ 741 Publication

Post-translational modificationi

One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ99616.
PRIDEiQ99616.

PTM databases

PhosphoSitePlusiQ99616.

Miscellaneous databases

PMAP-CutDBQ99616.

Expressioni

Tissue specificityi

Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.

Inductioni

By IL1/interleukin-1 and TNF.

Gene expression databases

BgeeiENSG00000181374.
CleanExiHS_CCL13.
ExpressionAtlasiQ99616. baseline and differential.
GenevisibleiQ99616. HS.

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB
  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi112260. 2 interactors.
DIPiDIP-5874N.
IntActiQ99616. 1 interactor.
MINTiMINT-103367.
STRINGi9606.ENSP00000225844.

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 34Combined sources3
Helixi45 – 47Combined sources3
Beta strandi48 – 53Combined sources6
Beta strandi58 – 60Combined sources3
Beta strandi63 – 67Combined sources5
Beta strandi72 – 75Combined sources4
Helixi80 – 89Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RA4X-ray1.70A/B24-98[»]
ProteinModelPortaliQ99616.
SMRiQ99616.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99616.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEQZ. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
InParanoidiQ99616.
KOiK16595.
OMAiSTCCFIF.
OrthoDBiEOG091G14KV.
PhylomeDBiQ99616.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAVLLCL LLMTAAFNPQ GLAQPDALNV PSTCCFTFSS KKISLQRLKS
60 70 80 90
YVITTSRCPQ KAVIFRTKLG KEICADPKEK WVQNYMKHLG RKAHTLKT
Length:98
Mass (Da):10,986
Last modified:May 1, 1997 - v1
Checksum:i612688DFCD308873
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93 – 98AHTLKT → LTP in CAB01111 (Ref. 12) Curated6

Mass spectrometryi

Molecular mass is 9314±30 Da from positions 17 - 98. Determined by MALDI. 1 Publication
Molecular mass is 8760±30 Da from positions 22 - 98. Determined by MALDI. 1 Publication
Molecular mass is 8575±30 Da from positions 24 - 98. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0241695A → S.Corresponds to variant rs3136677dbSNPEnsembl.1
Natural variantiVAR_04870629N → S.Corresponds to variant rs34566308dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46767 mRNA. Translation: AAB38703.1.
X98306 mRNA. Translation: CAA66950.1.
U59808 mRNA. Translation: AAD09362.1.
AJ001634 mRNA. Translation: CAA04888.1.
BT007385 mRNA. Translation: AAP36049.1.
AC002482 Genomic DNA. Translation: AAB67307.1.
CR450337 mRNA. Translation: CAG29333.1.
CH471147 Genomic DNA. Translation: EAW80206.1.
BC008621 mRNA. Translation: AAH08621.1.
Z77650 mRNA. Translation: CAB01111.1.
CCDSiCCDS11281.1.
RefSeqiNP_005399.1. NM_005408.2.
UniGeneiHs.414629.

Genome annotation databases

EnsembliENST00000225844; ENSP00000225844; ENSG00000181374.
GeneIDi6357.
KEGGihsa:6357.
UCSCiuc002hic.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL13 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46767 mRNA. Translation: AAB38703.1.
X98306 mRNA. Translation: CAA66950.1.
U59808 mRNA. Translation: AAD09362.1.
AJ001634 mRNA. Translation: CAA04888.1.
BT007385 mRNA. Translation: AAP36049.1.
AC002482 Genomic DNA. Translation: AAB67307.1.
CR450337 mRNA. Translation: CAG29333.1.
CH471147 Genomic DNA. Translation: EAW80206.1.
BC008621 mRNA. Translation: AAH08621.1.
Z77650 mRNA. Translation: CAB01111.1.
CCDSiCCDS11281.1.
RefSeqiNP_005399.1. NM_005408.2.
UniGeneiHs.414629.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RA4X-ray1.70A/B24-98[»]
ProteinModelPortaliQ99616.
SMRiQ99616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112260. 2 interactors.
DIPiDIP-5874N.
IntActiQ99616. 1 interactor.
MINTiMINT-103367.
STRINGi9606.ENSP00000225844.

PTM databases

PhosphoSitePlusiQ99616.

Polymorphism and mutation databases

BioMutaiCCL13.
DMDMi3024128.

Proteomic databases

PaxDbiQ99616.
PRIDEiQ99616.

Protocols and materials databases

DNASUi6357.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225844; ENSP00000225844; ENSG00000181374.
GeneIDi6357.
KEGGihsa:6357.
UCSCiuc002hic.3. human.

Organism-specific databases

CTDi6357.
DisGeNETi6357.
GeneCardsiCCL13.
HGNCiHGNC:10611. CCL13.
MIMi601391. gene.
neXtProtiNX_Q99616.
OpenTargetsiENSG00000181374.
PharmGKBiPA35544.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEQZ. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
InParanoidiQ99616.
KOiK16595.
OMAiSTCCFIF.
OrthoDBiEOG091G14KV.
PhylomeDBiQ99616.
TreeFamiTF334888.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181374-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.

Miscellaneous databases

EvolutionaryTraceiQ99616.
GenomeRNAii6357.
PMAP-CutDBQ99616.
PROiQ99616.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181374.
CleanExiHS_CCL13.
ExpressionAtlasiQ99616. baseline and differential.
GenevisibleiQ99616. HS.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL13_HUMAN
AccessioniPrimary (citable) accession number: Q99616
Secondary accession number(s): O95689, Q6ICQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein can bind heparin.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.