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Q99616

- CCL13_HUMAN

UniProt

Q99616 - CCL13_HUMAN

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Protein

C-C motif chemokine 13

Gene

CCL13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.

GO - Molecular functioni

  1. chemokine activity Source: UniProtKB
  2. receptor binding Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cellular calcium ion homeostasis Source: ProtInc
  3. chemotaxis Source: ProtInc
  4. cytoskeleton organization Source: UniProtKB
  5. eosinophil chemotaxis Source: UniProtKB
  6. immune response Source: InterPro
  7. inflammatory response Source: ProtInc
  8. regulation of cell shape Source: UniProtKB
  9. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 13
Alternative name(s):
CK-beta-10
Monocyte chemoattractant protein 4
Monocyte chemotactic protein 4
Short name:
MCP-4
NCC-1
Small-inducible cytokine A13
Cleaved into the following 3 chains:
Gene namesi
Name:CCL13
Synonyms:MCP4, NCC1, SCYA13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10611. CCL13.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 PublicationAdd
BLAST
Chaini17 – 9882C-C motif chemokine 13, long chainPRO_0000005201Add
BLAST
Chaini22 – 9877C-C motif chemokine 13, medium chainPRO_0000005202Add
BLAST
Chaini24 – 9875C-C motif chemokine 13, short chainPRO_0000005203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid; in short chain1 Publication
Disulfide bondi34 ↔ 581 Publication
Disulfide bondi35 ↔ 741 Publication

Post-translational modificationi

One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ99616.
PRIDEiQ99616.

PTM databases

PhosphoSiteiQ99616.

Miscellaneous databases

PMAP-CutDBQ99616.

Expressioni

Tissue specificityi

Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.

Inductioni

By IL1/interleukin-1 and TNF.

Gene expression databases

BgeeiQ99616.
CleanExiHS_CCL13.
ExpressionAtlasiQ99616. baseline and differential.
GenevestigatoriQ99616.

Interactioni

Protein-protein interaction databases

BioGridi112260. 2 interactions.
DIPiDIP-5874N.
IntActiQ99616. 1 interaction.
MINTiMINT-103367.
STRINGi9606.ENSP00000225844.

Structurei

Secondary structure

1
98
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 343
Helixi45 – 473
Beta strandi48 – 536
Beta strandi58 – 603
Beta strandi63 – 675
Beta strandi72 – 754
Helixi80 – 8910

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RA4X-ray1.70A/B24-98[»]
ProteinModelPortaliQ99616.
SMRiQ99616. Positions 26-90.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99616.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG84946.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
InParanoidiQ99616.
KOiK16595.
OMAiCCFTFSS.
OrthoDBiEOG7C5MC2.
PhylomeDBiQ99616.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99616-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSAVLLCL LLMTAAFNPQ GLAQPDALNV PSTCCFTFSS KKISLQRLKS
60 70 80 90
YVITTSRCPQ KAVIFRTKLG KEICADPKEK WVQNYMKHLG RKAHTLKT
Length:98
Mass (Da):10,986
Last modified:May 1, 1997 - v1
Checksum:i612688DFCD308873
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 986AHTLKT → LTP in CAB01111. 1 PublicationCurated

Mass spectrometryi

Molecular mass is 9314±30 Da from positions 17 - 98. Determined by MALDI. 1 Publication
Molecular mass is 8760±30 Da from positions 22 - 98. Determined by MALDI. 1 Publication
Molecular mass is 8575±30 Da from positions 24 - 98. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51A → S.
Corresponds to variant rs3136677 [ dbSNP | Ensembl ].
VAR_024169
Natural varianti29 – 291N → S.
Corresponds to variant rs34566308 [ dbSNP | Ensembl ].
VAR_048706

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46767 mRNA. Translation: AAB38703.1.
X98306 mRNA. Translation: CAA66950.1.
U59808 mRNA. Translation: AAD09362.1.
AJ001634 mRNA. Translation: CAA04888.1.
BT007385 mRNA. Translation: AAP36049.1.
AC002482 Genomic DNA. Translation: AAB67307.1.
CR450337 mRNA. Translation: CAG29333.1.
CH471147 Genomic DNA. Translation: EAW80206.1.
BC008621 mRNA. Translation: AAH08621.1.
Z77650 mRNA. Translation: CAB01111.1.
CCDSiCCDS11281.1.
RefSeqiNP_005399.1. NM_005408.2.
UniGeneiHs.414629.

Genome annotation databases

EnsembliENST00000225844; ENSP00000225844; ENSG00000181374.
GeneIDi6357.
KEGGihsa:6357.
UCSCiuc002hic.3. human.

Polymorphism databases

DMDMi3024128.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL13 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46767 mRNA. Translation: AAB38703.1 .
X98306 mRNA. Translation: CAA66950.1 .
U59808 mRNA. Translation: AAD09362.1 .
AJ001634 mRNA. Translation: CAA04888.1 .
BT007385 mRNA. Translation: AAP36049.1 .
AC002482 Genomic DNA. Translation: AAB67307.1 .
CR450337 mRNA. Translation: CAG29333.1 .
CH471147 Genomic DNA. Translation: EAW80206.1 .
BC008621 mRNA. Translation: AAH08621.1 .
Z77650 mRNA. Translation: CAB01111.1 .
CCDSi CCDS11281.1.
RefSeqi NP_005399.1. NM_005408.2.
UniGenei Hs.414629.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RA4 X-ray 1.70 A/B 24-98 [» ]
ProteinModelPortali Q99616.
SMRi Q99616. Positions 26-90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112260. 2 interactions.
DIPi DIP-5874N.
IntActi Q99616. 1 interaction.
MINTi MINT-103367.
STRINGi 9606.ENSP00000225844.

PTM databases

PhosphoSitei Q99616.

Polymorphism databases

DMDMi 3024128.

Proteomic databases

PaxDbi Q99616.
PRIDEi Q99616.

Protocols and materials databases

DNASUi 6357.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225844 ; ENSP00000225844 ; ENSG00000181374 .
GeneIDi 6357.
KEGGi hsa:6357.
UCSCi uc002hic.3. human.

Organism-specific databases

CTDi 6357.
GeneCardsi GC17P032684.
HGNCi HGNC:10611. CCL13.
MIMi 601391. gene.
neXtProti NX_Q99616.
PharmGKBi PA35544.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84946.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
InParanoidi Q99616.
KOi K16595.
OMAi CCFTFSS.
OrthoDBi EOG7C5MC2.
PhylomeDBi Q99616.
TreeFami TF334888.

Miscellaneous databases

EvolutionaryTracei Q99616.
GenomeRNAii 6357.
NextBioi 24692.
PMAP-CutDB Q99616.
PROi Q99616.
SOURCEi Search...

Gene expression databases

Bgeei Q99616.
CleanExi HS_CCL13.
ExpressionAtlasi Q99616. baseline and differential.
Genevestigatori Q99616.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of MCP-4, a novel CC chemokine related to MCP-1 and eotaxin."
    Power C.A., Meyer A., Rison S.C.G., Guye-Coulin F., Wells T.N.C.
    Eur. Cytokine Netw. 7:513-513(1996)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3."
    Garcia-Zepeda E.A., Combadiere C., Rothenberg M.E., Sarafi M.N., Lavigne F., Hamid Q., Murphy P.M., Luster A.D.
    J. Immunol. 157:5613-5626(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin."
    Uguccioni M., Loetscher P., Forssmann U., Dewald B., Li H., Lima S.H., Li Y., Kreider B., Garotta G., Thelen M., Baggiolini M.
    J. Exp. Med. 183:2379-2384(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 17-98, PYROGLUTAMATE FORMATION AT GLN-24, MASS SPECTROMETRY.
    Tissue: Fetus.
  4. "Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B."
    Berkhout T.A., Sarau H.M., Moores K., White J.R., Elshourbagy N., Appelbaum E., Reape T.J., Brawner M., Makwana J., Foley J.J., Schmidt D.B., Imburgia C., Macnulty D., Matthews J., O'Donnell K., O'Shannessy D., Scott M., Groot P.H.E., Macphee C.
    J. Biol. Chem. 272:16404-16413(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-33, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetus.
  5. "Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2."
    Godiska R., Chantry D., Raport C.J., Schweickart V.L., Trong H.L., Gray P.W.
    J. Leukoc. Biol. 61:353-360(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines."
    Hein H., Schluter C., Kulke R., Christophers E., Schroeder J.-M., Bartels J.
    Biochem. Biophys. Res. Commun. 255:470-476(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin fibroblast.
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  12. "Expression of a MCP-4 like novel CC-chemokine in human dermal fibroblasts: molecular cloning and RT-PCR analysis."
    Bartels J.H., Schlueter C., Richter E., Noso N., Christophers E., Schroeder J.-M.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-95.
    Tissue: Foreskin.
  13. "Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13)."
    Barinka C., Prahl A., Lubkowski J.
    Acta Crystallogr. D 64:273-278(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 24-98, DISULFIDE BONDS.

Entry informationi

Entry nameiCCL13_HUMAN
AccessioniPrimary (citable) accession number: Q99616
Secondary accession number(s): O95689, Q6ICQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein can bind heparin.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3