ID   DNJC7_HUMAN             Reviewed;         494 AA.
AC   Q99615;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   09-FEB-2010, entry version 94.
DE   RecName: Full=DnaJ homolog subfamily C member 7;
DE   AltName: Full=Tetratricopeptide repeat protein 2;
DE            Short=TPR repeat protein 2;
GN   Name=DNAJC7; Synonyms=TPR2, TTC2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 3-494.
RX   MEDLINE=96433003; PubMed=8836031; DOI=10.1089/dna.1996.15.727;
RA   Murthy A.E., Bernards A., Church D., Wasmuth J., Gusella J.F.;
RT   "Identification and characterization of two novel tetratricopeptide
RT   repeat-containing genes.";
RL   DNA Cell Biol. 15:727-735(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 2-26; 69-77; 80-90; 138-156; 192-238; 274-291 AND
RP   430-442, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryonic kidney;
RA   Bienvenut W.V., Waridel P., Quadroni M.;
RL   Submitted (MAR-2009) to UniProtKB.
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-50, AND MASS
RP   SPECTROMETRY.
RX   PubMed=15592455; DOI=10.1038/nbt1046;
RA   Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA   Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT   "Immunoaffinity profiling of tyrosine phosphorylation in cancer
RT   cells.";
RL   Nat. Biotechnol. 23:94-101(2005).
RN   [5]
RP   IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
RN   [6]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA   Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT   a refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
CC   -!- SUBUNIT: Interacts with the GAP domain of NF1.
CC   -!- SIMILARITY: Contains 1 J domain.
CC   -!- SIMILARITY: Contains 9 TPR repeats.
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DR   EMBL; U46571; AAB36872.1; ALT_INIT; mRNA.
DR   EMBL; BC011837; AAH11837.2; -; mRNA.
DR   EMBL; BC033772; AAH33772.1; ALT_INIT; mRNA.
DR   IPI; IPI00329629; -.
DR   RefSeq; NP_003306.3; -.
DR   UniGene; Hs.500156; -.
DR   SMR; Q99615; 34-354, 377-478.
DR   IntAct; Q99615; 3.
DR   STRING; Q99615; -.
DR   PhosphoSite; Q99615; -.
DR   PeptideAtlas; Q99615; -.
DR   PRIDE; Q99615; -.
DR   Ensembl; ENST00000457167; ENSP00000406463; ENSG00000168259; Homo sapiens.
DR   GeneID; 7266; -.
DR   CTD; 7266; -.
DR   GeneCards; GC17M037382; -.
DR   H-InvDB; HIX0013829; -.
DR   HGNC; HGNC:12392; DNAJC7.
DR   HPA; HPA023015; -.
DR   MIM; 601964; gene.
DR   PharmGKB; PA27424; -.
DR   HOGENOM; HBG717809; -.
DR   HOVERGEN; Q99615; -.
DR   InParanoid; Q99615; -.
DR   OMA; AVIEYEK; -.
DR   OrthoDB; EOG9X0QCT; -.
DR   PhylomeDB; Q99615; -.
DR   NextBio; 28407; -.
DR   PMAP-CutDB; Q99615; -.
DR   ArrayExpress; Q99615; -.
DR   Bgee; Q99615; -.
DR   CleanEx; HS_DNAJC7; -.
DR   Genevestigator; Q99615; -.
DR   GermOnline; ENSG00000168259; Homo sapiens.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; TAS:ProtInc.
DR   InterPro; IPR001623; DnaJ_N.
DR   InterPro; IPR015609; Hsp40/DnaJ_Rel.
DR   InterPro; IPR013026; TPR-contain.
DR   InterPro; IPR011990; TPR-like_helical.
DR   InterPro; IPR019734; TPR_repeat.
DR   Gene3D; G3DSA:1.25.40.10; TPR-like_helical; 2.
DR   PANTHER; PTHR11821; Hsp40/DnaJ_Rel; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   SMART; SM00271; DnaJ; 1.
DR   SMART; SM00028; TPR; 7.
DR   PROSITE; PS00636; DNAJ_1; FALSE_NEG.
DR   PROSITE; PS50076; DNAJ_2; 1.
DR   PROSITE; PS50005; TPR; 8.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Chaperone; Complete proteome; Direct protein sequencing;
KW   Phosphoprotein; Repeat; TPR repeat.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    494       DnaJ homolog subfamily C member 7.
FT                                /FTId=PRO_0000071058.
FT   REPEAT       28     61       TPR 1.
FT   REPEAT       62     95       TPR 2.
FT   REPEAT       96    129       TPR 3.
FT   REPEAT      142    175       TPR 4.
FT   REPEAT      177    209       TPR 5.
FT   REPEAT      210    243       TPR 6.
FT   REPEAT      256    289       TPR 7.
FT   REPEAT      294    327       TPR 8.
FT   REPEAT      328    361       TPR 9.
FT   DOMAIN      381    451       J.
FT   MOD_RES       2      2       N-acetylalanine.
FT   MOD_RES      50     50       Phosphotyrosine.
SQ   SEQUENCE   494 AA;  56441 MW;  81C60CF71BFE951D CRC64;
     MAAAAECDVV MAATEPELLD DQEAKREAET FKEQGNAYYA KKDYNEAYNY YTKAIDMCPK
     NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL REGKCHLSLG NAMAACRSFQ
     RALELDHKNA QAQQEFKNAN AVMEYEKIAE TDFEKRDFRK VVFCMDRALE FAPACHRFKI
     LKAECLAMLG RYPEAQSVAS DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA
     PDHEKACIAC RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR
     GTVNSKLRKL DDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQYEEAVRD YEKVYQTEKT
     KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA YRKRALMHHP DRHSGASAEV
     QKEEEKKFKE VGEAFTILSD PKKKTRYDSG QDLDEEGMNM GDFDPNNIFK AFFGGPGGFS
     FEASGPGNFF FQFG
//