Reviewed, UniProtKB/Swiss-Prot Q99615 (DNJC7_HUMAN)

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily C member 7

Alternative name(s):
Tetratricopeptide repeat protein 2
Short name=TPR repeat protein 2

Gene names

Name:	DNAJC7
Synonyms:	TPR2, TTC2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with the GAP domain of NF1.
Sequence similarities	Contains 1 J domain. Contains 9 TPR repeats.

Ontologies

Keywords
Domain	Repeat TPR repeat
Molecular function	Chaperone
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	protein folding Ref.1 Traceable author statement. Source: ProtInc
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 494	493	DnaJ homolog subfamily C member 7		PRO_0000071058
Regions
	Repeat	28 – 61	34	TPR 1
	Repeat	62 – 95	34	TPR 2
	Repeat	96 – 129	34	TPR 3
	Repeat	142 – 175	34	TPR 4
	Repeat	177 – 209	33	TPR 5
	Repeat	210 – 243	34	TPR 6
	Repeat	256 – 289	34	TPR 7
	Repeat	294 – 327	34	TPR 8
	Repeat	328 – 361	34	TPR 9
	Domain	381 – 451	71	J
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.3 Ref.6
	Modified residue	50	1	Phosphotyrosine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q99615-1 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: 81C60CF71BFE951D	FASTA	494	56,441
	10 20 30 40 50 60 MAAAAECDVV MAATEPELLD DQEAKREAET FKEQGNAYYA KKDYNEAYNY YTKAIDMCPK 70 80 90 100 110 120 NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL REGKCHLSLG NAMAACRSFQ 130 140 150 160 170 180 RALELDHKNA QAQQEFKNAN AVMEYEKIAE TDFEKRDFRK VVFCMDRALE FAPACHRFKI 190 200 210 220 230 240 LKAECLAMLG RYPEAQSVAS DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA 250 260 270 280 290 300 PDHEKACIAC RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR 310 320 330 340 350 360 GTVNSKLRKL DDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQYEEAVRD YEKVYQTEKT 370 380 390 400 410 420 KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA YRKRALMHHP DRHSGASAEV 430 440 450 460 470 480 QKEEEKKFKE VGEAFTILSD PKKKTRYDSG QDLDEEGMNM GDFDPNNIFK AFFGGPGGFS 490 FEASGPGNFF FQFG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of two novel tetratricopeptide repeat-containing genes." Murthy A.E., Bernards A., Church D., Wasmuth J., Gusella J.F. DNA Cell Biol. 15:727-735(1996) [PubMed: 8836031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-494.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Skin.
[3]	Bienvenut W.V., Waridel P., Quadroni M. Submitted (MAR-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-26; 69-77; 80-90; 138-156; 192-238; 274-291 AND 430-442, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[4]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-50, MASS SPECTROMETRY.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U46571 mRNA. Translation: AAB36872.1. Different initiation. BC011837 mRNA. Translation: AAH11837.2. BC033772 mRNA. Translation: AAH33772.1. Different initiation.
IPI	IPI00329629.
RefSeq	NP_003306.3.
UniGene	Hs.500156
3D structure databases
SMR	Q99615. Positions 34-354, 377-478.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99615. 3 interactions.
STRING	Q99615.
PTM databases
PhosphoSite	Q99615.
Proteomic databases
PeptideAtlas	Q99615.
PRIDE	Q99615.
Genome annotation databases
Ensembl	ENST00000457167; ENSP00000406463; ENSG00000168259; Homo sapiens. [Genome view]
GeneID	7266.
Organism-specific databases
CTD	7266.
GeneCards	GC17M037382.
H-InvDB	HIX0013829.
HGNC	HGNC:12392. DNAJC7.
HPA	HPA023015.
MIM	601964. gene.
PharmGKB	PA27424.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG717809.
HOVERGEN	HBG051376.
InParanoid	Q99615.
OMA	REAESFK.
OrthoDB	EOG9X0QCT.
PhylomeDB	Q99615.
Gene expression databases
ArrayExpress	Q99615.
Bgee	Q99615.
CleanEx	HS_DNAJC7.
Genevestigator	Q99615.
GermOnline	ENSG00000168259. Homo sapiens.
Family and domain databases
InterPro	IPR001623. DnaJ_N. IPR015609. Hsp40/DnaJ_Rel. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 2 hits.
PANTHER	PTHR11821. Hsp40/DnaJ_Rel. 1 hit.
Pfam	PF00226. DnaJ. 1 hit. [Graphical view]
SMART	SM00271. DnaJ. 1 hit. SM00028. TPR. 7 hits. [Graphical view]
SUPFAM	SSF46565. DnaJ_N. 1 hit.
PROSITE	PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. 1 hit. PS50005. TPR. 8 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	28407.
PMAP-CutDB	Q99615.
SOURCE	Search...

Entry information

Entry name

DNJC7_HUMAN

Accession

Primary (citable) accession number: Q99615

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	April 13, 2004
Last modified:	March 2, 2010
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.