Reviewed,
UniProtKB/Swiss-Prot Q99615 (DNJC7_HUMAN)
Last modified
March 2, 2010.
Version 95.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: DnaJ homolog subfamily C member 7 Alternative name(s): Tetratricopeptide repeat protein 2 Short name=TPR repeat protein 2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 494 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subunit structure | Interacts with the GAP domain of NF1. |
| Sequence similarities | Contains 1 J domain. Contains 9 TPR repeats. |
Ontologies
| Keywords | |
|---|---|
| Domain | Repeat TPR repeat |
| Molecular function | Chaperone |
| PTM | Acetylation Phosphoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | protein folding Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | heat shock protein binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.3 | ||||||
| Chain | 2 – 494 | 493 | DnaJ homolog subfamily C member 7 | PRO_0000071058 | |||||
Regions | |||||||||
| Repeat | 28 – 61 | 34 | TPR 1 | ||||||
| Repeat | 62 – 95 | 34 | TPR 2 | ||||||
| Repeat | 96 – 129 | 34 | TPR 3 | ||||||
| Repeat | 142 – 175 | 34 | TPR 4 | ||||||
| Repeat | 177 – 209 | 33 | TPR 5 | ||||||
| Repeat | 210 – 243 | 34 | TPR 6 | ||||||
| Repeat | 256 – 289 | 34 | TPR 7 | ||||||
| Repeat | 294 – 327 | 34 | TPR 8 | ||||||
| Repeat | 328 – 361 | 34 | TPR 9 | ||||||
| Domain | 381 – 451 | 71 | J | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine Ref.3 Ref.6 | ||||||
| Modified residue | 50 | 1 | Phosphotyrosine Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification and characterization of two novel tetratricopeptide repeat-containing genes." Murthy A.E., Bernards A., Church D., Wasmuth J., Gusella J.F. DNA Cell Biol. 15:727-735(1996) [PubMed: 8836031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-494. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Skin. |
| [3] | Bienvenut W.V., Waridel P., Quadroni M. Submitted (MAR-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-26; 69-77; 80-90; 138-156; 192-238; 274-291 AND 430-442, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [4] | "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-50, MASS SPECTROMETRY. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [6] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U46571 mRNA. Translation: AAB36872.1. Different initiation. BC011837 mRNA. Translation: AAH11837.2. BC033772 mRNA. Translation: AAH33772.1. Different initiation. |
| IPI | IPI00329629. |
| RefSeq | NP_003306.3. |
| UniGene | Hs.500156 |
3D structure databases | |
| SMR | Q99615. Positions 34-354, 377-478. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q99615. 3 interactions. |
| STRING | Q99615. |
PTM databases | |
| PhosphoSite | Q99615. |
Proteomic databases | |
| PeptideAtlas | Q99615. |
| PRIDE | Q99615. |
Genome annotation databases | |
| Ensembl | ENST00000457167; ENSP00000406463; ENSG00000168259; Homo sapiens. [Genome view] |
| GeneID | 7266. |
Organism-specific databases | |
| CTD | 7266. |
| GeneCards | GC17M037382. |
| H-InvDB | HIX0013829. |
| HGNC | HGNC:12392. DNAJC7. |
| HPA | HPA023015. |
| MIM | 601964. gene. |
| PharmGKB | PA27424. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG717809. |
| HOVERGEN | HBG051376. |
| InParanoid | Q99615. |
| OMA | REAESFK. |
| OrthoDB | EOG9X0QCT. |
| PhylomeDB | Q99615. |
Gene expression databases | |
| ArrayExpress | Q99615. |
| Bgee | Q99615. |
| CleanEx | HS_DNAJC7. |
| Genevestigator | Q99615. |
| GermOnline | ENSG00000168259. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001623. DnaJ_N. IPR015609. Hsp40/DnaJ_Rel. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view] |
| Gene3D | G3DSA:1.25.40.10. TPR-like_helical. 2 hits. |
| PANTHER | PTHR11821. Hsp40/DnaJ_Rel. 1 hit. |
| Pfam | PF00226. DnaJ. 1 hit. [Graphical view] |
| SMART | SM00271. DnaJ. 1 hit. SM00028. TPR. 7 hits. [Graphical view] |
| SUPFAM | SSF46565. DnaJ_N. 1 hit. |
| PROSITE | PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. 1 hit. PS50005. TPR. 8 hits. PS50293. TPR_REGION. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 28407. |
| PMAP-CutDB | Q99615. |
| SOURCE | Search... |
Entry information
| Entry name | DNJC7_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q99615 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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