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Protein

DnaJ homolog subfamily C member 7

Gene

DNAJC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).By similarity2 Publications

GO - Molecular functioni

  • ATPase activator activity Source: Reactome
  • heat shock protein binding Source: UniProtKB

GO - Biological processi

  • chaperone cofactor-dependent protein refolding Source: UniProtKB
  • protein folding Source: ProtInc
  • regulation of cellular response to heat Source: Reactome

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 7
Alternative name(s):
Tetratricopeptide repeat protein 2
Short name:
TPR repeat protein 2
Gene namesi
Name:DNAJC7
Synonyms:TPR2, TTC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000168259.14.
HGNCiHGNC:12392. DNAJC7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi101R → A: Impairs interaction with HSP90AA1 and HSPA1A/B. Abolishes interaction with HSP90AA1 and HSPA1A/B; when associated with A-333 and A-409. 1 Publication1
Mutagenesisi333R → A: Impairs interaction with HSP90AA1 and HSPA1A/B. Abolishes interaction with HSP90AA1 and HSPA1A/B; when associated with A-101 and A-409. 1 Publication1
Mutagenesisi409H → A: Predominantly nuclear localization. Abolishes interaction with HSP90AA1 and HSPA1A/B; when associated with A-101 and A-333. 2 Publications1

Organism-specific databases

DisGeNETi7266.
OpenTargetsiENSG00000168259.
PharmGKBiPA27424.

Polymorphism and mutation databases

BioMutaiDNAJC7.
DMDMi46397879.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000710582 – 494DnaJ homolog subfamily C member 7Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei393PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99615.
MaxQBiQ99615.
PaxDbiQ99615.
PeptideAtlasiQ99615.
PRIDEiQ99615.

PTM databases

iPTMnetiQ99615.
PhosphoSitePlusiQ99615.

Miscellaneous databases

PMAP-CutDBiQ99615.

Expressioni

Gene expression databases

BgeeiENSG00000168259.
CleanExiHS_DNAJC7.
ExpressionAtlasiQ99615. baseline and differential.
GenevisibleiQ99615. HS.

Organism-specific databases

HPAiHPA023015.
HPA052395.

Interactioni

Subunit structurei

Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1. Interacts with NR1I3. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity). Interacts with HSPA8.By similarity5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113117. 125 interactors.
CORUMiQ99615.
IntActiQ99615. 85 interactors.
MINTiMINT-1143801.
STRINGi9606.ENSP00000406463.

Structurei

3D structure databases

ProteinModelPortaliQ99615.
SMRiQ99615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 61TPR 1Add BLAST34
Repeati62 – 95TPR 2Add BLAST34
Repeati96 – 129TPR 3Add BLAST34
Repeati142 – 175TPR 4Add BLAST34
Repeati177 – 209TPR 5Add BLAST33
Repeati210 – 243TPR 6Add BLAST34
Repeati256 – 289TPR 7Add BLAST34
Repeati294 – 327TPR 8Add BLAST34
Repeati328 – 361TPR 9Add BLAST34
Domaini381 – 451JPROSITE-ProRule annotationAdd BLAST71

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0550. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00890000139418.
HOGENOMiHOG000210360.
HOVERGENiHBG051376.
InParanoidiQ99615.
KOiK09527.
OMAiPRKWQLM.
OrthoDBiEOG091G0898.
PhylomeDBiQ99615.
TreeFamiTF105166.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
1.25.40.10. 3 hits.
InterProiView protein in InterPro
IPR001623. DnaJ_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PF13181. TPR_8. 2 hits.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SM00028. TPR. 8 hits.
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF48452. SSF48452. 3 hits.
PROSITEiView protein in PROSITE
PS50076. DNAJ_2. 1 hit.
PS50005. TPR. 8 hits.
PS50293. TPR_REGION. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99615-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAECDVV MAATEPELLD DQEAKREAET FKEQGNAYYA KKDYNEAYNY
60 70 80 90 100
YTKAIDMCPK NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL
110 120 130 140 150
REGKCHLSLG NAMAACRSFQ RALELDHKNA QAQQEFKNAN AVMEYEKIAE
160 170 180 190 200
TDFEKRDFRK VVFCMDRALE FAPACHRFKI LKAECLAMLG RYPEAQSVAS
210 220 230 240 250
DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA PDHEKACIAC
260 270 280 290 300
RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR
310 320 330 340 350
GTVNSKLRKL DDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQYEEAVRD
360 370 380 390 400
YEKVYQTEKT KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA
410 420 430 440 450
YRKRALMHHP DRHSGASAEV QKEEEKKFKE VGEAFTILSD PKKKTRYDSG
460 470 480 490
QDLDEEGMNM GDFDPNNIFK AFFGGPGGFS FEASGPGNFF FQFG
Length:494
Mass (Da):56,441
Last modified:April 13, 2004 - v2
Checksum:i81C60CF71BFE951D
GO
Isoform 2 (identifier: Q99615-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:438
Mass (Da):50,097
Checksum:iC1C5BF7A49DF56B0
GO

Sequence cautioni

The sequence AAB36872 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH33772 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti375K → R in BX647209 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442791 – 56Missing in isoform 2. 2 PublicationsAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298860 mRNA. Translation: BAG60982.1.
BX647209 mRNA. No translation available.
AC105024 Genomic DNA. No translation available.
AC125257 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60788.1.
BC003601 mRNA. Translation: AAH03601.1.
BC011837 mRNA. Translation: AAH11837.2.
BC033772 mRNA. Translation: AAH33772.1. Different initiation.
U46571 mRNA. Translation: AAB36872.1. Different initiation.
CCDSiCCDS45677.1. [Q99615-1]
CCDS45678.1. [Q99615-2]
RefSeqiNP_001138238.1. NM_001144766.2. [Q99615-2]
NP_003306.3. NM_003315.3. [Q99615-1]
XP_011523469.1. XM_011525167.2. [Q99615-2]
XP_011523470.1. XM_011525168.2. [Q99615-2]
XP_011523471.1. XM_011525169.2. [Q99615-2]
XP_016880483.1. XM_017024994.1. [Q99615-2]
UniGeneiHs.500156.
Hs.744481.

Genome annotation databases

EnsembliENST00000316603; ENSP00000313311; ENSG00000168259. [Q99615-2]
ENST00000426588; ENSP00000394327; ENSG00000168259. [Q99615-2]
ENST00000457167; ENSP00000406463; ENSG00000168259. [Q99615-1]
GeneIDi7266.
KEGGihsa:7266.
UCSCiuc002hyo.4. human. [Q99615-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDNJC7_HUMAN
AccessioniPrimary (citable) accession number: Q99615
Secondary accession number(s): Q7Z784
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: September 27, 2017
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot