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Protein

Tetratricopeptide repeat protein 1

Gene

TTC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • protein folding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 1
Short name:
TPR repeat protein 1
Gene namesi
Name:TTC1
Synonyms:TPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113312.10
HGNCiHGNC:12391 TTC1
MIMi601963 gene
neXtProtiNX_Q99614

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7265
OpenTargetsiENSG00000113312
PharmGKBiPA37057

Polymorphism and mutation databases

DMDMi12585378

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063761 – 292Tetratricopeptide repeat protein 1Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99614
MaxQBiQ99614
PaxDbiQ99614
PeptideAtlasiQ99614
PRIDEiQ99614
TopDownProteomicsiQ99614

PTM databases

iPTMnetiQ99614
PhosphoSitePlusiQ99614

Expressioni

Gene expression databases

BgeeiENSG00000113312
CleanExiHS_TTC1
ExpressionAtlasiQ99614 baseline and differential
GenevisibleiQ99614 HS

Organism-specific databases

HPAiHPA036557
HPA057502

Interactioni

Subunit structurei

Interacts with the GAP domain of NF1 (PubMed:8836031). Interacts (via TPR repeats) with HSP90AA1 and HSPA8 (PubMed:15708368).2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113116, 94 interactors
IntActiQ99614, 41 interactors
STRINGi9606.ENSP00000231238

Structurei

3D structure databases

ProteinModelPortaliQ99614
SMRiQ99614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati116 – 149TPR 1Add BLAST34
Repeati155 – 188TPR 2Add BLAST34
Repeati189 – 222TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4234 Eukaryota
ENOG4111IF0 LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000231571
HOVERGENiHBG001208
InParanoidiQ99614
OMAiYSINFNQ
OrthoDBiEOG091G0OWV
PhylomeDBiQ99614
TreeFamiTF317515

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q99614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE
60 70 80 90 100
AHLQEDQGEE ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL
110 120 130 140 150
EKNMSDEEKQ KRREESTRLK EEGNEQFKKG DYIEAESSYS RALEMCPSCF
160 170 180 190 200
QKERSILFSN RAAARMKQDK KEMAINDCSK AIQLNPSYIR AILRRAELYE
210 220 230 240 250
KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN ERLKEEMLGK
260 270 280 290
LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR
Length:292
Mass (Da):33,526
Last modified:May 1, 1997 - v1
Checksum:iD8B460E56CAA8E42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101E → K in AAH00942 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46570 mRNA Translation: AAB36871.1
AK315262 mRNA Translation: BAG37679.1
CH471062 Genomic DNA Translation: EAW61570.1
CH471062 Genomic DNA Translation: EAW61571.1
BC000942 mRNA Translation: AAH00942.1
CCDSiCCDS4348.1
RefSeqiNP_001269429.1, NM_001282500.1
NP_003305.1, NM_003314.2
UniGeneiHs.519718

Genome annotation databases

EnsembliENST00000231238; ENSP00000231238; ENSG00000113312
ENST00000522793; ENSP00000429225; ENSG00000113312
GeneIDi7265
KEGGihsa:7265
UCSCiuc003lxu.5 human

Similar proteinsi

Entry informationi

Entry nameiTTC1_HUMAN
AccessioniPrimary (citable) accession number: Q99614
Secondary accession number(s): B2RCT2, D3DQJ8, Q9BVT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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