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UniProtKB - Q99614 (TTC1_HUMAN)

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Protein

Tetratricopeptide repeat protein 1

Gene

TTC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  • protein folding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 1
Short name:
TPR repeat protein 1
Gene namesi
Name:TTC1
Synonyms:TPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:12391. TTC1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HPA
  • peroxisomal membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7265.
OpenTargetsiENSG00000113312.
PharmGKBiPA37057.

Polymorphism and mutation databases

DMDMi12585378.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063761 – 292Tetratricopeptide repeat protein 1Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99614.
MaxQBiQ99614.
PaxDbiQ99614.
PeptideAtlasiQ99614.
PRIDEiQ99614.
TopDownProteomicsiQ99614.

PTM databases

iPTMnetiQ99614.
PhosphoSitePlusiQ99614.

Expressioni

Gene expression databases

BgeeiENSG00000113312.
CleanExiHS_TTC1.
ExpressionAtlasiQ99614. baseline and differential.
GenevisibleiQ99614. HS.

Organism-specific databases

HPAiHPA036557.
HPA057502.

Interactioni

Subunit structurei

Interacts with the GAP domain of NF1 (PubMed:8836031). Interacts (via TPR repeats) with HSP90AA1 and HSPA8 (PubMed:15708368).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RNF41Q9H4P410EBI-742074,EBI-2130266

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB
Complete GO annotation...

Protein-protein interaction databases

BioGridi113116. 92 interactors.
IntActiQ99614. 38 interactors.
MINTiMINT-1449702.
STRINGi9606.ENSP00000231238.

Structurei

3D structure databases

ProteinModelPortaliQ99614.
SMRiQ99614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati116 – 149TPR 1Add BLAST34
Repeati155 – 188TPR 2Add BLAST34
Repeati189 – 222TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4234. Eukaryota.
ENOG4111IF0. LUCA.
GeneTreeiENSGT00880000137906.
HOGENOMiHOG000231571.
HOVERGENiHBG001208.
InParanoidiQ99614.
OMAiYSINFNQ.
OrthoDBiEOG091G0OWV.
PhylomeDBiQ99614.
TreeFamiTF317515.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
PfamiView protein in Pfam
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 3 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE 
        60         70         80         90        100
AHLQEDQGEE ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL 
       110        120        130        140        150
EKNMSDEEKQ KRREESTRLK EEGNEQFKKG DYIEAESSYS RALEMCPSCF 
       160        170        180        190        200
QKERSILFSN RAAARMKQDK KEMAINDCSK AIQLNPSYIR AILRRAELYE 
       210        220        230        240        250
KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN ERLKEEMLGK 
       260        270        280        290 
LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR
Length:292
Mass (Da):33,526
Last modified:May 1, 1997 - v1
Checksum:iD8B460E56CAA8E42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101E → K in AAH00942 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46570 mRNA. Translation: AAB36871.1.
AK315262 mRNA. Translation: BAG37679.1.
CH471062 Genomic DNA. Translation: EAW61570.1.
CH471062 Genomic DNA. Translation: EAW61571.1.
BC000942 mRNA. Translation: AAH00942.1.
CCDSiCCDS4348.1.
RefSeqiNP_001269429.1. NM_001282500.1.
NP_003305.1. NM_003314.2.
UniGeneiHs.519718.

Genome annotation databases

EnsembliENST00000231238; ENSP00000231238; ENSG00000113312.
ENST00000522793; ENSP00000429225; ENSG00000113312.
GeneIDi7265.
KEGGihsa:7265.
UCSCiuc003lxu.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46570 mRNA. Translation: AAB36871.1.
AK315262 mRNA. Translation: BAG37679.1.
CH471062 Genomic DNA. Translation: EAW61570.1.
CH471062 Genomic DNA. Translation: EAW61571.1.
BC000942 mRNA. Translation: AAH00942.1.
CCDSiCCDS4348.1.
RefSeqiNP_001269429.1. NM_001282500.1.
NP_003305.1. NM_003314.2.
UniGeneiHs.519718.

3D structure databases

ProteinModelPortaliQ99614.
SMRiQ99614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113116. 92 interactors.
IntActiQ99614. 38 interactors.
MINTiMINT-1449702.
STRINGi9606.ENSP00000231238.

PTM databases

iPTMnetiQ99614.
PhosphoSitePlusiQ99614.

Polymorphism and mutation databases

DMDMi12585378.

Proteomic databases

EPDiQ99614.
MaxQBiQ99614.
PaxDbiQ99614.
PeptideAtlasiQ99614.
PRIDEiQ99614.
TopDownProteomicsiQ99614.

Protocols and materials databases

DNASUi7265.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231238; ENSP00000231238; ENSG00000113312.
ENST00000522793; ENSP00000429225; ENSG00000113312.
GeneIDi7265.
KEGGihsa:7265.
UCSCiuc003lxu.5. human.

Organism-specific databases

CTDi7265.
DisGeNETi7265.
GeneCardsiTTC1.
HGNCiHGNC:12391. TTC1.
HPAiHPA036557.
HPA057502.
MIMi601963. gene.
neXtProtiNX_Q99614.
OpenTargetsiENSG00000113312.
PharmGKBiPA37057.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4234. Eukaryota.
ENOG4111IF0. LUCA.
GeneTreeiENSGT00880000137906.
HOGENOMiHOG000231571.
HOVERGENiHBG001208.
InParanoidiQ99614.
OMAiYSINFNQ.
OrthoDBiEOG091G0OWV.
PhylomeDBiQ99614.
TreeFamiTF317515.

Miscellaneous databases

ChiTaRSiTTC1. human.
GeneWikiiTTC1.
GenomeRNAii7265.
PROiPR:Q99614.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113312.
CleanExiHS_TTC1.
ExpressionAtlasiQ99614. baseline and differential.
GenevisibleiQ99614. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
PfamiView protein in Pfam
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 3 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTTC1_HUMAN
AccessioniPrimary (citable) accession number: Q99614
Secondary accession number(s): B2RCT2, D3DQJ8, Q9BVT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1997
Last modified: June 7, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.