UniProtKB - Q99614 (TTC1_HUMAN)
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Protein
Tetratricopeptide repeat protein 1
Gene
TTC1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- unfolded protein binding Source: UniProtKB
GO - Biological processi
- protein folding Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Tetratricopeptide repeat protein 1Short name: TPR repeat protein 1 |
Gene namesi | Name:TTC1 Synonyms:TPR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000113312.10. |
HGNCi | HGNC:12391. TTC1. |
MIMi | 601963. gene. |
neXtProti | NX_Q99614. |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 7265. |
OpenTargetsi | ENSG00000113312. |
PharmGKBi | PA37057. |
Polymorphism and mutation databases
DMDMi | 12585378. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106376 | 1 – 292 | Tetratricopeptide repeat protein 1Add BLAST | 292 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 83 | PhosphoserineCombined sources | 1 | |
Modified residuei | 90 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99614. |
MaxQBi | Q99614. |
PaxDbi | Q99614. |
PeptideAtlasi | Q99614. |
PRIDEi | Q99614. |
TopDownProteomicsi | Q99614. |
PTM databases
iPTMneti | Q99614. |
PhosphoSitePlusi | Q99614. |
Expressioni
Gene expression databases
Bgeei | ENSG00000113312. |
CleanExi | HS_TTC1. |
ExpressionAtlasi | Q99614. baseline and differential. |
Genevisiblei | Q99614. HS. |
Organism-specific databases
HPAi | HPA036557. HPA057502. |
Interactioni
Subunit structurei
Interacts with the GAP domain of NF1 (PubMed:8836031). Interacts (via TPR repeats) with HSP90AA1 and HSPA8 (PubMed:15708368).2 Publications
Binary interactionsi
GO - Molecular functioni
- unfolded protein binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 113116. 94 interactors. |
IntActi | Q99614. 40 interactors. |
STRINGi | 9606.ENSP00000231238. |
Structurei
3D structure databases
ProteinModelPortali | Q99614. |
SMRi | Q99614. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 116 – 149 | TPR 1Add BLAST | 34 | |
Repeati | 155 – 188 | TPR 2Add BLAST | 34 | |
Repeati | 189 – 222 | TPR 3Add BLAST | 34 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG4234. Eukaryota. ENOG4111IF0. LUCA. |
GeneTreei | ENSGT00900000140844. |
HOGENOMi | HOG000231571. |
HOVERGENi | HBG001208. |
InParanoidi | Q99614. |
OMAi | YSINFNQ. |
OrthoDBi | EOG091G0OWV. |
PhylomeDBi | Q99614. |
TreeFami | TF317515. |
Family and domain databases
Gene3Di | 1.25.40.10. 1 hit. |
InterProi | View protein in InterPro IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical_dom_sf. IPR001440. TPR_1. IPR019734. TPR_repeat. |
Pfami | View protein in Pfam PF00515. TPR_1. 1 hit. PF13181. TPR_8. 1 hit. |
SMARTi | View protein in SMART SM00028. TPR. 3 hits. |
SUPFAMi | SSF48452. SSF48452. 1 hit. |
PROSITEi | View protein in PROSITE PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q99614-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE
60 70 80 90 100
AHLQEDQGEE ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL
110 120 130 140 150
EKNMSDEEKQ KRREESTRLK EEGNEQFKKG DYIEAESSYS RALEMCPSCF
160 170 180 190 200
QKERSILFSN RAAARMKQDK KEMAINDCSK AIQLNPSYIR AILRRAELYE
210 220 230 240 250
KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN ERLKEEMLGK
260 270 280 290
LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 101 | E → K in AAH00942 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46570 mRNA. Translation: AAB36871.1. AK315262 mRNA. Translation: BAG37679.1. CH471062 Genomic DNA. Translation: EAW61570.1. CH471062 Genomic DNA. Translation: EAW61571.1. BC000942 mRNA. Translation: AAH00942.1. |
CCDSi | CCDS4348.1. |
RefSeqi | NP_001269429.1. NM_001282500.1. NP_003305.1. NM_003314.2. |
UniGenei | Hs.519718. |
Genome annotation databases
Ensembli | ENST00000231238; ENSP00000231238; ENSG00000113312. ENST00000522793; ENSP00000429225; ENSG00000113312. |
GeneIDi | 7265. |
KEGGi | hsa:7265. |
UCSCi | uc003lxu.5. human. |
Similar proteinsi
Entry informationi
Entry namei | TTC1_HUMAN | |
Accessioni | Q99614Primary (citable) accession number: Q99614 Secondary accession number(s): B2RCT2, D3DQJ8, Q9BVT3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | May 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |