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Protein

Tetratricopeptide repeat protein 1

Gene

TTC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • protein folding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 1
Short name:
TPR repeat protein 1
Gene namesi
Name:TTC1
Synonyms:TPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:12391. TTC1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • peroxisomal membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37057.

Polymorphism and mutation databases

DMDMi12585378.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Tetratricopeptide repeat protein 1PRO_0000106376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831PhosphoserineCombined sources
Modified residuei90 – 901PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99614.
MaxQBiQ99614.
PaxDbiQ99614.
PeptideAtlasiQ99614.
PRIDEiQ99614.
TopDownProteomicsiQ99614.

PTM databases

iPTMnetiQ99614.
PhosphoSiteiQ99614.

Expressioni

Gene expression databases

BgeeiQ99614.
CleanExiHS_TTC1.
ExpressionAtlasiQ99614. baseline and differential.
GenevisibleiQ99614. HS.

Organism-specific databases

HPAiHPA036557.
HPA057502.

Interactioni

Subunit structurei

Interacts with the GAP domain of NF1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RNF41Q9H4P46EBI-742074,EBI-2130266

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113116. 92 interactions.
IntActiQ99614. 37 interactions.
MINTiMINT-1449702.
STRINGi9606.ENSP00000231238.

Structurei

3D structure databases

ProteinModelPortaliQ99614.
SMRiQ99614. Positions 114-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati116 – 14934TPR 1Add
BLAST
Repeati155 – 18834TPR 2Add
BLAST
Repeati189 – 22234TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4234. Eukaryota.
ENOG4111IF0. LUCA.
GeneTreeiENSGT00840000129775.
HOGENOMiHOG000231571.
HOVERGENiHBG001208.
InParanoidiQ99614.
OMAiRALEMCP.
OrthoDBiEOG7RBZBH.
PhylomeDBiQ99614.
TreeFamiTF317515.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE
60 70 80 90 100
AHLQEDQGEE ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL
110 120 130 140 150
EKNMSDEEKQ KRREESTRLK EEGNEQFKKG DYIEAESSYS RALEMCPSCF
160 170 180 190 200
QKERSILFSN RAAARMKQDK KEMAINDCSK AIQLNPSYIR AILRRAELYE
210 220 230 240 250
KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN ERLKEEMLGK
260 270 280 290
LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR
Length:292
Mass (Da):33,526
Last modified:May 1, 1997 - v1
Checksum:iD8B460E56CAA8E42
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011E → K in AAH00942 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46570 mRNA. Translation: AAB36871.1.
AK315262 mRNA. Translation: BAG37679.1.
CH471062 Genomic DNA. Translation: EAW61570.1.
CH471062 Genomic DNA. Translation: EAW61571.1.
BC000942 mRNA. Translation: AAH00942.1.
CCDSiCCDS4348.1.
RefSeqiNP_001269429.1. NM_001282500.1.
NP_003305.1. NM_003314.2.
UniGeneiHs.519718.

Genome annotation databases

EnsembliENST00000231238; ENSP00000231238; ENSG00000113312.
ENST00000522793; ENSP00000429225; ENSG00000113312.
GeneIDi7265.
KEGGihsa:7265.
UCSCiuc003lxu.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46570 mRNA. Translation: AAB36871.1.
AK315262 mRNA. Translation: BAG37679.1.
CH471062 Genomic DNA. Translation: EAW61570.1.
CH471062 Genomic DNA. Translation: EAW61571.1.
BC000942 mRNA. Translation: AAH00942.1.
CCDSiCCDS4348.1.
RefSeqiNP_001269429.1. NM_001282500.1.
NP_003305.1. NM_003314.2.
UniGeneiHs.519718.

3D structure databases

ProteinModelPortaliQ99614.
SMRiQ99614. Positions 114-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113116. 92 interactions.
IntActiQ99614. 37 interactions.
MINTiMINT-1449702.
STRINGi9606.ENSP00000231238.

PTM databases

iPTMnetiQ99614.
PhosphoSiteiQ99614.

Polymorphism and mutation databases

DMDMi12585378.

Proteomic databases

EPDiQ99614.
MaxQBiQ99614.
PaxDbiQ99614.
PeptideAtlasiQ99614.
PRIDEiQ99614.
TopDownProteomicsiQ99614.

Protocols and materials databases

DNASUi7265.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231238; ENSP00000231238; ENSG00000113312.
ENST00000522793; ENSP00000429225; ENSG00000113312.
GeneIDi7265.
KEGGihsa:7265.
UCSCiuc003lxu.5. human.

Organism-specific databases

CTDi7265.
GeneCardsiTTC1.
HGNCiHGNC:12391. TTC1.
HPAiHPA036557.
HPA057502.
MIMi601963. gene.
neXtProtiNX_Q99614.
PharmGKBiPA37057.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4234. Eukaryota.
ENOG4111IF0. LUCA.
GeneTreeiENSGT00840000129775.
HOGENOMiHOG000231571.
HOVERGENiHBG001208.
InParanoidiQ99614.
OMAiRALEMCP.
OrthoDBiEOG7RBZBH.
PhylomeDBiQ99614.
TreeFamiTF317515.

Miscellaneous databases

ChiTaRSiTTC1. human.
GeneWikiiTTC1.
GenomeRNAii7265.
PROiQ99614.
SOURCEiSearch...

Gene expression databases

BgeeiQ99614.
CleanExiHS_TTC1.
ExpressionAtlasiQ99614. baseline and differential.
GenevisibleiQ99614. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two novel tetratricopeptide repeat-containing genes."
    Murthy A.E., Bernards A., Church D., Wasmuth J., Gusella J.F.
    DNA Cell Biol. 15:727-735(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NF1.
    Tissue: Brain and Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 AND SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTTC1_HUMAN
AccessioniPrimary (citable) accession number: Q99614
Secondary accession number(s): B2RCT2, D3DQJ8, Q9BVT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.