TTC1

Functionⁱ

GO - Molecular functionⁱ

unfolded protein binding
Source: UniProtKB
Non-traceable author statementⁱ
- 8836031

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein folding
Source: UniProtKB
Non-traceable author statementⁱ
- 8836031

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tetratricopeptide repeat protein 1 Short name: TPR repeat protein 1
Gene namesⁱ	Name:TTC1 Synonyms:TPR1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113312.10.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12391. TTC1.
MIMⁱ	601963. gene.
neXtProtⁱ	NX_Q99614.

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7265.
Open Targets More...OpenTargetsⁱ	ENSG00000113312.
PharmGKBⁱ	PA37057.

Polymorphism and mutation databases

DMDMⁱ	12585378.

DMDMⁱ

12585378.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000106376	1 – 292	Tetratricopeptide repeat protein 1Add BLAST		292

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	83	PhosphoserineCombined sources		1
Modified residueⁱ	90	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q99614.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99614.
PaxDbⁱ	Q99614.
PeptideAtlas More...PeptideAtlasⁱ	Q99614.
PRIDEⁱ	Q99614.
TopDownProteomicsⁱ	Q99614.

PTM databases

iPTMnetⁱ	Q99614.
PhosphoSitePlusⁱ	Q99614.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000113312.
CleanExⁱ	HS_TTC1.
ExpressionAtlasⁱ	Q99614. baseline and differential.
Genevisibleⁱ	Q99614. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036557. HPA057502.

HPAⁱ

HPA036557.
HPA057502.

Interactionⁱ

Subunit structureⁱ

Interacts with the GAP domain of NF1 (PubMed:8836031). Interacts (via TPR repeats) with HSP90AA1 and HSPA8 (PubMed:15708368).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PSTPIP1	A0A0S2Z528	3	EBI-742074,EBI-16430249
RNF41	Q9H4P4	10	EBI-742074,EBI-2130266
YLR297W	Q05899	3	EBI-742074,EBI-33462	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).

Show more details

GO - Molecular functionⁱ

unfolded protein binding
Source: UniProtKB
Non-traceable author statementⁱ
- 8836031

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113116. 94 interactors.
IntActⁱ	Q99614. 40 interactors.
STRINGⁱ	9606.ENSP00000231238.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99614.
SMRⁱ	Q99614.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	116 – 149	TPR 1Add BLAST	34
Repeatⁱ	155 – 188	TPR 2Add BLAST	34
Repeatⁱ	189 – 222	TPR 3Add BLAST	34

Keywords - Domainⁱ

Repeat, TPR repeat

Phylogenomic databases

eggNOGⁱ	KOG4234. Eukaryota. ENOG4111IF0. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140844.
HOGENOMⁱ	HOG000231571.
HOVERGENⁱ	HBG001208.
InParanoidⁱ	Q99614.
OMAⁱ	YSINFNQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OWV.
PhylomeDBⁱ	Q99614.
TreeFamⁱ	TF317515.

Family and domain databases

Gene3Dⁱ	1.25.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical_dom_sf. IPR001440. TPR_1. IPR019734. TPR_repeat.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00515. TPR_1. 1 hit. PF13181. TPR_8. 1 hit.
SMARTⁱ	View protein in SMART SM00028. TPR. 3 hits.
SUPFAMⁱ	SSF48452. SSF48452. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q99614-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE 
        60         70         80         90        100
AHLQEDQGEE ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL 
       110        120        130        140        150
EKNMSDEEKQ KRREESTRLK EEGNEQFKKG DYIEAESSYS RALEMCPSCF 
       160        170        180        190        200
QKERSILFSN RAAARMKQDK KEMAINDCSK AIQLNPSYIR AILRRAELYE 
       210        220        230        240        250
KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN ERLKEEMLGK 
       260        270        280        290 
LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR

Length:292

Mass (Da):33,526

Last modified:May 1, 1997 - v1

Checksum:ⁱD8B460E56CAA8E42

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	101	E → K in AAH00942 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U46570 mRNA. Translation: AAB36871.1. AK315262 mRNA. Translation: BAG37679.1. CH471062 Genomic DNA. Translation: EAW61570.1. CH471062 Genomic DNA. Translation: EAW61571.1. BC000942 mRNA. Translation: AAH00942.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4348.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001269429.1. NM_001282500.1. NP_003305.1. NM_003314.2.
UniGeneⁱ	Hs.519718.

Genome annotation databases

Ensemblⁱ	ENST00000231238; ENSP00000231238; ENSG00000113312. ENST00000522793; ENSP00000429225; ENSG00000113312.
GeneIDⁱ	7265.
KEGGⁱ	hsa:7265.
UCSC genome browser More...UCSCⁱ	uc003lxu.5. human.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q99614	A0A2K5TKR3 A0A096MPZ3 H2PH88 A0A2K5EBE6 A0A2K6KY30 G1QWB8 Q53HD9 UPI0003AB582F A0A0D9RDE9 UPI00027F3B25 +20	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Papio anubis (Olive baboon) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Aotus nancymaae (Ma's night monkey) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Homo sapiens (Human) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Gorilla gorilla gorilla (Western lowland gorilla) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) And more	292	UniRef90_Q99614	Cluster: Tetratricopeptide repeat protein 1	31

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q99614	A0A2K5TKR3 A0A096MPZ3 F7AF32 UPI000C29B5D8 Q53HD9 G3QFT3 A0A2K6KY30 A0A2K5ISA2 H9FZ88 G7P6S4 +22	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Papio anubis (Olive baboon) Macaca mulatta (Rhesus macaque) Piliocolobus tephrosceles (Ugandan red Colobus) Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Colobus angolensis palliatus (Peters' Angolan colobus) Macaca nemestrina (Pig-tailed macaque) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) And more	292	UniRef50_Q99614	Cluster: Tetratricopeptide repeat protein 1	33

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U46570 mRNA. Translation: AAB36871.1. AK315262 mRNA. Translation: BAG37679.1. CH471062 Genomic DNA. Translation: EAW61570.1. CH471062 Genomic DNA. Translation: EAW61571.1. BC000942 mRNA. Translation: AAH00942.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4348.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001269429.1. NM_001282500.1. NP_003305.1. NM_003314.2.
UniGeneⁱ	Hs.519718.

3D structure databases

ProteinModelPortalⁱ	Q99614.
SMRⁱ	Q99614.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113116. 94 interactors.
IntActⁱ	Q99614. 40 interactors.
STRINGⁱ	9606.ENSP00000231238.

PTM databases

iPTMnetⁱ	Q99614.
PhosphoSitePlusⁱ	Q99614.

Polymorphism and mutation databases

DMDMⁱ	12585378.

DMDMⁱ

12585378.

Proteomic databases

EPDⁱ	Q99614.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99614.
PaxDbⁱ	Q99614.
PeptideAtlas More...PeptideAtlasⁱ	Q99614.
PRIDEⁱ	Q99614.
TopDownProteomicsⁱ	Q99614.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7265.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000231238; ENSP00000231238; ENSG00000113312. ENST00000522793; ENSP00000429225; ENSG00000113312.
GeneIDⁱ	7265.
KEGGⁱ	hsa:7265.
UCSC genome browser More...UCSCⁱ	uc003lxu.5. human.

Organism-specific databases

CTDⁱ	7265.
DisGeNET More...DisGeNETⁱ	7265.
EuPathDBⁱ	HostDB:ENSG00000113312.10.
GeneCardsⁱ	TTC1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12391. TTC1.
Human Protein Atlas More...HPAⁱ	HPA036557. HPA057502.
MIMⁱ	601963. gene.
neXtProtⁱ	NX_Q99614.
Open Targets More...OpenTargetsⁱ	ENSG00000113312.
PharmGKBⁱ	PA37057.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4234. Eukaryota. ENOG4111IF0. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140844.
HOGENOMⁱ	HOG000231571.
HOVERGENⁱ	HBG001208.
InParanoidⁱ	Q99614.
OMAⁱ	YSINFNQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OWV.
PhylomeDBⁱ	Q99614.
TreeFamⁱ	TF317515.

Miscellaneous databases

ChiTaRSⁱ	TTC1. human.
GeneWikiⁱ	TTC1.
GenomeRNAiⁱ	7265.
Protein Ontology More...PROⁱ	PR:Q99614.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113312.
CleanExⁱ	HS_TTC1.
ExpressionAtlasⁱ	Q99614. baseline and differential.
Genevisibleⁱ	Q99614. HS.

Family and domain databases

Gene3Dⁱ	1.25.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical_dom_sf. IPR001440. TPR_1. IPR019734. TPR_repeat.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00515. TPR_1. 1 hit. PF13181. TPR_8. 1 hit.
SMARTⁱ	View protein in SMART SM00028. TPR. 3 hits.
SUPFAMⁱ	SSF48452. SSF48452. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TTC1_HUMAN
Accessionⁱ	Q99614Primary (citable) accession number: Q99614 Secondary accession number(s): B2RCT2, D3DQJ8, Q9BVT3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	May 1, 1997
	Last modified:	March 28, 2018
	This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99614 (TTC1_HUMAN)

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Tetratricopeptide repeat protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ