ID KLF6_HUMAN Reviewed; 283 AA. AC Q99612; B2RE86; B4DDN0; D3DRR1; F5H3M5; Q5VUT7; Q5VUT8; Q9BT79; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 30-MAY-2000, sequence version 3. DT 27-MAR-2024, entry version 213. DE RecName: Full=Krueppel-like factor 6; DE AltName: Full=B-cell-derived protein 1; DE AltName: Full=Core promoter element-binding protein; DE AltName: Full=GC-rich sites-binding factor GBF; DE AltName: Full=Proto-oncogene BCD1; DE AltName: Full=Suppressor of tumorigenicity 12 protein; DE AltName: Full=Transcription factor Zf9; GN Name=KLF6; Synonyms=BCD1, COPEB, CPBP, ST12; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP PRELIMINARY NUCLEOTIDE SEQUENCE (ISOFORM 1). RX PubMed=9000136; RA El Rouby S., Newcomb E.W.; RT "Identification of Bcd, a novel proto-oncogene expressed in B-cells."; RL Oncogene 13:2623-2630(1996). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Placenta; RX PubMed=9083102; DOI=10.1074/jbc.272.14.9573; RA Koritschoner N.P., Bocco J.L., Panzetta-Dutari G.M., Dumur C.I., Flury A., RA Patrito L.C.; RT "A novel human zinc finger protein that interacts with the core promoter RT element of a TATA box-less gene."; RL J. Biol. Chem. 272:9573-9580(1997). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Hepatic stellate cell; RX PubMed=9689109; DOI=10.1073/pnas.95.16.9500; RA Ratziu V., Lalazar A., Wong L., Dang Q., Collins C., Shaulian E., RA Jensen S., Friedman S.L.; RT "Zf9, a Kruppel-like transcription factor up-regulated in vivo during early RT hepatic fibrosis."; RL Proc. Natl. Acad. Sci. U.S.A. 95:9500-9505(1998). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION. RC TISSUE=Leukocyte; RX PubMed=9685731; DOI=10.1093/oxfordjournals.jbchem.a022124; RA Suzuki T., Yamamoto T., Kurabayashi M., Nagai R., Yazaki Y., Horikoshi M.; RT "Isolation and initial characterization of GBF, a novel DNA-binding zinc RT finger protein that binds to the GC-rich binding sites of the HIV-1 RT promoter."; RL J. Biochem. 124:389-395(1998). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Koritschoner N.P.; RT "Genomic organization of the human COPEB/CPBP locus."; RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [11] RP INACTIVATION OF 9AATAD MOTIF. RX PubMed=31375868; DOI=10.1007/s00018-019-03251-w; RA Piskacek M., Havelka M., Jendruchova K., Knight A., Keegan L.P.; RT "The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with RT valines and intron reservoirs."; RL Cell. Mol. Life Sci. 77:1793-1810(2020). RN [12] RP INVOLVEMENT IN PC, VARIANTS ARG-64; PRO-116; ASP-123 AND PRO-169, AND RP CHARACTERIZATION OF VARIANTS ARG-64; PRO-116; ASP-123 AND PRO-169. RX PubMed=11752579; DOI=10.1126/science.1066326; RA Narla G., Heath K.E., Reeves H.L., Li D., Giono L.E., Kimmelman A.C., RA Glucksman M.J., Narla J., Eng F.J., Chan A.M., Ferrari A.C., RA Martignetti J.A., Friedman S.L.; RT "KLF6, a candidate tumor suppressor gene mutated in prostate cancer."; RL Science 294:2563-2566(2001). RN [13] RP INVOLVEMENT IN GASC, AND VARIANTS ARG-155; THR-172; LEU-180 AND LYS-198. RX PubMed=15824733; DOI=10.1038/sj.onc.1208670; RA Cho Y.G., Kim C.J., Park C.H., Yang Y.M., Kim S.Y., Nam S.W., Lee S.H., RA Yoo N.J., Lee J.Y., Park W.S.; RT "Genetic alterations of the KLF6 gene in gastric cancer."; RL Oncogene 24:4588-4590(2005). RN [14] RP INTERACTION WITH ZZEF1. RX PubMed=33227311; DOI=10.1016/j.jmb.2020.11.021; RA Yu Y., Tencer A., Xuan H., Kutateladze T.G., Shi X.; RT "ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krueppel-Like RT Factors."; RL J. Mol. Biol. 433:166722-166722(2021). CC -!- FUNCTION: Transcriptional activator (By similarity). Binds a GC box CC motif. Could play a role in B-cell growth and development. CC {ECO:0000250}. CC -!- SUBUNIT: Interacts with ZZEF1. {ECO:0000269|PubMed:33227311}. CC -!- INTERACTION: CC Q99612; P41250: GARS1; NbExp=3; IntAct=EBI-714994, EBI-724143; CC Q99612; P02545: LMNA; NbExp=3; IntAct=EBI-714994, EBI-351935; CC Q99612; Q04206: RELA; NbExp=6; IntAct=EBI-714994, EBI-73886; CC Q99612; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-714994, EBI-5235340; CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q99612-1; Sequence=Displayed; CC Name=2; CC IsoId=Q99612-2; Sequence=VSP_015715; CC Name=3; CC IsoId=Q99612-3; Sequence=VSP_045808; CC -!- TISSUE SPECIFICITY: Highly expressed in placenta followed by spleen, CC thymus, prostate, testis, small intestine and colon. Weakly expressed CC in pancreas, lung, liver, heart and skeletal muscle. Also expressed in CC fetal brain, spleen and thymus. CC -!- DOMAIN: The acidic N-terminal part may favor interaction with the basic CC domain of transcription factors. CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large CC number of yeast and animal transcription factors. In KLF6, the motif is CC inactive. {ECO:0000269|PubMed:31375868}. CC -!- DISEASE: Gastric cancer (GASC) [MIM:613659]: A malignant disease which CC starts in the stomach, can spread to the esophagus or the small CC intestine, and can extend through the stomach wall to nearby lymph CC nodes and organs. It also can metastasize to other parts of the body. CC The term gastric cancer or gastric carcinoma refers to adenocarcinoma CC of the stomach that accounts for most of all gastric malignant tumors. CC Two main histologic types are recognized, diffuse type and intestinal CC type carcinomas. Diffuse tumors are poorly differentiated infiltrating CC lesions, resulting in thickening of the stomach. In contrast, CC intestinal tumors are usually exophytic, often ulcerating, and CC associated with intestinal metaplasia of the stomach, most often CC observed in sporadic disease. {ECO:0000269|PubMed:15824733}. Note=The CC disease is caused by variants affecting the gene represented in this CC entry. CC -!- DISEASE: Prostate cancer (PC) [MIM:176807]: A malignancy originating in CC tissues of the prostate. Most prostate cancers are adenocarcinomas that CC develop in the acini of the prostatic ducts. Other rare histopathologic CC types of prostate cancer that occur in approximately 5% of patients CC include small cell carcinoma, mucinous carcinoma, prostatic ductal CC carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal CC cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell CC carcinoma and neuroendocrine carcinoma. {ECO:0000269|PubMed:11752579}. CC Note=The disease is caused by variants affecting the gene represented CC in this entry. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAC23699.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAA33050.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and CC Haematology; CC URL="https://atlasgeneticsoncology.org/gene/44002/KLF6"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U44975; AAC23699.1; ALT_INIT; mRNA. DR EMBL; AF001461; AAC39929.1; -; mRNA. DR EMBL; AB017493; BAA33050.1; ALT_INIT; mRNA. DR EMBL; AF284036; AAM73548.1; -; Genomic_DNA. DR EMBL; BT006778; AAP35424.1; -; mRNA. DR EMBL; AL513303; CAH74049.1; -; Genomic_DNA. DR EMBL; AL450322; CAH74049.1; JOINED; Genomic_DNA. DR EMBL; AK293259; BAG56791.1; -; mRNA. DR EMBL; AK316596; BAG38183.1; -; mRNA. DR EMBL; AL513303; CAH74050.1; -; Genomic_DNA. DR EMBL; AL450322; CAH74050.1; JOINED; Genomic_DNA. DR EMBL; AL450322; CAH71010.1; -; Genomic_DNA. DR EMBL; AL513303; CAH71010.1; JOINED; Genomic_DNA. DR EMBL; AL450322; CAH71011.1; -; Genomic_DNA. DR EMBL; AL513303; CAH71011.1; JOINED; Genomic_DNA. DR EMBL; CH471072; EAW86477.1; -; Genomic_DNA. DR EMBL; CH471072; EAW86479.1; -; Genomic_DNA. DR EMBL; BC000311; AAH00311.1; -; mRNA. DR CCDS; CCDS53490.1; -. [Q99612-3] DR CCDS; CCDS7060.1; -. [Q99612-1] DR PIR; JE0235; JE0235. DR RefSeq; NP_001153596.1; NM_001160124.1. DR RefSeq; NP_001153597.1; NM_001160125.1. [Q99612-3] DR RefSeq; NP_001291.3; NM_001300.5. [Q99612-1] DR AlphaFoldDB; Q99612; -. DR SMR; Q99612; -. DR BioGRID; 107711; 93. DR IntAct; Q99612; 81. DR STRING; 9606.ENSP00000419923; -. DR GlyGen; Q99612; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q99612; -. DR PhosphoSitePlus; Q99612; -. DR BioMuta; KLF6; -. DR DMDM; 7387592; -. DR EPD; Q99612; -. DR jPOST; Q99612; -. DR MassIVE; Q99612; -. DR MaxQB; Q99612; -. DR PaxDb; 9606-ENSP00000419923; -. DR PeptideAtlas; Q99612; -. DR ProteomicsDB; 26317; -. DR ProteomicsDB; 78355; -. [Q99612-1] DR ProteomicsDB; 78356; -. [Q99612-2] DR Antibodypedia; 4619; 253 antibodies from 36 providers. DR DNASU; 1316; -. DR Ensembl; ENST00000469435.1; ENSP00000419079.1; ENSG00000067082.15. [Q99612-2] DR Ensembl; ENST00000497571.6; ENSP00000419923.1; ENSG00000067082.15. [Q99612-1] DR Ensembl; ENST00000542957.1; ENSP00000445301.1; ENSG00000067082.15. [Q99612-3] DR GeneID; 1316; -. DR KEGG; hsa:1316; -. DR MANE-Select; ENST00000497571.6; ENSP00000419923.1; NM_001300.6; NP_001291.3. DR UCSC; uc001iha.4; human. [Q99612-1] DR AGR; HGNC:2235; -. DR CTD; 1316; -. DR DisGeNET; 1316; -. DR GeneCards; KLF6; -. DR HGNC; HGNC:2235; KLF6. DR HPA; ENSG00000067082; Tissue enhanced (bone). DR MalaCards; KLF6; -. DR MIM; 176807; phenotype. DR MIM; 602053; gene. DR MIM; 613659; phenotype. DR neXtProt; NX_Q99612; -. DR OpenTargets; ENSG00000067082; -. DR PharmGKB; PA26751; -. DR VEuPathDB; HostDB:ENSG00000067082; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000158085; -. DR HOGENOM; CLU_002678_33_4_1; -. DR InParanoid; Q99612; -. DR OMA; RRVHKCH; -. DR OrthoDB; 3168417at2759; -. DR PhylomeDB; Q99612; -. DR TreeFam; TF350556; -. DR PathwayCommons; Q99612; -. DR SignaLink; Q99612; -. DR SIGNOR; Q99612; -. DR BioGRID-ORCS; 1316; 31 hits in 1184 CRISPR screens. DR ChiTaRS; KLF6; human. DR GeneWiki; KLF6; -. DR GenomeRNAi; 1316; -. DR Pharos; Q99612; Tbio. DR PRO; PR:Q99612; -. DR Proteomes; UP000005640; Chromosome 10. DR RNAct; Q99612; Protein. DR Bgee; ENSG00000067082; Expressed in nipple and 214 other cell types or tissues. DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0001650; C:fibrillar center; IDA:HPA. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR GO; GO:0005730; C:nucleolus; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005634; C:nucleus; TAS:UniProtKB. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. DR GO; GO:0030183; P:B cell differentiation; NAS:UniProtKB. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; TAS:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd21586; KLF6_N; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR23235:SF41; KRUEPPEL-LIKE FACTOR 6; 1. DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1. DR Pfam; PF00096; zf-C2H2; 3. DR SMART; SM00355; ZnF_C2H2; 3. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3. DR Genevisible; Q99612; HS. PE 1: Evidence at protein level; KW Activator; Alternative splicing; DNA-binding; Metal-binding; Nucleus; KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; KW Zinc-finger. FT CHAIN 1..283 FT /note="Krueppel-like factor 6" FT /id="PRO_0000047171" FT ZN_FING 200..224 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 230..254 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 260..282 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT REGION 106..198 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 62..70 FT /note="9aaTAD; inactive" FT /evidence="ECO:0000269|PubMed:31375868" FT COMPBIAS 106..123 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 136..157 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 227..283 FT /note="EKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALH FT MKRHL -> QCPRGPRRAAAGGRHCIAPALEGAGPGCTGCGQGRQILTSSDVFHQSIRS FT FWSSE (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_015715" FT VAR_SEQ 227..283 FT /note="EKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALH FT MKRHL -> VFPGLTTWPCT (in isoform 3)" FT /evidence="ECO:0000305" FT /id="VSP_045808" FT VARIANT 64 FT /note="W -> R (found in prostate cancer samples; somatic FT mutation; does not up-regulates CDKN1A in a p53-independent FT manner and significantly reduces cell proliferation; FT dbSNP:rs121909142)" FT /evidence="ECO:0000269|PubMed:11752579" FT /id="VAR_065136" FT VARIANT 116 FT /note="S -> P (found in prostate cancer samples; somatic FT mutation; does not up-regulates CDKN1A in a p53-independent FT manner and significantly reduces cell proliferation; FT dbSNP:rs121909139)" FT /evidence="ECO:0000269|PubMed:11752579" FT /id="VAR_065137" FT VARIANT 123 FT /note="A -> D (found in prostate cancer samples; somatic FT mutation; does not up-regulates CDKN1A in a p53-independent FT manner and significantly reduces cell proliferation; FT dbSNP:rs121909141)" FT /evidence="ECO:0000269|PubMed:11752579" FT /id="VAR_065138" FT VARIANT 155 FT /note="S -> R (found in gastric cancer samples; somatic FT mutation; dbSNP:rs121909144)" FT /evidence="ECO:0000269|PubMed:15824733" FT /id="VAR_065139" FT VARIANT 169 FT /note="L -> P (found in prostate cancer samples; somatic FT mutation; does not up-regulates CDKN1A in a p53-independent FT manner and significantly reduces cell proliferation; FT dbSNP:rs121909143)" FT /evidence="ECO:0000269|PubMed:11752579" FT /id="VAR_065140" FT VARIANT 172 FT /note="P -> T (found in gastric cancer samples; somatic FT mutation)" FT /evidence="ECO:0000269|PubMed:15824733" FT /id="VAR_065141" FT VARIANT 180 FT /note="S -> L (found in gastric cancer samples; somatic FT mutation; dbSNP:rs372338890)" FT /evidence="ECO:0000269|PubMed:15824733" FT /id="VAR_065142" FT VARIANT 198 FT /note="R -> K (found in gastric cancer samples; somatic FT mutation)" FT /evidence="ECO:0000269|PubMed:15824733" FT /id="VAR_065143" FT CONFLICT 276 FT /note="A -> G (in Ref. 3; AAC39929)" FT /evidence="ECO:0000305" SQ SEQUENCE 283 AA; 31865 MW; 84294A7E6D0A0231 CRC64; MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ EDLWTKIILA REKKEESELK ISSSPPEDTL ISPSFCYNLE TNSLNSDVSS ESSDSSEELS PTAKFTSDPI GEVLVSSGKL SSSVTSTPPS SPELSREPSQ LWGCVPGELP SPGKVRSGTS GKPGDKGNGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL //